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Sokratis Apostolidis, MD
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Assistant Professor of Medicine (Rheumatology)
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Department: Medicine
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Graduate Group Affiliations
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Contact information
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421 Curie Blvd
40 BRB II/III, Floor 3, Room 310
Philadelphia, PA 19104
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40 BRB II/III, Floor 3, Room 310
Philadelphia, PA 19104
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Education:
21 7 MD 15 (Medicine) c
4f University of Athens School of Health Sciences, Greece, 2007.
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Permanent link21 7 MD 15 (Medicine) c
4f University of Athens School of Health Sciences, Greece, 2007.
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28 Autoimmunity after immunotherapy
23 Systemic Lupus Erythematosus
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2b Cancer Immunology and Immunotherapy
37 Precision Immunology and Measuring Immune Health
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Description of Clinical Expertise
1d Rheumatology28 Autoimmunity after immunotherapy
23 Systemic Lupus Erythematosus
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Description of Research Expertise
1d Autoimmunity2b Cancer Immunology and Immunotherapy
37 Precision Immunology and Measuring Immune Health
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39e Mark M Painter, Timothy S Johnston, Kendall A Lundgreen, Jefferson J S Santos, Juliana S Qin, Rishi R Goel, Sokratis A Apostolidis, Divij Mathew, Bria Fulmer, Justine C Williams, Michelle L McKeague, Ajinkya Pattekar, Ahmad Goode, Sean Nasta, Amy E Baxter, Josephine R Giles, Ashwin N Skelly, Laura E Felley, Maura McLaughlin, Joellen Weaver; Penn Medicine BioBank; Oliva Kuthuru, Jeanette Dougherty, Sharon Adamski, Sherea Long, Macy Kee, Cynthia Clendenin, Ricardo da Silva Antunes, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Alexander C Huang, Daniel J Rader, Scott E Hensley, Paul Bates, Allison R Greenplate, E John Wherry: Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection. Nat Immunol 24(10): 1711-1724, October 2023 Notes: doi: 10.1038/s41590-023-01613-y.
238 Herati RS, Knorr DA, Vella LA, Silva LV, Chilukuri L, Apostolidis SA, Huang AC, Muselman A, Manne S, Kuthuru O, Staupe RP, Adamski SA, Kannan S, Kurupati RK, Ertl HCJ, Wong JL, Bournazos S, McGettigan S, Schuchter LM, Kotecha RR, Funt SA, Voss MH, Motzer RJ, Lee CH, Bajorin DF, Mitchell TC, Ravetch JV, Wherry EJ: PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine. Nat Immunol 23(8): 1183-1192, August 2022 Notes: doi: 10.1038/s41590-022-01274-3.
a3 Apostolidis SA, Sarkar A, Giannini HM, Goel RR, Mathew D, Suzuki A, Baxter AE, Greenplate AR, Alanio C, Abdel-Hakeem M, 2a7 Sokratis A Apostolidis, Amrita Sarkar, Heather M Giannini, Rishi R Goel, Divij Mathew, Aae Suzuki, Amy E Baxter, Allison R Greenplate, Cécile Alanio, Mohamed Abdel-Hakeem, Oldridge DA, Giles JR, Wu JE, Chen Z, Huang YJ, Belman J, Pattekar A, Manne S, Kuthuru O, Dougherty J, Weiderhold B, Weisman AR, Ittner CAG, Gouma S, Dunbar D, Frank I, Huang AC, Vella LA; UPenn COVID Processing Unit, Reilly JP, Hensley SE, Rauova L, Zhao L, Meyer NJ, Poncz M, Abrams CS, Wherry EJ. : Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19. Front Immunol 13(834988), March 2022 Notes: doi: 10.3389/fimmu.2022.834988.
9c Goel RR, Painter MM, Apostolidis SA (co-first author), Mathew D, Meng W, Rosenfeld AM, Lundgreen KA, Reynaldi A, 7a Khoury DS, Pattekar A, Gouma S, Kuri-Cervantes L, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Baxter AE, 77 Oldridge DA, Giles JR, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Drapeau EM, Dougherty J, Long S, D'Andrea 7b K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O; UPenn COVID Processing Unit‡, Frank I, Betts MR, Vella 12a LA, Grifoni A, Weiskopf D, Sette A, Hensley SE, Davenport MP, Bates P, Luning Prak ET, Greenplate AR, Wherry EJ: mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern. Science 3(374): 6572, December 2021 Notes: doi: 10.1126/science.abm0829.
10f Apostolidis, SA, Kakara M, Painter MM, Goel RR, Mathew D, Lenzi K, Rezk A, Patterson KR, Espinoza DA, Kadri JC, Markowitz DM, E Markowitz C, Mexhitaj I, Jacobs D, Babb A, Betts MR, Prak ETL, Weiskopf D, Grifoni A, Lundgreen KA, 147 Gouma S, Sette A, Bates P, Hensley SE, Greenplate AR, Wherry EJ, Li R, Bar-Or A.: Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy. Nat Med 27(11): 1990-2001, November 2021 Notes: doi: 10.1038/s41591-021-01507-2.
2f1 Chang SE, Feng A, Meng W, Apostolidis SA (co-first author), Mack E, Artandi M, Barman L, Bennett K, Chakraborty S, Chang I, Cheung P, Chinthrajah S, Dhingra S, Do E, Finck A, Gaano A, Geßner R, Giannini HM, Gonzalez J, Greib S, Gündisch M, Hsu AR, Kuo A, Manohar M, Mao R, Neeli I, Neubauer A, Oniyide O, Powell AE, Puri R, Renz H, Schapiro J, Weidenbacher PA, Wittman R, Ahuja N, Chung HR, Jagannathan P, James JA, Kim PS, Meyer NJ, Nadeau KC, Radic M, Robinson WH, Singh U, Wang TT, Wherry EJ, Skevaki C, Luning Prak ET, Utz PJ: New-onset IgG autoantibodies in hospitalized patients with COVID-19. Nat Commun 12(1): 5417, September 2021 Notes: doi: 10.1038/s41467-021-25509-3.
104 Goel RR, Apostolidis SA, Painter MM, Mathew D, Pattekar A, Kuthuru O, Gouma S, Hicks P, Meng W, Rosenfeld AM, Dysinger S, Lundgreen KA, Kuri-Cervantes L, Adamski S, Hicks A, Korte S, Oldridge DA, Baxter AE, Giles JR, 17a Weirick ME, McAllister CM, Dougherty J, Long S, D'Andrea K, Hamilton JT, Betts MR, Luning Prak ET, Bates P, Hensley SE, Greenplate AR, Wherry EJ.: Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination. Sci Immunol 6(58): eabi6950, April 2021 Notes: doi: 10.1126/sciimmunol.abi6950.
159 Apostolidis SA, Stifano G, Tabib T, Rice LM, Morse CM, Kahaleh B, Lafyatis R.: Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin. Front Immunol 9(2191), October 2018 Notes: doi: 10.3389/fimmu.2018.02191.
145 Apostolidis SA, Rodríguez-Rodríguez N, Suárez-Fueyo A, Dioufa N, Ozcan E, Crispín JC, Tsokos MG, Tsokos GC.: Phosphatase PP2A is requisite for the function of regulatory T cells. Nature Immunology 17(5): 478-9, May 2016 Notes: doi: 10.1038/ni.3390.
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Selected Publications
dd Sokratis A. Apostolidis, Michela Locci: SLE B cells take an extrafollicular detour after mRNA vaccination. Nature Immunology 26: 4-6, December 2024.39e Mark M Painter, Timothy S Johnston, Kendall A Lundgreen, Jefferson J S Santos, Juliana S Qin, Rishi R Goel, Sokratis A Apostolidis, Divij Mathew, Bria Fulmer, Justine C Williams, Michelle L McKeague, Ajinkya Pattekar, Ahmad Goode, Sean Nasta, Amy E Baxter, Josephine R Giles, Ashwin N Skelly, Laura E Felley, Maura McLaughlin, Joellen Weaver; Penn Medicine BioBank; Oliva Kuthuru, Jeanette Dougherty, Sharon Adamski, Sherea Long, Macy Kee, Cynthia Clendenin, Ricardo da Silva Antunes, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Alexander C Huang, Daniel J Rader, Scott E Hensley, Paul Bates, Allison R Greenplate, E John Wherry: Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection. Nat Immunol 24(10): 1711-1724, October 2023 Notes: doi: 10.1038/s41590-023-01613-y.
238 Herati RS, Knorr DA, Vella LA, Silva LV, Chilukuri L, Apostolidis SA, Huang AC, Muselman A, Manne S, Kuthuru O, Staupe RP, Adamski SA, Kannan S, Kurupati RK, Ertl HCJ, Wong JL, Bournazos S, McGettigan S, Schuchter LM, Kotecha RR, Funt SA, Voss MH, Motzer RJ, Lee CH, Bajorin DF, Mitchell TC, Ravetch JV, Wherry EJ: PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine. Nat Immunol 23(8): 1183-1192, August 2022 Notes: doi: 10.1038/s41590-022-01274-3.
a3 Apostolidis SA, Sarkar A, Giannini HM, Goel RR, Mathew D, Suzuki A, Baxter AE, Greenplate AR, Alanio C, Abdel-Hakeem M, 2a7 Sokratis A Apostolidis, Amrita Sarkar, Heather M Giannini, Rishi R Goel, Divij Mathew, Aae Suzuki, Amy E Baxter, Allison R Greenplate, Cécile Alanio, Mohamed Abdel-Hakeem, Oldridge DA, Giles JR, Wu JE, Chen Z, Huang YJ, Belman J, Pattekar A, Manne S, Kuthuru O, Dougherty J, Weiderhold B, Weisman AR, Ittner CAG, Gouma S, Dunbar D, Frank I, Huang AC, Vella LA; UPenn COVID Processing Unit, Reilly JP, Hensley SE, Rauova L, Zhao L, Meyer NJ, Poncz M, Abrams CS, Wherry EJ. : Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19. Front Immunol 13(834988), March 2022 Notes: doi: 10.3389/fimmu.2022.834988.
9c Goel RR, Painter MM, Apostolidis SA (co-first author), Mathew D, Meng W, Rosenfeld AM, Lundgreen KA, Reynaldi A, 7a Khoury DS, Pattekar A, Gouma S, Kuri-Cervantes L, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Baxter AE, 77 Oldridge DA, Giles JR, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Drapeau EM, Dougherty J, Long S, D'Andrea 7b K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O; UPenn COVID Processing Unit‡, Frank I, Betts MR, Vella 12a LA, Grifoni A, Weiskopf D, Sette A, Hensley SE, Davenport MP, Bates P, Luning Prak ET, Greenplate AR, Wherry EJ: mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern. Science 3(374): 6572, December 2021 Notes: doi: 10.1126/science.abm0829.
10f Apostolidis, SA, Kakara M, Painter MM, Goel RR, Mathew D, Lenzi K, Rezk A, Patterson KR, Espinoza DA, Kadri JC, Markowitz DM, E Markowitz C, Mexhitaj I, Jacobs D, Babb A, Betts MR, Prak ETL, Weiskopf D, Grifoni A, Lundgreen KA, 147 Gouma S, Sette A, Bates P, Hensley SE, Greenplate AR, Wherry EJ, Li R, Bar-Or A.: Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy. Nat Med 27(11): 1990-2001, November 2021 Notes: doi: 10.1038/s41591-021-01507-2.
2f1 Chang SE, Feng A, Meng W, Apostolidis SA (co-first author), Mack E, Artandi M, Barman L, Bennett K, Chakraborty S, Chang I, Cheung P, Chinthrajah S, Dhingra S, Do E, Finck A, Gaano A, Geßner R, Giannini HM, Gonzalez J, Greib S, Gündisch M, Hsu AR, Kuo A, Manohar M, Mao R, Neeli I, Neubauer A, Oniyide O, Powell AE, Puri R, Renz H, Schapiro J, Weidenbacher PA, Wittman R, Ahuja N, Chung HR, Jagannathan P, James JA, Kim PS, Meyer NJ, Nadeau KC, Radic M, Robinson WH, Singh U, Wang TT, Wherry EJ, Skevaki C, Luning Prak ET, Utz PJ: New-onset IgG autoantibodies in hospitalized patients with COVID-19. Nat Commun 12(1): 5417, September 2021 Notes: doi: 10.1038/s41467-021-25509-3.
104 Goel RR, Apostolidis SA, Painter MM, Mathew D, Pattekar A, Kuthuru O, Gouma S, Hicks P, Meng W, Rosenfeld AM, Dysinger S, Lundgreen KA, Kuri-Cervantes L, Adamski S, Hicks A, Korte S, Oldridge DA, Baxter AE, Giles JR, 17a Weirick ME, McAllister CM, Dougherty J, Long S, D'Andrea K, Hamilton JT, Betts MR, Luning Prak ET, Bates P, Hensley SE, Greenplate AR, Wherry EJ.: Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination. Sci Immunol 6(58): eabi6950, April 2021 Notes: doi: 10.1126/sciimmunol.abi6950.
159 Apostolidis SA, Stifano G, Tabib T, Rice LM, Morse CM, Kahaleh B, Lafyatis R.: Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin. Front Immunol 9(2191), October 2018 Notes: doi: 10.3389/fimmu.2018.02191.
145 Apostolidis SA, Rodríguez-Rodríguez N, Suárez-Fueyo A, Dioufa N, Ozcan E, Crispín JC, Tsokos MG, Tsokos GC.: Phosphatase PP2A is requisite for the function of regulatory T cells. Nature Immunology 17(5): 478-9, May 2016 Notes: doi: 10.1038/ni.3390.
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