Zev Binder, M.D., Ph.D.

faculty photo
Research Assistant Professor of Neurosurgery
Scientific Director, Adult Brain Tumor Tissue Bank
Instructor, Department of Neurosurgery Perelman School of Medicine University of Pennsylvania
Department: Neurosurgery
Graduate Group Affiliations

Contact information
3600 Hamilton Walk
Stemmler Hall
Philadelphia, PA 19104
Office: 215-573-0837
Education:
BS (Biochemistry)
University of California, Davis, 2004.
M.D.
Pennsylvania State University College of Medicine, 2008.
Ph.D. (Chemical and Biomolecular Engineering)
Johns Hopkins University, 2014.
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Description of Research Expertise

Dr. Binder is a Research Assistant Professor, working with Dr. O'Rourke since 2015. He received a B.S. degree in Biochemistry from the University of California at Davis, an M.D. from Pennsylvania State University, and a Ph.D. in Chemical and Biomolecular Engineering from Johns Hopkins University. Dr. Binder's research focuses on translational GBM research with an emphasis on immuno-oncology. He also works on GBM model development, characterization, and incorporation into the ongoing research.

Selected Publications

Jingxian Liu, Song Cao, Kathleen J. Imbach, Marina A. Gritsenko, Tung-Shing M. Lih, Jennifer E. Kyle*, Tomer M. Yaron*, Zev A. Binder*, Yize Li*, Ilya Strunilin*, Yi-Ting Wang*, Chia-Feng Tsai*, Weiping Ma*, Lijun Chen*, Natalie M. Clark, Andrew Shinkle, Nataly Naser Al Deen, Wagma Caravan, Andrew Houston, Faria A. Simin, Matthew A. Wyczalkowski, Liang-Bo Wang, Erik Storrs, Siqi Chen, Ritvik Illindala, Yuping D. Li, Reyka G. Jayasinghe, Dmitry Rykunov, Sandra L. Cottingham, Rosalie K. Chu, Karl K. Weitz, Ronald J. Moore, Tyler Sagendorf, Vladislav A. Petyuk, Michael Nestor, Lisa M. Bramer, Kelly G. Stratton, Athena A. Schepmoes, Sneha P. Couvillion, Josie Eder, Young-Mo Kim, Yuqian Gao, Thomas L. Fillmore, Rui Zhao, Matthew E. Monroe, Austin N. Southard-Smith, Yang E. Li, Rita Jui-Hsien Lu, Jared L. Johnson, Maciej Wiznerowicz, Galen Hostetter, Chelsea J. Newton, Karen A. Ketchum, Ratna R. Thangudu, Jill S. Barnholtz-Sloan, Pei Wang, David Fenyö, Eunkyung An, Mathangi Thiagarajan, Ana I. Robles, D. R. Mani, Richard D. Smith, Eduard Porta-Pardo, Lewis C. Cantley, Antonio Iavarone, Feng Chen, Mehdi Mesri, MacLean P. Nasrallah, Hui Zhang, Adam C. Resnick, Milan G. Chheda, Karin D. Rodland, Tao Liu, Li Ding, Philadelphia Coalition for a Cure, Clinical Proteomic Tumor Analysis Consortium: Multi-scale signaling and tumor evolution in high-grade gliomas. Cancer Cell May 2024 Notes: * equal contribution.

Stephen J. Bagley, Meghan Logun, Joseph A. Fraietta, Xin Wang, Arati S. Desai, Linda J. Bagley, Danuta Jarocha, Rene Martins, Eileen Maloney, Lester Lledo, Carly Stein, Amy Marshall, Rachel Leskowitz, Julie K. Jadlowsky, Shannon Christensen, Bike Su Oner, Gabriela Plesa, Andrea Brennan, Vanessa Gonzalez, Fang Chen, Yusha Sun, Whitney Gladney, David Barrett, Ali Nabavizadeh, MacLean P. Nasrallah, Wei-Ting Hwang, Guo-Li Ming, Hongjun Song, Donald L. Siegel, Carl H. June, Elizabeth O. Hexner,Zev A. Binder*, Donald M. O'Rourke*: Intrathecal Bivalent CAR T Cells Targeting EGFR and IL13Rα2 in Recurrent Glioblastoma: Phase 1 Trial Interim Results. Nature Medicine March 2024 Notes: * co-senior author.

Jun Guo, Anahita Fathi Kazerooni, Erik Toorens, Hamed Akbari, Fanyang Yu, Chiharu Sako, Elizabeth Mamourian, Russell T. Shinohara, Constantinos Koumenis, Stephen J. Bagley, Jennifer J. D. Morrissette, Zev A. Binder, Steven Brem, Suyash Mohan, Robert A. Lustig, Donald M. O’Rourke, Tapan Ganguly, Spyridon Bakas, MacLean P. Nasrallah & Christos Davatzikos: Integrating imaging and genomic data for the discovery of distinct glioblastoma subtypes: a joint learning approach. Scientific Reports 14, February 2024.

Stephen J. Bagley*, Zev A. Binder*, Lamia Lamrani*, Eliana Marinari, Arati S. Desai, MacLean P. Nasrallah, Eileen Maloney, Steven Brem, Robert A. Lustig, Goldie Kurtz, Michelle Alonso-Basanta, Pierre-Emmanuel Bonté, Christel Goudot, Wilfrid Richer, Eliane Piaggio, Shawn Kothari, Lea Guyonnet, Coralie L. Guerin, Joshua J. Waterfall, Suyash Mohan, Wei-Ting Hwang, Oliver Y. Tang, Meghan Logun, Meghna Bhattacharyya, Kelly Markowitz, Devora Delman, Amy Marshall, E. John Wherry, Sebastian Amigorena, Gregory L. Beatty, Jennifer L. Brogdon, Elizabeth Hexner, Denis Migliorini, Cecile Alanio & Donald M. O’Rourke: Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial. Nature Cancer Jan 2024 Notes: * co-first author.

Elinor Willis, Jillian Verrelle, Esha Banerjee, Charles-Antoine Assenmacher, James C. Tarrant, Nicholas Skuli, Moriah L. Jacobson, Donald M. O’Rouke, Zev A. Binder*, and Enrico Radaelli1*: Humanization with CD34-positive hematopoietic stem cells in NOG-EXL mice results in improved long-term survival and less severe myeloid cell hyperactivation phenotype relative to NSG-SGM3 mice. Veterinary Pathology January 2024 Notes: * co-senior author.

David E. Reynolds, Yusha Sun, Xin Wang, Phoebe Vallapureddy, Jianhua Lim, Menghan Pan, Andres Fernandez Del Castillo, Jonathan C. T. Carlson, Mark A. Sellmyer, Maclean Nasrallah, Zev Binder, Donald M. O’Rourke, Guo-li Ming, Hongjun Song, and Jina Ko: Live Organoid Cyclic Imaging. Advanced Science January 2024.

Fanyang Yu, Jun Guo, Anahita Fathi Kazerooni, Hamed Akbari, Erik Toorens, Chiharu Sako, Elizabeth Mamourian, Stephen J Bagley, Zev Binder, Robert A Lustig, Steven Brem, Donald M O'Rourke, Tapan Ganguly, Spyridon Bakas, MacLean P Nasrallah, Pratik Chaudhari, Christos Davatzikos: NIMG-66. RADIOGENOMICS-BASED HETEROGENEITY ANALYSIS OF GLIOBLASTOMA REVEALS MR IMAGING PHENOTYPICAL CHARACTERIZATION OF EGFR MUTATIONS. Neuro-Oncology 25(Supplement_5), November 2023 Notes: Society for Neuro-Oncology Annual Meeting 2023.

Jesse L Rodriguez, Tyler E Papp, Logan Zhang, Kelly A Hicks, Hamideh Parhiz, Zev Binder and Donald O’Rourke: mRNA LNP vaccination with the tumor-specific antigen EGFRvIII bolsters CAR T cell activity in vivo Journal for ImmunoTherapy of Cancer November 2023 Notes: Society for Immunotherapy of Cancer Annual Meeting 2023.

Nannan Li, Jesse Rodriguez, Zev Binder, Donald O’Rourke: Dual antigen targeting CAR T cells armored with a dominant-negative TGF-β Receptor II enhance antitumor potency by overcoming TGF-β immunosuppression in GBM. Journal for ImmunoTherapy of Cancer November 2023 Notes: Society for Immunotherapy of Cancer Annual Meeting 2023.

Meghan Logun, Stephen J Bagley, Xin Wang, Daniel Zhang, Yusha Sun, Guo-li Ming, Ali Nabavizadeh, Amy Marshall, Eileen Maloney, Wei-Ting Hwang, Joseph Fraietta, Vanessa Gonzalez, Arati Desai, Linda Bagley, Elizabeth Hexner, MacLean P Nasrallah, Hongjun Song, Zev Binder, Donald M O'Rourke: CTIM-40. EARLY RADIOGRAPHIC RESPONSE AND ENGRAFTMENT OF PHASE I FIRST-IN-HUMAN BICISTRONIC CAR T CELLS CORRELATE WITH REAL-TIME AUTOLOGOUS GBM ORGANOID CYTOLYSIS. Neuro-Oncology 25(Supplement_5), November 2023 Notes: Society for Neuro-Oncology Annual Meeting 2023.

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Last updated: 05/07/2024
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