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Guo-li Ming, M.D., Ph.D.

Guo-li Ming, M.D., Ph.D.

faculty photo
Professor of Neuroscience
Department: Neuroscience
Graduate Group Affiliations

Contact information
Perelman School of Medicine
Department of Neuroscience
415 Curie Blvd
Clinical Research Building room 111A
Philadelphia, PA 19104
Office: 2157466686
Education:
M.D. (Medicine (OBGYN))
Tongji Medical University, P. R. China, 1994.
Ph.D. (Biology)
University of California at San Diego, California, 2002.
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Description of Research Expertise

Neurobiology of mental disorders
Neural development
human induced pluripotent stem cells
cell signalling
cell and molecular biology

Research in Dr. Guo-li Ming's laboratory centers on understanding molecular mechanisms underlying neurodevelopment and how its dysregulation may contribute to developmental neurological disorders. The lab uses a combination of experimental approaches that include molecular biology, biochemistry, mouse genetics, imaging, electrophysiology, electron microscopy, optogenetic manipulations, next generation sequencing, and behavioral tests to study neural development. We have been using two complementary model systems, the genetically modified mouse system and patient-derived induced pluripotent stem cell (iPSC) model systems. We are interested in addressing a broad range of topics, from neuronal migration, axon and dendritic development, synapse formation, circuitry integration to plasticity of developing neurons, and functional regeneration of mature neurons.

Selected Publications

Oh Yohan, Zhang Feiran, Wang Yaqing, Lee Emily M, Choi In Young, Lim Hotae, Mirakhori Fahimeh, Li Ronghua, Huang Luoxiu, Xu Tianlei, Wu Hao, Li Cui, Qin Cheng-Feng, Wen Zhexing, Wu Qing-Feng, Tang Hengli, Xu Zhiheng, Jin Peng, Song Hongjun, Ming Guo-Li, Lee Gabsang: Zika virus directly infects peripheral neurons and induces cell death. Nature neuroscience Jul 2017.

Kang Eunchai, Jiang Danye, Ryu Yun Kyoung, Lim Sanghee, Kwak Minhye, Gray Christy D, Xu Michael, Choi Jun H, Junn Sue, Kim Jieun, Xu Jing, Schaefer Michele, Johns Roger A, Song Hongjun, Ming Guo-Li, Mintz C David: Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway. PLoS biology 15(7): e2001246, Jul 2017.

Ming Guo-Li, Song Hongjun, Tang Hengli: Racing to Uncover the Link between Zika Virus and Microcephaly. Cell stem cell 20(6): 749-753, Jun 2017.

Wen Zhexing, Song Hongjun, Ming Guo-Li: How does Zika virus cause microcephaly? Genes & development 31(9): 849-861, May 2017.

Li Xiaowei, Tzeng Stephany Y, Zamboni Camila Gadens, Koliatsos Vassilis E, Ming Guo-Li, Green Jordan J, Mao Hai-Quan: Enhancing oligodendrocyte differentiation by transient transcription activation via DNA nanoparticle-mediated transfection. Acta biomaterialia 54: 249-258, May 2017.

Wan Jun, Su Yijing, Song Qifeng, Tung Brian, Oyinlade Olutobi, Liu Sheng, Ying Mingyao, Ming Guo-Li, Song Hongjun, Qian Jiang, Zhu Heng, Xia Shuli: Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration. eLife 6, May 2017.

Weng Yi-Lan, An Ran, Cassin Jessica, Joseph Jessica, Mi Ruifa, Wang Chen, Zhong Chun, Jin Seung-Gi, Pfeifer Gerd P, Bellacosa Alfonso, Dong Xinzhong, Hoke Ahmet, He Zhigang, Song Hongjun, Ming Guo-Li: An Intrinsic Epigenetic Barrier for Functional Axon Regeneration. Neuron 94(2): 337-346.e6, Apr 2017.

Qian Kun, Huang Hailong, Peterson Andrew, Hu Baoyang, Maragakis Nicholas J, Ming Guo-Li, Chen Hong, Zhang Su-Chun: Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo. Stem cell reports 8(4): 843-855, Apr 2017.

Beckervordersandforth Ruth, Ebert Birgit, Schäffner Iris, Moss Jonathan, Fiebig Christian, Shin Jaehoon, Moore Darcie L, Ghosh Laboni, Trinchero Mariela F, Stockburger Carola, Friedland Kristina, Steib Kathrin, von Wittgenstein Julia, Keiner Silke, Redecker Christoph, Hölter Sabine M, Xiang Wei, Wurst Wolfgang, Jagasia Ravi, Schinder Alejandro F, Ming Guo-Li, Toni Nicolas, Jessberger Sebastian, Song Hongjun, Lie D Chichung: Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis. Neuron 93(6): 1518, Mar 2017.

Qian Xuyu, Nguyen Ha Nam, Jacob Fadi, Song Hongjun, Ming Guo-Li: Using brain organoids to understand Zika virus-induced microcephaly. Development (Cambridge, England) 144(6): 952-957, Mar 2017.

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Last updated: 09/11/2017
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