M. Sean Grady, M.D.

faculty photo
Professor of Neurosurgery
Attending Neurosurgeon, The Children's Hospital of Philadelphia
Medical Director, Penn Neuroscience Service Line, The Hospital of The University of Pennsy1vania
Attending Neurosurgeon, Penn Presbyterian Medical Center
Department: Neurosurgery

Contact information
Perelman Center for Advance Medicine
Department of Neurosurgery
3400 Civic Center Blvd.
15th Floor, South Tower
Clinical: 215.662.3483
Administrative: 215.349.8325
Philadelphia, PA 19104
Graduate Group Affiliations
B.A. (Biology)
University of California, San Diego, 1977.
Georgetown University School of Medicine, 1981.
Post-Graduate Training
Intern, Department of Surgery, University of Virginia, Charlottesville, 1981-1982.
Resident , Neurological Surgery, University of Virginia, 1982-1987.
American Board of Neurological Surgery, 1990.
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Description of Research Expertise

Dr. Grady's research interests include memory dysfunction resulting from traumatic brain injury and minimally invasive neurosurgery.

Description of Clinical Expertise

Dr. Grady was appointed the Charles Harrison Frazier Professor & Chairman of the Department of Neurosurgery at the Perelman School of Medicine, University of Pennsylvania in March 1999. He received his undergraduate degree from the University of California, San Diego and medical degree from Georgetown University School of Medicine. He trained in Neurological Surgery at the University of Virginia from 1981-1987 and was a faculty member at the University of Washington from 1987-1999. He is Board Certified by the American Board of Neurological Surgeons and is a fellow of the American College of Surgeons. Dr. Grady served as the Secretary for American Board of Neurological Surgery from 2004-2008, and was appointed Chairman of the ABNS from 2008-2009. Dr. Grady served as a member of the editorial board for the Journal of Neurosurgery from 2000-2010.

Dr. Grady's clinical focus is in the area of Cranial Base Tumors, Pituitary Tumors, Meningiomas, Schwannomas, Malignant Skull Base Tumors as well as Cerebrovascular Disorders, Aneurysms, AVM's. Dr. Grady and Dr. Bert O’Malley (Chairman, Department of Otorhinolaryngology - Head and Neck Surgery) are co-directors of the Cranial Base Center. In addition, Dr. Grady performs general neurosurgery procedures for herniated discs of the back and neck.

Description of Other Expertise

Philadelphia Magazine Top Doctors 2004-2011.

Selected Publications

Miranda S.P., Blue R., Parasher A.K., Lerner D.K., Glicksman J.T., Detchou D., Dimentberg R., Thurlow J., Lebold D., Hudgins J., Ebesutani D., Lee J.Y.K., Storm P.B., O’Malley B.W., Palmer J.N., Yoshor D., Adappa N.D., Grady M.S. World Neurosurgery. In Press. : Implementation of a streamlined care pathway to reduce cost and length-of-stay for patients undergoing endoscopic transsphenoidal pituitary surgery. World Neurosurgery 2023 Notes: In Press

Reed-Guy L, Miranda SP, Alexander TD, Biggiani G, Grady MS, Jones JA, Bagley SJ, Kumar P, O'Connor NR.: Serious Illness Communication Practices in Glioblastoma: An Institutional Perspective. J Palliat Med 2022.

Selden NR, Barbaro NM, Barrow DL, Batjer HH, Branch CL, Burchiel KJ, Byrne RW, Dacey RG, Day AL, Dempsey RJ, Derstine P, Friedman AH, Giannotta SL, Grady MS, Harsh GR, Harbaugh RE, Mapstone TB, Muraszko KM, Origitano TC, Orrico KO, Popp AJ, Sagher O, Selman WR, Zipfel GJ.: Neurosurgery residency and fellowship education in the United States: 2 decades of system development by the One Neurosurgery Summit organizations. J Neurosurg 136: 565-574, Aug 2021.

Fathy R, Kuan E, Lee JYK, Grady MS, Alonso-Basanta M, Palmer JN, Adappa ND, O'Malley BW Jr, Brant J.: Factors Associated with and Temporal Trends in the Use of Radiation Therapy for the Treatment of Pituitary Adenoma in the National Cancer Database. J Neurol Surg B Skull Base 82: 285-294, Jun 2021.

Arjun K. Parasher MD,David K. Lerner MD,Jordan T. Glicksman MD, MPH,Stephen P. Miranda MD,Ryan Dimentberg BS,Darren Ebesutani BA,Michael Kohanski MD, PhD,John Y. K. Lee MD, MSCE,Phillip B. Storm MD,Bert W. O'Malley Jr. MD,James N. Palmer MD,M. Sean Grady MD,Nithin D. Adappa MD: Drivers of In-Hospital Costs Following Endoscopic Transphenoidal Pituitary Surgery. Laryngoscope 2021.

Hamedani AG, Thibault DP, Revere KE, Lee JYK, Grady MS, Willis AW, Liu GT.: Trends in the Surgical Treatment of Pseudotumor Cerebri Syndrome in the United States. JAMA Netw Open 3: e2029669, Dec 2020.

Arjun K. Parasher, David K. Lerner, Jordan T. Glicksman, Stephen P. Miranda, Ryan Dimentberg, Darren Ebesutani, Michael Kohanski, John Y. K. Lee, Phillip B. Storm, Bert W. O'Malley Jr., James N. Palmer, M. Sean Grady, Nithin D. Adappa: Drivers of In-Hospital Costs Following Endoscopic Transphenoidal Pituitary Surgery. Laryngoscope 00: 1-5, Aug 2020 Notes: Wiley Online Library.

Haldar D, Glauser G, Winter E, Dimentberg R, Goodrich S, Shultz K, Grady MS, McClintock SD, Malhotra NR.: The Effect of Race on Short-Term Pituitary Tumor Outcomes. World Neurosurg 137: e447-e453, May 2020.

Malhotra NR, Piazza M, Demoor R, McClintock SD, Hamilton K, Sharma N, Osiemo B, Berger I, Hossain E, Borovskiy Y, Maloney E, Smith LJ, Grady MS.: Impact of Reduced Preincision Antibiotic Infusion Time on Surgical Site Infection Rates: A Retrospective Cohort Study. Ann Surg 271: 774-780, Apr 2020.

Sullivan PZ, Albayar A, Ramayya AG, McShane B, Marcotte P, Malhotra NR, Ali ZS, Chen HI, Janjua MB, Saifi C, Schuster J, Grady MS, Jones J, Ozturk AK.: Association of spinal instability due to metastatic disease with increased mortality and a proposed clinical pathway for treatment. J Neurosurg Spine Neurosurg Spine, 2020.

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Last updated: 01/10/2023
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