Lynn Mara Schuchter, M.D.
Madlyn and Leonard Abramson Professor of Clinical Oncology
Department: Medicine
Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
3rd Floor, South Pavilion
Office #3-300
3400 Civic Center Blvd
Philadelphia, PA 19104
Perelman Center for Advanced Medicine
3rd Floor, South Pavilion
Office #3-300
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 215-662-3011
Education:
B.S.
University of Michigan, 1978.
M.D.
Chicago Medical School, 1982.
Permanent linkB.S.
University of Michigan, 1978.
M.D.
Chicago Medical School, 1982.
Selected Publications
Evgenii N Tcyganov, Emilio Sanseviero, Douglas Marvel, Thomas Beer, Hsin-Yao Tang, Peter Hembach, David W Speicher, Qianfei Zhang, Laxminarasimha R Donthireddy, Ali Mostafa, Sabina Tsyganova, Vladimir Pisarev, Terri Laufer, Dmitriy Ignatov, Soldano Ferrone, Christiane Meyer, Hélène Maby-El Hajjami, Daniel E Speiser, Sooner Altiok, Scott Antonia, Xiaowei Xu, Wei Xu, Cathy Zheng, Lynn M Schuchter, Ravi K Amaravadi, Tara C Mitchell, Giorgos C Karakousis, Zhe Yuan, Luis J Montaner, Esteban Celis, Dmitry I Gabrilovich : Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy. Cancer Cell October 2022.Emily J Anstadt, Brian Chu, Nikhil Yegya-Raman, Xiaoyan Han, Abigail Doucette, Kendra Poirier, Jahan J Mohiuddin, Amit Maity, Andrea Facciabene, Ravi K Amaravadi, Giorgos C Karakousis, Justine V Cohen, Tara C Mitchell, Lynn M Schuchter, John N Lukens: Moderate Colitis Not Requiring Intravenous Steroids Is Associated with Improved Survival in Stage IV Melanoma after Anti-CTLA4 Monotherapy, But Not Combination Therapy. The Oncologist. Oxford University Press, 27: 799-808, September 2022.
Ramin Sedaghat Herati, David A Knorr, Laura A Vella, Luisa Victoria Silva, Lakshmi Chilukuri, Sokratis A Apostolidis, Alexander C Huang, Alexander Muselman, Sasikanth Manne, Oliva Kuthuru, Ryan P Staupe, Sharon A Adamski, Senthil Kannan, Raj K Kurupati, Hildegund CJ Ertl, Jeffrey L Wong, Stylianos Bournazos, Suzanne McGettigan, Lynn M Schuchter, Ritesh R Kotecha, Samuel A Funt, Martin H Voss, Robert J Motzer, Chung-Han Lee, Dean F Bajorin, Tara C Mitchell, Jeffrey V Ravetch, E John Wherry: PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine. Nature Immunology August 2022.
Lei Guan, Bin Wu, Ting Li, Lynn A Beer, Gaurav Sharma, Mingyue Li, Chin Nien Lee, Shujing Liu, Changsong Yang, Lili Huang, Dennie T Frederick, Genevieve M Boland, Guangcan Shao, Tatyana M Svitkina, Kathy Q Cai, Fangping Chen, Meng-Qiu Dong, Gordon B Mills, Lynn M Schuchter, Giorgos C Karakousis, Tara C Mitchell, Keith T Flaherty, David W Speicher, Youhai H Chen, Meenhard Herlyn, Ravi K Amaravadi, Xiaowei Xu, Wei Guo: HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors. Nature communications July 2022.
Lingling Ou, Huaishan Wang, Hui Huang, Zhiyan Zhou, Qiang Lin, Yeye Guo, Tara Mitchell, Alexander C Huang, Giorgos Karakousis, Lynn Schuchter, Ravi Amaravadi, Wei Guo, Joseph Salvino, Meenhard Herlyn, Xiaowei Xu: Preclinical platforms to study therapeutic efficacy of human γδ T cells. Clinical and translational medicine June 2022.
Eric Li, Christopher Manz, Manqing Liu, Jinbo Chen, Corey Chivers, Jennifer Braun, Lynn Mara Schuchter, Pallavi Kumar, Mitesh S Patel, Lawrence N Shulman, Ravi B Parikh: Oncologist phenotypes and associations with response to a machine learning-based intervention to increase advance care planning: Secondary analysis of a randomized clinical trial. PLoS One 17, May 2022.
Ravi B Parikh, William Ferrell, Jonathan Wakim, Joelle Williamson, Neda Khan, Michael Kopinsky, Mohan Balachandran, Peter E Gabriel, Yichen Zhang, Lynn M Schuchter, Lawrence N Shulman, Jinbo Chen, Mitesh S Patel, Christopher R Manz : Patient and clinician nudges to improve symptom management in advanced cancer using patient-generated health data: study protocol for the PROStep randomised controlled trial. BMJ Open 12, May 2022.
Ravi B Parikh, Christopher R Manz, Maria N Nelson, Chalanda N Evans, Susan H Regli, Nina O'Connor, Lynn M Schuchter, Lawrence N Shulman, Mitesh S Patel, Joanna Paladino, Judy A Shea : Clinician perspectives on machine learning prognostic algorithms in the routine care of patients with cancer: a qualitative study. Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer 30: 4363-4372, May 2022.
Janice M Mehnert, Tara C Mitchell, Alexander C Huang, Tomas S Aleman, Benjamin J Kim, Lynn M Schuchter, Gerald P Linette, Giorgos C Karakousis 2, Sheryl Mitnick, Lydia Giles, Mary Carberry, Noelle Frey, Andrew Kossenkov, Roman Groisberg, Leonel F Hernandez-Aya, George Ansstas, Ann W Silk, Sunandana Chandra, Jeffrey A Sosman, Phyllis A Gimotty, Rosemarie Mick, Ravi K Amaravadi: BAMM (BRAF Autophagy and MEK Inhibition in Melanoma): A Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine in Advanced BRAFV600-mutant Melanoma. Clinical cancer research: an official journal of the American Association for Cancer Research 28: 1098-1106, March 2022.
Josephine R Giles, Sasikanth Manne, Elizabeth Freilich, Derek A Oldridge, Amy E Baxter, Sangeeth George, Zeyu Chen, Hua Huang, Lakshmi Chilukuri, Mary Carberry, Lydia Giles, Nan-Ping P Weng, Regina M Young, Carl H June, Lynn M Schuchter, Ravi K Amaravadi, Xiaowei Xu, Giorgos C Karakousis, Tara C Mitchell, Alexander C Huang, Junwei Shi, E John Wherry: Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers. Immunity 55(3): 557-574, March 2022.