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Elizabeth Olson Hexner, MD, MSTR
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Associate Professor of Medicine (Hematology-Oncology) at the Hospital of the University of Pennsylvania
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Department: Medicine
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Contact information
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Division of Hematology Oncology
2d Perelman Center for Advanced Medicine
22 12th Floor, South Pavilion
16 Office #12-151
3e 3400 Civic Center Boulevard
Philadelphia, PA 19104
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2d Perelman Center for Advanced Medicine
22 12th Floor, South Pavilion
16 Office #12-151
3e 3400 Civic Center Boulevard
Philadelphia, PA 19104
2e
Office: 215-614-1847
32 Fax: 215-615-5888
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32 Fax: 215-615-5888
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Links
75 Penn Center for Myeloproliferative Neoplasms
75 The Cell and Gene Therapy Toolkit for Junior Faculty
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75 Penn Center for Myeloproliferative Neoplasms
75 The Cell and Gene Therapy Toolkit for Junior Faculty
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Education:
21 9 A.B. 2c (French/Comparative Area Studies) c
28 Duke University, 1992.
21 5 1f (Premedical Studies) c
3c Harvard University Extension School, 1994.
21 9 M.D. 15 (Medicine) c
44 Columbia College of Physicians and Surgeons, 1999.
21 d M.S.T.R. 23 (Translational Research) c
33 University of Pennsylvania, 2009.
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Permanent link21 9 A.B. 2c (French/Comparative Area Studies) c
28 Duke University, 1992.
21 5 1f (Premedical Studies) c
3c Harvard University Extension School, 1994.
21 9 M.D. 15 (Medicine) c
44 Columbia College of Physicians and Surgeons, 1999.
21 d M.S.T.R. 23 (Translational Research) c
33 University of Pennsylvania, 2009.
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13 CAR T cells
18 Cellular therapy
28 Blood and Marrow Transplantation
24 Myeloproliferative Neoplasms
2b Umbilical Cord Blood Transplantation
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Description of Research Expertise
36 Genetically modified T Cell Therapies13 CAR T cells
18 Cellular therapy
28 Blood and Marrow Transplantation
24 Myeloproliferative Neoplasms
2b Umbilical Cord Blood Transplantation
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2f7 Gotlib, J., Reiter, A., Radia, D. H., Alvarez-Twose, I., Deininger, M. W., George, T. I., Panse, J. P., Mital, A., Pettit, K. M., Vannucchi, A. M., Platzbecker, U., Hermine, O., Elshoury, A., Livideanu, C., Mesa, R. A., Ustun, C., Triggiani, M., Dybedal, I., Jurcic, J. G., Zanotti, R., Oh, S. T., Yacoub, A., Hexner, E. O., Bose, P., Lee, S. G., Sperr, W. R., Griffiths, E. A., Butler, M., Lubke, J., Bidollari, I., Lin, H. M., Rylova, S. N., Dimitrijevic, S., Munoz-Gonzalez, J. I., DeAngelo, D. J.: Efficacy and safety of avapritinib in advanced systemic mastocytosis: 4-year follow-up of the PATHFINDER study. Blood Adv 10(10): 3676-3689, May 2026.
258 Xu, J., McCoy, M., Martinez, Z., Sussman, J. H., Gao, D., Vincent, T. L., Wang, H., Ma, C., Elghawy, O., Chen, G. M., Yang, A. G., Polonen, P., Natan, K., Shraim, R., Newman, H., Hofmann, T. J., Scoma, S., DiNofia, A. M., Hunger, S. P., Yang, J. J., Mullighan, C. G., Bernt, K. M., Hexner, E. O., Grupp, S. A., Watanabe, K., June, C. H., Tan, K., Teachey, D. T., Diorio, C.: CCR4 expression defines a targetable subset of T-cell acute lymphoblastic leukemia. Blood Adv 10(8): 2676-2686, Apr 28 2026.
313 Chen, G. M., Jain, A., Gering, D. T., Satulovsky, J., Datta, S., Lai, P., Karar, J., Gonzalez, V. E., Alexander, K., Chew, A., Jadlowsky, J. K., Ruella, M., Paruzzo, L., Amses, K. R., Rech, A. J., Stadtmauer, E. A., Frey, N. V., Hexner, E. O., Porter, D. L., Cohen, A. D., Gill, S. I., Garfall, A. L., Schuster, S. J., Mo, K. C., Liang, S. I., Spasic, M., Levine, B. L., Siegel, D. L., Ramirez-Fernandez, A., Cabanski, C. R., Yang, E., Mackall, C. L., Bushman, F. D., Good, Z., John Wherry, E., June, C. H., Fraietta, J. A.: Predictive biomarkers of response to chimeric antigen receptor (CAR) T-cell therapy for pan-haematologic cancer. Nat Biomed Eng 10(4): 803-814, Apr 2026.
2b3 Deng, M. Z., Sinha, T., Lai, M., Jiang, S., Kong, H., Cooper, V., Gu, M., Perelman, J., Zhang, C., Hanindya, C., Carpio, V., Keller, P., Jadlowsky, J. K., Leskowitz, R., McKenna, S., Four, M., Barranco, J. A. J., Cooper, N., Jain, A., Haines, K., Gohil, M., Garcia-Gerique, L., Russell, A., Kulikovskaya, I., Gonzalez, V., Fraietta, J. A., Plesa, G., Sheppard, N. C., Davis, M. M., Chew, A., Hexner, E., Frey, N., June, C. H., Svoboda, J., Riley, J. L.: Cell-derived Nanoparticles Provide a Robust Platform to Manufacture Therapeutic T cells. Res Sq Page: rs.3.rs-8436008. Feb 4 2026.
2d5 Louloudis, I. E., Chen, Y. B., Spyrou, N., Alousi, A., Katsivelos, N., Ayuk, F., Weber, D., Hogan, W. J., Etra, A. M., Qayed, M., Aguayo-Hiraldo, P., Akahoshi, Y., Malki, M. M. A., Bolanos-Meade, J., Chanswangphuwana, C., Diniz, M., Eder, M., Hexner, E., Kitko, C. L., Kraus, S., Merli, P., Olson, T., MacMillan, M. L., Pidala, J., Reshef, R., Schechter, T., Wolfl, M., Baez, J., Eng, G., Gleich, S., Young, R., Nakamura, R., Ferrara, J. L. M., Levine, J. E.: Performance of Treatment Response Assessment at Day 7 by Baseline Acute Graft-versus-Host Disease Severity. Transplant Cell Ther 32(1): 63 e1-63 e11, Jan 2026.
15f Salit RB, Hexner EO, Gagelmann N, Kröger N, McLornan DP, Jain T, Gupta V, Hobbs GS, Tamari R, Robin M, Scott B, Saber W: Defining remission following hematopoietic cell transplant for myelofibrosis: an international expert panel consensus. Leukemia 39(12): 2862-2865, Dec 2025.
339 Bagley, S. J., Desai, A. S., Fraietta, J. A., Silverbush, D., Chafamo, D., Freeburg, N. F., Gopikrishna, G. K., Rech, A. J., Nabavizadeh, A., Bagley, L. J., Park, J., Jarocha, D., Martins, R., Sarmiento, N., Maloney, E., Lledo, L., Stein, C., Marshall, A., Leskowitz, R. M., Jadlowsky, J. K., Mackey, S., Christensen, S., Oner, B. S., Plesa, G., Brennan, A., Gonzalez, V., Chen, F., Barrett, D., Colbourn, R., Nasrallah, M. P., Mourelatos, Z., Hwang, W. T., Alanio, C., Siegel, D. L., June, C. H., Hexner, E. O., Binder, Z. A., O'Rourke, D. M.: Author Correction: Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Ralpha2 in recurrent glioblastoma: a phase 1 trial. Nat Med 31(9): 3205, Sep 2025.
22e Akahoshi Y, Inamoto Y, Spyrou N, Nakasone H, Diniz M, Asada N, Ayuk FA, Choe HK, Doki N, Eto T, Etra AM, Hexner EO, Hiramoto N, Hogan WJ, Holler EPDm, Kataoka K, Kawakita T, Tanaka M, Tanaka T, Uchida N, Vasova I, Yoshihara S, Ishimaru F, Fukuda T, Chen YB, Kanda J, Nakamura R, Atsuta Y, Ferrara JLM, Kanda Y, Levine JE, Teshima T. : Refinement of Day 28 Treatment Response Criteria for Acute GVHD: A Collaboration Study of the JSTCT and MAGIC. Blood Adv. 9(18): 4640-4653. Sep 2025.
221 Aznar MA, Good CR, Barber-Rotenberg JS, Agarwal S, Wilson W, Watts A, Zhang Z, Gonzales D, Donahue G, Hwang WT, Rennels AK, Rech AJ, Kuramitsu S, Huang H, Glastad KM, Alexander KA, Plesa G, Dowd E, Brennan A, Siegel DL, Tanyi J, Haas A, Torigian DA, Nadolski G, Gonzalez VE, Hexner EO, Fraietta JA, Jadlowsky JK, Young RM, Berger SL, June CH, O'Hara MH: Clinical and molecular dissection of CAR T cell resistance in pancreatic cancer. Cell Rep Med 6(9): 102301. Sep 2025.
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Selected Publications
2b4 Barber-Rotenberg, J. S., Haas, A. R., Aggarwal, C., O'Hara, M., Hexner, E., Pequignot, E., Dowd, E., Ndeupen, S., Thai, E., Chen, F., Oner, B. S., Czuczman, C., Gonzalez, V. E., Fraietta, J. A., Hwang, W. T., Chew, A., Jadlowsky, J. K., Marshall, A., Shea, K. M., Jiang, Y., Cosey, A., Ferthio, R., Levine, B. L., Plesa, G., Siegel, D. L., Young, R. M., Sheppard, N. C., Albelda, S. M., June, C. H., Tanyi, J. L.: Phase 1 study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers. Mol Ther 34(5): 2653-2665, May 6 2026.2f7 Gotlib, J., Reiter, A., Radia, D. H., Alvarez-Twose, I., Deininger, M. W., George, T. I., Panse, J. P., Mital, A., Pettit, K. M., Vannucchi, A. M., Platzbecker, U., Hermine, O., Elshoury, A., Livideanu, C., Mesa, R. A., Ustun, C., Triggiani, M., Dybedal, I., Jurcic, J. G., Zanotti, R., Oh, S. T., Yacoub, A., Hexner, E. O., Bose, P., Lee, S. G., Sperr, W. R., Griffiths, E. A., Butler, M., Lubke, J., Bidollari, I., Lin, H. M., Rylova, S. N., Dimitrijevic, S., Munoz-Gonzalez, J. I., DeAngelo, D. J.: Efficacy and safety of avapritinib in advanced systemic mastocytosis: 4-year follow-up of the PATHFINDER study. Blood Adv 10(10): 3676-3689, May 2026.
258 Xu, J., McCoy, M., Martinez, Z., Sussman, J. H., Gao, D., Vincent, T. L., Wang, H., Ma, C., Elghawy, O., Chen, G. M., Yang, A. G., Polonen, P., Natan, K., Shraim, R., Newman, H., Hofmann, T. J., Scoma, S., DiNofia, A. M., Hunger, S. P., Yang, J. J., Mullighan, C. G., Bernt, K. M., Hexner, E. O., Grupp, S. A., Watanabe, K., June, C. H., Tan, K., Teachey, D. T., Diorio, C.: CCR4 expression defines a targetable subset of T-cell acute lymphoblastic leukemia. Blood Adv 10(8): 2676-2686, Apr 28 2026.
313 Chen, G. M., Jain, A., Gering, D. T., Satulovsky, J., Datta, S., Lai, P., Karar, J., Gonzalez, V. E., Alexander, K., Chew, A., Jadlowsky, J. K., Ruella, M., Paruzzo, L., Amses, K. R., Rech, A. J., Stadtmauer, E. A., Frey, N. V., Hexner, E. O., Porter, D. L., Cohen, A. D., Gill, S. I., Garfall, A. L., Schuster, S. J., Mo, K. C., Liang, S. I., Spasic, M., Levine, B. L., Siegel, D. L., Ramirez-Fernandez, A., Cabanski, C. R., Yang, E., Mackall, C. L., Bushman, F. D., Good, Z., John Wherry, E., June, C. H., Fraietta, J. A.: Predictive biomarkers of response to chimeric antigen receptor (CAR) T-cell therapy for pan-haematologic cancer. Nat Biomed Eng 10(4): 803-814, Apr 2026.
2b3 Deng, M. Z., Sinha, T., Lai, M., Jiang, S., Kong, H., Cooper, V., Gu, M., Perelman, J., Zhang, C., Hanindya, C., Carpio, V., Keller, P., Jadlowsky, J. K., Leskowitz, R., McKenna, S., Four, M., Barranco, J. A. J., Cooper, N., Jain, A., Haines, K., Gohil, M., Garcia-Gerique, L., Russell, A., Kulikovskaya, I., Gonzalez, V., Fraietta, J. A., Plesa, G., Sheppard, N. C., Davis, M. M., Chew, A., Hexner, E., Frey, N., June, C. H., Svoboda, J., Riley, J. L.: Cell-derived Nanoparticles Provide a Robust Platform to Manufacture Therapeutic T cells. Res Sq Page: rs.3.rs-8436008. Feb 4 2026.
2d5 Louloudis, I. E., Chen, Y. B., Spyrou, N., Alousi, A., Katsivelos, N., Ayuk, F., Weber, D., Hogan, W. J., Etra, A. M., Qayed, M., Aguayo-Hiraldo, P., Akahoshi, Y., Malki, M. M. A., Bolanos-Meade, J., Chanswangphuwana, C., Diniz, M., Eder, M., Hexner, E., Kitko, C. L., Kraus, S., Merli, P., Olson, T., MacMillan, M. L., Pidala, J., Reshef, R., Schechter, T., Wolfl, M., Baez, J., Eng, G., Gleich, S., Young, R., Nakamura, R., Ferrara, J. L. M., Levine, J. E.: Performance of Treatment Response Assessment at Day 7 by Baseline Acute Graft-versus-Host Disease Severity. Transplant Cell Ther 32(1): 63 e1-63 e11, Jan 2026.
15f Salit RB, Hexner EO, Gagelmann N, Kröger N, McLornan DP, Jain T, Gupta V, Hobbs GS, Tamari R, Robin M, Scott B, Saber W: Defining remission following hematopoietic cell transplant for myelofibrosis: an international expert panel consensus. Leukemia 39(12): 2862-2865, Dec 2025.
339 Bagley, S. J., Desai, A. S., Fraietta, J. A., Silverbush, D., Chafamo, D., Freeburg, N. F., Gopikrishna, G. K., Rech, A. J., Nabavizadeh, A., Bagley, L. J., Park, J., Jarocha, D., Martins, R., Sarmiento, N., Maloney, E., Lledo, L., Stein, C., Marshall, A., Leskowitz, R. M., Jadlowsky, J. K., Mackey, S., Christensen, S., Oner, B. S., Plesa, G., Brennan, A., Gonzalez, V., Chen, F., Barrett, D., Colbourn, R., Nasrallah, M. P., Mourelatos, Z., Hwang, W. T., Alanio, C., Siegel, D. L., June, C. H., Hexner, E. O., Binder, Z. A., O'Rourke, D. M.: Author Correction: Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Ralpha2 in recurrent glioblastoma: a phase 1 trial. Nat Med 31(9): 3205, Sep 2025.
22e Akahoshi Y, Inamoto Y, Spyrou N, Nakasone H, Diniz M, Asada N, Ayuk FA, Choe HK, Doki N, Eto T, Etra AM, Hexner EO, Hiramoto N, Hogan WJ, Holler EPDm, Kataoka K, Kawakita T, Tanaka M, Tanaka T, Uchida N, Vasova I, Yoshihara S, Ishimaru F, Fukuda T, Chen YB, Kanda J, Nakamura R, Atsuta Y, Ferrara JLM, Kanda Y, Levine JE, Teshima T. : Refinement of Day 28 Treatment Response Criteria for Acute GVHD: A Collaboration Study of the JSTCT and MAGIC. Blood Adv. 9(18): 4640-4653. Sep 2025.
221 Aznar MA, Good CR, Barber-Rotenberg JS, Agarwal S, Wilson W, Watts A, Zhang Z, Gonzales D, Donahue G, Hwang WT, Rennels AK, Rech AJ, Kuramitsu S, Huang H, Glastad KM, Alexander KA, Plesa G, Dowd E, Brennan A, Siegel DL, Tanyi J, Haas A, Torigian DA, Nadolski G, Gonzalez VE, Hexner EO, Fraietta JA, Jadlowsky JK, Young RM, Berger SL, June CH, O'Hara MH: Clinical and molecular dissection of CAR T cell resistance in pancreatic cancer. Cell Rep Med 6(9): 102301. Sep 2025.
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