Cores Day 2025 Participating Core Facilities

Please note the event will run in a single session from 10am-1pm.

Click here for the event map and here for the Live Core Facility Presentation schedule.

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Advanced Core for Microscope Engineering (ACME) - RRID:SCR_026289 (PSOM)

Our core seeks to provide custom built ad hoc optical microscopy solutions, advanced image analysis, and consultation services to researchers across the Penn campus and beyond. Microscopy capabilities are advancing at a rapid pace and the ability of most labs to access these capabilities depends on commercial instruments which are (1) often at least a decade behind the state-of-the-art in the literature, (2) expensive, (3) have limited flexibility/adaptability, (4) aren’t easily customizable/hackable due to proprietary technologies and software, and (5) when rendered obsolete or if unused have limited cost-recovery potential. Our goal is to overcome these limitations and provide the latest technologies and non-commercially available specialized advanced microscopy instrumentation to labs at Penn. Our team will work collaboratively to address the needs of individual labs, for example to implement custom super-resolution, light-sheet, and or multimodal imaging platforms designed around specific sample types and spatial and temporal resolution requirements.

Mustafa Mir
mustafa.mir@pennmedicine.upenn.edu

Melike Lakadamyali
melikel@pennmedicine.upenn.edu

Andrea Stout
astout@pennmedicine.upenn.edu

Yihui Shen
yihuis@seas.upenn.edu

Table Number: 3

Animal Model Core New Bolton Center - RRID:SCR_022435 (Penn Vet)

The Animal Model Core at Penn Vet is an ecosystem for medical translation and multidisciplinary collaboration. It leads and supports discovery, invention, and innovation in medical product development across a broad range of disciplines.

Services: Feasibility & Pilot Studies * 21CFR58 Compliance (GLP) * Project Planning / Grant Development * Test Article Prototyping & Testing * Model Development & Refinement * Planning & Execution of IND/IDE enabling Studies * Acute & Chronic Studies

Thomas Schaer, VMD
Director
tpschaer@vet.upenn.edu

Table Number: 13

Bioinformatics Core (Wistar)

The Wistar Bioinformatics Facility continuously develops new and efficient approaches to data analysis as a response to emerging research needs. Facility functions include: statistical analyses and computational modeling for all types of high-throughput data, advanced bioinformatics tools for integrative cancer biology, and data management.

Andrew Kossenkov, PhD
Co-Managing Director
akossenkov@wistar.org

Jozef Madzo, PhD
jmadzo@wistar.org

Priyankara Wickramasinghe, PhD
priyaw@wistar.org

Table Numbers: 1 & 2

Bioinformatics Core Facility (BIC) - RRID:SCR_022374 (PSOM)

The Bioinformatics Core (BIC) of the Institute for Biomedical Informatics (IBI) provides professional bioinformatics services that include data analysis and consultation to the University of Pennsylvania Biomedical research community. The BIC is dedicated to analyze various Next-Generation Sequencing (NGS) data, generated locally within NGSC and also elsewhere using in-house pipelines, open source tools and platforms.

Taehyong Kim, PhD
Director
taehyong@pennmedicine.upenn.edu

Table Number: 9

Biomedical Research Support (Wistar)

The Wistar Biomedical Research Support Core (BRSC) provides a robust infrastructure to support mechanistic, patient-oriented research. The BRSC manages the resource commitment associated with clinical studies, including supporting compliance with regulatory directives governing research in Human Subjects. This includes data collection, storage and extraction, data quality control, site monitoring, regulatory reporting, and connection with statistical teams for data analysis. Services include phlebotomy, tissue microarrays, collection of pathological specimens and support for clinical studies.

Livio Azzoni, PhD, MD
Managing Director
azzoni@wistar.org

Table Numbers: 1 & 2

BioRepository Resource Center - BioRC (CHOP)

The CHOP Biorepository Resource Center (BioRC) is a CAP-accredited biorepository and Special Processing Unit (SPU) that stores, processes and distributes research specimens for investigators across the Research Institute (RI). We collaborate with several IRB-governed biobanks throughout the RI to carefully preserve biological samples which can be accompanied by decades of disease follow-up data. Together, these samples together with their derivatives and data offer tremendous opportunities for translational research. Biobanks are fundamental to identifying genomic and phenomic prediction models, biomarkers for early detection of diseases, understanding risk factors, and informing effective prevention strategies. Our facilities and automation platforms are thoughtfully designed to serve CHOP’s biobanking needs, avoid specimen duplication, preserve precious materials, and provide broad access. The BioRC storage facility is located in a 3000 sq ft temperature controlled, card access, 24/7 monitored facility on the A-Level of the Colket Translational Research Building and the SPU is located in Lab 1207C in the Abramson Research Center.

Robert Perkinson, PhD
perkinsonr@chop.edu

Table Number: 33

Biostatistics Analysis Center (BAC) - RRID:SCR_022393 (PSOM)

The Biostatistics Analysis Center (BAC) is a University of Pennsylvania service center offered by the Perelman School of Medicine's Center for Clinical Epidemiology and Biostatistics. The BAC is staffed by professionally trained biostatisticians, biostatistical programmers and data managers, and provides a wide range of biostatistical and epidemiological consulting services to the University's biomedical research community, as well as services external to the University.

Scott Appel, MS
Co-Director, Senior Triage & Consulting Manager
appelsc@pennmedicine.upenn.edu

Table Number: 15

CDB Microscopy Core Facility - RRID:SCR_022373 (PSOM)

The CDB Microscopy Core provides access to confocal and widefield light microscopy equipment as well as to scanning electron microscopy (SEM) services. Services include staff-assisted imaging, training for independent users, and help with image analysis workflows.

Andrea Stout, PhD
Director
astout@pennmedicine.upenn.edu

Table Number: 3

Cell & Animal Radiation Core Facility (CARC) - RRID:SCR_022377 (PSOM)

The Cell and Animal Radiation Core (CARC) is one of the most advanced cell and animal radiation research facilities in the US, from providing basic cell and animal radiation needs, to modeling state-of-the-art radiation modalities currently used in the clinic. The CARC provides “turn-key” services to users for performing precision, image-guided radiotherapy with both Photons and Protons (the latter including FLASH radiotherapy) on cells, explant tissues, rodent models and canine patients. A dedicated team of Physicists also provides expert dosimetry and treatment planning capabilities. The CARC instrumentation consists of two Image Guided SARRP 200 Small Animal Radiation Research Platforms (Xstrahl), a research proton beamline (IBA, Roberts Proton Center), X-RAD 320ix cabinet x-ray irradiator (Precision X-Ray) and CIX1 bench-top cabinet x-ray irradiator (Xstrahl).

Shiva Shahrampour, PhD
Technical Director
shiva.shahrampour@pennmedicine.upenn.edu

Table Number: 17

Cell Center Services - RRID:SCR_022391 (PSOM)

The Cell Center Services Facility provides training and services in various cell culture and associated procedures to University of Pennsylvania investigators including: Cell Culture Training, Cell Culture Services, Large Scale Cell Culture, Hybridoma Production and Screening, and Transfection of Mammalian Cells.

Sabine Baxter
Technical Manager
baxters@pennmedicine.upenn.edu

Table Number: 16

Cell Center Stockroom - RRID:SCR_022399 (PSOM)

The Cell Center Stockroom serves University of Pennsylvania investigators and affiliate institutions by coordinating relations with various suppliers of molecular biological research materials. This involves not only bulk purchasing of these products, but the negotiation of discounts and convenient delivery arrangements. There are over 1,100 products on-site for immediate delivery in the Stockroom. Special ordering of non-regularly stocked products is available from 28 bioreagent vendors with discounted pricing and sometimes overnight delivery.

Joshua Varrone
Assistant Manager
jvarrone@pennmedicine.upenn.edu

Table Number: 18

Center for Applied Genomics (CHOP)

The Center for Applied Genomics at CHOP houses three service Cores to assist with your genomics research needs: CAG Biorepository Core, Genotyping Core, and Sequencing Core. CAG supports the scientific community with cutting-edge next generation sequencing, single-cell sequencing, genotyping, and biorespository research services. CAG also provides CLIA-certified DNA extraction, sequencing, and genotyping services.

Maria Lemma
garrism@chop.edu

Table Number: 19

Center for Human Phenomic Science (CHPS) - RRID:SCR_022402 (PSOM)

The Center for Human Phenomic Science (CHPS) was formed with the receipt of the Clinical and Translational Science Award (CTSA), an NIH Roadmap initiative. The CHPS has child and adult specific components at the Children's Hospital of Philadelphia and University of Pennsylvania. The goal of the CHPS is to provide the resources, environment, operations, and training to support and promote high-quality clinical and translational research by qualified investigators.

Carl Shaw, Med, MBE
shawcarl@pennmedicine.upenn.edu

Table Number: 9

CHOP Biobank (CHOP)

The CHOP Biobank is a disease-agnostic, institution-wide biobank that provides a robust biorepository of biospecimens and data accessible to the CHOP research community..

Kate Driesbaugh, PhD
Manager, CHOP Biobank
driesbaugk@chop.edu

Table Number: 33

CHOP Microbiome Center (CHOP)

The CHOP Microbiome Center is the sequencing and bioinformatics resource of the PennCHOP Microbiome Program, providing end-to-end solutions for microbiome research. The sequencing lab offers expertise in next-generation DNA sequencing for microbiome studies, working with customers to provide optimized workflows and protocols customized for each study. Our bioinformatics lab provides expertise in bioinformatics and statistical analysis of microbiome data. We develop a bioinformatics plan specific to your project and can integrate microbiome data with other data sources, such as metabolomics or dietary intake information.

Kristen Pidgeon
pidgeonk@chop.edu

Mistura Faro
farom@chop.edu

Table Number: 12

CHOP Research Institute Research Information Services (CHOP)

The Research Information Services (RIS) Department consists of several technology teams designed to meet the specific needs the CHOP Research Institute. This small high-performance team of IS experts focuses on delivering innovative technologies and customer service excellence to promote productivity and efficiency of researchers and administrators. The department is designed to supplement CHOP Digital & Technology Services, who provide CHOP-wide IS services and products.

Nick Kight
RIS Outreach Manager
kightn@chop.edu

David Schlich
schlichd@chop.edu

Table Number: 20

CHOP Transgenic Core (CHOP)

The Transgenic Core provides investigators with state-of-the-art experimental models to study human disease, advance research, and propel discovery. Our expertise and capabilities enable us to build complex disease models using a combination of cutting-edge and classical genetic engineering approaches. The Transgenic Core has successfully created more than 150 transgenic lines using the CRISPR system and recently created our first CRISPR knockout line.

Our Core offers fast, cost-effective generation and preservation of transgenic lines with the following services:
• CRISPR Cas9 mRNA microinjection
• CRISPR Cas9 RNP electroporation
• DNA construct microinjection
• Embryonic stem cell microinjection
• Strain rederivation and rescue
• Embryo cryopreservation, importation, and exportation
• Sperm cryopreservation, importation, and exportation

Adele Harman
Technical Director
harmana@chop.edu

Table Number: 24

CHOP-Penn Proteomics Core Facility - RRID:SCR_023099 (CHOP/PSOM)

We specialize in bottom-up, mass spectrometry-based proteomics with a commitment to quality, rigor, problem-solving, and innovation. Our goal is to provide expert guidance to the scientific community on optimizing the use of this technique for answering biological questions and to generate top-tier mass spectrometry-based proteomics datasets.

Services include but are not limited to Quantitative Proteomics, Immunopeptidomics (HLA peptides), Interactome Analysis, Deep Unbiased Proteomic Profiling for Biomarker Discovery (Plasma, CSF, other biofluids, FFPE), Protein Characterization and PTMs, and Pathway analysis.

Lynn Spruce
Technical Director
spruce@chop.edu

Table Number: 21

Clinical In Vivo Gene Therapy Core (CHOP)

The Clinical In Vivo Gene Therapy (CIGT) group at Children's Hospital of Philadelphia (CHOP) is dedicated to advancing clinical in vivo gene therapy. In vivo gene therapy involves directly infusing a new, corrected gene into a child’s body, with the goal of stopping disease or making it less severe. Through industry partnerships and clinical trials, CIGT seeks to make transformative discoveries and build upon CHOP’s legacy as a leader in this field.

Led by experts with extensive experience in gene therapy clinical trials, our team aims to offer more breakthrough therapies to our patients sooner, by streamlining complex gene therapy trials and ensuring licensed gene therapies are available in our clinics.

Julianne LaRosa, MPH
Clinical Research Coordinator
larosaj1@chop.edu

Table Number: 22

Clinical Research Collaboration Unit (CRCU) - RRID:SCR_022404 (PSOM)

The Clinical Research Collaboration Unit (CRCU) is an Academic Clinical Research Organization within the Center for Clinical Epidemiology and Biostatistics (CCEB) in the Perelman School of Medicine at the University of Pennsylvania. For more than 25 years, the CRCU has been expertly providing the full range of services essential for the conduct of clinical research, including Phase I-IV, multi-center, randomized, clinical trials, registry, and cohort studies.

The CRCU provides expertise in project management, data coordination, and research computing tailored to meet your project requirements. We specialize in study design and development, site management and training, data collection, processing, and quality control, regulatory requirements and reporting, database development, administration, security, data storage and proposal development. The CRCU fosters collaborative relationships with investigators in the CCEB, the School of Medicine, and throughout the University, taking an active role in identifying and meeting your research support needs.

Florence Speiser
crcu-contact@lists.upenn.edu

Table Number: 15

Clinical Vector Core

The Clinical Vector Core (CVC) facility, a division of the Raymond G. Perelman Center for Cellular and Molecular Therapeutics (CCMT) at the Children’s Hospital of Philadelphia (CHOP), manufactures pre-clinical and clinical grade Adeno-Associated Virus (AAV), lentivirus (LV) vectors, and lipid nanoparticles (LNP) for IND supporting non-clinical studies (e.g. Toxicology studies) and early phase clinical studies in compliance with current Good Manufacturing Practices (cGMP).

Johannes van der Loo
vanderlooj@chop.edu

Table Number: 26

Community Engagement & Research Core (CEAR) - RRID:SCR_022408 (PSOM)

The Community Engagement and Research Core aims to facilitate community-based research and community engagement, while enhancing the translation of research and technological developments to key public health and community stakeholders. This Core is part of the Penn-CHOP Clinical and Translational Science Award (CTSA).

Krista Scheffey, MPH/MSW
Research Project Manager
krista.scheffey@pennmedicine.upenn.edu

Table Number: 7

CRISPR/Cas9 Mouse Targeting Core Facility - RRID:SCR_022378 (PSOM)

MISSION STATEMENT (2017-2025)

The CRISPR-Cas9 mouse targeting core at the Perelman School of Medicine, University of Pennsylvania, has been operational since February 2017. Jorge HENAO-MEJIA has served as the Scientific Director, and Leonel JOANNAS as the Technical Director. The core is in the Institute for Immunology (IFI), and the Scientific and Technical Directors are part of the IFI. The mission of the CRISPR-Cas9 targeting core is to streamline procedures to facilitate the use of the CRISPR/Cas9 genome editing technology by the larger UPenn/CHOP community to generate novel mouse genetic tools rapidly and economically. This core has had a significant positive impact on the community. Researchers who work with mice and rats to model human diseases have enthusiastically taken up these tools. Projects that may have taken years using older techniques, such as examining the effects of disrupting several genes at once, generating point mutations, or inserting fluorescent proteins, now take just a couple of months. It is also easier to produce more subtle changes, like tweaking just a few DNA nucleotides in a gene in a way that simulates a variation found in humans. In addition, our R&D efforts in this area should enable UPenn/CHOP to remain at the forefront of this technology.

SUMMARY OF ACTIVITIES (2017-2025)

Using the CRISPR/Cas9 technology, we can now generate pre-clinical mouse and rat models for research in 3 to 4 weeks. Moreover, it allows us to create models more closely mimic human diseases. Hence, this has been a revolution in the biomedical research field, and its impact has already been observed in clinics. We have already developed over two hundred targeting strategies during our first two and a half years of operation. The CRISPR-Cas9 Mouse Targeting Core at Penn is a state-of-the-art facility with an outstanding record of producing genetically altered mice and rats for investigators at Penn and outside institutions, within the state of Pennsylvania and overseas.

Leonel Joannas, PhD
Technical Director
ljoannas@pennmedicine.upenn.edu

Table Number: 24

Electron Microscopy Resource Laboratory (EMRL) & Beckman Center for Cryo-EM - RRID:_SCR:022375

The Electron Microscopy Resource Lab (EMRL) at the Perelman School of Medicine, University of Pennsylvania, is a training and service facility dedicated to providing both conventional transmission electron microscopy of cells/tissues and state-of-the art cryo electron microscopy/cryo electron tomography services for structural investigation of macromolecules and cells. The core facility offers services to University of Pennsylvania research groups and external academic research groups in the greater Philadelphia area.

Camila Spaulonci
camila.spaulonci@pennmedicine.upenn.edu

Table number: 25

Engineered mRNA and Targeted Nanomedicine Core - RRID:SCR_023665 (PSOM)

Mission
The Engineered mRNA and targeted nanomedicine core is designed to address infrastructural barrier to clinical and translational research in gene therapy, vaccine development (cancer and infectious disease), stem cell reprograming, and other non-viral gene therapy based applications by providing high quality in vitro transcribed messenger RNA (IVT-mRNA) and lipid nanoparticles (LNPs).

The Engineered mRNA and targeted nanomedicine core supports the ITMAT and PSOM faculty, ITMAT partner institutions, and members of the Center for Targeted Therapeutics and Translational Nanomedicine (CT3N).

Goals
Our goal and focus is to lower the experimental barriers to PIs interested in exploring the mRNA technology, and lipid nanoparticles for various applications including tissue and cell targeting. We currently offer the following services:

-Optimization and production of in vitro transcribed mRNA.
-Small and large scale production of sequence optimized in vitro transcribed mRNA.
-Incorporation of modified nucleosides to modulate activity.
-Off the shelf in vitro transcribed mRNA encoding reporter genes (i.e. eGFP, mCherry, and Luc), or cancer
antigens (i.e. OVA).
-Encapsulation into proprietary (i.e. MC3, KC2 …) and non-proprietary lipid nanoparticles (i.e. DOTAP…).
-Surface modification of mRNA-LNPs for targeted delivery into specific tissues and cells.
-Labelled mRNA (i.e. Cy 5.5), labelled -LNPs (i.e. DiL, DiO, DiI), and Labelled mRNA-LNP (Dual labelling) for
nanoparticle tracking and microscopy.

The core also offers self-replicating mRNA (non-nucleoside modified mRNA) as an alternative to the canonical IVT mRNA.

Garima Dwivedi, PhD
Core Manager
garima.dwivedi@pennmedicine.upenn.edu

Table Number: 27

Environmental Health & Radiation Safety (Penn)

The University of Pennsylvania's Office of Environmental Health and Radiation Safety (EHRS) promotes health, safety and environmental protection in teaching, research, health care and administrative activities by providing services, advice and compliance assistance. EHRS provides leadership in developing, implementing and supporting high quality programs that allows students, faculty and staff to protect themselves from hazards they may encounter at the University. EHRS provides the expertise needed to direct efforts towards compliance with health and safety laws and regulations.

EHRS goals are to: Foster a productive, creative atmosphere founded on respect, trust and forthrightness, Integrate individual skills and contributions stressing teamwork, open communication and cooperation towards a common goal, Provide the expertise needed to direct efforts towards compliance with environmental, radiation and occupational health and safety laws and regulations.

Marie-Luise Faber
mlfaber@upenn.edu
ehrs@ehrs.upenn.edu

Table Number: 8

Extracellular Vesicle Core Facility - RRID:SCR_022444 (Penn Vet)

The Extracellular Vesicle (EV) Core Facility offers comprehensive or selective services for the necessary isolation, quantification, and characterization of EVs and other types of organic nanoparticles. We provide instruments for both isolation (ultracentrifuge and size exclusion chromatography) and analysis (Resistive pulse sensing techniques (nCS1, Spectradyne, LLC); Nanoparticle tracking analysis. Immunophenotype can be accomplished using nanoscale flow cytometry (NanoFCM and CytoFLEX nano) and/or chip array techniques (Unchained Labs).

Luca Musante, PhD
Director
musante@upenn.edu

Table Number: 21

Flow Cytometry Core (CHOP)

The Flow Cytometry Core Laboratory provides access to state-of-the-art instrumentation and professional flow cytometry services to researchers from The Children's Hospital of Philadelphia and University of Pennsylvania. The lab is located in Suite 1207 on the 12th floor of the Leonard and Madlyn Abramson Pediatric Research Center.

Our staff has extensive expertise in performing a variety of flow cytometry applications, including sample processing for surface and intracellular staining, functional assays, complex multi-color flow analyses and cell sorting. Most cytometers and sorters are located in Suite 1207 in Abramson Research Center (ARC) at CHOP.

Jennifer Murray
Senior Technical Specialist
murrayjb@chop.edu

Table Number: 19

Flow Cytometry Core (Wistar)

The Wistar Flow Cytometry Facility provides users with the technological resources and professional assistance for high quality, multiparameter flow cytometry analyses and sorting. Facility personnel aid investigators in creating efficient and cost-effective experimental designs, through optimizing cytometry-specific reagent and fluorochrome selection, and offer assistance in operation of analysis instruments. Technical support is also provided for analyses of flow and imaging cytometry data for publication, presentation, and inclusion in grant applications, management of cytometric data (storage, archiving, and retrieval), and management of a site license for low-cost analysis software.

Jeffrey Faust, BA, MBA
Managing Director
jfaust@wistar.org

Table Numbers: 1 & 2

Genetically Engineered Mouse Core RRID:SCR_022388 (PSOM)

The "Transgenic and Chimeric Mouse Facility" at the Perelman School of Medicine, University of Pennsylvania, is now known as the Genetically Engineered Mouse Core Facility (GEMC).
The Genetically Engineered Mouse Core (GEMC) is a state-of-the-art facility specializing in advanced mouse genome editing services. Utilizing the latest CRISPR-Cas9 technologies, we offer high-precision genome editing solutions to support a broad range of biomedical research.
In collaboration with the CRISPR/Cas9 Mouse Targeting Core we employ cutting-edge techniques to efficiently and cost-effectively generate custom genetically modified mouse models. Focused on innovation, efficiency, and quality, we help researchers accelerate discoveries through reliable and precise genetic modifications.
As a key component of Penn’s translational research ecosystem, the GEMC serves both internal investigators and external collaborators. We provide tailored project design, expert consultation, and technical support. Whether you need conditional knockouts, point mutations, reporter lines, or complex multi-gene modifications, our facility is equipped to deliver results with scientific rigor and excellence. GEMC also produces transgenic mice by DNA pronuclear injection and chimeric mice by embryonic stem cell incorporation into blastocysts.
Additionally, the GEMC offers sperm and embryo cryopreservation, in vitro fertilization, and the re-derivation of both live and cryopreserved lines. Our cryopreservation facility ensures the long-term storage of mouse sperm and embryo samples, safeguarding valuable genetic resources for future research.

Kathleen Moosbrugger
Technical Director
kthompso@pennmedicine.upenn.edu

Table Number: 13

Genomics Core (Wistar)

The Wistar Genomics Facility serves as a hub for consultation and scientific interaction relating to nucleic acid-based methods. It provides expertise and support to insure the best possible outcomes for genomic related projects. The Facility supports several state-of-the-art platforms for a wide variety of nucleic acid-based studies, including massively parallel sequencing as well as routine capillary sequencing. The facility also supports: transcriptomic projects including RNA-Seq, ChIP-Seq, methylation (MeDIP), small RNA-Seq and targeted sequencing; gene expression studies using Quant-Seq(3’ RNA-seq) and low input sequencing; single Cell-Seq (Takara iCell 8 MSND system); and targeted gene expression studies include the nanoString platform.

Sonali Majumdar, MS
Managing Director
smajumdar@wistar.org

Table Numbers: 1 & 2

Gnotobiotics and Naturalized Mouse Core - RRID:SCR_022384 (PSOM)

The Penn Gnotobiotics and Naturalized Mouse Core encompasses two complementary services related to standardizing and improving mouse models: (1) Gnotobiotics, where we use germ-free mice as a starting to control the specific microbes that colonize the animals, and (2) Naturalization, where we use “dirty mice” to mimic the microbial exposure experienced by free-living animals, including humans.

Our bodies’ surfaces are colonized with trillions of microorganisms that are part of our microbiota. These microorganisms provide important benefits such as digestion and strengthening the immune system. However, an imbalance in this symbiotic relationship is linked to many life-threatening infectious diseases and chronic conditions. Our Core facilitates cutting-edge research in this area by providing investigators with germ-free mice that are born and maintained in aseptic conditions free of microorganisms, as well as the associated husbandry and equipment to customize the model. Our newest addition to these services is a separate facility in which investigators can utilize mice that harbor pathogenic infectious agents from the “real world”, such as pet shop mice or wild mice, or work with our trained staff to introduce defined cocktails of opportunistic pathogens. These techniques can improve the physiological relevance of mouse models by mimicking the immune function, metabolism, and behavior of wild mammals.

Ken Cadwell
Ken.Cadwell@Pennmedicine.upenn.edu

Table Number: 29

Green Labs (Penn)

The Green Labs Program is a part of Environmental Health and Radiation Safety as well as Penn Sustainability. Green Labs aims to reduce waste and energy consumption across all labs at Penn through outreach, lab supply swaps, energy monitoring projects, and more.

Alisha Ramirez
alisharw@upenn.edu

Table Number: 8

High-Throughput Screening Core Facility - RRID:SCR_022379 (PSOM)

The UPenn High-throughput Screening Core (HTSC) in the Perelman School of Medicine educates scientists on the utilities of HTS and provides expertise and infrastructure to facilitate high-throughput screening projects. Services include recombinant protein expression and purification, HTS assay development, optimization, miniaturization, validation screening, data analysis, and post-screen validation studies. We have vast experience in biochemical and cell-based assay modalities, including well-based readouts, fluorescent microscopy, and flow-based assays, and we can develop new assays or run validated HTS assays. The Core can screen arrayed libraries of siRNAs, cDNAs, FDA approved drugs and biosimilars, or drug-like small molecules to identify genes or chemical modulators of biology in diverse models, including primary cells and iPSC derived models. The core can also prepare custom libraries of siRNAs of gene targets from omics data sets for testing and drug-like molecules for single-point or dose-response screening. The HTSC also provides assistance with the preparation of grant applications and Letters of Support, offering HTS resources and analysis expertise for the proposed research.

David Schultz, PhD
Technical Director
dschultz@pennmedicine.upenn.edu

Table Number: 17

High-Throughput Sequencing Core (CHOP)

High Throughput Sequencing Core is a full-service facility providing instrumentation, library preparation, and next-generation sequencing services on Illumina and Oxford Nanopore Platforms. The Core facility operates NovaSeq X Plus, NextSeq2000, and PromethION24 instruments.

Teodora Orendovici, PhD
Technical Director
orendovict@chop.edu

Table Number: 30

Histology Core (Wistar)

The Wistar Histotechnology Facility provides services for fixing, processing and paraffin or OCT-embedding of all types of tissues for light microscopy (e.g. routine stains, immunohistochemistry or in situ hybridization). The Facility staff performs routine hematoxylin and eosin staining, as well as specialized staining and slide preparation for immunohistochemistry and in situ hybridization. Frozen sectioning is also available, including consultation regarding freezing and fixing techniques to optimize experimental results.

Fangping Chen, HT (ASCP)
Managing Director
fchen@wistar.org

Table Numbers: 1 & 2

Human Immunology Core (HID) - RRID:SCR_22380 (PSOM)

The Human Immunology Core (HIC) (RRID: SCR_022380) is one of the first and most active immune monitoring cores in the United States. Our mission is to provide wet bench expertise for incorporation of the newest technologies into early phase clinical trials using validated immunology assays and protocols, while also offering turnkey services and expert scientific and technical consultation to investigators conducting basic and translational research. More specifically, we offer cell products, specimen processing services, cellular immunological assays, such as Luminex, ELISPOT, ELISA, Flow cytometry immunological assay, Simoa, MSD, etc., and molecular immunological assays such as TCR/BCR repertoire assays and immunology data analysis.

Contacts:
Nina Luning Prak
luning@pennmedicine.upenn.ed

Honghong Sun
hsun2@pennmedicine.upenn.edu

Table Number: 37

Human Pluripotent Stem Cell Core (CHOP)

The Human Pluripotent Stem Cell Core performs the following services for investigators at CHOP, Penn and nationwide: 1) Generation of control and disease-specific induced pluripotent stem cell (iPSC) lines including standardized quality control analyses 2) Gene editing using the CRISPR/Cas9 technology to create isogenic iPSC lines for downstream functional assays 3) Differentiation to all three germlayers and derivative tissues for modeling and therapeutic purposes

Giulia Pavani
pavanig@chop.edu

Table Number: 14

Imaging Core (Wistar)

The state-of-the-art Wistar Imaging Facility provides access to standard and advanced optical imaging systems capable of reaching these goals and offers assistance with advanced image analysis solutions. Researchers may be trained for unassisted use of all core instrumentation, while full service assistance by facility staff is also available for qualitative or quantitative image capture. The Facility also offers expert technical assistance with experimental design to optimize imaging results, enabling users to get more out of the imaging technology.

James Hayden, BA, RBP, FBCA
Managing Director
jhayden@wistar.org

Fengchong (Vic) Kong, MS
fkong@wistar.org

Table Numbers: 1 & 2

Induced Pluripotent Stem Cell Core Facility - RRID:SCR_022426 (PSOM)

The University of Pennsylvania induced Pluripotent Stem Cell Core provides resources for disseminating human pluripotent stem cell technology within UPenn and surrounding research communities. Our services include derivation of patient-specific iPSCs, genome engineering of stem cell lines using CRISPR/Cas9 technology, and lineage specific differentiation of iPSCs/hESCs. The Core has a large collection of patient-derived iPSC lines and cell lines of the gastrointestinal tract (esophageal, pancreatic and intestinal) available to users. The core is also committed to training investigators in stem cell culture techniques and providing quality tested stem cell reagents to users. To initiate a service, please first contact the Core director Wenli Yang to set up a consultation.

Wenli Yang, PhD
Director
wenliyan@pennmedicine.upenn.edu

Table Number: 14

Information Services Advisory Center - ISAAC (PSOM)

IS-concierge service that provide personalized support to faculty and staff in the Penn Medicine community on IS-related questions on Penn applications, research, IS security, and more.

Jennifer Moody
Senior Manager
jennifer.moody@pennmedicine.upenn.edu

Table Number: 31

Johnson Foundation Biophysical & Structural Biology Core Facility - RRID:SCR_022414 (PSOM)

The Department of Biochemistry and Biophysics, with help from the Johnson Foundation, is privileged to offer a wide range of unique equipment and expertise on a variety of services including:

-X-ray Crystallography, NMR, SAXS
-Mass Spectrometry
-Thermodynamics
-Analytical Ultracentrifugation
-Light Scattering
-High-Performance Computing

Kushol Gupta, PhD
Director
kgupta@pennmedicine.upenn.edu

Table Number: 27

Large Animal Imaging Core - LAIF (CHOP)

The LAIF Core facilitates advanced MR image-guided interventional and noninvasive procedures to study various disease areas, such as neurodegenerative, cardiothoracic, and reproductive diseases. Our imaging applications cover a wide range of applications: structural, diffusion, DCE and ASL perfusion, spectroscopy, angiography, cardiac, tissue elastography, functional imaging, flow quantification, and T1, T2 and T2* mapping. A major advantage of preclinical MRI is the ability to utilize the same imaging methods and pulse sequences in both preclinical and clinical scanners, offering a unique opportunity for seamless translation from bench to bedside.

In collaboration with the Division of Veterinary Resources (DVR) team, we encourage investigators to consult on all aspects of scientific, medical, and compliance issues related to research working with large animal models. Institutional Animal Care and Use Committee (IACUC) approval should be received before starting a study.

Pavan Jella
Research Lab Manager
jellap@chop.edu

Table Number: 6

Microbial Culture & Metabolomics Core - RRID:SCR_022417 (PSOM)

The Penn Microbial Culture and Metabolomics Core provides aerobic and anaerobic culturing services and targeted metabolomics analysis, as well as consultation towards experimental design, method development, and data analyses.

Culture studies include isolation of microbial taxa from mammalian samples; interrogation of the physiology of microbial strains under different conditions (e.g., anaerobic/microaerobic/aerobic, differing nutrient limitations) using isolated strains or strains obtained from culture collections (another service offered by the core); co-culturing of defined microbial consortia to investigate microbe-microbe interactions, and; preparation of microbial products (live bacteria, heat-killed bacteria, bacterial supernatants) from single or defined-mixed microbial cultures for use in mammalian cell culture and/or animal model systems. The metabolomics component of the core provides researchers with targeted metabolomics of amino, bile, and short chain fatty acids and features a Waters Acquity uPLC System with photodiode and QDa single quadropole mass detectors as well as an autosampler.

Elliot Friedman, PhD
Technical Director
elliotf@pennmedicine.upenn.edu

Table Number: 12

Molecular Pathology & Imaging Core Facility (MPIC) - RRID:SCR_022420 (PSOM)

The Molecular Pathology and Imaging Core (MPIC) is a histology, imaging, and spatial 'omics resource for researchers at Penn, CHOP, and beyond. We offer histological services, equipment, and technical expertise to assist in a variety of research projects.

Kate Bennett
Technical Director
bennk@pennmedicine.upenn.edu

Table Number: 34

Molecular Screening/Protein Expression Facility (Wistar)

The Wistar Molecular Screening and Protein Expression Facility fosters collaboration by providing expertise in biochemical and cell-based assay development for high-throughput screening and compound profiling. Such assays enable researchers to identify small molecule compounds which interact with a target protein of interest. These compounds can then be used as tools to further study the target proteins function and signaling pathways in cells. In addition, recombinant protein expression is offered in bacteria cells and other hosts on a case-by-case basis.

Joel Cassel
Managing Director
jcassel@wistar.org

Table Numbers: 1& 2

Neurobehavior Testing Core (NBTC) - RRID:SCR_022386

The mission of the Neurobehavior Testing Core is to provide facilities and services to assess behavior output of mouse models with clinically relevant physiological disruptions (e.g. mutation, metabolic, environmental, etc.). Furthermore, the core assists researchers from all disciplines to investigate the therapeutic efficacy of pre-clinical interventions (e.g. drug, gene, immunotherapy and nanoparticles) on behavior phenotypes. We offer consultation for customized behavior battery design, assistance with IACUC protocols and ULAR transfers. Core personnel can perform the procedures or train staff from the PI lab to do so.

W. Timothy O'Brien Ph.D.
obrienw@pennmedicine.upenn.edu

Table Number: 37

A wide variety of procedures are available to assess diverse behavior domains including developmental assays, sensory and motor evaluation, affective disorder-related tests, learning and memory, social behaviors, communication and circadian rhythm studies. In addition, EEG recordings may be acquired to analyze sleep and seizure.

Use of the core is simple. The PI or project lead and core staff discuss the aims, scope and endpoint of the project so that a behavior battery is designed to address the specific aim. After a formal estimate is provided to the PI, personnel and mice are added to the core IACUC protocol to ensure that all procedures are compliant with OAW guidance. Mice are relocated to the core facility where the strict environmental control is maintained to facilitate high quality behavior data.

Most procedures are recorded and graded by image analysis software to enhance rigor. All recordings are provided to the PI. Compiled data is returned to the PI for statistical analysis. Tissue can be obtained in the core or, by special arrangement, in the PI laboratory.

OCRC Tumor BioTrust Collection - RRID:SCR_022387 (PSOM)

The OCRC Tumor BioTrust collects cancer tissue specimens from all cases of gynecologic cancers. We handle collection, processing, storage and distribution of primary and recurrent tumor samples. All samples collected have clinical annotation including demographic patient profiles, pathological & clinical notations, treatment history, and detailed disease information.

Euihye Jung, MBA
Technical Director
euihye@pennmedicine.upenn.edu

Table Number: 22

Office of Clinical Research

The Office of Clinical Research seeks to promote human research for the advancement of healthcare while ensuring the highest level of research participant safety and facilitating the highest quality research by:

• Realizing the best research standards through adherence to university and government research policies and regulations;
• Supporting investigators and research teams through process improvement, innovative technologies, and education and training initiatives;
• Propagating best operational practices to maximize the efficiencies of research activities;
• Collaborating with University organizations involved with human research.

OCR can provide guidance and expertise with regulatory submissions and exemptions, contract support with external sponsors, research budgets and finance, training, research data management and systems, monitoring, clinicaltrials.gov and inspection support.

Nevine Mikhail
nevinem@upenn.edu

Table Number: 35

Pancreatic Islet Cell Biology Core Facility - RRID:SCR_022411 (PSOM)

The objective of the Islet Cell Biology Core is to provide state of the art support including experimental design, islet isolation, and performance of and/or training in an expansive range of assays for physiological and morphometric assessment of pancreatic islet function and growth. In addition to islet cell biology, we offer support and guidance to help adapt existing technologies to solve unique problems that standard methodologies cannot address utilizing a variety of model systems. The core has the advanced technology and expertise to examine calcium influx by fluorescence imaging (utilizing Fura-2 AM ratiometric calcium dye), metabolic and bioenergetic function with the XFe96 Seahorse Extracellular Flux Analyzer coupled with the BioTek Cytation 5 for Seahorse normalization, perifusion with or without respirometry, and “closed” respirometry experiments for our investigators. We foster collaborative initiatives that allow us to expand the services and support we can offer our users.

Andrea Rozo, PhD
Assistant Technical Director
arozo@pennmedicine.upenn.edu

Table Number: 10

Pathology Core Laboratory (CHOP)

The Pathology Core provides histopathology, Immunohistochemistry, tissue microarray, and imaging services to researchers at Children’s Hospital of Philadelphia Research Institute and the surrounding academic community. Our technical and professional staff has extensive experience in all aspects of tissue processing, histological techniques, antibody work-up, and morphologic analysis. In addition, we offer tools to facilitate high throughput analysis of tissue sections and imaging. The Pathology Core is located in the A Level of Colket Translational Research Building (CTRB) Room A410. Our staff is available for consultation, troubleshooting, and assistance in planning and interpreting experiments histopathology and related techniques.

Daniel Martinez
Director
martinezd@chop.edu

Table Number: 10

Penn Acute Research Collaboration (PARC) (PSOM)

The Penn Acute Research Collaboration (PARC) was established at Penn Presbyterian Medical Center in 2016 to serve as a focal point for multidisciplinary clinical and translational research that addresses acute pathophysiologic states and time-sensitive clinical care. PARC provides a trained, dedicated workforce of acute care clinical research staff who are able to screen and enroll eligible subjects 24 hours a day, 7 days a week. Importantly, the PARC research staff has sufficient IRB/regulatory training and experience to participate in a broad spectrum of acute care settings and research approaches at any time of the day or night. We also provide access and support in our fully equipped and capable molecular biology laboratory.

Antonio Davila, PhD
davilaa@pennmedicine.upenn.edu

Table Number: 36

Penn Cytomics & Cell Sorting Shared Resource Laboratory - RRID:SCR_022376 (PSOM)

Penn Cytomics is the sole flow cytometry shared resource laboratory (SRL) at the University of Pennsylvania. Our facility has 35+ instruments, which include analyzers, cell sorters, and small particle detectors. We also have a dual-fluorescence cell counter/viability instrument and a tissue dissociator for cell preparation. We provide both on-site and off-site support to our instrument users, including analyzer and cell sorter training. We also have a research and development team that collaborates/consults with principal investigators in developing high-dimensional panels, as well as staining, acquisition, and analysis. Penn Cytomics is an Abramson Cancer Center supported facility and has been recognized as "exceptional" by the National Cancer Center for over 30 years. Recently, our core became a "Recognized SRL" through the International Society for Advancement of Cytometry.

Derek Jones, PhD, SCYM(ASCP)CM
Senior Technical Director
jonesder@pennmedicine.upenn.edu

William Murphy, BA, SCYM(ASCP)CM
Technical Director
william.murphy@pennmedicine.upenn.edu

Table Number: 35

Penn Genomics & Sequencing Core Facility - RRID:SCR_024999 (PSOM)

The Penn Genomics and Sequencing Core (PGSC) provides a spectrum of sequencing, genomics and molecular biological services with a team of highly experienced and trained professionals under a Director and Technical Director. The services include consultation on experimental design to performing experiment to downstream data analyses.

We offer Next-Generation Sequencing on multiple platforms:
Short Read - Illumina NovaSeq X Plus, NextSeq 2000 and MiSeq
Long Read - PacBio Revio and Oxford Nanopore MinION

This includes DNA/RNA extraction from different sources, library preparation with quality control, sequencing followed by bioinformatics. Applications include mRNA-Seq, total RNA-Seq, small RNA-Seq, WGS, targeted sequencing, ChIP-Seq, ATAC-Seq on X Plus; WGS and whole methylome on PacBio etc. For single-cell genomics we use 10X Genomics Controller; the applications include scRNA-Seq and snRNA-Seq. Soon we are going to introduce multiplexed scRNA-Seq. Multiome including scATAC-Seq are under development.

Bioinformatics support is available for both core and externally generated datasets. Legacy Sequencing: Sanger Sequencing on ABI 3730 capillary sequencer. The capillary sequencer enables fragment analysis for microsatellite-based genotyping, cell line authentication and other applications. Targeted molecular profiling including genotyping and gene expression is performed using ThermoFisher QS6 Pro and Qiagen digital PCR instruments. Mouse genotyping is done using PCR-based approach.

Tapan Ganguly, PhD
Core Director
gangulyt@pennmedicine.upenn.edu

Erik Toorens
Laboratory Manager
toorens@pennmedicine.upenn.edu

Table Number: 16

Penn Libraries Holman Biotech Commons/Research Data & Digital Scholarship (Penn)

- Holman Biotech Commons: The Holman Biotech Commons is Penn’s biomedical library and recently completed a major renovation of the main floor. Librarians serving Penn Nursing, PSOM, Biology, and Penn Medicine are based here and are available for research consultations, library orientations, and workshops on the library’s various databases and resources. Additionally, Holman is home to the Bollinger Digital Fabrication Lab, providing research poster printing service as well as 3D printing, 3D scanning and laser cutting services. Holman offers 20 group study rooms, a collaborative classroom, and a reading room. Spaces still in development include: Podcasting/Video Lecture Recording Studio, Design Thinking Studio, and Mixed Reality Lab. The library is open to all – visit our website for our hours, to reserve a room, and to reach out to any of our staff.
- Research Data & Digital Scholarship: The Penn Libraries Research Data & Digital Scholarship team facilitates data-driven and data-literate research and scholarship across the disciplines. We provide one-on-one consultations and workshops related to quantitative and qualitative data software, GIS and mapping tools, and programming languages. We have wide ranging expertise in data management, data sharing and preservation, machine learning, text analysis, and AI. We also assist patrons with digital scholarship through our management of the institutional repository, ScholarlyCommons, and other forms of digital project development and publishing. Come see us in our space in Van Pelt called the Research Data & Digital Scholarship Exchange (RDDSx)!

https://www.library.upenn.edu/holman
https://www.library.upenn.edu/rdds

Jennifer Lege
jlege@upenn.edu

Lauren Phegley
lphegley@upenn.edu

Table Number: 32

Penn Medicine Academic Services (PMACS) (PSOM)

Originally formed in 2012 to provide computing services for the Perelman School of Medicine’s departments, centers, and institutes, Penn Medicine Academic Computing Services (PMACS) has grown and matured into a department of technology professionals providing a wide range of services including:

• Desktop Support
• Server Administration
• Storage Management
• Both High Performance Computing (HPC) and Limited Performance Computing (LPC)
• Web design and development

Consulting services that provide options to best support research initiatives
PMACS is focused on delivering state of the art technology solutions in the most cost-conscious manner in support of the education, administrative and research needs of the Perelman School of Medicine.

Vincent Frangiosa
Service Information Officer
frangiov@upenn.edu

Table Number: 31

Penn Medicine Biobank (PMBB) - RRID:SCR_022415 (PSOM)

At the Penn Medicine BioBank, we help researchers study diseases. We gather samples like blood and tissue from Penn Medicine patient volunteers, and connect it to clinical and genetic data. These samples and data can help researchers find better ways to diagnose, treat, and maybe even stop or cure diseases.

JoEllen Weaver
Technical Director
joellenw@pennmedicine.upenn.edu

Nawar Naseer
Director of Engagement
nnawar@pennmedicine.upenn.edu

Table Number: 28

Penn Metabolomics Core - RRID:SCR_022381 (PSOM)

The Penn Metabolomics Core provides expertise in targeted and untargeted metabolomics, 13C isotope tracing, and custom method development with 2 Agilent HPLC/triple quadrupole mass spectrometers and a Thermo HPLC/Orbitrap IDX mass spectrometer. Our mission is to perform the assays and assist in the interpretation of the results. The core is available to the entire Penn research community, external research investigators, and industry.

Christopher Petucci, PhD
Technical Director
christopher.petucci@pennmedicine.upenn.edu

Table Number: 11

Penn Vet Comparative Pathology Core - RRID:SCR_022438 (Penn Vet)

The Comparative Pathology Core (CPC), an Abramson Cancer Center shared resource, provides expert pathological characterization and validation of mouse and other animal models used in biomedical research by offering the expertise of board-certified veterinary pathologists and access to state-of-the-art histology, molecular staining of animal tissues, and digital pathology services.

Charley Assenmacher, DVM, MSc, DACVP
Technical Director
chasse@upenn.edu

Table Number: 23

Penn Vet Imaging Core - RRID:SCR_022436 (Penn Vet)

The Penn Vet Imaging Core provides access to a variety of microscope systems, including a Leica Stellaris 8 FALCON confocal and fluorescence lifetime microscope, a Leica SP8-MP upright 2-photon microscope, a Leica DM6000 widefield microscope, a Molecular Devices ImageXpress high content imaging system, and a DeltaVision OMX-SI structured illumination and TIRF microscope. Training and assistance on these microscopes is provided at no additional cost beyond the normal hourly rate for microscope use.

Gordon Ruthel, PhD
Core Manager
goruthel@vet.upenn.edu

Table Number: 4

Proteomics & Metabolomics Facility (Wistar)

The Wistar Proteomics and Metabolomics Facility provides high sensitivity proteomics and metabolomics analyses using state-of-the-art mass spectrometry instruments and methods. Proteomics services include: quantitative, in-depth global comparisons of sub-proteomes, complete proteomes, and secretomes using integrated ion current, SILAC or TMT labeling; global quantitative comparisons of posttranslational modifications (PTMs) such as ubiquitination, acetylation, or phosphorylation; detailed characterization of individual purified proteins including PTMs; identification of components in protein complexes (e.g. pull-downs) including estimation of stoichiometries (where appropriate); characterization of intact protein and peptide masses using either MALDI-MS or ESI-MS; and HPLC peptide mapping with UV detection. Metabolomics analyses include analysis of polar metabolites or lipids extracted from cells, biological fluids, conditioned media, or tissues.

Hsin-Yao Tang, PhD
Scientific Director
tangh@wistar.org

Aaron Goldman, PhD
Co-Scientific Director
agoldman@wistar.org

Wujuan Zhang, PhD
Managing Director
wzhang@wistar.org

Anneliese Faustino, PhD
afaustino@wistar.org

Table Numbers: 1 & 2

Qualitative Research Core (CHOP)

The QRC supports high caliber qualitative research. We are invested in advancing research innovation and skillsets across the CHOP Enterprise by providing methodological supports and training to investigators and research teams. Our different services are designed to meet various needs and can be used together to get the best fit for your team or project.

Katherine Kellom, BA
Director
kellomk@chop.edu

Table Number: 20

Recruitment Enhancement Core & Research Family Partners (CHOP)

The Recruitment Enhancement Core (REC) is a free service providing CHOP study teams with additional recruitment support. Services include recruitment strategy consultation for protocols and grant writing, recruitment strategy consultation for studies already in progress, writing and editing recruitment documents, IRB regulatory support related to recruitment, deploying recruitment emails/letters, tear pad advertising around CHOP’s campus, submissions to This Week at CHOP and CHOP social media tools, utilization of Clinical Trial Finder advertisement, recruitment in the community and more.

Research Family Partners helps to connect researchers with community members to provide diverse lived experience to study groups from the community perspective. CHOP has over 285 onboarded research and community family partners and works with departments, divisions, and individual researchers to add the community voice to research.

Heather Cathrall, CIP, MBE
Director, Clinical Trials Support Administration
cathrallh@chop.edu

Table Number: 7

Research Instrumentation Shop (RIS) - RRID:SCR_022424 (PSOM)

RIS has a long history of assisting researchers and graduate students from Penn and scientists outside the University and industry, with various disciplines and perspectives. RIS will promptly meet their needs to design, construct, and package their research project.

We are conveniently located in the basement of the John Morgan Building, Room 75. Please visit us to discuss your research requirements

Dieter Hunt
Machinist
dieter.hunt@pennmedicine.upenn.edu

Table Number: 25

Research Vector Core (CHOP)

The Research Vector Core (RVC), part of the Raymond G. Perelman Center for Cellular and Molecular Therapeutics (CCMT) at the Children’s Hospital of Philadelphia (CHOP), manufactures high-quality research-grade recombinant adeno-associated virus (AAV) and lentivirus (LV) vectors for basic research and preclinical studies. The RVC specializes in producing custom vector constructs at various scales using well-characterized processes, and provides advanced technologies and expert support for viral-based gene transfer applications.

Xueyuan Liu
Liuxu@chop.edu

Table Number: 26

Rodent Breeding Core (Penn)

The ULAR Breeding Core at the University of Pennsylvania offers murine breeding services to researchers. We will save you time and space by managing the breeding of your mouse colonies in our dedicated barrier facility. We will work with you to set and reach breeding goals to produce study cohorts which we will then transfer to your vivarium. We can also help identify potential breeding issues and suggest ways to help you manage your own colonies.

Kim Tulish
ktulish@upenn.edu

Emily Miedel
emiedel@upenn.edu

Table Number: 29

Rodent Cardiovascular Phenotyping Core - RRID:SCR_022419 (PSOM)

The Rodent Cardiovascular Phenotyping Core provides echocardiographic services to assess cardiovascular function in mouse models and to provide validated surgical models of heart and vascular disease in mice to assess genetic or therapeutic interventions. We will work with investigators to design and implement the study along with any associated grant applications, animal protocol submissions and manuscript preparation. While the central focus of the facility is cardiovascular research, the techniques employed are often useful to investigators in other fields. Our Core staff will work with you to assess your needs and provide the necessary technical training and scientific assistance in animal protocol preparation. The Core runs on a fee-for-service model. Accordingly, investigators will be responsible for the costs incurred for their projects and prior animal protocol approval by Penn IACUC.

Ling Lai, MD/PhD
Director & Cardiac Surgeon
linglai@pennmedicine.upenn.edu

Table Number: 5

Rodent Metabolic Phenotyping Core - RRID:SCR_022427 (PSOM)

The mission of the Rodent Metabolic Phenotyping Core is to provide the necessary resources and expertise to allow investigators to perform state-of-the-art studies of metabolism in rodent models.

Corey Holman, PhD
Technical Director
holmanc@pennmedicine.upenn.edu

Table Number: 5

Single Cell Technology Core (CHOP)

As part of the Center for Single Cell Biology, our service core provides convenient access to cutting-edge single-cell and spatial omics technologies for researchers at CHOP, UPenn, and beyond. Established in early 2022, we are equipped with state-of-the-art instrumentation and supported by experienced research staff and bioinformaticians to offer comprehensive experimental and computational support for single-cell research.

Mei Zhang, PhD
Director
zhangm5@chop.edu
3501 Civic Center Blvd, CTRB A450D
Philadelphia, PA 19104

Table Number: 30

Small Animal Imaging Core - SAIF (CHOP)

The Small Animal Imaging Core provides multi-modality radiological imaging in a clean and state-of-the-art animal facility.

The core offers the following services
• Magnetic Resonance Imaging (MRI)
• Positron Emission Tomography/Computed Tomography (PET/CT)
• Optical Imaging
• Ultrasound
• Microimaging and NMR

We conduct research in all preclinical anatomical, functional, and molecular imaging areas.

Sergey Magnitsky PhD
Director of Preclinical Imaging Facility
magnitsksm@chop.edu

Table Number: 6

Small Animal Imaging Facility (SAIF) - RRID:SCR_022385 (PSOM)

The SAIF combines state-of-the-art instrumentation and a nationally recognized staff to assist investigators with a wide range of imaging based experimental approaches. The SAIF currently provides a comprehensive suite of imaging modalities including: Magnetic resonance imaging (MRI) and spectroscopy (MRS), Optical imaging (including bioluminescence, fluorescence, and near-infrared imaging), Computed tomography (CT), Positron emission tomography (PET), Single photon emission computed tomography (SPECT) and Ultrasound (US). In addition, the facility provides dedicated housing for mice and rats undergoing longitudinal imaging studies.

Optical Imaging: James Delikatny: delikatn@pennmedicine.upenn.edu, Ching-Hui Huang : chinghu@pennmedicine.upenn.edu
MRI/MRS: Stephen Pickup: pickup@pennmedicine.upenn.edu, Weixia Liu: weixia@pennmedicine.upenn.edu
Nuclear Medicine: Mark A Sellmyer: Mark.Sellmyer@pennmedicine.upenn.edu, Eric Blankemeyer: eriblank@pennmedicine.upenn.edu
Ultrasound: Chandra Sehgal: Chandra.Sehgal@pennmedicine.upenn.edu

Table Number: 4

Small Molecule and Metabolite Core Laboratory (CHOP)

The Small Molecule and Metabolite Core Laboratory has the equipment necessary to support small molecule quantitative bioanalytical analysis.

Jim Bruton
Laboratory Manager
brutonj@chop.edu

Table Number: 34

Translational Core Laboratory - TCL (CHOP)

The Translational Core Laboratory (TCL) at the Children’s Hospital of Philadelphia (CHOP) Research Institute supports basic, pre-clinical, and clinical research for investigators from CHOP, the University of Pennsylvania, and external sites. The CHOP TCL performs immunoassays for the quantitation of protein/peptide biomarkers, cytokines, hormones, and antibodies in various body fluids. Over the years, TCL has gathered a breadth of instruments for protein biomarker detection, including clinical-grade, research-grade, and multiplex. The TCL also performs PBMC isolation, DNA extraction, QuantiFERON processing, blood chemistry assays (CMP, Lipid panel, Liver Function Panel), and CBC testing. We can test numerous biomarkers and provide a balance in cost, quality, and speed.

Nkecha Hughes, MS
HughesN@chop.edu

Table number: 18

Tumor Tissue & Biospecimen Bank - RRID:SCR_022430 (PSOM)

The University of Pennsylvania Tumor Tissue and Biospecimen Bank, also known as TTAB, became a new Core Facility & School of Medicine approved Service Center in July 2006. TTAB is a joint project under the auspices of the Department of Pathology and Laboratory Medicine of the Department of Pathology and the Abramson Cancer Center. Over 20 years, TTAB has established a centralized biosample bank and harmonized individual biospecimen banks that exist at the University of Pennsylvania.
In its role as a biorepository, TTAB supports organ-specific collections and clinical trials for Investigators while also collecting for the generalized bank of de-identified and identified tissue specimens to build stock and future resources for biospecimen banking at Penn. Additionally, functioning as a PSOM Service Center, TTAB currently offers a range of initial services for Investigators involved in Human Biospecimen Research. The Investigator is provided with the option to bank their collection on or off-site with specimen inventory virtually connected to TTAB using UPenn supported software, LabVantage.

Investigators have the option to utilize biorepository services at the level they believe may support/enhance their biospecimen collection and research efforts. Some Investigators may choose to conduct all their biobanking services directly through the bank opting for a “full” service model while other Investigators may seek out TTAB’s expertise through consultation or training. Each service is customized to meet user need with consummate detail.

Fred Valdivieso, BS
Technical Director
valdivie@pennmedicine.upenn.edu

Table Number: 28

University Animal Laboratory Resources (ULAR) (Penn)

ULAR provides the housing, husbandry, clinical care and health surveillance for all of the animals used in research at UPenn, as well as having pathology services should any animals become sick. Our group works with researchers in developing animal models of disease and we have a mouse breeding core facility (See the Rodent Breeding Core presentation). Lastly, we are responsible for the training of all of research personnel on campus who use animals.

James Marx, DVM, PhD, DACLAM
marx@upenn.edu

Table Number: 36

Viral Molecular High Density Sequencing Core - RRID:SCR_022433 (PSOM)

Sequencing core at Penn with expertise in viral integration site analysis and evaluating various cell and gene therapies (lentivirus, MLV, AAV, CRISPR). Currently assisting with over 20 gene therapy clinical trials globally across academic and corporate institutions, as both research and safety endpoints. We are experts in molecular analyses, custom informatics and assisting with regulatory approval documents and have contributed to over 80 publications. Under leadership of Dr. Frederic Bushman, Chair of Microbiology.

Aoife Doto, PhD
Technical Director
rochea@pennmedicine.upenn.edu

Table Number: 11

Wistar Animal Facility - WAF (Wistar)

The Animal Facility Shared Resource facilitates research through humane and efficient management of animal populations. The vivarium operates as a modified barrier facility and is equipped with quarantine and a procedure room, holding rooms with biosafety cabinets, an imaging/holding room equipped with a PerkinElmer IVIS SpectrumCT imaging system, SonoVol Vega ultrasound system and additional support areas. The Facility has rack space for more than 6,000 sterile, disposable, and individually ventilated mouse cages. Space for housing limited numbers of small animal species other than mice is also available upon request. Wistar’s Animal Care and Use Program, overseen by The Wistar Institutional Animal Care and Use Committee (IACUC), is fully accredited by AAALAC International since 1998, has an assurance on file with the Office of Laboratory Animal Welfare at the NIH, and is a registered USDA research institution.

Denise DiFrancesco, BA, RLATG, CMAR, ILAM
Managing Director
difrancesco@wistar.org

Table Numbers: 1 & 2

Zebrafish Core (CHOP)

The Zebrafish Core of the Children's Hospital of Philadelphia is a resource for all researchers at UPenn and CHOP to use zebrafish as an animal model. We provide training, expertise and resources to plan and perform zebrafish experiments and take care of the fish in our aquatic system. Our special expertises are disease modeling, analysis of disease phenotypes, and drug testing.

Christoph Seiler, PhD
Core Director
Children's Hospital of Philadelphia
1102B Abramson Research Center
3615 Civic Center Blvd
Philadelphia, PA 19104
seilerc@chop.edu

Table Number: 23