Craig H. Bassing, Ph.D.
Professor of Pathology and Laboratory Medicine
Member, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania
Member, Institute for Immunology
Member, Abramson Cancer Center - Pediatric Oncology Research
Member, Division of Cancer Pathobiology, Children's Hospital of Philadelphia, University of Pennsylvania
Investigator, Abramson Family Cancer Research Institute
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
1353 Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104
1353 Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-426-0311
Fax: 267-426-2791
Fax: 267-426-2791
Education:
B.A. (Biology)
The Johns Hopkins University, 1992.
Ph.D. (Biology)
Duke University, 1997.
Permanent linkB.A. (Biology)
The Johns Hopkins University, 1992.
Ph.D. (Biology)
Duke University, 1997.
Selected Publications
Allyn, B.M., Hayer, K.E., Oyeniran, C., Nganga, V., Lee, K., Sacan, A., Oltz, E.M., and Bassing, C.H.: Promoter- and enhancer-dependent cohesin loading initiates chromosome looping to fold Tcrb loci for long-rang recombination. Cell Reports 44, 2025.Estrada, M.D., Gebhardt, C.J., Salem, M.A., Rua, C.N., Sharma, K., Glynn, R.A., Bassing, C.H., Oltz, E.M., and Collins, P.L.: Transcriptional regulation of Ligase IV by an intronic regulatory element directs thymocyte development. Genes Immun 2025.
Glynn, R.A. and Bassing, C.H.: ATM-Dependent Phosphorylation of Nemo SQ Motifs is Dispensable for Nemo-Mediated Gene Expression Changes in Response to DNA Double Strand Breaks. The Journal of Immunology In Press, 2024.
Allyn, B.M., Hayer, K.E., Oyeniran, C., Nganga, V., Lee, K., Mishra, B., Sacan, A., Oltz, E.M., and Bassing, C.H.: Locus Folding Mechanisms Determine Modes of Antigen Receptor Gene Assembly. The Journal of Experimental Medicine 221, 2024.
Culberson, E.J., Shields, K.C., Glynn, R.A., Allyn, B.M., Hayer, K.E., and Bassing, C.H.: The Cyclin D3 Protein Enforces Monogenic TCRb Expression by Mediating TCRb Protein Signaled Feedback Inhibition of Vb Recombination The Journal of Immunology 212, 2024.
Burn, T.N., Miot, C., Gordon, S.M., Culberson, E.J., Diamond, T., Kreiger, P.A., Hayer, K.E., Bhattacharyya, A., Jones, J.M., Bassing, C.H.*, and Behrens, E.M.* *Co-corresponding authors: The RAG1 Ubiquitin Ligase Domain Stimulates Recombination of TCRb and a Genes and Influences Development of ab T Cell Lineages. The Journal of Immunology 209, 2022.
Glynn, R.A. and Bassing, C.H.: Nemo-dependent, ATM-mediated signals from RAG DNA breaks at Igk feedback inhibit Vk recombination to enforce Igκ allelic exclusion. The Journal of Immunology 208: 371-383, 2022.
Wu, G., Culberson, E.J., Allyn, B.M., and Bassing, C.H.: Poor-Quality Vb Recombination Signal Sequences and the DNA Damage Response ATM Kinase Collaborate to Establish TCRb Gene Repertoire and Allelic Exclusion. The Journal of Immunology doi: 10.4049/jimmunol.2100489, 2022.
Culberson, E.J. and Bassing, C.H.: Monogenic TCRb Assembly and Expression is Paramount for Uniform Antigen Receptor Specificity of Individual ab T Lymphocytes. The Journal of Immunology 209, 2022.
Beilinson, H.A., Glynn, R.A., Yadavailli, A.D., Xiao, J., Corbett, E., Saribasak, H., Arya, R., Miot, C., Bhattacharyya, A., Jones, J.M., Pongubala, J., Bassing, C.H., and Schatz, D.G. : The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination. Journal of Experimental Medicine. Oct 4;218(10):e20210250. doi: 10.1084/jem.20210250. (eds.). 218(10): :e20210250, 2021.