Zainul Shoyeb Hasanali, MD, PhD
Department: Medicine
Contact information
3620 Hamilton Walk
230 John Morgan Building
Philadelphia, PA 19104
230 John Morgan Building
Philadelphia, PA 19104
Publications
Education:
BS (Chemistry)
Boston College, 2009.
PhD (Molecular Medicine)
Pennsylvania State University, 2017.
MD (Doctorate of Medicine)
Pennsylvania State College of Medicine, 2017.
Permanent linkBS (Chemistry)
Boston College, 2009.
PhD (Molecular Medicine)
Pennsylvania State University, 2017.
MD (Doctorate of Medicine)
Pennsylvania State College of Medicine, 2017.
Description of Clinical Expertise
Plasma Cell DyscrasiasMultiple Myeloma
AL Amyloidosis
Myeloma CART and Bispecific Antibody Therapy
Description of Research Expertise
Mouse and Human Plasma CellsGenetic Mouse Models
Myeloma Patient Derived Xenograft Models
Multiple Myeloma Modeling
Myeloma Cell Biology
The Unfolded Protein Response
Selected Publications
Fingrut, Warren B., Troyer, James, Russell, Eddrika, Aviles, Melanie, Della-Moretta, Sherraine, Dobson, Dre’Von, Hasanali, Zainul, Hu, Bei, Lapite, Ajibike, Pillai, Pallavi M., Schramm, Joseph W., Villagomez, Lynda M., Vo, Phuong, Wang’ondu, Ruth, Yui, Jennifer, Weyand, Angela C.: The American Society of Hematology Health Equity Compendium: examining health equity across the Blood journals. Blood Advances. American Society of Hematology, 8(17): 4616-4624, 2024.Tang, Yan, Liu, Wei, Kadu, Siddhant, Johnson, Omar, Hasanali, Zainul S., Kelly, Andre, Shestov, Alexander, Pajarillo, Raymone, Greenblatt, Eli, Holmes, Matthew, Wang, Li-Ping, Shih, Natalie, O’Connor, Roddy S., Ruella, Marco, Garfall, Alfred L., Allman, David, Vogl, Dan T., Cohen, Adam, June, Carl H., Sheppard, Neil C.: Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy. Blood. American Society of Hematology, 143(2): 139-151, 2024.
Ishikawa, Masaki, Hasanali, Zainul S., Zhao, Yongge, Das, Arundhoti, Lavaert, Marieke, Roman, Carly J., Londregan, Jennifer, Allman, David, Bhandoola, Avinash: Bone marrow plasma cells require P2RX4 to sense extracellular ATP. Nature. Springer Science and Business Media LLC, 626(8001): 1102-1107, 2024.
Hasanali, Zainul S., Garfall, Alfred L., Burzenski, Lisa, Shultz, Leonard D., Tang, Yan, Kadu, Siddhant, Sheppard, Neil C., Dopkin, Derek, Vogl, Dan T., Cohen, Adam D., Waxman, Adam J., Susanibar-Adaniya, Sandra P., Carroll, Martin, Stadtmauer, Edward A., Allman, David: Human IL-6 fosters long-term engraftment of patient derived disease-driving myeloma cells in immunodeficient mice. Cold Spring Harbor Laboratory, 2024.
LeBlanc, Francis R., Hasanali, Zainul S., Stuart, August, Shimko, Sara, Sharma, Kamal, Leshchenko, Violetta V., Parekh, Samir, Fu, Haiqing, Zhang, Ya, Martin, Melvenia M., Kester, Mark, Fox, Todd, Liao, Jiangang, Loughran, Thomas P., Evans, Juanita, Pu, Jeffrey J., Spurgeon, Stephen E., Aladjem, Mirit I., Epner, Elliot M.: Combined epigenetic and immunotherapy for blastic and classical mantle cell lymphoma. Oncotarget. Impact Journals, LLC, 13(1): 986-1002, 2022.
Hasanali, Zainul, Garfall, Alfred L., Carroll, Martin P., Secreto, Anthony, Skuli, Nicolas, Roman, Carly, Shultz, Leonard, Sheppard, Neil, Stadtmauer, Edward A., Allman, David: The NSG-hIL6 Mouse As a Novel Murine Patient Derived Xenograft Model of Plasma Cell Dyscrasias for Study of Disease Biology and Therapeutic Development. Blood. American Society of Hematology, 140(Supplement 1): 9921-9922, 2022.
Spurgeon, Stephen E., Sharma, Kamal, Claxton, David F., Ehmann, Christopher, Pu, Jeffrey, Shimko, Sara, Stewart, August, Subbiah, Nan, Palmbach, Gundula, LeBlanc, Francis, Latour, Emile, Chen, YiYi, Mori, Motomi, Hasanali, Zainul, Epner, Elliot M.: Phase 1–2 study of vorinostat (SAHA), cladribine and rituximab (SCR) in relapsed B‐cell non‐Hodgkin lymphoma and previously untreated mantle cell lymphoma. British Journal of Haematology. Wiley, 186(6): 845-854, 2019.
Hasanali, Zainul S., O’Hara, Christopher: Visual Diagnosis: A 7-week-old Boy with Tachypnea and Poor Feeding. Pediatrics In Review. American Academy of Pediatrics (AAP), 38(2): e6–e9-e6–e9, 2017.
Epner, Elliot M., Saroya, Bikramajit Singh, Hasanali, Zainul S., Loughran, Thomas P.: Combination epigenetic and immunotherapy overcomes resistance to monoclonal antibodies in hematologic malignancies: A new therapeutic approach. Experimental Hematology. Elsevier BV, 44(3): 157-160, 2016.
Hasanali, Zainul S., Saroya, Bikramajit Singh, Stuart, August, Shimko, Sara, Evans, Juanita, Shah, Mithun Vinod, Sharma, Kamal, Leshchenko, Violetta V., Parekh, Samir, Loughran, Thomas P., Epner, Elliot M.: Epigenetic therapy overcomes treatment resistance in T cell prolymphocytic leukemia. Science Translational Medicine. American Association for the Advancement of Science (AAAS), 7(293), 2015.