Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Mark L. Kahn, M.D., B.A.

Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
11-123 Smilow Center for Translational Research
3400 Civic Center Boulevard, Bldg. 421
Philadelphia, PA 19104-5159
Office: (215) 898-9007
Fax: (215) 573-2094
B.A. (Science)
Brown University, 1984.
M.D. (Internal Medicine)
Brown University School of Medicine, 1987.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Thrombosis / Hemostasis

CVI Research Description:
The Kahn Lab investigates signaling pathways in platelets that mediate thrombosis and signaling pathways in vascular endothelial cells of the blood and lymphatic system utilized during cardiovascular development.

Selected Publications

Jakus Zoltán, Gleghorn Jason P, Enis David R, Sen Aslihan, Chia Stephanie, Liu Xi, Rawnsley David R, Yang Yiqing, Hess Paul R, Zou Zhiying, Yang Jisheng, Guttentag Susan H, Nelson Celeste M, Kahn Mark L: Lymphatic function is required prenatally for lung inflation at birth. The Journal of experimental medicine 211(5): 815-26, May 2014.

Zheng Xiangjian, Riant Florence, Bergametti Françoise, Myers Cynthia D, Tang Alan T, Kleaveland Benjamin, Pan Wei, Yang Jisheng, Tournier-Lasserve Elisabeth, Kahn Mark L: Cerebral cavernous malformations arise independent of the heart of glass receptor. Stroke; a journal of cerebral circulation 45(5): 1505-9, May 2014.

Boulaftali Yacine, Hess Paul R, Kahn Mark L, Bergmeier Wolfgang: Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity. Circulation research 114(7): 1174-84, Mar 2014.

Hess Paul R, Rawnsley David R, Jakus Zoltán, Yang Yiqing, Sweet Daniel T, Fu Jianxin, Herzog Brett, Lu MinMin, Nieswandt Bernhard, Oliver Guillermo, Makinen Taija, Xia Lijun, Kahn Mark L: Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life. The Journal of clinical investigation 124(1): 273-84, Jan 2014.

Liang X, Russell S R, Estelle S, Jones L H, Cho S, Kahn M L, Berndt M C, Bunting S T, Ware J, Li R: Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site. Journal of thrombosis and haemostasis : JTH 11(12): 2155-62, Dec 2013.

Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L: Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature Sept 2013 Notes: Epub ahead of print.

Rawnsley DR, Xiao J, Lee J, Liu X, Mericko-Ishizuka P, Kumar V, He J, Basu A, Lu M, Lynn FC, Pack M, Gasa R, Kahn ML: The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development. Journal of Biology and Chemistry Jul 2013 Notes: Epub ahead of print.

Stanger BZ, Kahn ML: Platelets and tumor cells: a new form of border control. Cancer Cell 8(24): 9-11, Jul 2013.

Kahn ML, Rader DJ: Lymphatics as a new player in cholesterol transport. Cell Metabolism 17(5): 627-8, May 2013.

Zou Z, Enis D, Bui H, Khandros E, Kumar V, Jakus Z, Thom C, Yang Y, Dhillon V, Chen M, Lu M, Weiss MJ, Kahn ML: The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythopoiesis. Blood Apr 2013 Notes: Epub ahead of print.

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Last updated: 07/09/2014
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