Elizabeth Olson Hexner, MD, MSTR
Associate Professor of Medicine (Hematology-Oncology) at the Hospital of the University of Pennsylvania
Department: Medicine
Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
12th Floor, South Pavilion
Office #12-151
3400 Civic Center Boulevard
Philadelphia, PA 19104
Perelman Center for Advanced Medicine
12th Floor, South Pavilion
Office #12-151
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-614-1847
Fax: 215-615-5888
Fax: 215-615-5888
Links
Penn Center for Myeloproliferative Neoplasms
The Cell and Gene Therapy Toolkit for Junior Faculty
Penn Center for Myeloproliferative Neoplasms
The Cell and Gene Therapy Toolkit for Junior Faculty
Education:
A.B. (French/Comparative Area Studies)
Duke University, 1992.
(Premedical Studies)
Harvard University Extension School, 1994.
M.D. (Medicine)
Columbia College of Physicians and Surgeons, 1999.
M.S.T.R. (Translational Research)
University of Pennsylvania, 2009.
Permanent linkA.B. (French/Comparative Area Studies)
Duke University, 1992.
(Premedical Studies)
Harvard University Extension School, 1994.
M.D. (Medicine)
Columbia College of Physicians and Surgeons, 1999.
M.S.T.R. (Translational Research)
University of Pennsylvania, 2009.
Description of Research Expertise
Genetically modified T Cell TherapiesCAR T cells
Cellular therapy
Blood and Marrow Transplantation
Myeloproliferative Neoplasms
Umbilical Cord Blood Transplantation
Selected Publications
Xu, J., McCoy, M., Martinez, Z., Sussman, J. H., Gao, D., Vincent, T. L., Wang, H., Ma, C., Elghawy, O., Chen, G. M., Yang, A. G., Polonen, P., Natan, K., Shraim, R., Newman, H., Hofmann, T. J., Scoma, S., DiNofia, A. M., Hunger, S. P., Yang, J. J., Mullighan, C. G., Bernt, K. M., Hexner, E. O., Grupp, S. A., Watanabe, K., June, C. H., Tan, K., Teachey, D. T., Diorio, C.: CCR4 expression defines a targetable subset of T-cell acute lymphoblastic leukemia. Blood Adv 2026.Louloudis, I. E., Chen, Y. B., Spyrou, N., Alousi, A., Katsivelos, N., Ayuk, F., Weber, D., Hogan, W. J., Etra, A. M., Qayed, M., Aguayo-Hiraldo, P., Akahoshi, Y., Malki, M. M. A., Bolanos-Meade, J., Chanswangphuwana, C., Diniz, M., Eder, M., Hexner, E., Kitko, C. L., Kraus, S., Merli, P., Olson, T., MacMillan, M. L., Pidala, J., Reshef, R., Schechter, T., Wolfl, M., Baez, J., Eng, G., Gleich, S., Young, R., Nakamura, R., Ferrara, J. L. M., Levine, J. E.: Performance of Treatment Response Assessment at Day 7 by Baseline Acute Graft-versus-Host Disease Severity. Transplant Cell Ther 32(1): 63 e1-63 e11, 2026.
Gotlib, J., Reiter, A., Radia, D. H., Alvarez-Twose, I., Deininger, M. W., George, T. I., Panse, J. P., Mital, A., Pettit, K. M., Vannucchi, A. M., Platzbecker, U., Hermine, O., Elshoury, A., Livideanu, C., Mesa, R. A., Ustun, C., Triggiani, M., Dybedal, I., Jurcic, J. G., Zanotti, R., Oh, S. T., Yacoub, A., Hexner, E. O., Bose, P., Lee, S. G., Sperr, W. R., Griffiths, E. A., Butler, M., Lubke, J., Bidollari, I., Lin, H. M., Rylova, S. N., Dimitrijevic, S., Munoz-Gonzalez, J. I., DeAngelo, D. J.: Efficacy and safety of avapritinib in advanced systemic mastocytosis: 4-year follow-up of the PATHFINDER study. Blood Adv 2026.
Deng, M. Z., Sinha, T., Lai, M., Jiang, S., Kong, H., Cooper, V., Gu, M., Perelman, J., Zhang, C., Hanindya, C., Carpio, V., Keller, P., Jadlowsky, J. K., Leskowitz, R., McKenna, S., Four, M., Barranco, J. A. J., Cooper, N., Jain, A., Haines, K., Gohil, M., Garcia-Gerique, L., Russell, A., Kulikovskaya, I., Gonzalez, V., Fraietta, J. A., Plesa, G., Sheppard, N. C., Davis, M. M., Chew, A., Hexner, E., Frey, N., June, C. H., Svoboda, J., Riley, J. L.: Cell-derived Nanoparticles Provide a Robust Platform to Manufacture Therapeutic T cells. Res Sq 2026.
Chen, G. M., Jain, A., Gering, D. T., Satulovsky, J., Datta, S., Lai, P., Karar, J., Gonzalez, V. E., Alexander, K., Chew, A., Jadlowsky, J. K., Ruella, M., Paruzzo, L., Amses, K. R., Rech, A. J., Stadtmauer, E. A., Frey, N. V., Hexner, E. O., Porter, D. L., Cohen, A. D., Gill, S. I., Garfall, A. L., Schuster, S. J., Mo, K. C., Liang, S. I., Spasic, M., Levine, B. L., Siegel, D. L., Ramirez-Fernandez, A., Cabanski, C. R., Yang, E., Mackall, C. L., Bushman, F. D., Good, Z., John Wherry, E., June, C. H., Fraietta, J. A.: Predictive biomarkers of response to chimeric antigen receptor (CAR) T-cell therapy for pan-haematologic cancer. Nat Biomed Eng 2026.
Barber-Rotenberg, J. S., Haas, A. R., Aggarwal, C., O'Hara, M., Hexner, E., Pequignot, E., Dowd, E., Ndeupen, S., Thai, E., Chen, F., Oner, B. S., Czuczman, C., Gonzalez, V. E., Fraietta, J. A., Hwang, W. T., Chew, A., Jadlowsky, J. K., Marshall, A., Shea, K. M., Jiang, Y., Cosey, A., Ferthio, R., Levine, B. L., Plesa, G., Siegel, D. L., Young, R. M., Sheppard, N. C., Albelda, S. M., June, C. H., Tanyi, J. L.: Phase 1 study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers. Mol Ther 2026.
Salit RB, Hexner EO, Gagelmann N, Kröger N, McLornan DP, Jain T, Gupta V, Hobbs GS, Tamari R, Robin M, Scott B, Saber W: Defining remission following hematopoietic cell transplant for myelofibrosis: an international expert panel consensus. Leukemia Oct 2025 Notes: doi: 10.1038/s41375-025-02754-9. Online ahead of print.
Aznar MA, Good CR, Barber-Rotenberg JS, Agarwal S, Wilson W, Watts A, Zhang Z, Gonzales D, Donahue G, Hwang WT, Rennels AK, Rech AJ, Kuramitsu S, Huang H, Glastad KM, Alexander KA, Plesa G, Dowd E, Brennan A, Siegel DL, Tanyi J, Haas A, Torigian DA, Nadolski G, Gonzalez VE, Hexner EO, Fraietta JA, Jadlowsky JK, Young RM, Berger SL, June CH, O'Hara MH: Clinical and molecular dissection of CAR T cell resistance in pancreatic cancer. Cell Rep Med 6(9): 102301. Sep 2025.
Bagley SJ, Desai AS, Fraietta JA, Silverbush D, Chafamo D, Freeburg NF, Gopikrishna GK, Rech AJ, Nabavizadeh A, Bagley LJ, Park J, Jarocha D, Martins R, Sarmiento N, Maloney E, Lledo L, Stein C, Marshall A, Leskowitz RM, Jadlowsky JK, Mackey S, Christensen S, Oner BS, Plesa G, Brennan A, Gonzalez V, Chen F, Barrett D, Colbourn R, Nasrallah MP, Mourelatos Z, Hwang WT, Alanio C, Siegel DL, June CH, Hexner EO, Binder ZA, O'Rourke DM.: Author Correction: Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial Nat Med 31(9): 3205, Sep 2025.
Akahoshi Y, Inamoto Y, Spyrou N, Nakasone H, Diniz M, Asada N, Ayuk FA, Choe HK, Doki N, Eto T, Etra AM, Hexner EO, Hiramoto N, Hogan WJ, Holler EPDm, Kataoka K, Kawakita T, Tanaka M, Tanaka T, Uchida N, Vasova I, Yoshihara S, Ishimaru F, Fukuda T, Chen YB, Kanda J, Nakamura R, Atsuta Y, Ferrara JLM, Kanda Y, Levine JE, Teshima T. : Refinement of Day 28 Treatment Response Criteria for Acute GVHD: A Collaboration Study of the JSTCT and MAGIC. Blood Adv. 9(18): 4640-4653. Sep 2025.