Juan D Matute, MD
Assistant Professor of Pediatrics (Neonatology & Newborn Services)
Investigator, Children’s Hospital of Philadelphia Research Institute
Neonatologist, Newborn/Infant Intensive Care Unit (N/IICU), Children's Hospital of Philadelphia, University of Pennsylvania
Department: Pediatrics
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
3401 Civic Center Boulevard
Philadelphia, PA 19104
3401 Civic Center Boulevard
Philadelphia, PA 19104
Email:
matutelab@chop.edu
matutelab@chop.edu
Education:
MD (Medicine)
Universidad de Antioquia, Colombia, 2007.
Permanent linkMD (Medicine)
Universidad de Antioquia, Colombia, 2007.
Description of Clinical Expertise
Neonatal critical careNeonatal gastrointestinal tract
Neonatal inflammatory disorders
Clinical effects of early life host-microbiota in the intestine
Description of Research Expertise
Our team studies how early-life host-environment interactions, especially those involving diet and microbiota, affect the intestine under normal conditions, and how disturbances in these processes can contribute to intestinal inflammatory conditions like necrotizing enterocolitis and inflammatory bowel disease and systemic inflammatory diseases such as obesity.Key research themes encompass:
- Immune System Development and Function in Host Homeostasis
- Precision Immunology and Measuring Immune Health
- Mucosal Immunology
Selected Publications
Duan J, Sun Y, Matute JD*, Blumberg RS*: Characterizing CD4 Tcell differentiation in mouse small intestine using Tcell transfer, lamina propria preparation, and flow cytometry. STAR Protoc 4(3): 102485, August 2023 Notes: https://doi.org/10.1016/j.xpro.2023.102485.*Co-Senior Author.Duan J*, Matute JD*, Unger LW, Hanley T, Schnell A, Lin X, Krupka N, Griebel P, Lambden C, Sit B, Grootjans J, Pyzik M, Sommer F, Kaiser S, Falk-Paulsen M, Grasberger H, Kao JY, Fuhrer T, Li H, Paik D, Lee Y, Refetoff S, Glickman JN, Paton AW, Bry L, Paton JC, Sauer U, Macpherson AJ, Rosenstiel P, Kuchroo VK, Waldor MK, Huh JR, Kaser A, Blumberg RS: Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut. Immunity 56(5): 1115-1131.e9, May 2023 Notes: doi: 10.1016/j.immuni.2023.02.018. Epub 2023 Mar 13. *Co-First Author.
Matute JD, Duan J, Flak MB, Griebel P, Tascon-Arcila JA, Doms S, Hanley T, Antanaviciute A, Gundrum J, Mark Welch JL, Sit B, Abtahi S, Fuhler GM, Grootjans J, Tran F, Stengel ST, White JR, Krupka N, Haller D, Clare S, Lawley TD, Kaser A, Simmons A, Glickman JN, Bry L, Rosenstiel P, Borisy G, Waldor MK, Baines JF, Turner JR, Blumberg RS: Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila. J Exp Med 220(1): e20211938, January 2023 Notes: doi: 10.1084/jem.20211938. Epub 2022 Nov 22.
Aurora M, Keyes ML, Acosta JG, Swartz K, Lombay J, Ciaramitaro J, Rudnick A, Kelleher C, Hally S, Gee M, Madhavan V, Roumiantsev S, Cummings BM, Nelson BD, Lerou PH, Matute JD: Standardizing the Evaluation and Management of Necrotizing Enterocolitis in a Level IV NICU Pediatrics 150(4): e2022056616, October 2022 Notes: doi: 10.1542/peds.2022-056616.
Matute JD, Finander B, Pepin D, Ai X, Smith NP, Li JZ, Edlow AG, Villani AC, Lerou PH, Kalish BT: Single-cell immunophenotyping of the fetal immune response to maternal SARS-CoV-2 infection in late gestation. Pediatr Res 91(5): 1090-1098, April 2022 Notes: doi: 10.1038/s41390-021-01793-z. Epub 2021 Nov 8.
Mead BE, Hattori K, Levy L, Imada S, Goto N, Vukovic M, Sze D, Kummerlowe C, Matute JD, Duan J, Langer R, Blumberg RS, Ordovas-Montanes J, Yilmaz ÖH, Karp JM, Shalek AK: Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation. Nat Biomed Eng 6(4): 476-494, April 2022 Notes: doi: 10.1038/s41551-022-00863-9. Epub 2022 Mar 21.
Atyeo C, Pullen KM, Bordt EA, Fischinger S, Burke J, Michell A, Slein MD, Loos C, Shook LL, Boatin AA, Yockey LJ, Pepin D, Meinsohn MC, Nguyen NMP, Chauvin M, Roberts D, Goldfarb IT, Matute JD, James KE, Yonker LM, Bebell LM, Kaimal AJ, Gray KJ, Lauffenburger D, Edlow AG, Alter G: Compromised SARS-CoV-2-specific placental antibody transfer Cell 184(3): 628-642.e10, February 2021 Notes: doi: 10.1016/j.cell.2020.12.027. Epub 2020 Dec 23.
Keyes ML, Healy H, Sparger KA, Orth LE, Geha M, Roumiantsev S, Matute JD : Necrotizing Enterocolitis in Neonates With Hyperinsulinemic Hypoglycemia Treated With Diazoxide. Pediatrics 147(2): e20193202, February 2021 Notes: doi: 10.1542/peds.2019-3202.
Edlow AG, Li JZ, Collier AY, Atyeo C, James KE, Boatin AA, Gray KJ, Bordt EA, Shook LL, Yonker LM, Fasano A, Diouf K, Croul N, Devane S, Yockey LJ, Lima R, Shui J, Matute JD, Lerou PH, Akinwunmi BO, Schmidt A, Feldman J, Hauser BM, Caradonna TM, De la Flor D, D'Avino P, Regan J, Corry H, Coxen K, Fajnzylber J, Pepin D, Seaman MS, Barouch DH, Walker BD, Yu XG, Kaimal AJ, Roberts DJ, Alter G: Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic. JAMA Netw Open 3(12): e2030455, December 2020 Notes: doi: 10.1001/jamanetworkopen.2020.30455.
Lima R, Gootkind EF, De la Flor D, Yockey LJ, Bordt EA, D'Avino P, Ning S, Heath K, Harding K, Zois J, Park G, Hardcastle M, Grinke KA, Grimmel S, Davidson SP, Forde PJ, Hall KE, Neilan AM, Matute JD, Lerou PH, Fasano A, Shui JE, Edlow AG, Yonker LM : Establishment of a pediatric COVID-19 biorepository: unique considerations and opportunities for studying the impact of the COVID-19 pandemic on children. BMC Med Res Methodol 20(1): 228, September 2020 Notes: doi: 10.1186/s12874-020-01110-y.