Vikram R Paralkar, MD

faculty photo
Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
BRB II/III Room 551
421 Curie Boulevard
Philadelphia, PA 19104
Office: 215-573-9252
Lab: 215-573-9831
Education:
HSC
DG Ruparel College, Mumbai, India, 1998.
MD
Seth GS Medical College, Mumbai, India, 2004.
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Description of Clinical Expertise

Acute and Chronic Myeloid Malignancies

Description of Research Expertise

RESEARCH INTERESTS:
The Paralkar Lab studies how genes regulating ribosome biogenesis guide normal hematopoiesis, and how mutations in these genes lead to acute or chronic myeloid leukemias.

KEYWORDS:
Hematopoiesis, Leukemia, Gene regulation, Ribosome biogenesis, Stem cells

RESEARCH DETAILS:
Hematopoiesis is a complex and highly regulated process by which stem cells residing in bone marrow produce a constant stream of blood cells to preserve a functional hematopoietic system throughout the duration of a human lifespan. Mutations in epigenetic regulators, transcription factors, splicing proteins and tumor suppressors can derange the normal course of hematopoiesis, and lead to clonal expansion and leukemia. Several mutated proteins also regulate ribosomal biogenesis. Normal ribosomal function is crucial for hematopoiesis, and dysfunction can either lead to bone marrow failure or myeloproliferation. The mechanisms by which most of these mutated genes produce malignancy remain poorly understood.

In the Paralkar Lab, we apply state-of-the art molecular biology techniques to in vitro and in vivo models of hematopoiesis and leukemia to study normal blood development and the mechanisms of leukemogenesis, and gain insight into the delicate balance between normal differentiation and malignancy.

ROTATION PROJECTS:
Please contact vikram.paralkar@pennmedicine.upenn.edu to discuss research projects.

LAB MEMBERS:
Patrick Somers - Lab Manager/Technician
Gabrielle Ochoco - Lab Manager/Technician
Charles Aruljothi, PhD - Postdoctoral fellow
Aishwarya Pawar - Graduate Student

Selected Publications

Xu P, Palmer LE, Lechauve C, Zhao G, Yao Y, Luan J, Vourekas A, Tan H, Peng J, Scheutz JD, Mourelatos Z, Wu G, Weiss MJ, Paralkar VR: Regulation of gene expression by miR-144/451 during mouse erythropoiesis. Blood 133(23): 2518-2528, Jun 6 2019.

Traxler EA, Thom CS, Yao Y, Paralkar V, Weiss MJ: Non-specific inhibition of erythropoiesis by short hairpin RNAs. Blood 131(24): 2733-2736, Jun 14 2018.

Paralkar VR, Taborda CC, Huang P, Yao Y, Kossenkov AV, Prasad R, Luan J, Davies JO, Hughes JR, Hardison RC, Blobel GA, Weiss MJ: Unlinking an lncRNA from Its Associated cis Element. Mol Cell. 62(1): 104-10, Apr 7 2016.

Paralkar VR, Mishra T, Luan J, Yao Y, Kossenkov AV, Anderson SM, Dunagin M, Pimkin M, Gore M, Sun D, Konuthula N, Raj A, An X, Mohandas N, Bodine DM, Hardison RC, Weiss MJ: Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development. Blood 123(12): 1927-37, Mar 20 2014.

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Last updated: 01/22/2020
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