Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Mark L. Kahn, M.D., B.A.

Edward S. Cooper, M.D./Norman Roosevelt and Elizabeth Meriwether McLure Professor
Department: Medicine
Graduate Group Affiliations

Contact information
11-123 Smilow Center for Translational Research
3400 Civic Center Boulevard, Bldg. 421
Philadelphia, PA 19104-5159
Office: (215) 898-9007
Fax: (215) 573-2094
B.A. (Science)
Brown University, 1984.
M.D. (Internal Medicine)
Brown University School of Medicine, 1987.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Thrombosis / Hemostasis

CVI Research Description:
The Kahn Lab investigates signaling pathways in platelets that mediate thrombosis and signaling pathways in vascular endothelial cells of the blood and lymphatic system utilized during cardiovascular development.

Selected Publications

Yang Yiqing, Enis David, Zheng Hui, Chia Stephanie, Yang Jisheng, Chen Mei, Dhillon Veerpal, Papayannapoulou Thalia, Kahn Mark L: Cell Adhesion Mediated by VCAM-ITGa9 Interactions Enables Lymphatic Development. Arteriosclerosis, thrombosis, and vascular biology Mar 2015.

Kahn Mark L: A critical role of platelet glycoprotein ibα in arterial remodeling. Arteriosclerosis, thrombosis, and vascular biology 35(3): 498-9, Mar 2015.

Zhou Zinan, Rawnsley David R, Goddard Lauren M, Pan Wei, Cao Xing-Jun, Jakus Zoltan, Zheng Hui, Yang Jisheng, Arthur J Simon C, Whitehead Kevin J, Li Dean, Zhou Bin, Garcia Benjamin A, Zheng Xiangjian, Kahn Mark L: The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression. Developmental cell 32(2): 168-80, Jan 2015.

Sweet DT, Jimenez JM, Chang J, Hess PR, Mericko P, Fu J, Xia L, Davies PF, Kahn ML.: Lymph flow regulates collecting lymphatic vessel maturation in vivo. Journal of Clinical Investigation In Press, 2015.

Jakus Zoltán, Gleghorn Jason P, Enis David R, Sen Aslihan, Chia Stephanie, Liu Xi, Rawnsley David R, Yang Yiqing, Hess Paul R, Zou Zhiying, Yang Jisheng, Guttentag Susan H, Nelson Celeste M, Kahn Mark L: Lymphatic function is required prenatally for lung inflation at birth. The Journal of experimental medicine 211(5): 815-26, May 2014.

Zheng Xiangjian, Riant Florence, Bergametti Françoise, Myers Cynthia D, Tang Alan T, Kleaveland Benjamin, Pan Wei, Yang Jisheng, Tournier-Lasserve Elisabeth, Kahn Mark L: Cerebral cavernous malformations arise independent of the heart of glass receptor. Stroke; a journal of cerebral circulation 45(5): 1505-9, May 2014.

Boulaftali Yacine, Hess Paul R, Kahn Mark L, Bergmeier Wolfgang: Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity. Circulation research 114(7): 1174-84, Mar 2014.

Hess Paul R, Rawnsley David R, Jakus Zoltán, Yang Yiqing, Sweet Daniel T, Fu Jianxin, Herzog Brett, Lu MinMin, Nieswandt Bernhard, Oliver Guillermo, Makinen Taija, Xia Lijun, Kahn Mark L: Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life. The Journal of clinical investigation 124(1): 273-84, Jan 2014.

Liang X, Russell S R, Estelle S, Jones L H, Cho S, Kahn M L, Berndt M C, Bunting S T, Ware J, Li R: Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site. Journal of thrombosis and haemostasis : JTH 11(12): 2155-62, Dec 2013.

Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L: Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature Sept 2013 Notes: Epub ahead of print.

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Last updated: 07/14/2015
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