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Katalin Kariko, PhD

Adjunct Associate Professor of Neurosurgery
Senior Research Investigator, Department of Neurosurgery
Department: Neurosurgery

Contact information
371b Stemmler Hall
Philadelphia, PA 19104
Office: 215-662-7927
Fax: 215-349-8157
Education:
BS (Biology)
József Attila University, Szeged, Hungary, 1978.
PHD (Biochemistry)
József Attila University, Szeged, Hungary, 1982.
Post-Graduate Training
Postdoctoral Fellow, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary, 1982-1985.
Postdoctoral Fellow, Department of Biochemistry, Temple University, Philadelphia, PA, 1985-1988.
Postdoctoral Fellow, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, 1988-1989.
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Description of Research Expertise

Messenger RNA-based gene therapy.
RNA-induced immune reactions.
Molecular bases of ischemic tolerance.
Treatment of brain ischemia

Selected Publications

Anderson B, Muramatsu H, Nallagatla SR, Bevilacqua P, Sansing L, Weissman D, Karikó K: Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation. Nucleic Acids Res 38: 5884-92, 2010.

Karikó, K., Muramatsu, H., Welsh, FA., Ludwig, J., Kato, H., Akira, S., Weissman, D.: Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Molecular Therapy 16: 1833-1840, 2008.

Karikó K, Buckstein M, Ni H, Weissman D.: Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23(2): 165-75, 2005.

Karikó K, Weissman D, Welsh FA: Inhibition of toll-like receptor and cytokine signaling--a unifying theme in ischemic tolerance. J Cereb Blood Flow Metab 24(11): 1288-304, 2004.

Karikó K, Ni H, Capodici J, Lamphier M, Weissman D.: mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 279(13): 12542-12550, 2004.

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Last updated: 03/18/2013
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