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Mark L. Kahn, M.D., B.A.

Edward S. Cooper, M.D./Norman Roosevelt and Elizabeth Meriwether McLure Professor
Department: Medicine
Graduate Group Affiliations

Contact information
11-123 Smilow Center for Translational Research
3400 Civic Center Boulevard, Bldg. 421
Philadelphia, PA 19104-5159
Office: (215) 898-9007
Fax: (215) 573-2094
Education:
B.A. (Science)
Brown University, 1984.
M.D. (Internal Medicine)
Brown University School of Medicine, 1987.
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Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Thrombosis / Hemostasis

CVI Research Description:
The Kahn Lab investigates signaling pathways in platelets that mediate thrombosis and signaling pathways in vascular endothelial cells of the blood and lymphatic system utilized during cardiovascular development.

Selected Publications

Bui Hung M, Enis David, Robciuc Marius R, Nurmi Harri J, Cohen Jennifer, Chen Mei, Yang Yiqing, Dhillon Veerpal, Johnson Kathy, Zhang Hong, Kirkpatrick Robert, Traxler Elizabeth, Anisimov Andrey, Alitalo Kari, Kahn Mark L: Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD. The Journal of clinical investigation May 2016.

Zhou Z, Tang AT, Wong WY, Bamezai S, Goddard LM, Shenkar R, Zhou S, Yang J, Wright AC, Foley M, Arthur JS, Whitehead KJ, Awad IA, Li DY, Zheng X, Kahn ML: Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signaling. Nature 532(7597): 122-6, April 2016.

Maltzman Jonathan S, Reed Hasina Outtz, Kahn Mark L: HA-ving lymphatics improves lung transplantation. The Journal of clinical investigation 125(11): 3999-4001, Nov 2015.

Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, Fu J, Xia L, Davies PF, Kahn ML: Lymph flow regulates collecting lymphatic vessel maturation in vivo. Journal of Clinical Investigation 125(8): 2995-3007, Aug 2015.

Kahn Mark L: Vascular development for climate control. Developmental cell 33(3): 241-2, May 2015.

Yang Yiqing, Enis David, Zheng Hui, Chia Stephanie, Yang Jisheng, Chen Mei, Dhillon Veerpal, Papayannapoulou Thalia, Kahn Mark L: Cell adhesion mediated by VCAM-ITGa9 interactions enables lymphatic development. Arteriosclerosis, Thrombosis, and Vascular Biology 35(5): 1175-89, Mar 2015.

Kahn Mark L: A critical role of platelet glycoprotein ibα in arterial remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology 35(3): 498-9, Mar 2015.

Zhou Zinan, Rawnsley David R, Goddard Lauren M, Pan Wei, Cao Xing-Jun, Jakus Zoltan, Zheng Hui, Yang Jisheng, Arthur J Simon C, Whitehead Kevin J, Li Dean, Zhou Bin, Garcia Benjamin A, Zheng Xiangjian, Kahn Mark L: The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression. Developmental Cell 32(2): 168-80, Jan 2015.

Jakus Zoltán, Gleghorn Jason P, Enis David R, Sen Aslihan, Chia Stephanie, Liu Xi, Rawnsley David R, Yang Yiqing, Hess Paul R, Zou Zhiying, Yang Jisheng, Guttentag Susan H, Nelson Celeste M, Kahn Mark L: Lymphatic function is required prenatally for lung inflation at birth. The Journal of Experimental Medicine 211(5): 815-26, May 2014.

Zheng Xiangjian, Riant Florence, Bergametti Françoise, Myers Cynthia D, Tang Alan T, Kleaveland Benjamin, Pan Wei, Yang Jisheng, Tournier-Lasserve Elisabeth, Kahn Mark L: Cerebral cavernous malformations arise independent of the heart of glass receptor. Stroke: A Journal of Cerebral Circulation 45(5): 1505-9, May 2014.

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Last updated: 06/14/2016
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