Laura Vella, M.D., Ph.D.

faculty photo
Assistant Professor of Pediatrics (Infectious Diseases)
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
Education:
BA (Major: Biology, Minor: English)
University of Delaware, 2002.
PhD (Immunology)
University of Pittsburgh School of Medicine, 2008.
MD
University of Pittsburgh School of Medicine, 2010.
MSTR (Translational Research)
University of Pennsylvania, 2019.
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Selected Publications

Thomson Z, He Z, Swanson E, Henderson K, Phalen C, Zaim SR, Pebworth MP, Okada LY, Heubeck AT, Roll CR, Hernandez V, Weiss M, Genge PC, Reading J, Giles JR, Manne S, Dougherty J, Jasen CJ, Greenplate AR, Becker LA, Graybuck LT, Vasaikar SV, Szeto GL, Savage AK, Speake C, Buckner JH, Li X-j, Bumol TF, Wherry EJ, Torgerson TR, Vella LA,‡ Henrickson SE,‡ Skene PJ,†* Gustafson CE†* : Tri-modal single cell profiling reveals a novel pediatric CD8aa T cell subset and broad age-related molecular reprogramming across the T cell compartment. Nature Immunology 24: 1947-1959, November 2023.

Conrey PE, Denu L, O'Boyle KC, Rozich I, Green J, Maslanka J, Lubin JB, Duranova T, Haltzman BL, Gianchett L, Oldridge DA, De Luna N, Vella LA, Allman D, Spergel J, Tanes C, Bittinger K, Henrickson SE, Silverman MA: IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation. Science Immunology 8(83): eade2335, May 2023.

Wu VH, Nguyen S, Nordin JML, Joy J, Mampe F, del Rio Estrada PM, Torres-Ruiz F, González-Navarro M, Luna-Villalobos YA, Ávila-Ríos S, Reyes-Terán G, Tebas P, Montaner LJ, Bar KJ, Vella LA*, Betts MR*: Profound phenotypic and epigenetic heterogeneity of the HIV-1 infected CD4+ T cell reservoir. Nature Immunology 24(2): 359-370, December 2022.

Herati RS#*, Knorr DA#, Vella LA, Silva LV, Chilukuri L, Apostolidis SA, Huang AC, Muselman A, Manne S, Kuthuru O, Staupe RP, Adamski SA, Kannan S, Kurupati RK, Ertl HCJ, Wong JLL, Bournazos S, McGettigan S, Schuchter LM, Kotecha RR, Funt S, Voss MH, Motzer RJ, Lee CH, Bajorin DF, Mitchell TC, Ravetch JV, Wherry EJ*: PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine. Nature Immunology 23(8): 1183-1192, July 2022.

Apostolidis SA, Sarkar A, Giannini HM, Goel RR, Mathew D, Suzuki A, Baxter AE, Greenplate AR, Alanio C, Abdel-Hakeem M, Oldridge DA, Giles JR, Wu JE, Chen Z, Huang YJ, Ajinkya, P, Manne S, Kuthuru O, Dougherty J, Weiderhold B, Weisman, AR, Ittner CAG, Dunbar D, Frank I, Huang AC, Vella LA, The UPenn COVID Processing Unit, Reilly JP, Hensley SE, Rauova L, Zhao L, Meyer NJ, Poncz M, Abrams CA, Wherry EJ: Signaling through FcgRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19. Frontiers in Immunology 13 : DOI: 10.3389/fimmu.2022.834988, March 2022 Notes: epub.

Downes KJ, Sharova A, Boge CLK, Vader D, Mitrou M, Hayes M, Galetaki DM, Gianchetti L, Vella LA, Li Y.: CMV infection and management among pediatric solid organ transplant recipients. Pediatr Transplant 26(3): e14220, January 2022.

Diorio C, Shraim R, Vella LA, Giles JR, Baxter AE, Oldridge DA, Canna SW, Henrickson SE, McNerney KO, Balamuth F, Burudpakdee C, Lee J, Leng T, Farrell A, Lambert MP, Sullivan KE, Wherry EJ, Teachey DT, Bassiri H, Behrens EM. : Proteomic Profiling of MIS-C Patients Reveals Heterogeneity Relating to Interferon Gamma Dysregulation and Vascular Endothelial Dysfunction. Nature Communications 12(1): doi: 10.1038/s41467-021-27544-6, December 2021.

Goel RR, Painter MM, Apostolidis SA, Mathew D, Meng W, Rosenfeld AM, Lundgreen KA, Reynaldi A, Khoury DS, Pattekar A, Gouma S, Kuri-Cervantes L, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Baxter AE, Oldridge DA, Giles JR, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Drapeau EM, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O; UPenn COVID Processing Unit‡, Frank I, Betts MR, Vella LA, Grifoni A, Weiskopf D, Sette A, Hensley SE, Davenport MP, Bates P, Luning Prak ET, Greenplate AR, Wherry EJ: mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern. Science 364(6572): DOI: 10.1126/science.abm0829, December 2021.

Vella LA, Rowley AH: Current Insights into the Pathophysiology of Multisystem Inflammatory Syndrome in Children. Current Pediatrics Reports 9(4): 83-92, October 2021.

Bange EM*, Han NA*, Wileyto P, Kim JY, Gouma S, Robinson J, Greenplate AR, Porterfield F, Owoyemi O, Naik K, Zhen C, Galantino M, Weisman AR, Ittner CAG, Kugler EM, Baxter AE, Oniyide O, Agyekum RS, Dunn TG, Jones TK, Giannini HM, Weirick ME, McAllister CM, Babady NE, Kumar A, Widman AJ, DeWolf S, Boutemine SR, Roberts C, Budzik KR, Tollett S, Wright C, Perloff T, Sun L, Mathew D, Giles JR, Oldridge DA, Wu JE, Alanio C, Adamski S, Garfall AL, Vella LA, Kerr SJ, Cohen JV, Oyer RA, Massa R, Maillard IP, The UPenn COVID Processing Unit, Maxwell KN, Reilly JP, Maslak PG, Vonderheide RH, Wolchok JD, Hensley SE, Wherry EJ, Meyer N, DeMichele AM, Vardhana SA*, Mamtani R*, Huang AC*: CD8 T cells compensate for impaired humoral immunity in COVID-19 patients with hematologic cancer. Nature Medicine 27(7): DOI: 10.21203/rs.3.rs-162289/v1, July 2021.

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Last updated: 11/03/2023
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