Marco Ruella, MD

faculty photo
Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
South Tower 8-112
Perelman Center for Advanced Medicine
3400 Civic Center Blvd
Philadelphia, PA 191004
Office: 215-746-4880
Fax: 215-573-3638
Lab: 215-573-8538
Education:
MD (Medical Degree)
University of Torino, Italy , 2007.
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Description of Clinical Expertise

Dr. Ruella treat patients affected by hematological cancers and specializes in immunotherapy approaches.

Description of Research Expertise

Dr. Ruella's laboratory focuses on the mechanisms of relapse after chimeric antigen receptor T cell (CART) immunotherapies with the goal of rationally design innovative combined immunotherapies for relapsing/refractory leukemia and lymphoma.

Marco Ruella, MD, is Assistant Professor of Medicine in the Division of Hematology/Oncology and the Center for Cellular Immunotherapies and Scientific Director of the Lymphoma Program at the Hospital of the University of Pennsylvania. His research focuses on the study of the mechanisms of relapse after chimeric antigen receptor T cell (CART) immunotherapies with the goal of rationally designing combined innovative immunotherapies for relapsing/refractory leukemia and lymphoma. He is the author of numerous peer-reviewed publications on targeted immunotherapies for hematological cancers and is an inventor in several patents on CAR T therapy. His work has been recognized through numerous awards including the inaugural SITC EMD-Serono Cancer Immunotherapy Clinical Fellowship (2014), the AACR-BMS Oncology Fellowship in Clinical Cancer Research (2015), the ASH Scholar Award (2016), a NIH K99-R00 award (2017), the “Paola Campese” Award Leukemia Research (2017), the Cancer Support Community Award (2018), and most recently the 2018 American Society of Hematology Joanne Levy, MD, Memorial Award for Outstanding Achievement. Dr. Ruella obtained his medical degree with high honors and completed his specialization in clinical hematology at the University of Torino, Italy. After completing his fellowship, he was an attending physician in the Hematology and Cell Therapy Division of the Mauriziano Hospital and an Instructor at the Biotechnology School at the University of Torino. From 2012, he was a postdoctoral fellow, and then an instructor at the University of Pennsylvania in the Center for Cellular Immunotherapies where he worked with Drs. June and Gill until appointment to his current position in 2018.

Selected Publications

Marco Ruella, David M Barrett, Olga Shestova, Jessica Perazzelli, Avery D Posey, Jr., Seok Jae Hong, Miroslaw Kozlowski, Simon F Lacey, J. Joseph Melenhorst, Carl H. June, Saar Gill : A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor positive cells Blood November 2019.

1. Singh, Nathan, MD, Frey, Noelle V., Engels, Boris, PhD, Barret, David M., Shestova, Olga, PhD, Ravikumar, Pranali, MS, Shyu, Amy, Highfill, Steven PhD, Zhao, Linlin, Peng, Liaomin, Granda, Brian, Ramones, Melissa, Lu, Xueqing Maggie, Christian, David A, PhD, Perazzelli, Jessica, Lacey, Simon F., PhD, Roy, Nathan, Burkhardt, Janis K., PhD, Colomb, Florent, Abdel-Mohsen, Mohamed, Young, Regina M., PhD, Brogdon, Jennifer, PhD, Grupp, Stephan, MD, PhD, June, Carl H, MD Maude, Shannon L., MD, PhD, Gill, Saar I. MD, PhD and Ruella, Marco, MD : Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy American Society of Hematology Annual Meeting Orlando, Florida(247), 2019.

Svoboda, Jakub, MD, Ballard, Hatcher J., BS, Chong, Elise A., MD, LaRose, Meredith I, MD, Bair, Steven M., MD, Namoglu, Esin C., B.S., Hughes, Mitchell E., PharmD, Nasta, Sunita Dwivedy, MD, Landsburg, Daniel J., MD, Barta, Stefan K., MD, MRCP, MS, Gerson, James N., MD, Weber, Elizabeth, BSN, RN, Walling, Chase BS, Ruella, Marco, MD, Frey, Noelle V., MD, Porter, David L., MD and Schuster, Stephen J., MD: Use of Bendamustine for Lymphodepletion before Tisagenlecleucel (anti-CD19 CAR T cells) for Aggressive B-Cell Lymphomas. American Society of Hematology Annual Meeting Orlando, Florida(1606), 2019.

Nasta, Sunita Dwivedy, MD, Hughes, Mitchell E. PharmD, Namoglu, Esin C. B.S., Landsburgh, Daniel J., MD, Chong, Elise A., MD, Barta, Stefan K. MD, MRCP, MS, Frey, Noelle V., MD, Gerson, James N., MD, Maity, Amit, MD, PhD, Plastaras, John, MD, Porter, David L., MD, Ruella, Marco, MD, Svoboda, Jakub, MD, Ballard, Hatcher J., BS and Schuster, Stephen J., MD : A Characterization of Bridging Therapies Leading up to Commercial CAR T-Cell Therapy American Society of Hematology Annual Meeting Orlando, Florida(4108), 2019.

Marco Ruella, Carl H. June: Beat Pediatric ALL MRD: CD28 CAR-T and Transplant. Blood 2019.

Nasta, Sunita Dwivedy, MD, Namoglu, Esin C., B.S., Hughes, Mitchell E., PharmD, Chong, Elise A., MD, Svoboda, Jakub, MD, Ballard, Hatcher J., BS, Landsburg, Daniel J., MD, LaRose, Meredith I, MD, Barta, Stefan K., MD, MRCP, MS, Gerson, James N., MD, Ruella, Marco, MD, Frey, Noelle V., MD, Schuster, Stephen J., MD and Porter, David L., MD: Hospitalization Patterns with Commercial CAR T-Cell Therapy: A Single Institution Experience. American Society of Hematology Annual Meeting Orlando, Florida(3240), 2019.

Wang, Meng, BS, Pruteanu, Iulian, PhD, Cohen, Adam D., MD, Garfall, Alfred L, MD, Milone, Michael C., Tian, Lifeng, PhD, Gonzalez, Vanessa E., Gill, Saar, MD, MRCP, FRCPath, Frey, Noelle V., MD, Barrett, David M., Ruella, Marco, MD, Lacey, Simon F, PhD, Svoboda, Jakub MD, Chong, Elise A. MD, Fraietta, Joseph A, PhD, Davis, Megan, PhD, Nasta, Sunita D, MD, Levine, Bruce L, PhD, Siegel, Don L., MD, PhD, Maude, Shannon L., MD, PhD, Schuster, Stephen J., MD, Stadtmauer, Edward A., MD, FACP, Grupp, Stephan, MD, PhD, Porter, David L., MD, June, Carl H MD and Melenhorst, J. Joseph PhD: Identification and Validation of Predictive Biomarkers to CD19- and BCMA-Specific CAR T-Cell Responses in CAR T-Cell Precursors. American Society of Hematology Annual Meeting Orlando, Florida(622), 2019.

Ghione P, Moskowitz AJ, De Paola NEK, Horwitz SM, Ruella M.: Novel Immunotherapies for T Cell Lymphoma and Leukemia. Curr Hematol Malig Rep. Oct 13 2018.

Ruella M, Xu J, Barrett DM, Fraietta JA, Reich TJ, Ambrose DE, Klichinsky M, Shestova O, Patel PR, Kulikovskaya I, Nazimuddin F, Bhoj VG, Orlando EJ, Fry TJ, Bitter H, Maude SL, Levine BL, Nobles CL, Bushman FD, Young RM, Scholler J, Gill SI, June CH, Grupp SA, Lacey SF, Melenhorst JJ.: Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Nat Med. 24(10):1499-1503, Oct 2018.

Ascierto Paolo A, Brugarolas James, Buonaguro Luigi, Butterfield Lisa H, Carbone David, Daniele Bruno, Ferris Robert, Fox Bernard A, Galon Jérôme, Gridelli Cesare, Kaufman Howard L, Klebanoff Christopher A, Melero Ignacio, Nathan Paul, Paulos Chrystal M, Ruella Marco, Sullivan Ryan, Zarour Hassane, Puzanov Igor: Perspectives in immunotherapy: meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy). Journal for immunotherapy of cancer 6(1): 69, Jul 2018.

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Last updated: 11/13/2019
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