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Jorge Ivan Alvarez, PhD
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- Cell and Molecular Biology 5c
- Immunology 64
- Neuroscience e
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27 H412
Philadelphia, PA 19104
alvaj@vet.upenn.edu
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156 Search PubMed for articles
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21 8 BSc 19 (Microbiology) c
31 Universidad de los Andes, 1997.
21 8 PhD 28 (Microbiology and Immunology) c
20 UTHSCSA, 2007.
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Description of Research Expertise
4f2The Alvarez lab aims to define how CNS-intrinsic signals modulate immune cell function within different neurovascular niches. Upon infection or injury, the concerted actions of both systems create a balance between immune attack and tissue repair to promote healing. Nonetheless, during disease these protective mechanisms can be inadequate or aberrant, leading to persistent inflammation and long-term sequelae. As the first line of defense against chemicals and blood-borne molecules, the CNS barriers shield the delicate CNS microenvironment from the constant fluctuations of the periphery. They are composed of the blood-brain barrier (BBB) and the blood-meningeal barrier (BMB). However, their roles during neuroinflammation remain poorly characterized. Thus, my research program has been built to identify the mechanisms regulating the immune and neurovascular interactions initiating at the level of the CNS barriers and progressing to the perivascular space into the brain parenchyma. Currently, we use a combination of ex-vivo, in vitro, in vivo, and post-mortem approaches to determine the neurovascular mechanisms supporting the pathogenesis of neuroinflammatory diseases like multiple sclerosis (MS) and neuropsychiatric disorders.
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Selected Publications
136 Crockett, A. M., Kebir, H., Anderson, S. A., Jyonouchi, S., Romberg, N., Alvarez, J. I.: 22q11.2 Deletion-Associated Blood-Brain Barrier Permeability Potentiates Systemic Capillary Leak Syndrome Neurologic Features. 44(4): 87, 2024.117 Crockett, A. M., Kebir, H., Benallegue, N., Adelman, P., Gur, R. E., Sullivan, K., Anderson, S. A., Alvarez, J. I.: Immune status of the murine 22q11.2 deletion syndrome model. 53(1): e2249840, 2023.
1e3 Linnerbauer, M., Beyer, T., Nirschl, L., Farrenkopf, D., Lößlein, L., Vandrey, O., Peter, A., Tsaktanis, T., Kebir, H., Laplaud, D., Oellinger, R., Engleitner, T., Alvarez, J. I., Rad, R., Korn, T., Hemmer, B., Quintana, F. J., Rothhammer, V.: PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation. 14(1): 5555, 2023.
199 Li, C., Niu, C., Bi, H., Zhao, J., Ivan Alvarez, J., Yuan, F., Gai, X., Wei, L., Du, Y., Qiao, Y., Kebir, H., Xiao, Y., Yang, H.: Tibetan mineral-herbal medicine Zuotai alleviates the depressive-like behaviors in chronic restraint-stressed mice while regulating stress hormone, inflammation and monoamine. 14: 1098378, 2023.
c1 Benallegue, N., Kebir, H., Alvarez, J. I.: Neuroinflammation: Extinguishing a blaze of T cells. 311(1): 151-176, 2022.
e1 Koronyo-Hamaoui, M., Gaire, B. P., Frautschy, S. A., Alvarez, J. I.: Editorial: Role of Inflammation in Neurodegenerative Diseases. 13: 958487, 2022.
1c3 Fournier, A. P., Zandee, S., Charabati, M., Peelen, E., Tastet, O., Alvarez, J. I., Kebir, H., Bourbonnière, L., Larouche, S., Lahav, B., Klement, W., Tea, F., Bouthillier, A., Moumdjian, R., Cayrol, R., Duquette, P., Girard, M., Larochelle, C., Arbour, N., Prat, A.: CLMP Promotes Leukocyte Migration Across Brain Barriers in Multiple Sclerosis. 9(6), 2022.
17b Benallegue, N., Kebir, H., Kapoor, R., Crockett, A., Li, C., Cheslow, L., Abdel-Hakeem, M. S., Gesualdi, J., Miller, M. C., Wherry, E. J., Church, M. E., Blanco, M. A., Alvarez, J. I.: The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation. 144(6): 1670-1683, 2021.
193 Crockett, A. M., Ryan, S. K., Vásquez, A. H., Canning, C., Kanyuch, N., Kebir, H., Ceja, G., Gesualdi, J., Zackai, E., McDonald-McGinn, D., Viaene, A., Kapoor, R., Benallegue, N., Gur, R., Anderson, S. A., Alvarez, J. I.: Disruption of the blood-brain barrier in 22q11.2 deletion syndrome. 144(5): 1351-1360, 2021.
17e Church, M. E., Ceja, G., McGeehan, M., Miller, M. C., Farias, P., Sánchez, M. D., Swain, G. P., Assenmacher, C. A., Stopa, E. G., Vite, C. H., Bar-Or, A., Alvarez, J. I.: Meningeal B Cell Clusters Correlate with Submeningeal Pathology in a Natural Model of Multiple Sclerosis. 207(1): 44-54, 2021.
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