Kellie Ann Jurado, PhD
Stemmler Hall 474A
Philadelphia, PA 19123
B.S. (Biology, Microbiology)
New Mexico State University, 2011.
Ph.D. (Medical Sciences)
Harvard University, 2015.
Description of Research ExpertiseOur research group focuses on delineating disease pathogenesis of emerging viruses in order to uncover mechanisms of immune control. We primarily focus on emerging viral pathogens that present with unknown mechanisms of disease in the nervous system or placenta. Both regions of infection have interfaces (maternal-fetal and blood-brain) that provide extra protection to an essential organ or allogenic fetus. These interfaces necessitate a delicate balance of initiating an effective antiviral response while also ensuring that there is limited damage and tolerance is maintained. In order to achieve this balance, immune responses in these regions have evolved intricate layers of distinct control which are only now beginning to be fully appreciated.
As we are a newly formed group, we are currently recruiting motivated students and postdocs. Please feel free to contact us if interested!
Selected PublicationsVazquez C and Jurado KA: Playing Favorites: Integrin αvβ5 Mediates Preferential Zika Infection of Neural Stem Cells. Cell Stem Cell 26(2): 133-135, February 2020.
Orzalli MH, Smith A, Jurado KA, Iwasaki A, Garlick JA, Kagan JC: An antiviral branch of the IL-1 signaling pathway restricts immune-evasion virus replication. Mol. Cell. 71(5): 825-840, September 2018.
Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y: Type I interferons instigate fetal demise after Zika virus infection. Science Immunology 3(19): 1680, August 2018.
Jurado KA, Yockey LJ, Wong PW, Lee S, Hutner A, Iwasaki A: Antiviral CD8 T cells underlie Zika virus associated paralysis in mice. Nature Microbiology 3(2): 141-147, February 2018.
Jurado KA and Iwasaki A: Zika virus targets blood monocytes Nature Microbiology 2(11): 1460-1, November 2017.
Zhu S, DDing S, Wang P, Wei Z, Yang Y, Li H, Pan W, Wang G, Lei X, Yu H, Palm NW, Zoete M, Zheng Y, Zhao J, Chen H, Zhao Y, Jurado KA, Feng N, Shan L,, Kulger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA: Nlrp9b inflammasome recognized an restricts rotavirus infection in intestinal epithelial cells. Nature 546(7660): 667-670, June 2017.
Uraki R, Jurado KA, Hwang J, Szigeti-Buck K, Horvath TL, Iwasaki A, Fikrig E.: Fetal growth restriction caused by sexual transmission of Zika virus in mice. J. Infect Dis 215(11): 1720 - 1724, June 2017.
Wang W, Zhou J, Halambage Y, Jurado KA, Jamin A, Wang Y, Engelman A: Inhibition of HIV-1 maturation via small molecule targeting of the amino-terminal domain in the viral capsid protein. J. Virol. 13(91): e02155-16, April 2017.
Uraki R, Hwang J, Jurado KA, Householer S, Yockey L, Hastings A, Homer R, Iwasaki A, Fikrig E: Zika virus causes testicular atrophy. Science Advances 3(2): e1602899, February 2017.
Simoni MK, Jurado KA, Abrahams VM, Fikrig E, Guller S: Zika virus productively infects primary human placenta-specific macrophages. JCI Insight 1(13): e88461, August 2016.