Lynn Mara Schuchter, M.D.
Madlyn and Leonard Abramson Professor of Clinical Oncology
Department: Medicine
Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
3rd Floor, South Pavilion
Office #3-300
3400 Civic Center Blvd
Philadelphia, PA 19104
Perelman Center for Advanced Medicine
3rd Floor, South Pavilion
Office #3-300
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 215-662-3011
Education:
B.S.
University of Michigan, 1978.
M.D.
Chicago Medical School, 1982.
Permanent linkB.S.
University of Michigan, 1978.
M.D.
Chicago Medical School, 1982.
Selected Publications
Ravi B Parikh, Emily Schriver, William J Ferrell, Jonathan Wakim, Joelle Williamson, Neda Khan, Michael Kopinsky, Mohan Balachandran, Peter E Gabriel, Lynn M Schuchter, Mitesh S Patel, Lawrence N Shulman, Christopher R Manz : Remote Patient-Reported Outcomes and Activity Monitoring to Improve Patient-Clinician Communication Regarding Symptoms and Functional Status: A Randomized Controlled Trial. JCO Oncol Pract October 2023.Sarah A Weiss, Mario Sznol, Montaser Shaheen, Miguel-Angel Berciano-Guerrero, Eva Muñoz-Couselo, Delvys Rodríguez-Abreu, Valentina Boni, Lynn M Schuchter, Maria Gonzalez Cao, Ana Arance Fernandez, Wei Wei, Apar Kishor Ganti, Ralph J Hauke, Alfonso Berrocal, Nicholas O Iannotti, Frank J Hsu, Harriet M Kluge: A Phase II Trial of the CD40 Agonist Sotigalimab (APX005M) in Combination with Nivolumab in Subjects with Metastatic Melanoma with Disease Progression on Anti-PD-1. Clin Cancer Res August 2023.
Lingling Ou, Shujing Liu, Huaishan Wang, Yeye Guo, Lei Guan, Longbin Shen, Ruhui Luo, David E Elder, Alexander C Huang, Giorgos Karakousis, John Miura, Tara Mitchell, Lynn Schuchter, Ravi Amaravadi, Ahron Flowers, Haiwei Mou, Fan Yi, Wei Guo, Jina Ko, Qing Chen, Bin Tian, Meenhard Herlyn, Xiaowei Xu : Patient-derived melanoma organoid models facilitate the assessment of immunotherapies. EBioMedicine June 2023.
Payal D Shah, Alexander C Huang, Xiaowei Xu, Robert Orlowski, Ravi K Amaravadi, Lynn M Schuchter, Paul Zhang, Julia Tchou, Tina Matlawski, Amanda Cervini, Joanne Shea, Joan Gilmore, Lester Lledo, Karen Dengel, Amy Marshall, E John Wherry, Gerald P Linette, Andrea Brennan, Vanessa Gonzalez, Irina Kulikovskaya, Simon F Lacey, Gabriela Plesa, Carl H June, Robert H Vonderheide, Tara C Mitchell : Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma. Cancer Res Commun May 2023.
Christopher R Manz, Yichen Zhang, Kan Chen, Qi Long, Dylan S Small, Chalanda N Evans, Corey Chivers, Susan H Regli, C William Hanson, Justin E Bekelman, Jennifer Braun, Charles A L Rareshide, Nina O'Connor, Pallavi Kumar, Lynn M Schuchter, Lawrence N Shulman, Mitesh S Patel, Ravi B Parikh: Long-term Effect of Machine Learning-Triggered Behavioral Nudges on Serious Illness Conversations and End-of-Life Outcomes Among Patients With Cancer: A Randomized Clinical Trial. JAMA Oncol March 2023.
Evgenii N Tcyganov, Emilio Sanseviero, Douglas Marvel, Thomas Beer, Hsin-Yao Tang, Peter Hembach, David W Speicher, Qianfei Zhang, Laxminarasimha R Donthireddy, Ali Mostafa, Sabina Tsyganova, Vladimir Pisarev, Terri Laufer, Dmitriy Ignatov, Soldano Ferrone, Christiane Meyer, Hélène Maby-El Hajjami, Daniel E Speiser, Sooner Altiok, Scott Antonia, Xiaowei Xu, Wei Xu, Cathy Zheng, Lynn M Schuchter, Ravi K Amaravadi, Tara C Mitchell, Giorgos C Karakousis, Zhe Yuan, Luis J Montaner, Esteban Celis, Dmitry I Gabrilovich : Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy. Cancer Cell October 2022.
Emily J Anstadt, Brian Chu, Nikhil Yegya-Raman, Xiaoyan Han, Abigail Doucette, Kendra Poirier, Jahan J Mohiuddin, Amit Maity, Andrea Facciabene, Ravi K Amaravadi, Giorgos C Karakousis, Justine V Cohen, Tara C Mitchell, Lynn M Schuchter, John N Lukens: Moderate Colitis Not Requiring Intravenous Steroids Is Associated with Improved Survival in Stage IV Melanoma after Anti-CTLA4 Monotherapy, But Not Combination Therapy. The Oncologist. Oxford University Press, 27: 799-808, September 2022.
Ramin Sedaghat Herati, David A Knorr, Laura A Vella, Luisa Victoria Silva, Lakshmi Chilukuri, Sokratis A Apostolidis, Alexander C Huang, Alexander Muselman, Sasikanth Manne, Oliva Kuthuru, Ryan P Staupe, Sharon A Adamski, Senthil Kannan, Raj K Kurupati, Hildegund CJ Ertl, Jeffrey L Wong, Stylianos Bournazos, Suzanne McGettigan, Lynn M Schuchter, Ritesh R Kotecha, Samuel A Funt, Martin H Voss, Robert J Motzer, Chung-Han Lee, Dean F Bajorin, Tara C Mitchell, Jeffrey V Ravetch, E John Wherry: PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine. Nature Immunology August 2022.
Lei Guan, Bin Wu, Ting Li, Lynn A Beer, Gaurav Sharma, Mingyue Li, Chin Nien Lee, Shujing Liu, Changsong Yang, Lili Huang, Dennie T Frederick, Genevieve M Boland, Guangcan Shao, Tatyana M Svitkina, Kathy Q Cai, Fangping Chen, Meng-Qiu Dong, Gordon B Mills, Lynn M Schuchter, Giorgos C Karakousis, Tara C Mitchell, Keith T Flaherty, David W Speicher, Youhai H Chen, Meenhard Herlyn, Ravi K Amaravadi, Xiaowei Xu, Wei Guo: HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors. Nature communications July 2022.
Lingling Ou, Huaishan Wang, Hui Huang, Zhiyan Zhou, Qiang Lin, Yeye Guo, Tara Mitchell, Alexander C Huang, Giorgos Karakousis, Lynn Schuchter, Ravi Amaravadi, Wei Guo, Joseph Salvino, Meenhard Herlyn, Xiaowei Xu: Preclinical platforms to study therapeutic efficacy of human γδ T cells. Clinical and translational medicine June 2022.