Hajera Amatullah, PhD
Assistant Professor of Pharmacology
Affiliate Member, Center of Excellence in Environmental Toxicology
Member, PENN-CHOP Lung Biology Institute
Member, PENN Epigenetics Institute
Department: Systems Pharmacology and Translational Therapeutics
Graduate Group Affiliations
Contact information
421 Curie Blvd
Room 1312, Biomedical Research Building II/III
Philadelphia, PA 19104
Room 1312, Biomedical Research Building II/III
Philadelphia, PA 19104
Lab: 215-573-7795
Publications
Education:
BS (Biochemistry)
University of Toronto, 2009.
MPH (Occupational and Environmental Health)
University of Toronto, 2011.
PhD (Physiology)
University of Toronto, 2016.
Permanent linkBS (Biochemistry)
University of Toronto, 2009.
MPH (Occupational and Environmental Health)
University of Toronto, 2011.
PhD (Physiology)
University of Toronto, 2016.
Selected Publications
McAlpine CS, Kiss MG, Zuraikat FM, Cheek D, Schiroli G, Amatullah H, Bhatti MZ, Wong LP, Poller WC, Mindur JE, Chan CT, Janssen H, Downey J, Singh S, Sadreyev RI, Nahrendorf M, Jeffrey KL, Scadden DT, Naxerova K, St-Onge M, Swirski FK: Sleep exerts lasting effects on hematopoietic stem cell function and diversity. Journal of Experimental Medicine 219(11): e20220081, November 2022 Notes: https://pubmed.ncbi.nlm.nih.gov/36129517/Fraschilla I, Amatullah H, Rahman RU, Jeffrey KL: Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease. Cell Host & Microbe 30(10): 1370-1381, October 2022 Notes: https://pubmed.ncbi.nlm.nih.gov/36130593/
Gupta S, Amatullah H, Tsoporis JN, Wei K, Monteiro APT, Ektesabi AM, Varkouhi AK, Vaswani CM, Formosa A, Fabro AT, Batchu SN, Fjell C, Russell JA, Walley KR, Advani A, Parker TG, Marshall JC, Rocco PRM, Fairn GD, Mak TW, Dos Santos CC: DJ-1 binds to Rubicon to Impair LC-3 Associated Phagocytosis. Cell Death Differ 29(10): 2024-2033, October 2022 Notes: https://pubmed.ncbi.nlm.nih.gov/35641782/
dos Santos CC, Amatullah H, Vaswani CM, Maron-Gutierrez T, 7 Kim M, Mei SHJ, Szaszi K, Monteiro APT, Varkouhi AK, Herreroz R, Lorente JA, Marshall JC, Rocco PRM, Marsden P, Weiss DJ, Stewart DJ, Hu P, Liles WC.: Mesenchymal Stromal (stem) Cell (MSC) Therapy Modulates miR-193b-5p Expression to Attenuate Sepsis-Induced Acute Lung Injury. European Respiratory Journal 59(1): 2004216, Jan 2022 Notes: https://pubmed.ncbi.nlm.nih.gov/34112731/
Adiliaghdam F, Amatullah H, Digumarthi S, Saunders TL, Rahman RU, Wong LP, Sadreyev R, Droit L, Paquette J, Goyette P, Rioux JD, Hodin R, Mihindukulasuriya KA, Handley SA, Jeffrey KL: Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation. Sci Immunol 70(7): eabn6660, 2022 Notes: eabn6660.
Amatullah H, Fraschilla I, Digumarthi S, Huang J, Adiliaghdam F, Bonilla G, Wong LP, Rivard ME, Beauchamp C, Mercier V, Goyette P, Sadreyev RI, Anthony RM, Rioux JD, Jeffrey KL: Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases. Cell 18;185(17): 3232-3247, 2022.
Fraschilla I, Amatullah H, Jeffrey KL: One genome, many cell states: epigenetic control of innate immunity. Curr Opin Immunol 75: 102173, 2022.
Tsoporis JN, Drosatos IA, Gupta S, Amatullah H, Izhar S, dos Santos CC, Salpeas V, Rigopoulos AG, Toumpoulis IK, Triantafyllis AS, Sakadakis E, Kavantzas N, Marshall JC, Rizos IK, Parker TG.: Cytoprotective mechanisms of DJ-1: Implications in cardiac pathophysiology. Molecules 26(13): 3795, 2021.
Varkouhi AK, He X, Teixeira Monteiro AP, Amatullah H, Tsoporis JN, Gupta S, Ektesabi AM, Mei SHJ, Stewart DJ, Keating A, dos Santos CC: Immunophenotypic Characterization and Therapeutic Effects of Human Bone Marrow- and Umbilical Cord-derived Mesenchymal Stromal Cells in an Experimental Modelof Sepsis. Exp Cell Res Page: 112473, 2021.
Amatullah H, Maron-Gutierrez T, Shan Y, Gupta S, Tsoporis JN, Varkouhi, AK, Monteiro APT, He X, Yin J, Marshall JC, Rocco PRM, Kuebler WM, dos Santos CC: Protective function of DJ-1/PARK7 in Lipopolysaccharide and Ventilator-Induced Acute Lung Injury. Redox Biology 38: 101796, 2021.