Mark H. O'Hara, MD

faculty photo
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-306
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: (215)360-0735
Fax: (215)662-4646
Education:
BS (Biology - Molecular Genetics)
University of Rochester, 2004.
MD (Medicine)
Stony Brook School of Medicine, 2008.
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Description of Clinical Expertise

GI cancers, Phase 1 trials, Pancreatic cancer, Colorectal cancer, Anal cancer, Esophageal cancer, Gastric cancer, Hepatocellular carcinoma, Cholangiocarcinoma, Neuroendocrine tumor

Description of Research Expertise

Pancreatic cancer, colorectal cancer, GI cancers, Phase 1, CAR T cell therapy

Selected Publications

Haas Andrew R, Tanyi Janos L, O'Hara Mark H, Gladney Whitney L, Lacey Simon F, Torigian Drew A, Soulen Michael C, Tian Lifeng, McGarvey Maureen, Nelson Anne Marie, Farabaugh Caitlin S, Moon Edmund, Levine Bruce L, Melenhorst J Joseph, Plesa Gabriela, June Carl H, Albelda Steven M, Beatty Gregory L: Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers. Molecular therapy : the journal of the American Society of Gene Therapy Jul 2019.

Karasic Thomas B, O'Hara Mark H, Loaiza-Bonilla Arturo, Reiss Kim A, Teitelbaum Ursina R, Borazanci Erkut, De Jesus-Acosta Ana, Redlinger Colleen, Burrell Jessica A, Laheru Daniel A, Von Hoff Daniel D, Amaravadi Ravi K, Drebin Jeffrey A, O'Dwyer Peter J: Effect of Gemcitabine and nab-Paclitaxel With or Without Hydroxychloroquine on Patients With Advanced Pancreatic Cancer: A Phase 2 Randomized Clinical Trial. JAMA oncology 5(7): 993-998, Jul 2019.

Bauman Brittany, Mick Rosemarie, Martinez Eileen, Lawless Theresa M, Zinck Lindsey, Sinclair Paige, Fuhrer Mary, O'Hara Mark, Schneider Charles J, O'Dwyer Peter, Plastaras John, Teitelbaum Ursina, Reiss Kim A: Efficacy of Oral Cryotherapy During Oxaliplatin Infusion in Preventing Oral Thermal Hyperalgesia: A Randomized Trial. Journal of the National Comprehensive Cancer Network : JNCCN 17(4): 358-364, Apr 2019.

Lee Jae W, Stone Meredith L, Porrett Paige M, Thomas Stacy K, Komar Chad A, Li Joey H, Delman Devora, Graham Kathleen, Gladney Whitney L, Hua Xia, Black Taylor A, Chien Austin L, Majmundar Krishna S, Thompson Jeffrey C, Yee Stephanie S, O'Hara Mark H, Aggarwal Charu, Xin Dong, Shaked Abraham, Gao Mingming, Liu Dexi, Borad Mitesh J, Ramanathan Ramesh K, Carpenter Erica L, Ji Ailing, de Beer Maria C, de Beer Frederick C, Webb Nancy R, Beatty Gregory L: Hepatocytes direct the formation of a pro-metastatic niche in the liver. Nature 567(7747): 249-252, 03 2019.

Maity Amit, Mick Rosemarie, Huang Alexander C, George Sangeeth M, Farwell Michael D, Lukens John N, Berman Abigail T, Mitchell Tara C, Bauml Josh, Schuchter Lynn M, O'Hara Mark, Lin Lilie L, Demichele Angela, Christodouleas John P, Haas Naomi B, Patsch Dana M, Hahn Stephen M, Minn Andy J, Wherry E John, Vonderheide Robert H: A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours. British journal of cancer 119(10): 1200-1207, Oct 2018.

Shabason JE, Chen J, Apisarnthanarax S, Damjanov N, Giantonio B, Loaiza-Bonilla A, O'Dwyer PJ, O'Hara M, Reiss KA, Teitelbaum U, Wissel P, Drebin JA, Vollmer C, Kochman M, Mick R, Vergara N, Jhala N, Doucette A, Lukens JN, Plastaras JP, Metz JM, Ben-Josef E.: A phase I dose escalation trial of nab-paclitaxel and fixed dose radiation in patients with unresectable or borderline resectable pancreatic cancer. Cancer Chemother Pharmacol. 81(3): 609-614, Jan 23 2018 Notes: doi: 10.1007/s00280-018-3519-6 Epub ahead of print.

Reiss KA, Maxwell KN, Nathanson K, Teitelbaum UR, O’Hara MH, O’Dwyer PJ, Schneider C, Carpenter EL, Mick R, Domcheck SM. : A single arm phase II study of rucapariob maintenance in patients with advanced pancreatic adenocarcinoma and a known deleterious BRCA1, BRCA2 or PALB2 mutation who have achieved stability on platinum therapy. J Clin Oncol 36(4S_suppl), TPS531 2018 Notes: "Poster Presentation"

Reiss KA, Ben-Josef E, Damjanov N, Hoteit M, O’Hara MH, Karasic TB, Teitelbaum UR, Schneider C, O’Dwyer PJ, Carpenter EL, Mick R, Vonderheide RH. : A pilot study of galunisertib (LY2157299) plus stereotactic body radiotherapy (SBRT) in advanced hepatocellular carcinoma (HCC). J Clin Oncol 36(4S_suppl), TPS528 2018 Notes: "Poster Presentation"

Karasic TB, O’Hara MH, Teitelbaum UR, Damjanov N, Giantonio BJ, d’Entremont TS, Gallagher M, Zhang PJ, O’Dwyer PJ. : Phase II trial of palbociclib in patients with advanced esophageal or gastric cancer. J Clin Oncol, (4S_suppl), 68 36, 2018 Notes: "Poster Presentation"

Beatty Gregory L, O'Hara Mark H, Lacey Simon F, Torigian Drew A, Nazimuddin Farzana, Chen Fang, Kulikovskaya Irina M, Soulen Michael C, McGarvey Maureen, Nelson Anne Marie, Gladney Whitney L, Levine Bruce L, Melenhorst J Joseph, Plesa Gabriela, June Carl H: Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial. Gastroenterology 155(1): 29-32, 07 2018.

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Last updated: 10/09/2019
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