Joshua D Brandstadter, MD PhD MSc
Instructor A of Medicine (Hematology-Oncology)
Department: Medicine
Contact information
Biomedical Research Building II/III
Bay 449
421 Curie Blvd
Philadelphia, PA 19014
Bay 449
421 Curie Blvd
Philadelphia, PA 19014
Publications
Education:
BA (Molecular Biology & Biochemistry; Economics)
Wesleyan University, 2006.
MSc (Integrated Immunology)
University of Oxford, 2007.
MD-PhD (Medicine; Molecular Cancer Biology)
Duke University, 2015.
Permanent linkBA (Molecular Biology & Biochemistry; Economics)
Wesleyan University, 2006.
MSc (Integrated Immunology)
University of Oxford, 2007.
MD-PhD (Medicine; Molecular Cancer Biology)
Duke University, 2015.
Description of Clinical Expertise
Castleman disease, histiocytic disorders, lymphoma, lymphoproliferative disordersDescription of Research Expertise
Castleman Disease, lymphoproliferative disorders, lymphoma, lymph node stromal cells, fibroblastic stromal cellsSelected Publications
Sheila K Pierson, Joshua D Brandstadter, Drew Torigian, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat MD, Corey Casper, Amy Chadburn, Shanmuganathan Chandrakasan, Angela Dispenzieri, Alexander Fosså, Christian Hoffmann, Makoto Ide, Razelle Kurzrock, Sudipto Mukherjee, Sunita D Nasta, José-Tomás Navarro, Ariela Noy, Eric Oksenhendler, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Matthew J Streetly, Raymond Siu Ming Wong, Lu Zhang, Megan S Lim, Gordan Srkalovic, Frits van Rhee, David C Fajgenbaum: Characterizing the heterogeneity of Castleman disease and oligocentric subtype: Findings from the ACCELERATE registry. Blood Advances February 2025.Anneka Allman, Brian T Gaudette, Samantha Kelly, Nagham Alouche, Léolène J Carrington, Eric Perkey, Joshua D Brandstadter, Riley Outen, Ashley Vanderbeck, Katlyn Lederer, Yeqiao Zhou, Robert B Faryabi, Tanner F Robertson, Janis K Burkhardt, Anastasia Tikhonova, Iannis Aifantis, Leonardo Scarpellino, Ute Koch, Freddy Radtke, Mechthild Lütge, Angelina De Martin, Burkhard Ludewig, Lena Tveriakhina, Achim Gossler, Lluc Mosteiro, Christian W Siebel, Daniela Gómez Atria, Sanjiv A Luther, David Allman, Ivan Maillard: Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs. Immunity. CellPress, 58(1), January 2025.
Brandstadter JD, Lutge M, Lim MS, Bagg A, Miller ID, Gonzalez MV, Austin B, Priore SF, Ludewig B, Fajgenbaum DC, Maillard I.: Myofibroblast to T-Zone Reticular Cell Ratio Identifies Unicentric Castleman Disease Lymph Nodes. American Society of Hematology Annual Meeting, San Diego, CA.(1155), Dec 2024 Notes: "Oral Presentation"
Bustamante MS, Pierson SK, Ren Y, Bagg A, Brandstadter JD, Srkalovic G, Mango N, Alapat D, Lechowicz MJ, Li H, Van Rhee F, Lim MS, Fajgenbaum DC.: Longitudinal, natural history study reveals the disease burden of idiopathic multicentric Castleman disease. Haematologica 109: 2196-2206, Jul 2024.
Shyamsundar S, Pierson SK, Connolly CM, Teles M, Segev DL, Werbel WA, van Rhee F, Casper C, Brandstadter JD, Noy A, Fajgenbaum DC.: Castleman disease patients report mild COVID-19 symptoms and mount a humoral response to SARS-CoV-2 vaccination. Blood Neoplasia 1(1): 100002. doi: 10.1016/j.bneo.2024.100002. Mar 2024.
Rubenstein AI, Pierson SK, Shyamsundar S, Bustamante MS, Gonzalez MV, Milller ID, Brandstadter JD, Mumau MD, Fajgenbaum DC.: Immune-mediated thrombocytopenia and IL-6-mediated thrombocytosis observed in idiopathic multicentric Castleman disease. Br J Haematol 204(3): 921-930, Mar 2024.
Mango NA, Pierson SK, Sarmiento Bustamante M, Brandstadter JD, van Rhee F, Fajgenbaum DC.: Siltuximab administration results in spurious IL-6 elevation in peripheral blood. Am J Hematol 99(1): E15-E18. Jan 2024.
Pierson SK, Lim MS, Srkalovic G, Brandstadter JD, Sarmiento Bustamante M, Shyamsundar S, Mango N, Lavery C, Austin B, Alapat D, Lechowicz MJ, Bagg A, Li H, Casper C, van Rhee F, Fajgenbaum DC.: Treatment Consistent with Idiopathic Multicentric Castleman Disease Guidelines is Associated with Improved Outcomes. Blood Adv 7(21): 6652-6664, Sep 2023.
Sarmiento Bustamante M, Shyamsundar S, Coren FR, Bagg A, Srkalovic G, Alapat D, van Rhee F, Lim MS, Lechowicz MJ, Brandstadter JD, Pierson SK, Fajgenbaum DC.: Ongoing symptoms following complete surgical excision in unicentric Castleman disease. Am J Hematol 98(11): E334-E337. Aug 2023.
Brandstadter JD, Outen R, Maillard I.: Having it both ways: how STAT3 deficiency blocks graft-versus-host disease while preserving graft-versus-leukemia activity. J Clin Invest 133(15): e172251, Aug 2023.