Jeanmarie Perrone, MD

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Professor of Emergency Medicine at the Hospital of the University of Pennsylvania
Director, Division of Medical Toxicology and Addiction Medicine Initiatives, Department of Emergency Medicine, University of Pennsylvania
Founding Director , Penn Medicine Center for Addiction Medicine and Policy
Department: Emergency Medicine

Contact information
Department of Emergency Medicine
Ground Silverstein, Rm. 260
3400 Spruce Street
Philadelphia, PA 19104-4283
Office: 2156626698
B.S. (Microbiology)
University of Maryland, cum laude , 1985.
University of Maryland School of Medicine, 1990.
Post-Graduate Training
Emergency Medicine Residency , Thomas Jefferson University Hospital, Philadelphia, PA, 1990-1993.
Chief Resident, Emergency Medicine , Thomas Jefferson University Hospital, Philadelphia, PA, 1992-1993.
Medical Toxicology Fellowship, New York University/Bellevue/New York City Poison Center , 1993-1995.
American Board of Emergency Medicine, 1994.
American College of Medical Toxicology, 1997.
American Board of Emergency Medicine, 2004.
American College of Medical Toxicology, 2007.
American Board of Emergency Medicine, 2014.
American Board of Medical Toxicology, 2016.
American Board of Preventive Medicine: Addiction Medicine, 2019.
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Description of Research Expertise

Evaluating methods and policies to limit initiation of new opioid use and modify opioid misuse through interventions in the ED, regionally and nationally and creating pathways to treatment for patients with opioid use and other substance use disorders.

Description of Clinical Expertise

Enhancing medication safety and evaluation processes for high risk drugs in the ED and hospital.
Identifying and tracking trends in substance misuse, including the role of a Prescription Drug Monitoring Programs in improving opioid prescription safety.
Evaluation of possible adverse drug events associated with COVID-19 therapeutics.
Developing pathways and mitigating barriers to substance use treatment in the ED, via telehealth and community engagement.

Description of Other Expertise

Dr. Perrone is a Professor in the Department of Emergency Medicine at the University of Pennsylvania and Director of Addiction Medicine Initiatives from the ED. She has led numerous investigations in opioid stewardship and has advocated at the national level for emergency treatment for Opioid Use Disorder; her work has been featured in media including the New York Times, USA Today and National Public Radio.  She has served on the Philadelphia Mayor's Task Force, the PA State Opioid and PDMP task forces, the National Quality Forum, and advisory committees with the CDC and FDA to address judicious opioid prescribing. She has won numerous awards for education and mentorship, and is triple boarded in emergency medicine, medical toxicology and addiction medicine. She was inducted into the Penn Academy of Master Clinicians in 2014.

Selected Publications

Perrone J, Nelson LS: Medication Reconciliation for Controlled Substances-An Ideal Prescription-Drug Monitoring Program. New England Journal of Medicine 10, June 2012.

Herring AA, Perrone J, Nelson LS: Managing Opioid Withdrawal in the Emergency Department with Buprenorphine. Annals of Emerg Med. S0196-0644(18)31482-3, 2019.

Khatri UG, Viner K, Perrone J : Lethal Fentanyl and Cocaine Intoxication. New England Journal of Medicine 379(18): 1782, November 2018.

Clarke DL, Drobatz KJ, Korzekwa C, Nelson LS, Perrone J: Trends in Opioid Prescribing by Veterinarians in Pennsylvania. JAMA Network Open 2(1), Jan 2019.

Nelson LS, Perrone J.: Curbing the opioid epidemic in the United States: the Risk Evaluation and Mitigation Strategy (REMS). JAMA 308: 457-8, August 2012.

Perrone J, Weiner SG, Nelson LS: Stewarding Recovery From the Opioid Crisis Through Health System Initiatives. West Journal of Emerg Med 20(2): 198-202, Mar 2019.

Gugelmann Hallam M, Perrone Jeanmarie: Can prescription drug monitoring programs help limit opioid abuse? JAMA 306(20): 2258-9, Nov 2011.

Delgado MK, Shofer FS, Patel MS, Halpern S, Edwards C, Meisel ZF, Perrone J: Association between Electronic Medical Record Implementation of Default Opioid Prescription Quantities and Prescribing Behavior in Two Emergency Departments. Journal of General Internal Medicine 33(4): 409-411, Jan 2018.

Meisel ZF, Metlay JP, Sinnenberg L, Kilaru AS, Grossestreuer A, Barg FK, Shofer FS, Rhodes KV, Perrone J: A Randomized Trial Testing the Effect of Narrative Vignettes Versus Guideline Summaries on Provider Response to a Professional Organization Clinical Policy for Safe Opioid Prescribing. Annals of Emergency Medicine 68(6): 719-728, Dec 2016.

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Last updated: 07/16/2024
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