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Douglas H. Smith, M.D.

Robert A. Groff Professor of Teaching and Research in Neurosurgery
Member , Mental Retardation Research Center, University of Pennsylvania
Member , Institute of Medicine and Engineering, University of Pennsylvania
Member , Functional Imaging Center, University of Pennsylvania
Director , Center for Brain Injury and Repair, University of Pennsylvania
Vice Chairman, Teaching and Research, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania
Department: Neurosurgery

Contact information
Department of Neurosurgery
3320 Smith Walk
Hayden Hall 105
Philadelphia, PA 19104-6316
Office: 215-573-3156
Fax: 215-573-3808
B.S. (Biology)
University of Connecticut, 1981.
M.D. (Medicine)
University of Noreste, 1986.
Post-Graduate Training
Postdoctoral Fellow in Molecular Biology and Protein Chemistry, University of Connecticut Health Center, 1986-1988.
Postdoctoral Fellow in Neuropharmacology and Trauma, University of Connecticut Health Center, 1989-1990.
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Description of Research Expertise

Douglas H. Smith, M.D. is the Director of the Center for Brain Injury and Repair and Professor of Neurosurgery at the Perelman School of Medicine, University of Pennsylvania. Penn's multidisciplined CBIR includes over twenty-five principal investigators and their laboratory staff collectively studying mechanisms, diagnosis and potential treatments of traumatic brain injury. Over the last 18 years, Dr. Smith has devoted his full-time efforts to neurotrauma research following completion of fellowships in both molecular biology and neurotrauma at the University of Connecticut. He has been an active member of the National Neurotrauma Society and currently serves as an officer. In addition, Dr. Smith is director of a multi-center NIH program grant on mild traumatic brain injury and he oversees an NIH training grant for brain injury research. His laboratory’s research interests include investigating the biomechanical effects of traumatic brain injury, imaging techniques to diagnose diffuse axonal injury, and the link between diffuse axonal injury and Alzheimer's disease. Dr Smith's laboratory has also engineered nervous tissue constructs that have been shown to repair spinal cord and nerve damage. These collective efforts have resulted in over 170 published reports.

To view the website for Dr. Smith’s lab, please click here

Click here to view the website for the Center for Brain Injury & Repair (CBIR).

Selected Publications

Dollé Jean-Pierre, Rodgers Jeffrey M, Browne Kevin D, Troxler Thomas, Gai Feng, Smith Douglas H: Newfound effect of N-acetylaspartate in preventing and reversing aggregation of amyloid-beta in vitro. Neurobiology of disease 117: 161-169, Sep 2018.

Zanier Elisa R, Bertani Ilaria, Sammali Eliana, Pischiutta Francesca, Chiaravalloti Maria Antonietta, Vegliante Gloria, Masone Antonio, Corbelli Alessandro, Smith Douglas H, Menon David K, Stocchetti Nino, Fiordaliso Fabio, De Simoni Maria-Grazia, Stewart William, Chiesa Roberto: Induction of a transmissible tau pathology by traumatic brain injury. Brain : a journal of neurology 141(9): 2685-2699, Sep 2018.

Knoll Renata M, Reinshagen Katherine L, Barber Samuel R, Ghanad Iman, Swanson Randel, Smith Douglas H, Abdullah Kalil G, Jung David H, Remenschneider Aaron K, Kozin Elliott D: Computed Tomography Atlas of the Porcine Temporal Bone and Skull Base: Anatomical Correlates for Traumatic Brain Injury Research. Journal of neurotrauma Jul 2018.

Smith Douglas H, Stewart William: Traumatic brain injury: a platform for studies in Aβ processing: Commentary on: "Rapid Aβ oligomer and protofibril accumulation in traumatic brain injury". Brain pathology (Zurich, Switzerland) 28(4): 463-465, Jul 2018.

Kovacs Gabor G, Xie Sharon X, Robinson John L, Lee Edward B, Smith Douglas H, Schuck Theresa, Lee Virginia M-Y, Trojanowski John Q: Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain. Acta neuropathologica communications 6(1): 50, Jun 2018.

DeWitt Douglas, Hawkins Bridget E, Dixon C Edward, Kochanek Patrick M, Armstead William M, Bass Cameron 'Dale', Bramlett Helen M, Büki András, Dietrich W Dalton, Ferguson Adam R, Hall Edward D, Hayes Ronald L, Hinds Ii Col Sidney R, LaPlaca Michelle, Long Joseph, Meaney David, Mondello Stefania, Noble-Haeusslein Linda, Poloyac Samuel M, Prough Donald S, Robertson Claudia S, Saatman Kathryn E, Shultz Sandy Richard, Shear Deborah A, Smith Douglas H, Valadka Alex, VandeVord Pamela J, Zhang Liying: Preclinical Testing of Therapies for Traumatic Brain Injury. Journal of neurotrauma May 2018.

Nagata Katsuhiro, Suto Yujin, Cognetti John, Browne Kevin D, Kumasaka Kenichiro, Johnson Victoria E, Kaplan Lewis, Marks Joshua, Smith Douglas H, Pascual Jose L: Early low-anticoagulant desulfated heparin after traumatic brain injury: Reduced brain edema and leukocyte mobilization is associated with improved watermaze learning ability weeks after injury. The journal of trauma and acute care surgery 84(5): 727-735, May 2018.

Johnson Victoria E, Weber Maura T, Xiao Rui, Cullen D Kacy, Meaney David F, Stewart William, Smith Douglas H: Mechanical disruption of the blood-brain barrier following experimental concussion. Acta neuropathologica 135(5): 711-726, May 2018.

Suto Yujin, Nagata Katsuhiro, Ahmed Syed M, Jacovides Christina, Browne Kevin D, Cognetti John, Weber Maura T, Johnson Victoria E, Leone Ryan, Kaplan Lewis J, Smith Douglas H, Pascual Jose L: A CONCOMITANT BONE FRACTURE DELAYS COGNITIVE RECOVERY FROM TRAUMATIC BRAIN INJURY. The journal of trauma and acute care surgery Apr 2018.

Dollé Jean-Pierre, Jaye Andrew, Anderson Stewart A, Ahmadzadeh Hossein, Shenoy Vivek B, Smith Douglas H: Newfound sex differences in axonal structure underlie differential outcomes from in vitro traumatic axonal injury. Experimental neurology 300: 121-134, Feb 2018.

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Last updated: 09/17/2018
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