Monica E. Calkins, PhD

Monica Calkins, PhDDr. Calkins is Professor of Psychology in Psychiatry at the University of Pennsylvania Perelman School of Medicine. Her research program focuses on the clinical characterization and treatment of psychopathology, especially psychotic disorders, and the evaluation of biobehavioral measures of psychosis risk. The overarching goal of this collaborative research program is to contribute to enhanced early identification of psychosis and increased understanding of its pathophysiological processes. Dr. Calkins is Co-Director of the Pennsylvania Early Intervention Center/HeadsUp, which provides ongoing education, training and outreach support for Pennsylvania First Episode Psychosis programs and other stakeholder groups. As the Director of Clinical Research Assessment in the Neurodevelopment and Psychosis Section, Dr. Calkins has led the conceptualization of assessment approaches, development, adaptation and implementation of instruments, training and supervision of assessors, establishment and maintenance of quality control procedures, and use and interpretation of clinical data across numerous NIMH funded grants. Drawing from these experiences, she has participated with global leaders in think tanks aiming to enhance clinical characterization of the psychosis spectrum, playing a role in determining the field’s definitions of clinical high risk constructs. Locally, she is the Associate Director of the Penn Psychosis Evaluation and Recovery Center (PERC). She has delivered many local, national and international lectures on topics including biobehavioral risk factors for psychosis, early identification of psychosis, psychopathology assessment, careers in psychology, and research ethics. Dr. Calkins involves and mentors students (undergraduate, graduate, medical, resident, post-doctoral) and research coordinators in research design, data collection, data analysis, and manuscript and thesis preparation, and provides clinical supervision to trainees through PERC. She has received career awards from the International Congress on Schizophrenia Research, the American College of Neuropsychopharmacology, the National Alliance on Mentally Illness, and an NIMH KO8 Mentored Clinical Scientist Award. Dr. Calkins has authored more than 200 publications in peer-reviewed journals. She is a member of the University of Pennsylvania Institutional Review Board, and has served as an ad-hoc reviewer for NIMH, several international grant review panels, and for more than 30 journals.


  • 1991 – B.A. Temple University: Psychology Honors
  • 2002 – Ph.D. University of Minnesota: Clinical Science and Psychopathology Research
  • 2002-2004 – NIMH Post-Doctoral Fellowship in Neuropsychiatry, Department of Psychiatry, University of Pennsylvania School of Medicine
  • 2002-2004 – Scottish Rite Schizophrenia Research Fellowship, Department of Psychiatry, University of Pennsylvania School of Medicine

Academic Positions

  • 2004-2015 – Assistant Professor of Psychology in Psychiatry, Perelman School of Medicine, University of Pennsylvania 
  • 2015-2023 – Associate Professor of Psychology in Psychiatry at the Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine
  • 2023-present – Professor of Psychology in Psychiatry at the Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine

Hospital and Administrative Appointments

  • 2010 – Director of Clinical Research Assessment, Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania
  • 2013 – Member, Institutional Review Board, University of Pennsylvania


  • 2015 – National Alliance on Mental Illness Research Award: Recognizing Research Focused on First Episode Psychosis
  • 2007-2012 – Mentored Clinical Scientist Career Development Award (K08): National Institute of Mental Health
  • 2008 – Early Career Development Award: American College of Neuropsychopharmacology
  • 2005 – Young Investigator Award: International Congress on Schizophrenia Research
  • 2002, 2000 – Harrison Gough Research Travel Award, University of Minnesota, Department of Psychology
  • 2001 – Graduate Research Partnership Program Award, University of Minnesota Graduate School
  • 2001 – Doctoral Dissertation Supplemental Grant, University of Minnesota Graduate School
  • 2000-2001 – Doctoral Dissertation Fellowship, University of Minnesota Graduate School
  • 1999-2000 – Graduate Research Ethics Participant Grant, National Science Foundation and the Association for Practical and Professional Ethics
  • 1996-1998 – Neurobehavioral Aspects of Personality and Psychopathology Training Grant, National Institute of Mental Health, University of Minnesota
  • 1994-1995 – Department of Psychology Graduate Fellowship, University of Minnesota



Dong F, Moore TM, Westfall M, Kohler C, Calkins ME.: Development of empirically derived brief program evaluation measures in Pennsylvania first-episode psychosis coordinated specialty care programs. Early Interv Psychiatry Mar 2022.

Kohler CG, Wolf DH, Abi-Dargham A, Anticevic A, Cho YT, Fonteneau C, Gil R, Girgis RR, Gray DL, Grinband J, Javitch J, Kantrowitz JT, Krystal JH, Lieberman JA, Murray JD, Ranganathan M, Santamauro N, Van Snellenberg JX, Tamayo Z, TRANSCENDS Group, Gur RC, Gur RE, Calkins ME: Illness Phase as a Key Assessment and Intervention Window for Psychosis. Biological Psychiatry 3: 340-350, Jun 2023 Notes: In Press.

Addington J, Woods SW, Yung AR, Calkins ME, Fusar-Poli P.: Harmonizing the structured interview for psychosis-risk syndromes (SIPS) and the comprehensive assessment of at-risk mental states (CAARMS): An initial approach. Early Interv Psychiatry Jan 2023.

Taylor JH, Calkins ME, Gur RE.: Markers of Psychosis Risk in the General Population. Biol Psychiatry 88: 337-348, Aug 2020.

Calkins Monica E, Merikangas Kathleen R, Moore Tyler M, Burstein Marcy, Behr Meckenzie A, Satterthwaite Theodore D, Ruparel Kosha, Wolf Daniel H, Roalf David R, Mentch Frank D, Qiu Haijun, Chiavacci Rosetta, Connolly John J, Sleiman Patrick M A, Gur Ruben C, Hakonarson Hakon, Gur Raquel E: The Philadelphia Neurodevelopmental Cohort: constructing a deep phenotyping collaborative. Journal of child psychology and psychiatry, and allied disciplines 56(12): 1356-69, Apr 2015.

Calkins Monica E, Moore Tyler M, Merikangas Kathleen R, Burstein Marcy, Satterthwaite Theodore D, Bilker Warren B, Ruparel Kosha, Chiavacci Rosetta, Wolf Daniel H, Mentch Frank, Qiu Haijun, Connolly John J, Sleiman Patrick A, Hakonarson Hakon, Gur Ruben C, Gur Raquel E: The psychosis spectrum in a young U.S. community sample: findings from the Philadelphia Neurodevelopmental Cohort. World psychiatry : official journal of the World Psychiatric Association (WPA) 13(3): 296-305, Oct 2014.

Calkins Monica E, Moore Tyler M, Satterthwaite Theodore D, Wolf Daniel H, Turetsky Bruce I, Roalf David R, Merikangas Kathleen R, Ruparel Kosha, Kohler Christian G, Gur Ruben C, Gur Raquel E: Persistence of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort: a prospective two-year follow-up. World psychiatry : official journal of the World Psychiatric Association (WPA) 16(1): 62-76, Feb 2017.

Westfall MBE, Kohler CG, Hurford I, Abegunde C, Agosti D, Brinen A, Cadman ML, Conroy C, Ered A, Fooks A, Franco O, Huque ZM, Namowicz D, O'Connor S, Oross M, Payne E, Sarpal DK, Schmidt LR, Swigart A, Wenzel RM, Calkins ME.: Pennsylvania coordinated specialty care programs for first-episode psychosis: 6- and 12-month outcomes. Early Interv Psychiatry Dec 2021.

Calkins ME, Woods SW, Bearden CE, Liu L, Moore TM, Cadenhead KS, Cannon TD, Cornblatt BA, McGlashan TH, Perkins DO, Seidman LJ, Tsuang MT, Walker EF, Mathalon DH, Keshavan M, Stone WS, Addington J.: Concordance and factor structure of subthreshold positive symptoms in youth at clinical high risk for psychosis. Schizophr Res 227: 72-77, Jan 2021.

Moore TM, Calkins ME, Rosen AFG, Butler ER, Ruparel K, Fusar-Poli P, Koutsouleris N, McGuire P, Cannon TD, Gur RC, Gur RE.: Development of a probability calculator for psychosis risk in children, adolescents, and young adults. Psychol Med sychol Med, Jan 2021.

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