A Prospective Study of Endophenotypes in At-Risk Youths and Their Siblings (NAYA-K)

The purpose of this study is to obtain baseline clinical measures in youths (ages 10-25) with psychotic disorders, and those at risk for the development of a psychotic disorder in comparison to age matched healthy volunteers. In addition, a blood sample will be collected for examination of the genetic material (DNA).  This study will lay the foundation for a longitudinal characterization of the neurodevelopmental course of schizophrenia in the adolescent and young adult periods, and combine endophenotype and prodromal risk strategies to further facilitate early identification of individuals at risk for schizophrenia.  The study design is longitudinal (5 years).  Subjects will be assessed every 6 months for the first year of participation, then on a yearly basis until study completion.  The first portion of the study consists of a semi-structured interview (~2-3 hours), self-report questionnaires (~30 minutes), and a blood draw (~10 minutes, first visit only).  Information from a collateral informant will be required for minor subjects and requested for those over 18.  The second part of the study consists of a computerized neuropsychological testing battery (~2-3 hours).  The third portion of the study consists of psychophysiological measurements taken while wearing an electrode cap (EEG) and specialized eye-glasses (~3-5 hours).  Participants will receive $35-$50 for each procedure (at visits 2, 4, and 6 they will receive a $10 bonus; subjects will receive a $25 bonus after completing all requested visits).  Collateral informants will receive $10 for their time and travel expenses.  There are no more than minimal risks associated with this study.

Principal Investigator: Monica Calkins, Ph.D.

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