Department of Emergency Medicine

Department of Emergency Medicine Leadership & Faculty

David H. Jang, MD, MSc FACMT

faculty photo
Assistant Professor of Emergency Medicine at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Department: Emergency Medicine

Contact information
Department of Emergency Medicine Research Offices
Blockley Hall
423 Guardian Drive, Room 415
Philadelphia, PA 19104
Fax: 215-898-0868
Education:
BS (Magna cum laude with Department Honors, Psychology and Neuroscience)
University of Massachusetts-Amherst, 2001.
MD (Doctor of Medicine)
Tufts University School of Medicine, 2006.
MSc (Clinical Investigation)
New York University CTSI, 2013.
Post-Graduate Training
Emergency Medicine, University of Pittsburgh, Medical Center Pittsburgh, PA, 2006-2009.
Medical Toxicology, New York University School of Medicine, 2009-2011.
National Heart, Lung and Blood Institute and Emergency Medicine Career Development Program (K12), University of Pennsylvania, 2014-2016.
Certifications
United States Medical Licensing Exam Steps-I-II-III (PASS), 2003.
Advanced Trauma Support (Provider), 2006.
Advanced Cardiac Support (Provider), 2006.
Pediatric Advanced Life Support (Provider), 2006.
Medical Command Physician Pennsylvania Department of Health (Certification), 2007.
Advanced Cardiac Life Support (Instructor), 2008.
American Board of Emergency Medicine, 2012.
American Board of Emergency Medicine-Medical Toxicology Subspecialty , 2012.
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Description of Clinical Expertise

Emergency Medicine
University of Pittsburgh-2009

Medical Toxicology
New York University Medical Toxicology Fellowship-2011

Description of Other Expertise

Attending physician in the Division of Medical Toxicology and Critical Care Medicine (ResCCU)

Investigator, Penn Acute Care Collaboration (PARC), University of Pennsylvania
-Mitochondrial bioenergetics and dynamics in Emergency Medicine (MitoEM)

Description of Research Expertise

"Abnormal Mitochondrial Bioenergetic and Motility Signatures in Acute Care Illness in a Translational Approach from Bench to Bedside."

We are interested in studying the interaction of mitochondrial bioenergetics and dynamics in the area of acute care that includes sepsis and acute toxicological poisoning. We are currently taking a translational approach studying the mitochondria at a cell-based level all the way to the clinical setting actively enrolling patients with these acute medical conditions with the goal to develop better prognostic measures with the potential for mitochondrial-directed therapy.

We have both the latest model of the O2k-FluoRespirometer (O2k-Series H) and Seahorse XFe24 to study mitochondrial respiration in both intact and permeabilized cells. In addition we also study mitochondrial dynamics examining both mitochondrial motility and fusion/fission events with microscopy while also examining other mitochondrial functions such as membrane potential and ROS. Combining these elements we aim to better understand the complex interactions of both bioenergetics and motility in issues of acute care to better improve patient care and outcomes.

Our other area of interest includes research objectives relevant to the Office of Naval Research (ONR) where we leverage our expertise in this area to study cellular dysfunction in response to decompression injuries from the cell to clinical in a translational fashion. Our research in this area is also to study more effective treatments directed at the mitochondrial-level to improve function which will result in better safety and performance in naval personnel.

This work is supported by:
1. K08HL136858 (Jang, PI)
2. K12HL109005-Completed
3. Penn Acute Research Collaboration (PARC)

http://www.uphs.upenn.edu/surgery/Research/trauma/PARC/PARC_home.html

Selected Publications

Jang David H, Owiredu Shawn, Ranganathan Abhay, Eckmann David M: Acute decompression following simulated dive conditions alters mitochondrial respiration and motility. American journal of physiology. Cell physiology Aug 2018.

Jang David H, Orloski Clinton J, Owiredu Shawn, Shofer Frances S, Greenwood John C, Eckmann David M: Alterations in Mitochondrial Function in Blood Cells Obtained from Patients with Sepsis Presenting to an Emergency Department. Shock (Augusta, Ga.) Jun 2018.

Jang David H, Khatri Utsha G, Mudan Anita, Love Jennifer S, Owiredu Shawn, Eckmann David M: Translational Application of Measuring Mitochondrial Functions in Blood Cells Obtained from Patients with Acute Poisoning. Journal of medical toxicology : official journal of the American College of Medical Toxicology 14(2): 144-151, Jun 2018.

Jang David H, Khatri Utsha G, Shortal Brenna P, Kelly Matthew, Hardy Kevin, Lambert David S, Eckmann David M: Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive care medicine experimental 6(1): 4, Jan 2018.

Jang David H, Greenwood John C, Owiredu Shawn, Ranganathan Abhay, Eckmann David M: Mitochondrial networking in human blood cells with application in acute care illnesses. Mitochondrion Dec 2017.

Jang David H, Seeger Sarah C, Grady Martha E, Shofer Frances S, Eckmann David M: Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes. Biology open 6(12): 1831-1839, Dec 2017.

Jang David H, Kelly Matthew, Hardy Kevin, Lambert David S, Shofer Frances S, Eckmann David M: A preliminary study in the alterations of mitochondrial respiration in patients with carbon monoxide poisoning measured in blood cells. Clinical toxicology (Philadelphia, Pa.) 55(6): 579-584, Jul 2017.

Jang David H, Greenwood John C, Spyres Meghan B, Eckmann David M: Measurement of Mitochondrial Respiration and Motility in Acute Care: Sepsis, Trauma, and Poisoning. Journal of intensive care medicine 32(1): 86-94, Jan 2017.

Jang David H, Lampe Joshua W, Becker Lance B: The Potential Application of Mitochondrial Medicine in Toxicologic Poisoning. Journal of medical toxicology : official journal of the American College of Medical Toxicology 11(2): 201-7, Jun 2015.

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Last updated: 12/11/2018
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