Carla R Scanzello, MD, PhD

faculty photo
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Division of Rheumatology
University of Pennsylvania, School of Medicine
5th Floor White Bldg
3400 Spruce Street
&
CMC VA Medical Center
3900 Woodland Ave.
Bldg 21, Rm A215
Philadelphia, PA 19104
Office: 215-823-5800 x5666
Lab: 215-823-5800 x7777
Education:
B.S. (Biochemistry)
University of Delaware, Newark, DE, 1991.
M.D.
Temple University, School of Medicine, Philadelphia, PA, 2001.
Ph.D (Immunology & Microbiology)
Temple University, School of Medicine, Philadelphia, PA, 2001.
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Description of Research Expertise

My research focuses on the molecular stimuli and clinical consequences of synovial inflammation in early-stage osteoarthritis (OA) and meniscal injury. We have identified a set of inflammatory mediators that are over-expressed in patients with early-stage knee OA. These include sCD14, IL-15 and CCL19. We are now trying to understand how these mediators and downstream pathways impact OA development or progression after joint injury, with the goal of developing novel anti-inflammatory strategies.

Selected Publications

CR Scanzello, B McKeon, BH Swaim, E DiCarlo, EU Asomugha, V Kanda, A Nair, DM Lee, JC Richmond, JN Katz, MK Crow, SR Goldring. : Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship with symptoms. Arthritis & Rheumatism 63(2): 391-400, 2011.

Q Wang, AL Rozelle, CM Lepus, CR Scanzello, JJ Song, DM Larsen, JF Crish, G Bebek, SY Ritter, TM Lindstrom, I Hwang, HH Wong, L Punzi, A Encarnacion, M Shamloo, SB Goodman, T Wyss-Coray, SR Goldring, R Gobezie, MK Crow, VM Holers DM Lee, WH Robinson: Identification of a central role for complement in osteoarthritis. Nature Medicine 17(12): 1674-9, 2011.

A Nair, V Kanda, C Bush-Joseph, N Verma, S Chubinskaya, K Mikecz, TT Glant, A-M Malfait, MK Crow, GT Spear, A Finnegan, CR Scanzello: Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to TLR-4 and TLR-2 ligands via soluble CD14. Arthritis & Rheumatism 64(7): 2268-77, 2012.

CR Scanzello, AS Albert, E DiCarlo, KB Rajan, V Kanda, EU Asomugha, BH Swaim, JN Katz, SR Goldring, JC Richmond, B McKeon. : The influence of synovial inflammation and hyperplasia on symptomatic outcomes up to two-years post-operatively in patients undergoing partial meniscectomy. Osteoarthritis Cartilage 21(9): 1392-9, 2013.

Nair A, Gan J, Bush-Joseph C, Verma N, Tetreault MW, Saha K, Margulis A, Fogg L, Scanzello CR.: Synovial chemokine expression and relationship with knee symptoms in patients with meniscal tears. Osteoarthritis Cartilage 23(7): 1158-64, Jul 2015.

Scanzello Carla R: Chemokines and inflammation in osteoarthritis: Insights from patients and animal models. Journal of orthopaedic research 35(4): 735-739, Apr 2017.

Sambamurthy Nisha, Nguyen Vu, Smalley Ryan, Xiao Rui, Hankenson Kurt, Gan Justin, Miller Rachel E, Malfait Anne-Marie, Dodge George R, Scanzello Carla R: Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis. Journal of orthopaedic research 36(3): 864-87, March 2018.

Sambamurthy Nisha, Zhou Cheng, Nguyen Vu, Smalley Ryan, Hankenson Kurt D, Dodge George R, Scanzello Carla R: Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis. PloS One 13(11): e0206217, Nov 2018.

RE Miller, CR Scanzello, A-M Malfait: An Emerging Role for Toll-like Receptors at the Neuroimmune Interface in Osteoarthritis. Semin Immunopathol Page: doi: 10.1007/s00281-019-00762-3, Oct 2019.

S Kolasinski, T Neogi, M Hochberg, C Oatis, GH Guyatt, J Block, L Callahan, C Copenhaver, C Dodge, D Felson, K Geller, W Harvey, G Hawker, E Herzig, K Kwoh, A Nelson, J Samuels, C Scanzello, D White, B Wise, R Altman, D DiRenzo, J Fontanarosa, G Giradi, M Ishimori, D Misra, A Shah, A Shmagel, L Thoma, M Turgunbaev, A Turner, J Reston.: 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip and Knee. Arthritis & Rheumatology In Press, 2019.

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Last updated: 11/08/2019
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