Saar I Gill, MBBS, PhD
Professor of Medicine (Hematology-Oncology) at the Hospital of the University of Pennsylvania
Department: Medicine
Graduate Group Affiliations
Contact information
Room 8-101
Smilow Translational Research Center
3400 Civic Center Blvd
Philadelphia, PA 19104
Smilow Translational Research Center
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 650 213 6249
Lab: (215) 573-4015
Lab: (215) 573-4015
Education:
MBBS (medicine)
University of Melbourne, 1999.
PhD (immunology)
University of Melbourne, 2011.
Permanent linkMBBS (medicine)
University of Melbourne, 1999.
PhD (immunology)
University of Melbourne, 2011.
Description of Clinical Expertise
Blood and Marrow TransplantationLeukemia
Myelodysplastic Syndromes
Myeloproliferative Neoplasms
Lymphoproliferative Neoplasms
Bone Marrow Failure
Description of Research Expertise
Tumor ImmunologyChimeric Antigen Receptor T cells
Mouse Models of Human Leukemia
Murine Xenografts
Adoptive Cellular Therapy
Genetic Engineering of T cells
Flow Cytometry
Selected Publications
Blumenberg V, Diorio C, Gauthier J, Agrusa JE, Dreyzin A, Hänel G, Espinoza-Gutarra MR, Geer M, Perales MA, Ramakrishna S, Jain MD, Gill S, Locke FL, Shouval R, Subklewe M, Komanduri KV, Chapuis AG, Paczesny S, Rejeski K, Shah NN.: Expert Panel Review and Practical Guidance on Biomarker Testing with Engineered Immune Effector Cells. Transplant Cell Ther May 2026.Durgin JS, Seo SH, Kazmi S, Valentić B, Leff C, Markovska M, Jin X, Shen F, Berjis A, Mukherjee N, Sannecy A, Plesa G, Gabunia K, Scholler J, Gill SI, O'Connor RS, June CH, Ghassemi S.: Single-day nonactivated IL-18-armed CAR T cells establish a durable, stemlike state with enhanced persistence. Blood Apr 2026.
Chen GM, Jain A, Gering DT, Satulovsky J, Datta S, Lai P, Karar J, Gonzalez VE, Alexander K, Chew A, Jadlowsky JK, Ruella M, Paruzzo L, Amses KR, Rech AJ, Stadtmauer EA, Frey NV, Hexner EO, Porter DL, Cohen AD, Gill SI, Garfall AL, Schuster SJ, Mo KC, Liang SI, Spasic M, Levine BL, Siegel DL, Ramírez-Fernández A, Cabanski CR, Yang E, Mackall CL, Bushman FD, Good Z, John Wherry E, June CH, Fraietta JA.: Predictive biomarkers of response to chimeric antigen receptor (CAR) T-cell therapy for pan-haematologic cancer. Nat Biomed Eng 2026.
Altun B, Zhao G, Wang B, Mao X, Manfredo-Vieira S, Willis E, Radaelli E, Goodman EE, Boesteanu AC, Gill SI, Patel DR, Wong S, Cottman-Thomas E, Hogan JJ, Payne AS.: Preclinical evaluation of antigen-specific B-cell depletion for phospholipase A2 receptor membranous nephropathy with chimeric autoantibody receptor T cells. Kidney Int 2026.
Bot A, Stephan MT, Gill S.: The dawn of in vivo immune cell engineering in oncology. Nat Biotechnol 2026.
Bowman M, Gounder S, Singh V, Shestova O, Robinson T, Zhang A, Gandhi A, Bandopadhyay R, Cai SF, Levine RL, Gill SI, Miles LA, Bowman RL.: scDNA: Single Cell DNA analysis software toolkit for subclonality discovery and assessment. bioRxiv Dec 2025.
McFarland AG, Ooi SK, Tafuri D, Kamali E, Cooper N, Cook EJ, Reddy S, Jarocha D, Wellhausen N, Gill SI, Roche AM, Fraietta JA, Bushman FD, Herbst F.: An integrated enzymatic and computational pipeline for quantifying off-target base-editing. bioRxiv Aug 2025.
Naik S, Aplenc R, Baumeister SHC, Becilli M, Bhagwat AS, Bonifant CL, Budde LE, Chien CD, Curran KJ, Daniyan AF, Dreyzin A, Gardner RA, Ghorashian S, Gottschalk S, Hill LC, Kohler ME, Lamble AJ, Locatelli F, Mamonkin M, Omer B, Park JH, Quintarelli C, Rambaldi B, Richards RM, Sallman DA, Sauer T, Shah NN, Subklewe M, Summers C, Tasian SK, Taylor N, Tettamanti S, Verneris MR, Velasquez MP, Gill SI.: International Consensus Guidelines for the Conduct and Reporting of CAR T-Cell Clinical Trials in AML. Blood Adv 9: 6047-6058, Aug 2025.
Mellors PW, Lange AN, Casino Remondo B, Shestov M, Planer JD, Peterson AR, Ying Y, Zhou S, Christie JD, Diamond JM, Cantu E, Basil MC, Gill S.: Shared roles of immune and stromal cells in the pathogenesis of human bronchiolitis obliterans syndrome. JCI Insight 10: e176596, Apr 2025.
Sande CM, Chen S, Mitchell DV, Lin P, Abraham DM, Cheng JM, Gebhard T, Deolikar RJ, Freeman C, Zhou M, Kumar S, Bowman M, Bowman RL, Zheng S, Munkhbileg B, Chen Q, Stanley NL, Guo K, Lapite A, Hausler R, Taylor DM, Corines J, Morrissette JJ, Lieberman DB, Yang G, Shestova O, Gill S, Zheng J, Smith-Simmer K, Banaszak LG, Shoger KN, Reinig EF, Peterson M, Nicholas P, Walne AJ, Dokal I, Rosenheck JP, Oetjen KA, Link DC, Gelman AE, Reilly CR, Dutta R, Lindsley RC, Brundige KJ, Agarwal S, Bertuch AA, Churpek JE, Tague LK, Johnson FB, Olson TS, Babushok DV.: ATM-dependent DNA damage response constrains cell growth and drives clonal hematopoiesis in telomere biology disorders. J Clin Invest 135: e181659, Apr 2025.