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Mark L. Kahn, M.D.

Edward S. Cooper, M.D./Norman Roosevelt and Elizabeth Meriwether McLure Professor
Department: Medicine
Graduate Group Affiliations

Contact information
11-123 Smilow Center for Translational Research
3400 Civic Center Boulevard, Bldg. 421
Philadelphia, PA 19104-5159
Office: (215) 898-9007
Fax: (215) 573-2094
Education:
B.A. (Biology)
Brown University, 1984.
M.D. (Medicine)
Brown University School of Medicine, 1987.
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Description of CVI Expertise

Director, Center for Vascular Biology

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Thrombosis / Hemostasis

CVI Research Description:
The Kahn Lab investigates signaling pathways in platelets that mediate thrombosis and signaling pathways in vascular endothelial cells of the blood and lymphatic system utilized during cardiovascular development.

Selected Publications

Keller IV TCS, Lim L, Shewale S, McDaid K, Marti-Pamies I, Tang AT, Wittig C, Guerrero AA, Sterling S, Leu NA, Scherrer-Crosbie M, Gimotty PA, and Kahn, ML: Genetic Blockade of Lymphangiogenesis does not Impair Cardiac Function after Myocardial Infarction. Journal of Clinical Investigation August 2021.

Snellings DA, Hong CC, Ren AA, Lopez-Ramirez MA,Girard R, Srinath A, Marchuk DA, Ginsberg MH, Awad IA, Kahn ML : Cerebral Cavernous Malformation: From Mechanism to Therapy Circulation Research 129(1): 195-215, Jun 2021.

Ren AA, Snellings DA, Su SY, Hong CC, Castro M, Tang AT, Detter MR, Hobson N, Girard R, Romanos S, Lightle R, Moore T, Shenkar R, Benavides C, Beaman MM, Helge Mueller-Fielitz H, Chen M, Mericko P, Yang J, Sung DC, Lawton MT, Ruppert M, Schwaninger M, Körbelin J, Potente M, Awad IA, Marchuk DA and Kahn ML: PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism. Nature 594(7862): 271-276, Jun 2021.

Stratman AN, Burns MC, Farrelly OM, Davis AE, Li W, Pham VN, Castranova D, Yano JJ, Goddard LM, Nguyen O, Galanternik MV, Bolan TJ, Kahn ML, Mukouyama YS, Weinstein BM: Chemokine mediated signalling within arteries promotes vascular smooth muscle cell recruitment. Communications Biology Dec 2020.

Hong CC, Tang AT, Detter MR, Choi JP, Wang R, Yang X, Guerrero AA, Wittig CF, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Goddard LM, Ren AA, Leu NA, Sterling S, Yang J, Li L, Chen M, Mericko-Ishizuka P, Dow LE, Watanabe H, Schwaninger M, Min W, Marchuk DA, Zheng X, Awad IA, Kahn ML, : Cerebral cavernous malformation are driven by ADAMTS5 proteolysis of versican. The Journal of Experimental Medicine Oct 2020.

Nicolson PL, Welsh JD, Chauhan A, Thomas MR, Kahn ML, Watson SP: A rationale for blocking thromboinflammation in COVID-19 with Btk inhibitors. Platelets 31(5): 685-690, Jul 2020.

Betterman KL, Sutton DL, Secker GA, Kazenwadel J, Oszmiana A, Lim L, Miura N, Sorokin L, Hogan BM, Kahn ML, McNeill H, Harvey NL.: Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow. Journal of Clinical Investigation June 2020.

Polster SP, Sharma A, Tanes C, Tang AT, Mericko P, Cao Y, Carrión-Penagos J, Girard R, Koskimäki J, Zhang D, Stadnik A, Romanos SG, Lyne SB, Shenkar R, Yan K, Lee C, Akers A, Morrison L, Robinson M, Zafar A, Bittinger K, Kim H, Gilbert JA, Kahn ML, Shen L, Awad IA: Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma. Nature Communications May 2020.

Welsh JD, Hoofnagle MH, Bamezai S, Oxendine M, Lim L, Hall JD, Yang J, Schultz S, Engel JD, Kume T, Oliver G, Jimenez JM, Kahn ML: Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis. The Journal of Clinical Investigation Dec 2019.

Tang Alan T, Sullivan Katie R, Hong Courtney C, Goddard Lauren M, Mahadevan Aparna, Ren Aileen, Pardo Heidy, Peiper Amy, Griffin Erin, Tanes Ceylan, Mattei Lisa M, Yang Jisheng, Li Li, Mericko-Ishizuka Patricia, Shen Le, Hobson Nicholas, Girard Romuald, Lightle Rhonda, Moore Thomas, Shenkar Robert, Polster Sean P, Roedel Claudia J, Li Ning, Zhu Qin, Whitehead Kevin J, Zheng Xiangjian, Akers Amy, Morrison Leslie, Kim Helen, Bittinger Kyle, Lengner Christopher J, Schwaninger Markus, Velcich Anna, Augenlicht Leonard, Abdelilah-Seyfried Salim, Min Wang, Marchuk Douglas A, Awad Issam A, Kahn Mark L: Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation. Science translational medicine 11(520), Nov 2019.

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Last updated: 12/01/2021
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