Selected Publications

Bowman RL, Hennessey RC, Weiss TJ, Tallman DA, Crawford ER, Murphy BM, Webb A, Zhang S, La Perle KM, Burd CJ, Levine RL, Shain AH, Burd CE.: UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma. Life Science Alliance 4(9), 2021 Notes: DOI: 10.26508/lsa.202101135.

Xiao W, Chan A, Waarts MR, Mishra T, Liu Y, Cai SF, Yao J, Gao Q, Bowman RL, Koche RP, Csete IS, DelGaudio NL, Derkach A, Baik J, Yanis S, Famulare CA, Patel M, Arcila ME, Stahl M, Rampal RK, Tallman MS, Zhang Y, Dogan A, Goldberg AD, Roshal M, Levine RL.: Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1-mutated acute myeloid leukemia Blood Page: 1377-1391, 2021.

Klemm F, Möckl A, Salamero-Boix A, Alekseeva T, Schäffer A, Schulz M, Niesel K, Maas RR, Groth M, Elie BT, Bowman RL, Hegi ME, Daniel RT, Zeiner PS, Zinke J, Harter PN, Plate KH, Joyce JA, Sevenich L.: Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis. Nature Cancer 2(10), 2021 Notes: DOI: 10.1038/s43018-021-00254-0.

Maas RR, Soukup K, Klemm F, Kornete M, Bowman RL, Bedel R, Marie DN, Álvarez-Prado ÁF, Labes D, Wilson A, Brouland JP, Daniel RT, Hegi ME, Joyce JA.: An integrated pipeline for comprehensive analysis of immune cells in human brain tumor clinical samples. Nature Protocols 16(10): 4692-4721, 2021 Notes: DOI: 10.1038/s41596-021-00594-2.

Miles LA, Bowman RL, Merlinsky TR, Csete IS, Ooi AT, Durruthy-Durruthy R, Bowman M, Famulare C, Patel MA, Mendez P, Ainali C, Demaree B, Delley CL, Abate AR, Manivannan M, Sahu S, Goldberg AD, Bolton KL, Zehir A, Rampal R, Carroll MP, Meyer SE, Viny AD, Levine RL.: Single-cell mutation analysis of clonal evolution in myeloid malignancies. Nature 587(7834): 477-482, 2020 Notes: DOI: 10.1038/s41586-020-2864-x.

Akkari L, Bowman RL, Tessier J, Klemm F, Handgraaf SM, de Groot M, Quail DF, Tillard L, Gadiot J, Huse JT, Brandsma D, Westerga J, Watts C, Joyce JA.: Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance. Science Translational Medicine 12(552), 2020 Notes: DOI: 10.1126/scitranslmed.aaw7843.

Dumas AA, Pomella N, Rosser G, Guglielmi L, Vinel C, Millner TO, Rees J, Aley N, Sheer D, Wei J, Marisetty A, Heimberger AB, Bowman RL, Brandner S, Joyce JA, Marino S.: Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment. The EMBO Journal 39(15), 2020 Notes: DOI: 10.15252/embj.2019103790.

Klemm F, Maas RR, Bowman RL, Kornete M, Soukup K, Nassiri S, Brouland JP, Iacobuzio-Donahue CA, Brennan C, Tabar V, Gutin PH, Daniel RT, Hegi ME, Joyce JA.: Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells. Cell 181(7): 1643-1660, 2020.

Xiao W, Miles LA, Bowman RL, Durani V, Tian HS, DelGaudio NL, Mishra T, Zhu M, Zhang Y, Stump SE, Tallman MS, Levine RL, Cai SF.: A JAK2/IDH1-mutant MPN clone unmasked by ivosidenib in an AML patient without antecedent MPN. Blood Advances 4(23): 6034-6038, 2020.

Comen EA, Bowman RL, Selenica P, Kleppe M, Farnoud NR, Pareja F, Weigelt B, Hill CE, Alon A, Geyer FC, Akturk G, Reis-Filho JS, Norton L, Levine RL.: Evaluating Clonal Hematopoiesis in Tumor-Infiltrating Leukocytes in Breast Cancer and Secondary Hematologic Malignancies. Journal of the National Cancer Institute 112(1): 107-110, 2020 Notes: DOI: 10.1093/jnci/djz157.