Ioannis I. Verginadis, M.Sc., Ph.D.

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Research Assistant Professor of Radiation Oncology
Senior Research Investigator, Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Department: Radiation Oncology

Contact information
University of Pennsylvania, Perelman School of Medicine
3400 Civic Center Blvd., Bldg 421
Smilow Center for Translational Research, 8th Floor, Room 8-155
Philadelphia, PA 19104
B.S. (Biology)
Department of Biological Applications and Technology, University of Ioannina, Ioannina, Greece., 2006.
Ph.D. (Physiology)
Ph.D. in Physiology, Department of Physiology, School of Medicine, University of Ioannina, Ioannina, Greece., 2011.
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Description of Research Expertise

Tumor microenvironment, Integrated Stress Response pathway, single-cell transcriptomics, cancer-associated fibroblasts, angiogenesis, radiation-induced gastrointestinal toxicity, radiation-induced heart disease, screening for small molecules as novel radiosensitizers/radioprotectors, FLASH radiotherapy, fibrosis, biomarkers of radiation-induced toxicity, radiation-induced inflammation

Selected Publications

Kyle Kim#, Michele M. Kim#, Giorgos Skoufos, Eric S. Diffenderfer, Seyyedeh Azar Oliaei Motlagh, Michail Kokkorakis, Ilektra Koliaki, George Morcos, Khayrullo Shoniyozov, Joanna Griffin, Artemis G. Hatzigeorgiou, James M. Metz, Alexander Lin, Steven J. Feigenberg, Keith A. Cengel, Bonnie Ky, Constantinos Koumenis, Ioannis I. Verginadis: FLASH proton radiotherapy mitigates inflammatory and fibrotic pathways and preserves cardiac function in a preclinical mouse model of radiation-induced heart disease. Int J Radiat Oncol Biol Phys February 2024 Notes: DOI: 10.1016/j.ijrobp.2024.01.224.

Zhen Lu, Eun-Ah Bae, Ioannis I Verginadis, Hongru Zhang, Christina Cho, Noreen McBrearty, Subin S George, J Alan Diehl, Constantinos Koumenis, Linda M Bradley, Serge Y Fuchs: Induction of the activating transcription factor-4 in the intratumoral CD8+ T cells sustains their viability and anti-tumor activities. Cancer Immunol Immunother April 2023 Notes: DOI: 10.1007/s00262-022-03286-2.

Frank Verhaegen, Karl T Butterworth, Anthony J Chalmers, Rob P Coppes, Dirk de Ruysscher, Sophie Dobiasch, John D Fenwick, Patrick V Granton, Stefan H J Heijmans, Mark A Hill, Constantinos Koumenis, Kirsten Lauber, Brian Marples, Katia Parodi, Lucas C G G Persoon, Nick Staut, Anna Subiel, Rianne D W Vaes, Stefan J van Hoof, Ioannis I Verginadis, Jan J Wilkens, Kaye J Williams, George D Wilson, Ludwig J Dubois: Roadmap for Precision preclinical x-ray radiation studies. Physics in Medicine and Biology March 2023 Notes: DOI: 10.1088/1361-6560/acaf45.

Clara Morral, Arshad Ayyaz, Hsuan-Cheng Kuo, Mardi Fink, Ioannis Verginadis, Andrea R Daniel, Danielle N Burner, Lucy M Driver, Sloane Satow, Stephanie Hasapis, Reem Ghinnagow, Lixia Luo, Yan Ma, Laura D Attardi, Costas Koumenis, Andy J Minn, Jeffrey L Wrana, Chang-Lung Lee, David G Kirsch: p53 promotes revival stem cells in the regenerating intestine after severe radiation injury. bioRxiv 2023.

Alexandra D. Dreyfuss, Anastasia Velalopoulou, Harris Avgousti, Brett I. Bell and Ioannis I. Verginadis: Preclinical models of radiation-induced cardiac toxicity: Potential mechanisms and biomarkers. Frontiers in Oncology October 2022 Notes: DOI: 10.3389/fonc.2022.920867.

Ioannis I. Verginadis, Harris Avgousti, James Monslow, Giorgos Skoufos, Frank Chinga, Kyle Kim, Nektaria Maria Leli, Ilias V. Karagounis, Brett I. Bell, Anastasia Velalopoulou, Carlo Salas Salinas, Victoria S. Wu, Yang Li, Jiangbin Ye, David A. Scott, Andrei L. Osterman, Arjun Sengupta, Aalim Weljie, Menggui Huang, Duo Zhang, Yi Fan, Enrico Radaelli, John W. Tobias, Jonathan Schug, Florian Rambow, Panagiotis Karras, Jean-Christophe Marine, Xiaowei Xu, Artemis G. Hatzigeorgiou, Sandra Ryeom, Alan J. Diehl, Serge Y. Fuchs, Ellen Puré, and Constantinos Koumenis.: An Integrated Stress Response Pathway activates Perivascular Cancer-Associated Fibroblasts to Drive Angiogenesis and Tumor Progression. Nature Cell Biology 24(6): 940-953, June 2022 Notes: DOI: 10.1038/s41556-022-00918-8.

Anahita Fathi Kazerooni, Sanjay Saxena, Erik Toorens, Danni Tu, Vishnu Bashyam, Hamed Akbari, Elizabeth Mamourian, Chiharu Sako, Costas Koumenis, Ioannis Verginadis, Ragini Verma, Russell T Shinohara, Arati S Desai, Robert A Lustig, Steven Brem, Suyash Mohan, Stephen J Bagley, Tapan Ganguly, Donald M O'Rourke, Spyridon Bakas, MacLean P Nasrallah, Christos Davatzikos : Clinical measures, radiomics, and genomics offer synergistic value in AI-based prediction of overall survival in patients with glioblastoma. Sci Rep 12(1), May 2022 Notes: DOI: 10.1038/s41598-022-12699-z.

Kerry C Roby, Allyson Lieberman, Bang-Jin Kim, Nicole Zaragoza Rodríguez, Jessica M Posimo, Tiffany Tsang, Ioannis I Verginadis, Ellen Puré, Donita C Brady, Constantinos Koumenis, Sandra Ryeom: Loss of p19Arf promotes fibroblast survival during leucine deprivation. Biol Open 11(2), February 2022 Notes: DOI: 10.1242/bio.058728.

Anastasia Velalopoulou, Ilias V Karagounis, Gwendolyn M Cramer, Michele M Kim, Giorgos Skoufos, Denisa Goia, Sarah Hagan, Ioannis I Verginadis, Khayrullo Shoniyozov, June Chiango, Michelle Cerullo, Kelley Varner, Lutian Yao, Ling Qin, Artemis G Hatzigeorgiou, Andy J Minn, Mary Putt, Matthew Lanza, Charles-Antoine Assenmacher, Enrico Radaelli, Jennifer Huck, Eric Diffenderfer, Lei Dong, James Metz, Constantinos Koumenis, Keith A Cengel, Amit Maity, Theresa M Busch.: FLASH proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response. Cancer Research 81(18): 4808-4821, September 2021 Notes: DOI: 10.1158/0008-5472.CAN-21-1500.

Michele M. Kim*, Ioannis I. Verginadis*, Denisa Goia, Allison Haertter, Khayrullo Shoniyozov, Wei Zou, Amit Maity, Theresa M. Busch, James Metz, Keith Cengel, Lei Dong, Costas Koumenis and Eric S. Diffenderfer. (*authors contributed equally to this study): Comparison of FLASH proton entrance and the spread-out Bragg peak dose regions in the sparing of mouse intestinal crypts and in a pancreatic tumor model. Cancers 13(16), August 2021 Notes: DOI: 10.3390/cancers13164244.

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Last updated: 03/16/2024
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