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Vaibhav Jain, PhD
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Department: Medicine
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Contact information
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University of Pennsylvania
16 838 BRB-II/III
30 421 Curie Blvd
Philadephia, PA 19104
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16 838 BRB-II/III
30 421 Curie Blvd
Philadephia, PA 19104
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Education:
21 7 BS 31 (Bachelor of Sciences, Life Sciences ) c
40 Charan Singh University, Meerut, India., 2006.
21 7 MS 1a (Biotechnology) c
3b Jiwaji University, Gwalior, India., 2008.
21 7 MS 38 (Master of Technology, Medical Biotechnology) c
38 University of Hyderabad, India., 2010.
21 8 PhD 18 (Biosciences) c
31 CSIR-IGIB, Delhi, India., 2018.
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Permanent link21 7 BS 31 (Bachelor of Sciences, Life Sciences ) c
40 Charan Singh University, Meerut, India., 2006.
21 7 MS 1a (Biotechnology) c
3b Jiwaji University, Gwalior, India., 2008.
21 7 MS 38 (Master of Technology, Medical Biotechnology) c
38 University of Hyderabad, India., 2010.
21 8 PhD 18 (Biosciences) c
31 CSIR-IGIB, Delhi, India., 2018.
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Description of Research Expertise
27b Experienced research scientist with strong expertise in cancer biology, metabolism, and immunology. In my 10+ years of research I have worked at the interface of basic and translational research. I have developed the ability to handle research projects independently at intellectual as well as technical levels, while at the same time building a collaborative relationship with my supervisors, collaborators, and co‐workers to achieve the best outcome of the scientific problems I have handled. I am committed to an academic research career as an independent investigator and leader in the field of cancer metabolism.e 29
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172 Bhardwaj M, Lee JJ, Versace AM, Harper SL, Goldman AR, Crissey MAS, Jain V, Singh MP, Vernon M, Aplin AE, Lee S, Morita M, Winkler JD, Liu Q, Speicher DW, Amaravadi RK. : Lysosomal lipid peroxidation regulates tumor immunity. J Clin Invest 133(8): e164596. Apr 2023 Notes: DOI: 10.1172/JCI164596
194 Jain V, Harper SL, Versace AM, Fingerman D, Brown GS, Bhardwaj M, Crissey MAS, Goldman AR, Ruthel G, Liu Q, Zivkovic A, Stark H, Herlyn M, Gimotty PA, Speicher DW, Amaravadi RK. : Targeting UGCG overcomes resistance to lysosomal autophagy inhibition. Cancer Discov 13(2): 454-473, Feb 2023 Notes: DOI: 10.1158/2159-8290.CD-22-0535
10e Jain V, Amaravadi RK.: Pumping Iron: Ferritinophagy Promotes Survival and Therapy Resistance in Pancreatic Cancer. Cancer Discov 12(9): 2023-2025, Sep 2022 Notes: DOI: 10.1158/2159-8290.CD-22-0734
ba Lee JJ, Jain V, Amaravadi RK. : Clinical Translation of Combined MAPK and Autophagy Inhibition in RAS Mutant Cancer. Int J Mol Sci 2 4f 22(22): 12402, Nov 2021 Notes: DOI: 10.3390/ijms222212402
e2 Wang Y, Jain V, Versace A, Bhardwaj M, Ann S Crissey M, Amaravadi RK, Winkler JD. : Anticancer properties of bisaminoquinolines with modified linkers. Bioorg Med Chem Lett 2 52 49: 128272. Oct 2021 Notes: DOI: 10.1016/j.bmcl.2021.128272
146 Gheware A, Panda L, Khanna K, Bhatraju NK, Jain V, Sagar S, Kumar M, Singh VP, KannanS, Subramanian V, Mukerji M, Agrawal A, Prasher B.: Adhatoda vasica rescues the hypoxia-dependent severe asthma symptoms and mitochondrial dysfunction. Am J Physiol Lung Cell Mol Physiol 2 58 320(5): L757-L769. May 2021 Notes: DOI: 10.1152/ajplung.00511.2020
172 Gheware A, Dholakia D, Kannan S, Panda L, Rani R, Pattnaik BR, Jain V, Parekh Y, Enayathullah MG, Bokara KK, Subramanian V, Mukerji M, Agrawal A, Prasher B.: Adhatoda Vasica attenuates inflammatory and hypoxic responses in preclinical mouse models: potential for repurposing in COVID-19-like conditions. Respir Res 50 22(1): 99, Apr 2021 Notes: DOI: 10.1186/s12931-021-01698-9
186 Rehman R, Vijayakumar VE, Jaiswal A, Jain V, Mukherjee S, Vellarikkal SK, Dieffenbach PB, Fredenburgh LE, Prakash YS, Ghosh B, Agrawal A, Mabalirajan U. : Noncanonical role for Ku70/80 in the prevention of allergic airway inflammation via maintenance of airway epithelial cell organelle homeostasis. Am J Physiol Lung Cell Mol Physiol 2 58 319(4): L728-L741. Oct 2020 Notes: DOI: 10.1152/ajplung.00522.2019
173 Sharma G, Ojha R, Noguera-Ortega E, Rebecca VW, Attanasio J, Liu S, Piao S, Lee JJ, Nicastri MC, Harper SL, Ronghe A, Jain V, Winkler JD, Speicher DW, Mastio J, Gimotty PA,Xu X, Wherry EJ, Gabrilovich DI, Amaravadi RK. : PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma. JCI Insight 2 2e 5(17): e133225. Sep 2020.
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Selected Publications
9f Jain V, Singh MP, Amaravadi RK. : Recent Advances in Targeting Autophagy in Cancer. Trends Pharmacol Sci 2 55 44(5): 290-302, May 2023 Notes: DOI: 10.1016/j.tips.2023.02.003172 Bhardwaj M, Lee JJ, Versace AM, Harper SL, Goldman AR, Crissey MAS, Jain V, Singh MP, Vernon M, Aplin AE, Lee S, Morita M, Winkler JD, Liu Q, Speicher DW, Amaravadi RK. : Lysosomal lipid peroxidation regulates tumor immunity. J Clin Invest 133(8): e164596. Apr 2023 Notes: DOI: 10.1172/JCI164596
194 Jain V, Harper SL, Versace AM, Fingerman D, Brown GS, Bhardwaj M, Crissey MAS, Goldman AR, Ruthel G, Liu Q, Zivkovic A, Stark H, Herlyn M, Gimotty PA, Speicher DW, Amaravadi RK. : Targeting UGCG overcomes resistance to lysosomal autophagy inhibition. Cancer Discov 13(2): 454-473, Feb 2023 Notes: DOI: 10.1158/2159-8290.CD-22-0535
10e Jain V, Amaravadi RK.: Pumping Iron: Ferritinophagy Promotes Survival and Therapy Resistance in Pancreatic Cancer. Cancer Discov 12(9): 2023-2025, Sep 2022 Notes: DOI: 10.1158/2159-8290.CD-22-0734
ba Lee JJ, Jain V, Amaravadi RK. : Clinical Translation of Combined MAPK and Autophagy Inhibition in RAS Mutant Cancer. Int J Mol Sci 2 4f 22(22): 12402, Nov 2021 Notes: DOI: 10.3390/ijms222212402
e2 Wang Y, Jain V, Versace A, Bhardwaj M, Ann S Crissey M, Amaravadi RK, Winkler JD. : Anticancer properties of bisaminoquinolines with modified linkers. Bioorg Med Chem Lett 2 52 49: 128272. Oct 2021 Notes: DOI: 10.1016/j.bmcl.2021.128272
146 Gheware A, Panda L, Khanna K, Bhatraju NK, Jain V, Sagar S, Kumar M, Singh VP, KannanS, Subramanian V, Mukerji M, Agrawal A, Prasher B.: Adhatoda vasica rescues the hypoxia-dependent severe asthma symptoms and mitochondrial dysfunction. Am J Physiol Lung Cell Mol Physiol 2 58 320(5): L757-L769. May 2021 Notes: DOI: 10.1152/ajplung.00511.2020
172 Gheware A, Dholakia D, Kannan S, Panda L, Rani R, Pattnaik BR, Jain V, Parekh Y, Enayathullah MG, Bokara KK, Subramanian V, Mukerji M, Agrawal A, Prasher B.: Adhatoda Vasica attenuates inflammatory and hypoxic responses in preclinical mouse models: potential for repurposing in COVID-19-like conditions. Respir Res 50 22(1): 99, Apr 2021 Notes: DOI: 10.1186/s12931-021-01698-9
186 Rehman R, Vijayakumar VE, Jaiswal A, Jain V, Mukherjee S, Vellarikkal SK, Dieffenbach PB, Fredenburgh LE, Prakash YS, Ghosh B, Agrawal A, Mabalirajan U. : Noncanonical role for Ku70/80 in the prevention of allergic airway inflammation via maintenance of airway epithelial cell organelle homeostasis. Am J Physiol Lung Cell Mol Physiol 2 58 319(4): L728-L741. Oct 2020 Notes: DOI: 10.1152/ajplung.00522.2019
173 Sharma G, Ojha R, Noguera-Ortega E, Rebecca VW, Attanasio J, Liu S, Piao S, Lee JJ, Nicastri MC, Harper SL, Ronghe A, Jain V, Winkler JD, Speicher DW, Mastio J, Gimotty PA,Xu X, Wherry EJ, Gabrilovich DI, Amaravadi RK. : PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma. JCI Insight 2 2e 5(17): e133225. Sep 2020.
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