Nduka M. Amankulor
Presidential Associate Professor in Neurosurgery
Chief, Neurosurgical Oncology, Hospital of the University of Pennsylvania
Director U. Penn Brain Tumor Center, University of Pennsylvania Department Abramson Cancer Center
Director, Brain Tumor Center, Hospital of the University of Pennsylvania
Diversity Search Advisor, Department of Neurosurgery, University of Pennsylvania
Vice Chair, Diversity Equity and Inclusion, University of Pennsylvania, Department of Neurosurgery
Department: Neurosurgery
Contact information
3400 Civic Center Blvd
PCAM 15th Floor South
Philadelphia, PA 19104
PCAM 15th Floor South
Philadelphia, PA 19104
Office: 215-662-3487
Fax: 215-349-5534
Fax: 215-349-5534
Education:
BA (Philosophy)
New York University, 1998.
MD (Medicine)
Yale School of Medicine, 2004.
BA (Philosophy)
New York University, 1998.
MD (Medicine)
Yale School of Medicine, 2004.
Post-Graduate Training
Intern, Department of Surgery, Yale New Haven Hospital, New Haven, CT, 2004-2005.
Resident, Department of Neurosurgery, Yale School of Medicine, New Haven, CT, 2005-2010.
Postdoctoral Research Fellow, Department of Cancer, Biology & Genetics, Department of Neurosurgery , Memorial Sloan-Kettering Cancer Center, New York, NY, 2007-2009.
Chief Resident, Department of Neurosurgery , Yale School of Medicine, New Haven, CT, 2010-2011.
Clinical Fellow, Department of Neurosurgical Oncology, Memorial Sloan- Kettering Cancer Center, New York, NY, 2011-2012.
Intern, Department of Surgery, Yale New Haven Hospital, New Haven, CT, 2004-2005.
Resident, Department of Neurosurgery, Yale School of Medicine, New Haven, CT, 2005-2010.
Postdoctoral Research Fellow, Department of Cancer, Biology & Genetics, Department of Neurosurgery , Memorial Sloan-Kettering Cancer Center, New York, NY, 2007-2009.
Chief Resident, Department of Neurosurgery , Yale School of Medicine, New Haven, CT, 2010-2011.
Clinical Fellow, Department of Neurosurgical Oncology, Memorial Sloan- Kettering Cancer Center, New York, NY, 2011-2012.
Certifications
American Board of Neurological Surgeons (ABNS) - Board Certified, 2017.
Permanent linkAmerican Board of Neurological Surgeons (ABNS) - Board Certified, 2017.
Selected Publications
Kathryn Levy Feldman: Geddy's Gift. The Pennsylvania Gazette July 2025 Notes: Collaboration with Penn Vet for surgical and research development in canine glioblastoma.Akbari H, Bakas S, Sako C, Fathi Kazerooni A, Villanueva-Meyer J, Garcia JA, Mamourian E, Liu F, Cao Q, Shinohara RT, Baid U, Getka A, Pati S, Singh A, Calabrese E, Chang S, Rudie J, Sotiras A, LaMontagne P, Marcus DS, Milchenko M, Nazeri A, Balana C, Capellades J, Puig J, Badve C, Barnholtz-Sloan JS, Sloan AE, Vadmal V, Waite K, Ak M, Colen RR, Park YW, Ahn SS, Chang JH, Choi YS, Lee SK, Alexander GS, Ali AS, Dicker AP, Flanders AE, Liem S, Lombardo J, Shi W, Shukla G, Griffith B, Poisson LM, Rogers LR, Kotrotsou A, Booth TC, Jain R, Lee M, Mahajan A, Chakravarti A, Palmer JD, DiCostanzo D, Fathallah-Shaykh H, Cepeda S, Santonocito OS, Di Stefano AL, Wiestler B, Melhem ER, Woodworth GF, Tiwari P, Valdes P, Matsumoto Y, Otani Y, Imoto R, Aboian M, Koizumi S, Kurozumi K, Kawakatsu T, Alexander K, Satgunaseelan L, Rulseh AM, Bagley SJ, Bilello M, Binder ZA, Brem S, Desai AS, Lustig RA, Maloney E, Prior T, Amankulor N, Nasrallah MP, O'Rourke DM, Mohan S, Davatzikos C; ReSPOND consortium.: Machine learning-based prognostic subgrouping of glioblastoma: A multicenter study. Neuro Oncol 27: 1102-1115, May 2025.
Till JE, Seewald NJ, Yazdani Z, Wang Z, Ballinger D, Samberg H, Dandu S, Macia C, Yin M, Abdalla A, Prior T, Shah SS, Patel T, McCoy E, Mansour M, Wills CA, Bochenek V, Serrano J, Snuderl M, Phillips RE, O'Rourke DM, Amankulor NM, Nabavizadeh A, Desai AS, Gollomp K, Binder ZA, Zhou W, Bagley SJ, Carpenter EL.: Corticosteroid-Dependent Association between Prognostic Peripheral Blood Cell-Free DNA Levels and Neutrophil-Mediated NETosis in Patients with Glioblastoma. Clin Cancer Res 31: 1292-1304, Apr 2025.
Pai EL, Matsumoto Y, Dou D, Nelluri S, Devi P, Priori S, Amankulor N, Alonso-Basanta M, Singh O, Abdullaev Z, Aldape K, Desai A, Mohan S, Nasrallah MP.: Letter to the Editor: Molecularly defined oligodendroglioma evolving to osseous metastases. J Neuropathol Exp Neurol Apr 2025.
Wen PY, Manzanera A, Duault C, Gonzalez-Kozlova E, Lopez L, Grossman SA, Ye X, Fisher J, Lee I, Walbert T, Snyder J, Brem S, Desai A, Bagley SJ, Kakani C, Strowd R, Tatter S, Laxton A, Lesser G, Amankulor N, Lieberman F, Drappatz J, Mantica M, Triggs D, Haymaker C, Wistuba II, Al-Atrash G, Mendoza Perez J, Futreal A, Little LD, Islam MDH, Duose D, Jiang P, Reuben A, Lawler SE, Pichavant M, Gentles A, Bendall S, Kong A, Camacho C, Del Valle D, Kim-Schulze S, Gnjatic S, Sharon E, Nowicki MO, Peruzzi P, Lane D, Aguilar-Cordova E, Aguilar LK, Nichols G, Dwyer J, Tak PP, Maecker H, Barone F, Chiocca EA.: A multi-institutional phase 1 clinical trial exploring upfront multimodal standard of care and combined immunotherapies for newly diagnosed glioblastoma. Neuro Oncol Mar 2025.
Jonathan H. Sussman, Anthony R. Cillo, Sajeev , Carly Cardello, Jonathan Patterson, Ebrar Akca, Angelo Angione, David Moon, Katharine Krueger, Ali Ghamari, Emily Xu, Jessica Xu, Antonio C. Tarbay, Alex Li, Bhargavi R. Budihal, Xiaoran Zhang, Omar Elghawy, Wojciech K. Panek, Prajwal Rajappa, Kai Tan, Dario A.A. Vignali3, Tullia C. Bruno, Nduka M. Amankulor: Single-cell profiling of peripheral and local immune compartments reveal unique genotype- independent prognostic immune signatures across IDH-stratified glioma. Neuro-Oncology. Oxford University Press, 2025 Notes: Accepted.
Rachel Blue Paul A. Soden John YK Lee Nduka Amankulor: Brain Metastases and Neoplastic Meningitis. Abeloff's Clinical Oncology. Ronald DiMatteo (eds.). Elsevier, 7th Edition, 2025 Notes: final version accepted for print.
Mallela AN, Iheagwara UK, Fogg D, Anthony A, Gersey ZC, Zhang X, Abou-Al-Shaar H, Anand SK, Xu E, Zinn PO, Burton S, Quinn A, Ozhasoglu C, Clump DA, Siddiqui Z, Amankulor NM.: Preoperative stereotactic radiosurgery for cerebral metastases: safe, effective, and decreases steroid dependency. J Neurosurg May 2024.
Canella A, Nazzaro M, Artomov M, Rao Venkata LP, Thomas D, Lyberger J, Ukhatov A, Xing YL, Miller K, Behbehani G, Amankulor NM, Petritsch CK, Rajappa P.: BRAF V600E in a preclinical model of pleomorphic Xanthoastrocytoma: Analysis of the tumor microenvironment and immune cell infiltration dynamics in vivo. Mol Ther Oncol 32: 200808, Apr 2024.
Rao A, Zhang X, Cillo AR, Sussman JH, Sandlesh P, Tarbay AC, Mallela AN, Cardello C, Krueger K, Xu J, Li A, Xu J, Patterson J, Akca E, Angione A, Jaman E, Kim WJ, Allen J, Venketeswaran A, Zinn PO, Parise R, Beumer J, Duensing A, Holland EC, Ferris R, Bagley SJ, Bruno TC, Vignali DAA, Agnihotri S, Amankulor NM.: All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis. bioRxiv Apr 2024.