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Joshua D Brandstadter, MD PhD MSc
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Assistant Professor of Medicine (Hematology-Oncology) at the Hospital of the University of Pennsylvania
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Department: Medicine
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Contact information
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3600 Civic Center Blvd
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Philadelphia, PA 19014
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2e Room 15-109
Philadelphia, PA 19014
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Publications
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Links
bd Search PubMed for articles
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Education:
21 7 BA 38 (Molecular Biology & Biochemistry; Economics) c
2c Wesleyan University, 2006.
21 8 MSc 22 (Integrated Immunology) c
2d University of Oxford, 2007.
21 b MD-PhD 2f (Medicine; Molecular Cancer Biology) c
28 Duke University, 2015.
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Permanent link21 7 BA 38 (Molecular Biology & Biochemistry; Economics) c
2c Wesleyan University, 2006.
21 8 MSc 22 (Integrated Immunology) c
2d University of Oxford, 2007.
21 b MD-PhD 2f (Medicine; Molecular Cancer Biology) c
28 Duke University, 2015.
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Description of Clinical Expertise
61 Castleman disease, histiocytic disorders, lymphoma, lymphoproliferative disorders71
Description of Research Expertise
80 Castleman Disease, lymphoproliferative disorders, lymphoma, lymph node stromal cells, fibroblastic stromal cellse 29
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eb Laczko D, Pillai V, Frank D, Brandstadter JD, Fajgenbaum DC: How I diagnose Castleman disease. American Journal of Clinical Pathology 165(3): aqaf147, March 2026.
176 Shyamsundar S, Sarmiento Bustamante M, Borys L, Lim MS, Bagg A, Lechowicz MJ, Alapat D, Chadburn A, Srkalovic G, van Rhee F, Austin B, Brandstadter JD, Fajgenbaum DC: Breast-implant associated unicentric castleman disease: a case report. Current Problems in Cancer Case Reports 21: 100404, March 2026.
17b Kurz L, Lutge M, De Martin A, Cheng H-W, Bugar E, Stanossek Y, Meili S, Brandstadter JD, Maillard I, Onder L, Ludewig B: A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes. Journal of Experimental Medicine 2(223): e20242300, February 2026.
1a9 McHugh K, Huang Y, Austin B, Borys L, Irvine A, Alapat D, Bagg A, Chadburn A, Lechowicz MJ, Lim M, Srkalovic G, van Rhee F, Fajgenbaum D, Zhang L, Brandstadter J: Idiopathic multicentric castleman disease unresponsive to one IL-6 inhibitor may respond to another IL-6 inhibitor. American Society of Hematology Annual Meeting, Orlando, FL December 2025.
1b0 Steven Rowe, Mariam Goubran, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Bridget Austin, Kathleen McNicholas, Marley Blommers, Junyan Shi, Lisa K Peterson, Lusia Sepiashvili, Andre Mattman, Joshua D Brandstadter, David C Fajgenbaum, Luke Y C Chen: Ferritin, C-Reactive Protein, and Soluble CD25 Distinguish TAFRO From HLH. Am J Hematol September 2025.
1a4 Mechthild Lütge, Lisa Kurz, Yves Stanossek, Samuel Meili, Hung-Wei Cheng, Angelina De Martin, Joshua Brandstadter, Ivan Maillard, Mark D Robinson, Sandro J Stoeckli, Natalia B Pikor, Lucas Onder, Burkhard Ludewig: Fibroblastic reticular cells form reactive myeloid cell niches in human lymph nodes. Science Immunology 10(107): eads6820, May 2025.
23f Dave Maurice De Sousa, Eric Perkey, Laure Le Corre, Salix Boulet, Daniela Gómez Atria, Anneka Allman, Frédéric Duval, Jean-François Daudelin, Joshua D Brandstadter, Katlyn Lederer, Sarah Mezrag, Livia Odagiu, Myriam Ennajimi, Marion Sarrias, Hélène Decaluwe, Ute Koch, Freddy Radtke, Burkhard Ludewig, Christian W Siebel, Ivan Maillard, Nathalie Labrecque : Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation. J Exp Med 5(222): e20231758, May 2025.
2d9 Sheila K Pierson, Joshua D Brandstadter, Drew Torigian, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat MD, Corey Casper, Amy Chadburn, Shanmuganathan Chandrakasan, Angela Dispenzieri, Alexander Fosså, Christian Hoffmann, Makoto Ide, Razelle Kurzrock, Sudipto Mukherjee, Sunita D Nasta, José-Tomás Navarro, Ariela Noy, Eric Oksenhendler, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Matthew J Streetly, Raymond Siu Ming Wong, Lu Zhang, Megan S Lim, Gordan Srkalovic, Frits van Rhee, David C Fajgenbaum: Characterizing the heterogeneity of Castleman disease and oligocentric subtype: Findings from the ACCELERATE registry. Blood Advances February 2025.
2f8 Anneka Allman, Brian T Gaudette, Samantha Kelly, Nagham Alouche, Léolène J Carrington, Eric Perkey, Joshua D Brandstadter, Riley Outen, Ashley Vanderbeck, Katlyn Lederer, Yeqiao Zhou, Robert B Faryabi, Tanner F Robertson, Janis K Burkhardt, Anastasia Tikhonova, Iannis Aifantis, Leonardo Scarpellino, Ute Koch, Freddy Radtke, Mechthild Lütge, Angelina De Martin, Burkhard Ludewig, Lena Tveriakhina, Achim Gossler, Lluc Mosteiro, Christian W Siebel, Daniela Gómez Atria, Sanjiv A Luther, David Allman, Ivan Maillard: Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs. Immunity. CellPress, 58(1), January 2025.
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Selected Publications
10d Brandstadter JD, Lurain K, Nasta SD, and Fajgenbaum DC: Chapter 59: Castleman Disease and Rosai-Dorfman-Destombes Disease. Classical Hematology. Springer Nature Switzerland, Page: 601, May 2026.eb Laczko D, Pillai V, Frank D, Brandstadter JD, Fajgenbaum DC: How I diagnose Castleman disease. American Journal of Clinical Pathology 165(3): aqaf147, March 2026.
176 Shyamsundar S, Sarmiento Bustamante M, Borys L, Lim MS, Bagg A, Lechowicz MJ, Alapat D, Chadburn A, Srkalovic G, van Rhee F, Austin B, Brandstadter JD, Fajgenbaum DC: Breast-implant associated unicentric castleman disease: a case report. Current Problems in Cancer Case Reports 21: 100404, March 2026.
17b Kurz L, Lutge M, De Martin A, Cheng H-W, Bugar E, Stanossek Y, Meili S, Brandstadter JD, Maillard I, Onder L, Ludewig B: A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes. Journal of Experimental Medicine 2(223): e20242300, February 2026.
1a9 McHugh K, Huang Y, Austin B, Borys L, Irvine A, Alapat D, Bagg A, Chadburn A, Lechowicz MJ, Lim M, Srkalovic G, van Rhee F, Fajgenbaum D, Zhang L, Brandstadter J: Idiopathic multicentric castleman disease unresponsive to one IL-6 inhibitor may respond to another IL-6 inhibitor. American Society of Hematology Annual Meeting, Orlando, FL December 2025.
1b0 Steven Rowe, Mariam Goubran, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Bridget Austin, Kathleen McNicholas, Marley Blommers, Junyan Shi, Lisa K Peterson, Lusia Sepiashvili, Andre Mattman, Joshua D Brandstadter, David C Fajgenbaum, Luke Y C Chen: Ferritin, C-Reactive Protein, and Soluble CD25 Distinguish TAFRO From HLH. Am J Hematol September 2025.
1a4 Mechthild Lütge, Lisa Kurz, Yves Stanossek, Samuel Meili, Hung-Wei Cheng, Angelina De Martin, Joshua Brandstadter, Ivan Maillard, Mark D Robinson, Sandro J Stoeckli, Natalia B Pikor, Lucas Onder, Burkhard Ludewig: Fibroblastic reticular cells form reactive myeloid cell niches in human lymph nodes. Science Immunology 10(107): eads6820, May 2025.
23f Dave Maurice De Sousa, Eric Perkey, Laure Le Corre, Salix Boulet, Daniela Gómez Atria, Anneka Allman, Frédéric Duval, Jean-François Daudelin, Joshua D Brandstadter, Katlyn Lederer, Sarah Mezrag, Livia Odagiu, Myriam Ennajimi, Marion Sarrias, Hélène Decaluwe, Ute Koch, Freddy Radtke, Burkhard Ludewig, Christian W Siebel, Ivan Maillard, Nathalie Labrecque : Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation. J Exp Med 5(222): e20231758, May 2025.
2d9 Sheila K Pierson, Joshua D Brandstadter, Drew Torigian, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat MD, Corey Casper, Amy Chadburn, Shanmuganathan Chandrakasan, Angela Dispenzieri, Alexander Fosså, Christian Hoffmann, Makoto Ide, Razelle Kurzrock, Sudipto Mukherjee, Sunita D Nasta, José-Tomás Navarro, Ariela Noy, Eric Oksenhendler, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Matthew J Streetly, Raymond Siu Ming Wong, Lu Zhang, Megan S Lim, Gordan Srkalovic, Frits van Rhee, David C Fajgenbaum: Characterizing the heterogeneity of Castleman disease and oligocentric subtype: Findings from the ACCELERATE registry. Blood Advances February 2025.
2f8 Anneka Allman, Brian T Gaudette, Samantha Kelly, Nagham Alouche, Léolène J Carrington, Eric Perkey, Joshua D Brandstadter, Riley Outen, Ashley Vanderbeck, Katlyn Lederer, Yeqiao Zhou, Robert B Faryabi, Tanner F Robertson, Janis K Burkhardt, Anastasia Tikhonova, Iannis Aifantis, Leonardo Scarpellino, Ute Koch, Freddy Radtke, Mechthild Lütge, Angelina De Martin, Burkhard Ludewig, Lena Tveriakhina, Achim Gossler, Lluc Mosteiro, Christian W Siebel, Daniela Gómez Atria, Sanjiv A Luther, David Allman, Ivan Maillard: Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs. Immunity. CellPress, 58(1), January 2025.
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