publications of current students
Plentz R, Park JS, Rhim AD, Abravanel D, Hezel AF, Sharma SV, Gurumurthy S, Deshpande V, Kenific C, Settleman J, Majumder PK, Stanger BZ, Bardeesy N. Inhibition of y-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology. 2009 May;136(5):1741-9.e6.
Caravaca JM, Donahue G, Becker JS, He X, Vinson C, Zaret KS. Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes. Genes & Development. 2013 Jan;27(3):251-60.
Li P, McElligott S, Bergquist H, Schwartz JS, Doshi JA. Effect of the Medicare Part D coverage gap on medication use among patients with hypertension and hyperlipidemia. Ann Intern M. 2012, Jun 5;156(11):776-84
Puig A, McElligott S, Bergquist H, Doshi JA. Albuterol and levalbuterol use and spending in Medicare beneficiaries with chronic obstructive pulmonary disease. American Journal of Geriatric Pharmacotherapy. 8(6):571-582; 2010.
Epidemiology: General Principles and Practical Research Guidelines. Edited by Van den Broeck J and Brestoff JR, A forthcoming textbook to be published by Springer. Approx. 600 pages with 100 illustrations.
Brestoff JR, Van den Broeck J, Book Review: Epidemiological Research Terms and Concepts. Int J of Epidemiol, 2012. In press.
Van den Broeck J, Brestoff JR, Book Review: Up from Clinical Epidemiology and EBM (Evidence Based Medicine). Eur J Epidemiol, 2012. In press.
Brestoff JR and Van den Broeck J. Global Health and Nutrition. In: Encyclopedia of Global Studies. Ed. Jeurgensmeyer M and Anheier HK. Thousand Oaks: SAGE Reference, 2012. ISBN 9781412964296
Brestoff JR, Perry IJ, Van den Broeck J. Challenging the role of social norms regarding body weight as an explanation for weight and BMI misreporting bias: Development and application of a new approach to examining misreporting bias in surveys. BMC Public Health 11:331, 2011.
Brown SES, Ratcliffe SJ, Kahn JM, Halpern SD. The Epidemiology of Intensive Care Unit Readmissions in the United States. Am J Respir Crit Care Med. 2012 Jan 26.
Young M, Brown SES, Truog R, Halpern SD. Rationing ICU Beds: Disclose or Disguise? Crit Care Med. 2011 Sep 15
Burke JF, Long NM, Zaghloul KA, Sharan AD, Sperling MR, Kahana MJ. Human intracranial high-frequency activity maps episodic memory formation in space and time. Neuroimage. 2013 Jul 1. pii: S1053-8119(13)00705-2.
Burke JF, Zaghloul KA, Jacobs J, Williams RB, Sperling MR, Sharan AD, and Kahana, MJ. Synchronous and asynchronous theta and gamma activity during episodic memory formation. The Journal of Neuroscience. 2013. 33(1), 292–304. doi:10.1523/JNEUROSCI.2057-12.2013
Busch JI, Martinez-Lage M, Ashbridge E, Grossman M, Van Deerlin VM, Hu F, Lee VMY, Trojanowski JQ, Chen-Plotkin AS. Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain. Acta Neuropathologica Communications. 2013 July 11; 1:36.
Busch JI, Martinez-Lage M, Ashbridge E, Grossman M, Van Deerlin V, Hu F, Lee VM, Trojanowski JQ, and Chen-Plotkin AS. "Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain." Acta Neuropathologica Communications 2013 Jul 11, 1:36doi:10.1186/2051-5960-1-36.
Chen-Plotkin AS, Unger TL, Gallagher MD, Bill E, Kwong LK, Volpicelli-Daley L, Busch JI, Akle S, Grossman M, Van Deerlin V, Trojanowski JQ, Lee VM. "TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways."J Neurosci. 2012 Aug 15;32(33):11213-27.
Kandalaft LE, Motz GT, Busch J, Coukos G. Angiogenesis and the Tumor Vasculature as Antitumor Immune Modulators: The Role of Vascular Endothelial Growth Factor and Endothelin. Curr Top Microbiol Immunol. 2011;344:129-48.
Butt OH, Benson NC, Datta R, Aguirre GK. The fine-scale functional correlation of striate cortex in sighted and blind people. J Neurosci. 2013 Oct 9;33(41):16209-19. doi: 10.1523/JNEUROSCI.0363-13.2013.
Benson NC, Butt OH, Datta R, Radoeva PD, Brainard DH, Aguirre GK. The retinotopic organization of striate cortex is well predicted by surface topology. Curr Biol. 2012 Nov 6;22(21):2081-5. doi: 10.1016/j.cub.2012.09.014.
Charlson ES, and Bittinger K, Chen J, Diamond J, Li H, Collman RG and Bushman FD. Assessing bacterial populations in the lung by replicate analysis of samples from the upper and lower respiratory tracts. PLoS One. 2012;7(9):e42786.
Charlson ES, Diamond J, Bittinger K, Fitzgerald AS, Yadav A, Haas A, Bushman FD and Collman RG. Lung-enriched organisms and aberrant bacterial and fungal respiratory microbiota following lung transplant. Am J Respir Crit Care Med. 2012 Sep 15;186(6):536-45.
Chen J, Bittinger K, Charlson ES, Hoffmann C, Lewis J, Wu GD, Collman RG, Bushman FD, Li H. Associating microbiome composition with environmental covariates using generalized UniFrac distances. Bioinformatics. 2012 Aug 15;28(16):2106-13.
Knights D, Kuczynski J, Charlson ES, Zaneveld J, Mozer MC, Collman RG, Bushman FD, Knight R, Kelley ST. Bayesian community-wide culture-independent microbial source tracking. Nature Methods. 2011 Jul 17;8(9):761-3.
Charlson ES, Bittinger K, Haas AR, Fitzgerald AS, Frank I, Yadav A, Bushman FD, Collman RG. Topographical Continuity of Bacterial Populations in the Healthy Human Respiratory Tract. Am J Respir Crit Care Med. 2011 Jun 23.
Yilmaz P, Kottmann R, Field D, Knight R, Cole JR, Amaral-Zettler L, Gilbert JA, Karsch-Mizrachi I, Johnston A, Cochrane G, Vaughan R, Hunter C, Park J, Morrison N, Rocca-Serra P, Sterk P, Arumugam M, Bailey M, Baumgartner L, Birren BW, Blaser MJ, Bonazzi V, Booth T, Bork P, Bushman FD, Buttigieg PL, Chain PS, Charlson ES, Costello EK, Huot-Creasy H, Dawyndt P, DeSantis T, Fierer N, Fuhrman JA, Gallery RE, Gevers D, Gibbs RA, San Gil I, Gonzalez A, Gordon JI, Guralnick R, Hankeln W, Highlander S, Hugenholtz P, Jansson J, Kau AL, Kelley ST, Kennedy J, Knights D, Koren O, Kuczynski J, Kyrpides N, Larsen R, Lauber CL, Legg T, Ley RE, Lozupone CA, Ludwig W, Lyons D, Maguire E, Methé BA, Meyer F, Muegge B, Nakielny S, Nelson KE, Nemergut D, Neufeld JD, Newbold LK, Oliver AE, Pace NR, Palanisamy G, Peplies J, Petrosino J, Proctor L, Pruesse E, Quast C, Raes J, Ratnasingham S, Ravel J, Relman DA, Assunta-Sansone S, Schloss PD, Schriml L, Sinha R, Smith MI, Sodergren E, Spo A, Stombaugh J, Tiedje JM, Ward DV, Weinstock GM, Wendel D, White O, Whiteley A, Wilke A, Wortman JR, Yatsunenko T, Glöckner FO. Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications. Nat Biotechnol. 2011 May;29(5):415-20.
Charlson ES, Chen J, Custers-Allen R, Bittinger K, Li H, Sinha R, Hwang J, Bushman FD, Collman RG. Disordered microbial communities in the upper respiratory tract of cigarette smokers. PLoS One. 2010 Dec 20;5(12 ):e15216.
Bortnick A, Chernova I, Quinn WJ 3rd, Mugnier M, Cancro MP, Allman D. Long-lived plasma cells are induced early in response to T-cell independent and T-cell dependent antigens, J Immunol. 2012 Jun 1;188(11):5389-96
Tang J, Cho NW, Cui G, Manion EM, Shanbhag NM, Botuyan MV, Mer G, and Greenberg RA. Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat Struct Mol Biol. 2013 Feb 3.
Barnett BE, Ciocca ML, Goenka R, Barnett LG, Wu J, Laufer TM, Burkhardt JK, Cancro MP, Reiner SL. Asymmetric B cell division in the germinal center reaction. Science. 2012 Jan 20;335(6066):342-4
Ciocca ML, Barnett BE, Burkhardt JK, Chang JT, Reiner SL. Cutting edge: Asymmetric memory T cell division in response to re-challenge. J Immunol. 2012 May 1;188(9):4145-8
Chang JT, Ciocca ML, Kinjyo I, Palanivel VR, McClurkin CE, Dejong CS, Mooney EC, Kim JS, Steinel NC, Oliaro J, Yin CC, Florea BI, Overkleeft HS, Berg LJ, Russell SM, Koretzky GA, Jordan MS, Reiner SL. Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity. 2011 Apr 22;34(4):492-504.
Hara T, Koh K, Combs DJ, Sehgal A. Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant. J Neurosci, 2011 31(27): 9982-90.
Daye D, Keller B, Conant EF, Chen J, Schnall MD, Maidment AD, Kontos D. Mammographic parenchymal patterns as an imaging marker of endogenous hormonal exposure: a preliminary study in a high-risk population. Acad Radiol. 2013 May;20(5):635-46. doi: 10.1016/j.acra.2012.12.016.
Li LZ, Kadlececk S, Xu HN, Daye D, Pullinger B, Profka H, Chodosh L, Rizi R.. Ratiometric analysis in hyperpolarized NMR (I): test of the two-site exchange model and the quantification of reaction rate constants.NMR Biomed. 2013 Apr 29. doi: 10.1002/nbm.2953.
Ashraf A, Gavenonis S, Daye D, Mies C, Rosen M, Kontos D. A Multichannel Markov Random Field Framework for Tumor Segmentation with an Application to Classification of Gene Expression-based Breast Cancer Recurrence Risk. IEEE Trans Med Imaging. 2013 Apr;32(4):637-48. doi: 10.1109/TMI.2012.2219589.
Daye D, Wellen KE. Metabolic Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis. Semin Cell Dev Biol. 2012 Jun;23(4):362-9
Ashraf AB, Gavenonis S, Daye D, Mies C, Feldman M, Rosen M, Kontos D. A multichannel Markov random field approach for automated segmentation of breast cancer tumor in DCE-MRI data using kinetic observation model. Med Image Comput Comput Assist Interv. 2011;14(Pt 3):546-53.
Didigu CA, Wilen CB, Wang J, Duong J, Secreto AJ, Danet-Desnoyers GA, Riley JL, Gregory PD, June CH, Holmes MC, Doms RW. Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection. bloodjournal.hematologylibrary.org. Blood first edition, Oct 25, 2013.
Singer EM, Shin DB, Nattkemper LA, Benoit BM, Klein RS, Didigu CA, Loren AW, Dentchev T, Wysocka M, Yosipovitch G, Rook AH. Interleukin-31 Is Produced by the Malignant T-Cell Population in Cutaneous T-Cell Lymphoma and Correlates with CTCL Pruritus. J. Invest. Dermatol. 2013 May 22.
Wojcechowskyj JA, Didigu CA, Lee JY, Parrish NF, Sinha R, Hahn BH, Bushman FD, Jensen ST, Seeholzer SH, Doms RW. Quantitative Phosphoproteomics Reveals Extensive Cellular Reprogramming during HIV-1 Entry. Cell Host Microbe. 2013 May 15;13(5):613–23. NIHMS ID: NIHMS473947
Parker ZF, Iyer SS, Wilen CB, Parrish NF, Chikere KC, Lee F-H, Didigu CA, Berro R, Klasse PJ, Lee B, Moore JP, Shaw GM, Hahn BH, Doms RW. Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5. Journal of Virology. 2013 Mar;87(5):2401–11.
Richardson MW, Jadlowsky J, Didigu CA, Doms RW, Riley JL. Kruppel-like Factor 2 Modulates CCR5 Expression and Susceptibility to HIV-1 Infection. J Immunol. 2012 Oct 15;189(8):3815–21.
Zheng X, Xu C, Smith AO, Stratman AN, Zou Z, Kleaveland B, Yuan L, Didigu C, Sen A, Liu X, Skuli N, Zaslavsky A, Chen M, Cheng L, Davis GE, Kahn ML. Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth. Dev. Cell. 2012 Aug 14;23(2):342–55.
Tilton JC, Wilen CB, Didigu CA, Sinha R, Harrison JE, Agrawal-Gamse C, Henning EA, Bushman FD, Martin JN, Deeks SG, Doms RW. A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5. J Virol. 2010 Oct;84(20):10863-76
Zachary Gerhart-Hines, Dan Feng*, Matthew J. Emmett*, Logan J. Everett, Emanuele Loro, Erika R. Briggs, Anne Bugge, Catherine Hou, Christine Ferrara, Patrick Seale, Daniel A. Pryma, Tejvir S. Khurana & Mitchell A. Lazar. The nuclear receptor Rev-erba controls circadian thermogenic plasticity. 2013 Oct 27. doi: 10.1038/nature12642.
Hunter CS, Dixit S, Cohen T, Ediger B, Wilcox C, Ferreira M, Westphal H, Stein R, May CL. Islet a-, b-, and d-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor. Diabetes. 2013 March; 62(3): 875-886.
Li RC, Finkelman BS, Chen J, Booth SL, Bershaw L, Brensinger CM, Kimmel SE. Dietary Vitamin K Intake and Therapeutic Anticoagulation Control During the Initiation Phase of Warfarin Therapy: A Prospective Cohort Study. J Thromb Haemost. 2013 Mar; 110(1):195-6.
Finkelman BS, Rubinstein WS, Friedman S, Friebel TM, Rebbeck TR, et al, for the PROSE Consortium. Breast and Ovarian Cancer Risk and Risk Reduction in Jewish BRCA1/2 Mutation Carriers. J Clin Oncol. 2012 Apr; 30(12): 1321-28.
Finkelman BS, Gage BF, Johnson JA, Brensinger CM, Kimmel SE. Genetic Warfarin Dosing: Tables vs. Algorithms. J Am Coll Cardiol. 2011 Feb 1;57(5):612-8.
Zhang Z, Kofonow JM, Finkelman BS, Doghramji L, Chiu AG, Kennedy DW, Cohen NA, Palmer JN. Clinical factors associated with bacterial biofilm formation in chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2011 Mar;144(3):457-62.
Zhang Z, Linkin DR, Finkelman BS, O'Malley BW Jr, Thaler ER, Doghramji L, Kennedy DW, Cohen NA, Palmer JN. Asthma and biofilm-forming bacteria are independently associated with revision sinus surgeries for chronic rhinosinusitis. J Allergy Clin Immunol. 2011 Jul;128(1):221-223.e1.
Schelleman H, Brensinger CM, Chen J, Finkelman BS, Rieder MJ, Kimmel SE. (2010) New genetic variant that might improve warfarin dose prediction in African Americans. Br J Clin Pharmacol. 2010 Sep;70(3):393-9.
Friedman AB. Effects of Medicaid on Clinical Outcomes. N Engl J Med. 2013; Aug 8;369(6):582.
Van den Broeck J, Brestoff JR, Friedman AB, Becker N, Hoaglin MC, Robberstad B. The Measurement Plan. In: Epidemiology: Van den Broeck J, Brestoff JR, eds. Principles and Practical Guidelines. 1st ed. New York, NY: Springer;2013: 197-240.
Friedman AB, Mendola TS. To Cover Their Child, One Couple Navigates A Health Insurance Maze In Pennsylvania. Health Aff May 2013 vol. 32 no. 5 994-997.
Friedman AB, Becker N. Understanding the Individual Mandate's SCOTUS Pivot Points. LDI Health Economist. April 2012.
Ezzati M, Horwitz ME, Thomas DS, Friedman AB, Roach R, Clark T, Murray CJ, Honigman B. Altitude, life expectancy and mortality from ischaemic heart disease, stroke, COPD and cancers: national population-based analysis of US counties. J Epidemiol Community Health. 2012 Jul;66(7):e17. doi: 10.1136/jech.2010.112938
Dionisio KL, Rooney MS, Arku RE, Friedman AB, Hughes AF, Vallarino J, Agyei-Mensah S, Spengler JD, Ezzati M. Within-neighborhood patterns and sources of particle pollution: mobile monitoring and geographic information system analysis in four communities in Accra, Ghana. Environmental Health Perspectives 2010. 118(5):607-13.
Kim, H.J., N.C.Kim, Y.D. Wang, E.A. Scarborough, J. Moore, Z. Diaz, K.S. MacLea, B. Freibaum, S. Li, A. Molliex, A.P. Kanagaraj, R. Carter, K.B. Boylan, A.M. Wojtas, R. Rademakers, J.L. Pinkus, S.A. Greenberg, J.Q. Trojanowski, B.J. Traynor, B.N. Smith, S. Topp, A.S. Gkazi, J. Miller, C.E. Shaw, M. Kottlors, J. Kirschner, A. Pestronk, Y.R. Li, A.F. Ford, A.D. Gitler, M. Benatar, O.D. King, V.E. Kimonis, E.D. Ross, C.C. Weihl, J. Shorter, and J.P. Taylor. Mutations in prion-like domains in hnRNPs cause multisystem proteinopathy and ALS. Nature. 2013 March 28; 495:467-473.
Gill, A., Kolson, D. Dimethyl fumarate modulation of immune and antioxidant responses: application to HIV therapy (Review Paper). Crit Rev Immunol. 2013 33(4);307-359.
Levesque M.J., Ginart P., Wei Y., Raj A., Visualizing SNVs to quantify allele-apecific expression in single cells. Nat Methods. 2013 Sep; 10(9): 865-7. PMCID: PMC3771873
Jamiolkowski RM, Guo LY, Li YR, Shaffer SM, Naji A. Islet transplantation in type I diabetes mellitus. Yale J Biol Med. 2012 Mar; 85(1):37-43.
Singh N*, Gupta M*, Trivedi CM, Singh MK, Li L, Epstein JA. Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. Developmental Biol. 2013 May;377(2):333–44.
Shen CJ, Raghavan S, Xu Z, Baranski JD, Yu X, Wozniak MA, Miller JS, Gupta M, Buckbinder L, Chen CS. Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner. Exp Cell Res. 2011 Aug 1;317(13):1860-71.
Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, Zhang Y, Yang W, Gruber PJ, Epstein JA, Morrisey EE. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell. 2011 Apr 8;8(4):376-88.
Hergott CB, Mitra M, Guo J, Wu T, Miller JT, Iwatani Y, Gorelick RJ, Levin JG. Zinc finger function of HIV-1 nucleocapsid protein is required for removal of 5'-terminal genomic RNA fragments: a paradigm for RNA removal reactions in HIV-1 reverse transcription. Virus Res. 2013 Feb;171(2):346-55.
Boulaftali Y, Hess PR, Kahn ML, Bergmeier W. Platelet Immunoreceptor Tyrosine-Based Activation Motif Signaling and Vascular Integrity. Circ Res. 2014 Mar 28;114(7):1174-84.
Hess PR, Rawnsley DR, Jakus Z, Yang Y, Sweet DT, Fu J, Herzog B, Lu M, Nieswandt B, Oliver G, Makinen T, Xia L, Kahn ML. Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life. J Clin Invest. 2014 Jan 2;124(1):273-84.
Wannemacher KM, Jiang H, Hess PR, Shin Y, Suzuki-Inoue K, Brass LF. An expanded role for semaphorin 4D in platelets includes contact-dependent amplification of Clec-2 signaling. J Thromb Haemost. 2013 Dec;11(12):2190-3.
Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013 Oct 3;502(7469):105-9. Epub 2013 Sep 1.
Boulaftali Y, Hess PR, Getz TM, Cholka A, Stolla M, Mackman N, Owens AP 3rd, Ware J, Kahn ML, Bergmeier W. Platelet ITAM signaling is critical for vascular integrity in inflammation. J Clin Invest. 2013 Jan 25.
Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. 2012 Aug 24;37(2):276-89
Zlotoff DA, Zhang SL, De Obaldia ME, Hess PR, Todd SP, Logan TD, Bhandoola A. Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation. Blood. 2011 Jun 9
Bertozzi CC, Schmaier AA, Mericko P, Hess PR, Zou Z, Chen M, Chen C, Xu B, Lu M, Zhou D, Sebzda E, Santore MT, Merianos DJ, Stadtfeld M, Flake AW, Graf T, Skoda R, Maltzman JS, Koretzky GA, Kahn ML. Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood. 2010 Jul 29;116(4):661-70.
Signarvic RS, Cierniewska A, Stalker TJ, Fong KP, Chatterjee MS, Hess PR, Ma P, Diamond SL, Neubig RR, Brass LF. RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury. Blood. 2010 Dec 23;116(26):6092-100.
Bertozzi CC, Hess PR, Kahn ML. Platelets: covert regulators of lymphatic development. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2368-71.
Kassim SH, Li H, Vandenberghe LH, Hinderer C, Bell P, Marchadier D, Wilson A, Cromley D, Redon V, Yu H, Wilson JM, Rader DJ. Gene Therapy in a Humanized Mouse Model of Familial Hypercholesterolemia Leads to Marked Regression of Atherosclerosis. PLoS One. 2010 Oct 19;5(10):e13424.
Mace EM, Wu WW, Ho T, Mann SS, Hsu HT, Orange JS. NK cell lytic granules are highly motile at the immunological synapse and require f-actin for post-degranulation persistence. J Immunol. 2012 Nov 15;189(10):4870-80
Moscato EH, Jain A, Peng X, Hughes EG, Dalmau J, Balice-Gordon RJ. Mechanisms underlying autoimmune synaptic encephalitis leading to disorders of memory, behavior and cognition: insights from molecular, cellular and synaptic studies. (2010) Eur J Neurosci 32(2):298-309
Kumar MA, Jain A, Dechant VE, Saito T, Rafael T, Aizawa H, Dysart KC, Katayama T, Ito Y, Araki N, Abe T, Balice-Gordon R, Dalmau J. Anti-N-methyl-D-aspartate receptor encephalitis during pregnancy. Arch Neurol 2010 67(7):884-7.
Dreses-Werringloer U, Lambert JC, Vingtdeux V, Zhao H, Vais H, Siebert A, Jain A, Koppel J, Rovelet-Lecrux A, Hannequin D, Pasquier F, Galimberti D, Scarpini E, Mann D, Lendon C, Campion D, Amouyel P, Davies P, Foskett JK, Campagne F, Marambaud P. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. Cell 2008 133(7):1149-61.
Jamiolkowski RM, Guo LY, Li YR, Shaffer SM, Naji A. Islet transplantation in type I diabetes mellitus. Yale J Biol Med. 2012 Mar;85(1):37-43.
Riese MJ, Wang L-CS, Moon EK, Joshi RP, Ranganathan A, June CH, et al. Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases. Cancer Res. 2013 Apr 10.
Joshi RP, Koretzky GA. Diacylglycerol kinases: regulated controllers of T cell activation, function, and development. Int J Mol Sci. 2013;14(4):6649–73. Review.
Juntilla MM, Patil VD, Calamito M, Joshi RP, Birnbaum MJ, Koretzky GA. AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. Blood. 2010 May 20;115(20):4030-8.
Kadauke S, Picarelli A, Di Tola M, Parikh RK, Naylor P, Zhou WL, Bowman J, Bullock D, Tobi M. Letter: Adnab-9 as a potential non-invasive biomarker for prediction of malignancy in coeliac disease. Aliment Pharmacol Ther. 2013 Apr;37(7):761-2
Kadauke S, Blobel GA. Mitotic bookmarking by transcription factors. Epigenetics Chromatin. 2013 Apr 2;6(1):6
Kadauke S, Blobel GA. "Remembering" tissue-specific transcription patterns through mitosis. Cell Cycle. 2012 Nov 1;11(21):3911-2.
Kadauke S, Udugama MI, Pawlicki JM, Achtman JC, Jain DP, Cheng Y, Hardison RC, Blobel GA. Tissue-specific mitotic bookmarking by hematopoietic transcription factor GATA1. Cell. 2012 Aug 17;150(4):725-37.
Lamonica JM, Deng W, Kadauke S, Campbell AE, Gamsjaeger R, Wang H, Cheng Y, Billin AN, Hardison RC, Mackay JP, Blobel GA. Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes. Proc Natl Acad Sci U S A. 2011 May 31;108(22):E159-68.
Kadauke S and Blobel GA. Chromatin loops in gene regulation. Biochim Biophys Acta. 2009 1789 (1):17-25
Blobel GA, Kadauke S, Wang E, Lau AW, Zuber J, Chou MM, Vakoc CR. A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit. Mol Cell. 2009 Dec 25;36(6):970-83.
Idema T, Dubuis JO, Kang L, Manning ML, Nelson PC, Lubensky TC, Liu AJ. The syncytial Drosophila embryo as a mechanically excitable medium. PLoS ONE. (In press).
Sawamukai N, Satake A, Schmidt AM, Lamborn IT, Ojha P, Tanaka Y, Kambayashi T. Cell-autonomous role of TGFβ and IL-2 receptors in CD4+ and CD8+ inducible regulatory T-cell generation during GVHD. Blood. 2012 Jun 7;119(23):5575-83.
Lazarus JE, Moughamian AJ, Tokito M, Holzbaur EL. Dynactin subunit p150Glued is a neuron-specific anti-catastrophe factor. In press at PLoS Biology.
Moughamian AJ, Osborn G, Lazarus JE, Holzbaur EL. End-binding proteins recruit dynactin to the microtubule plus-end through CLIP-170 for efficient transport initiation. In press at J Neurosci.
Zhang J, Twelvetrees AE, Lazarus JE, Blasier KR, Yao X, Inamda NA, Holzbaur EL, Pfister K, Xiang X. Establishing a novel transgenic mouse line for studying neuronal cytoplasmic dynein under normal and pathogenic conditions. Cytoskeleton. 2013 Apr;70(4):215-27.
Hendricks AG*, Lazarus JE*, Perlson, E, Gardner M, Odde D, Tokito M, Goldman YE, Holzbaur EL. Dynein tethers and stabilizes dynamic microtubule plus ends. Current Biology. 2012 Apr 10;22 (7): 632-7. * Denotes equal contribution.
Hendricks AG, Lazarus JE, Holzbaur EL. Dynein at odd angles? Nat Cell Biol. 2010 Dec;12(12):1126-8.
Dixit R, Barnett B, Lazarus JE, Tokito M, Goldman YE, Holzbaur EL. Microtubule plus-end tracking by CLIP-170 requires EB1. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):492-7.
Vaites LP, Lee EK, Lian Z, Barbash O, Roy D, Wasik M, Klein-Szanto AJ, Rustgi AK, Diehl JA. The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation. Mol Cell Biol. 2011 Nov;31(22):4513-23.
Barbash O, Lee EK, Diehl JA. Phosphorylation-dependent regulation of SCFFbx4dimerization and activity involves a novel component, 14-3-3ε. Oncogene. 2011 Apr 28;30(17):1995-2002.
Lee EK, Diehl JA. Breast cancer go sMAD: Cyclin towards aggressive phenotypes. Cell Cycle.2011 Jan 15;10(2):187.
Nabel CS, Lee JW, Wang LC, Kohli RM. Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase. Proc Natl Acad Sci USA. 2013 Aug 27; 110(35): 14225-30.
Li ML, Greenberg RA. Links between genome integrity and BRCA1 tumor suppression. (Review paper) Trends Biochem Sci. 2012 Oct; 37(10):418-24. PMCID:PMC3459146
Hadziahmetovic M, Kumar U, Song Y, Grieco S, Song D, Li Y, Tobias JW, Dunaief JL. Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE. Invest Ophthalmol Vis Sci. 2012 Aug 7;53(9):5231-41.
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