publications of current students

Plentz R, Park JS, Rhim AD, Abravanel D, Hezel AF, Sharma SV, Gurumurthy S, Deshpande V, Kenific C, Settleman J, Majumder PK, Stanger BZ, Bardeesy N. Inhibition of y-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology. 2009 May;136(5):1741-9.e6.

Caravaca JM, Donahue G, Becker JS, He X, Vinson C, Zaret KS. Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes. Genes & Development. 2013 Jan;27(3):251-60.

Li P, McElligott S, Bergquist H, Schwartz JS, Doshi JA. Effect of the Medicare Part D coverage gap on medication use among patients with hypertension and hyperlipidemia. Ann Intern M. 2012, Jun 5;156(11):776-84

Puig A, McElligott S, Bergquist H, Doshi JA. Albuterol and levalbuterol use and spending in Medicare beneficiaries with chronic obstructive pulmonary disease. American Journal of Geriatric Pharmacotherapy. 8(6):571-582; 2010.

Epidemiology: General Principles and Practical Research Guidelines. Edited by Van den Broeck J and Brestoff JR, A forthcoming textbook to be published by Springer. Approx. 600 pages with 100 illustrations.

Brestoff JR, Van den Broeck J, Book Review: Epidemiological Research Terms and Concepts. Int J of Epidemiol, 2012. In press.

Van den Broeck J, Brestoff JR, Book Review: Up from Clinical Epidemiology and EBM (Evidence Based Medicine). Eur J Epidemiol, 2012. In press.

Brestoff JR and Van den Broeck J. Global Health and Nutrition. In: Encyclopedia of Global Studies. Ed. Jeurgensmeyer M and Anheier HK. Thousand Oaks: SAGE Reference, 2012. ISBN 9781412964296

Brestoff JR, Perry IJ, Van den Broeck J. Challenging the role of social norms regarding body weight as an explanation for weight and BMI misreporting bias: Development and application of a new approach to examining misreporting bias in surveys. BMC Public Health 11:331, 2011.

Brown SES, Ratcliffe SJ, Kahn JM, Halpern SD.  The Epidemiology of Intensive Care Unit Readmissions in the United States.  Am J Respir Crit Care Med. 2012 Jan 26.

Young M, Brown SES, Truog R, Halpern SD.  Rationing ICU Beds: Disclose or Disguise? Crit Care Med. 2011 Sep 15

Burke JF, Long NM, Zaghloul KA, Sharan AD, Sperling MR, Kahana MJ. Human intracranial high-frequency activity maps episodic memory formation in space and time. Neuroimage. 2013 Jul 1. pii: S1053-8119(13)00705-2.

Burke JF, Zaghloul KA, Jacobs J, Williams RB, Sperling MR, Sharan AD, and Kahana, MJ. Synchronous and asynchronous theta and gamma activity during episodic memory formation. The Journal of Neuroscience. 2013. 33(1), 292–304. doi:10.1523/JNEUROSCI.2057-12.2013

Busch JI, Martinez-Lage M, Ashbridge E, Grossman M, Van Deerlin VM, Hu F, Lee VMY, Trojanowski JQ, Chen-Plotkin AS. Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain. Acta Neuropathologica Communications. 2013 July 11; 1:36.

Busch JI, Martinez-Lage M, Ashbridge E, Grossman M, Van Deerlin V, Hu F, Lee VM, Trojanowski JQ, and Chen-Plotkin AS. "Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain." Acta Neuropathologica Communications 2013 Jul 11, 1:36doi:10.1186/2051-5960-1-36.

Chen-Plotkin AS, Unger TL, Gallagher MD, Bill E, Kwong LK, Volpicelli-Daley L, Busch JI, Akle S, Grossman M, Van Deerlin V, Trojanowski JQ, Lee VM. "TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways."J Neurosci. 2012 Aug 15;32(33):11213-27.

Kandalaft LE, Motz GT, Busch J, Coukos G. Angiogenesis and the Tumor Vasculature as Antitumor Immune Modulators: The Role of Vascular Endothelial Growth Factor and Endothelin.  Curr Top Microbiol Immunol. 2011;344:129-48.

Butt OH, Benson NC, Datta R, Aguirre GK. The fine-scale functional correlation of striate cortex in sighted and blind people. J Neurosci. 2013 Oct 9;33(41):16209-19. doi: 10.1523/JNEUROSCI.0363-13.2013.

Benson NC, Butt OH, Datta R, Radoeva PD, Brainard DH, Aguirre GK. The retinotopic organization of striate cortex is well predicted by surface topology. Curr Biol. 2012 Nov 6;22(21):2081-5. doi: 10.1016/j.cub.2012.09.014.

Charlson ES, and Bittinger K, Chen J, Diamond J, Li H, Collman RG and Bushman FD. Assessing bacterial populations in the lung by replicate analysis of samples from the upper and lower respiratory tracts. PLoS One. 2012;7(9):e42786.

Charlson ES, Diamond J, Bittinger K, Fitzgerald AS, Yadav A, Haas A, Bushman FD and Collman RG. Lung-enriched organisms and aberrant bacterial and fungal respiratory microbiota following lung transplant. Am J Respir Crit Care Med. 2012 Sep 15;186(6):536-45.

Chen J, Bittinger K, Charlson ES, Hoffmann C, Lewis J, Wu GD, Collman RG, Bushman FD, Li H.  Associating microbiome composition with environmental covariates using generalized UniFrac distances. Bioinformatics. 2012 Aug 15;28(16):2106-13.

Knights D, Kuczynski J, Charlson ES, Zaneveld J, Mozer MC, Collman RG, Bushman FD, Knight R, Kelley ST. Bayesian community-wide culture-independent microbial source tracking. Nature Methods. 2011 Jul 17;8(9):761-3.

Charlson ES, Bittinger K, Haas AR, Fitzgerald AS, Frank I, Yadav A, Bushman FD, Collman RG. Topographical Continuity of Bacterial Populations in the Healthy Human Respiratory Tract. Am J Respir Crit Care Med. 2011 Jun 23.

Yilmaz P, Kottmann R, Field D, Knight R, Cole JR, Amaral-Zettler L, Gilbert JA, Karsch-Mizrachi I, Johnston A, Cochrane G, Vaughan R, Hunter C, Park J, Morrison N, Rocca-Serra P, Sterk P, Arumugam M, Bailey M, Baumgartner L, Birren BW, Blaser MJ, Bonazzi V, Booth T, Bork P, Bushman FD, Buttigieg PL, Chain PS, Charlson ES, Costello EK, Huot-Creasy H, Dawyndt P, DeSantis T, Fierer N, Fuhrman JA, Gallery RE, Gevers D, Gibbs RA, San Gil I, Gonzalez A, Gordon JI, Guralnick R, Hankeln W, Highlander S, Hugenholtz P, Jansson J, Kau AL, Kelley ST, Kennedy J, Knights D, Koren O, Kuczynski J, Kyrpides N, Larsen R, Lauber CL, Legg T, Ley RE, Lozupone CA, Ludwig W, Lyons D, Maguire E, Methé BA, Meyer F, Muegge B, Nakielny S, Nelson KE, Nemergut D, Neufeld JD, Newbold LK, Oliver AE, Pace NR, Palanisamy G, Peplies J, Petrosino J, Proctor L, Pruesse E, Quast C, Raes J, Ratnasingham S, Ravel J, Relman DA, Assunta-Sansone S, Schloss PD, Schriml L, Sinha R, Smith MI, Sodergren E, Spo A, Stombaugh J, Tiedje JM, Ward DV, Weinstock GM, Wendel D, White O, Whiteley A, Wilke A, Wortman JR, Yatsunenko T, Glöckner FO. Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications. Nat Biotechnol. 2011 May;29(5):415-20.

Charlson ES, Chen J, Custers-Allen R, Bittinger K, Li H, Sinha R, Hwang J, Bushman FD, Collman RG. Disordered microbial communities in the upper respiratory tract of cigarette smokers. PLoS One. 2010 Dec 20;5(12 ):e15216.

Bortnick A, Chernova I, Quinn WJ 3rd, Mugnier M, Cancro MP, Allman D. Long-lived plasma cells are induced early in response to T-cell independent and T-cell dependent antigens, J Immunol. 2012 Jun 1;188(11):5389-96

Tang J, Cho NW, Cui G, Manion EM, Shanbhag NM, Botuyan MV, Mer G, and Greenberg RA. Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat Struct Mol Biol. 2013 Feb 3.  

Barnett BE, Ciocca ML, Goenka R, Barnett LG, Wu J, Laufer TM, Burkhardt JK, Cancro MP, Reiner SL. Asymmetric B cell division in the germinal center reaction. Science. 2012 Jan 20;335(6066):342-4

Ciocca ML, Barnett BE, Burkhardt JK, Chang JT, Reiner SL. Cutting edge: Asymmetric memory T cell division in response to re-challenge. J Immunol. 2012 May 1;188(9):4145-8

Chang JT, Ciocca ML, Kinjyo I, Palanivel VR, McClurkin CE, Dejong CS, Mooney EC, Kim JS, Steinel NC, Oliaro J, Yin CC, Florea BI, Overkleeft HS, Berg LJ, Russell SM, Koretzky GA, Jordan MS, Reiner SL. Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity. 2011 Apr 22;34(4):492-504.

Hara T, Koh K, Combs DJ, Sehgal A. Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in  new timeless mutant. J Neurosci, 2011 31(27): 9982-90.

Daye D, Keller B, Conant EF, Chen J, Schnall MD, Maidment AD, Kontos D. Mammographic parenchymal patterns as an imaging marker of endogenous hormonal exposure: a preliminary study in a high-risk population. Acad Radiol. 2013 May;20(5):635-46. doi: 10.1016/j.acra.2012.12.016.

Li LZ, Kadlececk S, Xu HN, Daye D, Pullinger B, Profka H, Chodosh L, Rizi R.. Ratiometric analysis in hyperpolarized NMR (I): test of the two-site exchange model and the quantification of reaction rate constants.NMR Biomed. 2013 Apr 29. doi: 10.1002/nbm.2953.

Ashraf A, Gavenonis S, Daye D, Mies C, Rosen M, Kontos D.  A Multichannel Markov Random Field Framework for Tumor Segmentation with an Application to Classification of Gene Expression-based Breast Cancer Recurrence Risk. IEEE Trans Med Imaging. 2013 Apr;32(4):637-48. doi: 10.1109/TMI.2012.2219589.

Daye D, Wellen KE. Metabolic Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis. Semin Cell Dev Biol. 2012 Jun;23(4):362-9

Ashraf AB, Gavenonis S, Daye D, Mies C, Feldman M, Rosen M, Kontos D. A multichannel Markov random field approach for automated segmentation of breast cancer tumor in DCE-MRI data using kinetic observation model. Med Image Comput Comput Assist Interv. 2011;14(Pt 3):546-53.

Didigu CA, Wilen CB, Wang J, Duong J, Secreto AJ, Danet-Desnoyers GA, Riley JL, Gregory PD, June CH, Holmes MC, Doms RW. Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection. Blood first edition, Oct 25, 2013.

Singer EM, Shin DB, Nattkemper LA, Benoit BM, Klein RS, Didigu CA, Loren AW, Dentchev T, Wysocka M, Yosipovitch G, Rook AH. Interleukin-31 Is Produced by the Malignant T-Cell Population in Cutaneous T-Cell Lymphoma and Correlates with CTCL Pruritus. J. Invest. Dermatol. 2013 May 22.

Wojcechowskyj JA, Didigu CA, Lee JY, Parrish NF, Sinha R, Hahn BH, Bushman FD, Jensen ST, Seeholzer SH, Doms RW. Quantitative Phosphoproteomics Reveals Extensive Cellular Reprogramming during HIV-1 Entry. Cell Host Microbe. 2013 May 15;13(5):613–23. NIHMS ID: NIHMS473947

Parker ZF, Iyer SS, Wilen CB, Parrish NF, Chikere KC, Lee F-H, Didigu CA, Berro R, Klasse PJ, Lee B, Moore JP, Shaw GM, Hahn BH, Doms RW. Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5. Journal of Virology. 2013 Mar;87(5):2401–11.

Richardson MW, Jadlowsky J, Didigu CA, Doms RW, Riley JL. Kruppel-like Factor 2 Modulates CCR5 Expression and Susceptibility to HIV-1 Infection. J Immunol. 2012 Oct 15;189(8):3815–21.

Zheng X, Xu C, Smith AO, Stratman AN, Zou Z, Kleaveland B, Yuan L, Didigu C, Sen A, Liu X, Skuli N, Zaslavsky A, Chen M, Cheng L, Davis GE, Kahn ML. Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth. Dev. Cell. 2012 Aug 14;23(2):342–55.

Tilton JC, Wilen CB, Didigu CA, Sinha R, Harrison JE, Agrawal-Gamse C, Henning EA, Bushman FD, Martin JN, Deeks SG, Doms RW. A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5. J Virol. 2010 Oct;84(20):10863-76

Zachary Gerhart-Hines, Dan Feng*, Matthew J. Emmett*, Logan J. Everett, Emanuele Loro, Erika R. Briggs, Anne Bugge, Catherine Hou, Christine Ferrara, Patrick Seale, Daniel A. Pryma, Tejvir S. Khurana & Mitchell A. Lazar. The nuclear receptor Rev-erba controls circadian thermogenic plasticity. 2013 Oct 27. doi: 10.1038/nature12642. 

Hunter CS, Dixit S, Cohen T, Ediger B, Wilcox C, Ferreira M, Westphal H, Stein R, May CL. Islet a-, b-, and d-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor. Diabetes. 2013 March; 62(3): 875-886.

Li RC, Finkelman BS, Chen J, Booth SL, Bershaw L, Brensinger CM, Kimmel SE. Dietary Vitamin K Intake and Therapeutic Anticoagulation Control During the Initiation Phase of Warfarin Therapy: A Prospective Cohort Study. J Thromb Haemost. 2013 Mar; 110(1):195-6.

Finkelman BS, Rubinstein WS, Friedman S, Friebel TM, Rebbeck TR, et al, for the PROSE Consortium. Breast and Ovarian Cancer Risk and Risk Reduction in Jewish BRCA1/2 Mutation Carriers. J Clin Oncol. 2012 Apr; 30(12): 1321-28.

Finkelman BS, Gage BF, Johnson JA, Brensinger CM, Kimmel SE. Genetic Warfarin Dosing: Tables vs. Algorithms. J Am Coll Cardiol. 2011 Feb 1;57(5):612-8.

Zhang Z, Kofonow JM, Finkelman BS, Doghramji L, Chiu AG, Kennedy DW, Cohen NA, Palmer JN. Clinical factors associated with bacterial biofilm formation in chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2011 Mar;144(3):457-62.

Zhang Z, Linkin DR, Finkelman BS, O'Malley BW Jr, Thaler ER, Doghramji L, Kennedy DW, Cohen NA, Palmer JN. Asthma and biofilm-forming bacteria are independently associated with revision sinus surgeries for chronic rhinosinusitis. J Allergy Clin Immunol. 2011 Jul;128(1):221-223.e1.

Schelleman H, Brensinger CM, Chen J, Finkelman BS, Rieder MJ, Kimmel SE. (2010) New genetic variant that might improve warfarin dose prediction in African Americans. Br J Clin Pharmacol. 2010 Sep;70(3):393-9.

Friedman AB. Effects of Medicaid on Clinical Outcomes. N Engl J Med. 2013; Aug 8;369(6):582.

Van den Broeck J, Brestoff JR, Friedman AB, Becker N, Hoaglin MC, Robberstad B. The Measurement Plan. In: Epidemiology: Van den Broeck J, Brestoff JR, eds. Principles and Practical Guidelines. 1st ed. New York, NY: Springer;2013: 197-240.

Friedman AB, Mendola TS. To Cover Their Child, One Couple Navigates A Health Insurance Maze In Pennsylvania. Health Aff May 2013 vol. 32 no. 5 994-997.

Friedman AB, Becker N.  Understanding the Individual Mandate's SCOTUS Pivot Points.  LDI Health Economist. April 2012.

Ezzati M, Horwitz ME, Thomas DS, Friedman AB, Roach R, Clark T, Murray CJ, Honigman B. Altitude, life expectancy and mortality from ischaemic heart disease, stroke, COPD and cancers: national population-based analysis of US counties. J Epidemiol Community Health. 2012 Jul;66(7):e17. doi: 10.1136/jech.2010.112938

Dionisio KL, Rooney MS, Arku RE, Friedman AB, Hughes AF, Vallarino J,  Agyei-Mensah S, Spengler JD, Ezzati M. Within-neighborhood patterns and sources of particle pollution: mobile monitoring and geographic information system analysis in four communities in Accra, Ghana. Environmental Health Perspectives 2010. 118(5):607-13.

Kim, H.J., N.C.Kim, Y.D. Wang, E.A. Scarborough, J. Moore, Z. Diaz, K.S. MacLea, B. Freibaum, S. Li, A. Molliex, A.P. Kanagaraj, R. Carter, K.B. Boylan, A.M. Wojtas, R. Rademakers, J.L. Pinkus, S.A. Greenberg, J.Q. Trojanowski, B.J. Traynor, B.N. Smith, S. Topp, A.S. Gkazi, J. Miller, C.E. Shaw, M. Kottlors, J. Kirschner, A. Pestronk, Y.R. Li, A.F. Ford, A.D. Gitler, M. Benatar, O.D. King, V.E. Kimonis, E.D. Ross, C.C. Weihl, J. Shorter, and J.P. Taylor. Mutations in prion-like domains in hnRNPs cause multisystem proteinopathy and ALS. Nature. 2013 March 28; 495:467-473. 

Gill, A., Kolson, D. Dimethyl fumarate modulation of immune and antioxidant responses: application to HIV therapy (Review Paper). Crit Rev Immunol. 2013 33(4);307-359. 

Levesque M.J., Ginart P., Wei Y., Raj A., Visualizing SNVs to quantify allele-apecific expression in single cells. Nat Methods. 2013 Sep; 10(9): 865-7. PMCID: PMC3771873

Jamiolkowski RM, Guo LY, Li YR, Shaffer SM, Naji A. Islet transplantation in type I diabetes mellitus.  Yale J Biol Med. 2012 Mar; 85(1):37-43.

Singh N*, Gupta M*, Trivedi CM, Singh MK, Li L, Epstein JA. Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. Developmental Biol. 2013 May;377(2):333–44.

Shen CJ, Raghavan S, Xu Z, Baranski JD, Yu X, Wozniak MA, Miller JS, Gupta M, Buckbinder L, Chen CS. Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner. Exp Cell Res. 2011 Aug 1;317(13):1860-71.

Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, Zhang Y, Yang W, Gruber PJ, Epstein JA, Morrisey EE. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell. 2011 Apr 8;8(4):376-88.

Hergott CB, Mitra M, Guo J, Wu T, Miller JT, Iwatani Y, Gorelick RJ, Levin JG. Zinc finger function of HIV-1 nucleocapsid protein is required for removal of 5'-terminal genomic RNA fragments: a paradigm for RNA removal reactions in HIV-1 reverse transcription. Virus Res. 2013 Feb;171(2):346-55. 

Boulaftali Y, Hess PR, Kahn ML, Bergmeier W. Platelet Immunoreceptor Tyrosine-Based Activation Motif Signaling and Vascular Integrity. Circ Res. 2014 Mar 28;114(7):1174-84.

Hess PR, Rawnsley DR, Jakus Z, Yang Y, Sweet DT, Fu J, Herzog B, Lu M, Nieswandt B, Oliver G, Makinen T, Xia L, Kahn ML. Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life. J Clin Invest. 2014 Jan 2;124(1):273-84.

Wannemacher KM, Jiang H, Hess PR, Shin Y, Suzuki-Inoue K, Brass LF. An expanded role for semaphorin 4D in platelets includes contact-dependent amplification of Clec-2 signaling. J Thromb Haemost. 2013 Dec;11(12):2190-3.

Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013 Oct 3;502(7469):105-9. Epub 2013 Sep 1.

Boulaftali Y, Hess PR, Getz TM, Cholka A, Stolla M, Mackman N, Owens AP 3rd, Ware J, Kahn ML, Bergmeier W. Platelet ITAM signaling is critical for vascular integrity in inflammation. J Clin Invest. 2013 Jan 25.

Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. 2012 Aug 24;37(2):276-89

Zlotoff DA, Zhang SL, De Obaldia ME, Hess PR, Todd SP, Logan TD, Bhandoola A. Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation. Blood. 2011 Jun 9

Bertozzi CC, Schmaier AA, Mericko P, Hess PR,  Zou Z, Chen M, Chen C, Xu B, Lu M, Zhou D, Sebzda E, Santore MT, Merianos DJ, Stadtfeld M, Flake AW, Graf T, Skoda R, Maltzman JS, Koretzky GA, Kahn ML. Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood. 2010 Jul 29;116(4):661-70.

Signarvic RS, Cierniewska A, Stalker TJ, Fong KP, Chatterjee MS, Hess PR, Ma P, Diamond SL, Neubig RR, Brass LF. RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury. Blood. 2010 Dec 23;116(26):6092-100.

Bertozzi CC, Hess PR, Kahn ML. Platelets: covert regulators of lymphatic development. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2368-71.

Kassim SH, Li H, Vandenberghe LH, Hinderer C, Bell P, Marchadier D, Wilson A, Cromley D, Redon V, Yu H, Wilson JM, Rader DJ. Gene Therapy in a Humanized Mouse Model of Familial Hypercholesterolemia Leads to Marked Regression of Atherosclerosis.  PLoS One. 2010 Oct 19;5(10):e13424. 

Mace EM, Wu WW, Ho T, Mann SS, Hsu HT, Orange JS. NK cell lytic granules are highly motile at the immunological synapse and require f-actin for post-degranulation persistence. J Immunol. 2012 Nov 15;189(10):4870-80

Moscato EH, Jain A, Peng X, Hughes EG, Dalmau J, Balice-Gordon RJ. Mechanisms underlying autoimmune synaptic encephalitis leading to disorders of memory, behavior and cognition: insights from molecular, cellular and synaptic studies. (2010) Eur J Neurosci 32(2):298-309

Kumar MA, Jain A, Dechant VE, Saito T, Rafael T, Aizawa H, Dysart KC, Katayama T, Ito Y, Araki N, Abe T, Balice-Gordon R, Dalmau J. Anti-N-methyl-D-aspartate receptor encephalitis during pregnancy. Arch Neurol 2010 67(7):884-7.

Dreses-Werringloer U, Lambert JC, Vingtdeux V, Zhao H, Vais H, Siebert A, Jain A, Koppel J, Rovelet-Lecrux A, Hannequin D, Pasquier F, Galimberti D, Scarpini E, Mann D, Lendon C, Campion D, Amouyel P, Davies P, Foskett JK, Campagne F, Marambaud P. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. Cell 2008 133(7):1149-61.

Jamiolkowski RM, Guo LY,  Li YR, Shaffer SM, Naji A. Islet transplantation in type I diabetes mellitus. Yale J Biol Med. 2012 Mar;85(1):37-43.

Riese MJ, Wang L-CS, Moon EK, Joshi RP, Ranganathan A, June CH, et al. Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases. Cancer Res. 2013 Apr 10.

Joshi RP, Koretzky GA. Diacylglycerol kinases: regulated controllers of T cell activation, function, and development. Int J Mol Sci. 2013;14(4):6649–73. Review.

Juntilla MM, Patil VD, Calamito M, Joshi RP, Birnbaum MJ, Koretzky GA.  AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. Blood. 2010 May 20;115(20):4030-8.

Kadauke S, Picarelli A, Di Tola M, Parikh RK, Naylor P, Zhou WL, Bowman J, Bullock D, Tobi M. Letter: Adnab-9 as a potential non-invasive biomarker for prediction of malignancy in coeliac disease. Aliment Pharmacol Ther. 2013 Apr;37(7):761-2

Kadauke S, Blobel GA. Mitotic bookmarking by transcription factors. Epigenetics Chromatin. 2013 Apr 2;6(1):6

Kadauke S, Blobel GA. "Remembering" tissue-specific transcription patterns through mitosis. Cell Cycle. 2012 Nov 1;11(21):3911-2.

Kadauke S, Udugama MI, Pawlicki JM, Achtman JC, Jain DP, Cheng Y, Hardison RC, Blobel GA. Tissue-specific mitotic bookmarking by hematopoietic transcription factor GATA1. Cell. 2012 Aug 17;150(4):725-37.

Lamonica JM, Deng W, Kadauke S, Campbell AE, Gamsjaeger R, Wang H, Cheng Y, Billin AN, Hardison RC, Mackay JP, Blobel GA. Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes. Proc Natl Acad Sci U S A. 2011 May 31;108(22):E159-68.

Kadauke S and Blobel GA. Chromatin loops in gene regulation. Biochim Biophys Acta. 2009 1789 (1):17-25

Blobel GA, Kadauke S, Wang E, Lau AW, Zuber J, Chou MM, Vakoc CR. A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit. Mol Cell. 2009 Dec 25;36(6):970-83.

Idema T, Dubuis JO, Kang L, Manning ML, Nelson PC, Lubensky TC, Liu AJ. The syncytial Drosophila embryo as a mechanically excitable medium. PLoS ONE. (In press).

Sawamukai N, Satake A, Schmidt AM, Lamborn IT, Ojha P, Tanaka Y, Kambayashi T. Cell-autonomous role of TGFβ and IL-2 receptors in CD4+ and CD8+ inducible regulatory T-cell generation during GVHD.  Blood. 2012 Jun 7;119(23):5575-83.

Lazarus JE, Moughamian AJ, Tokito M, Holzbaur EL. Dynactin subunit p150Glued is a neuron-specific anti-catastrophe factor. In press at PLoS Biology.

Moughamian AJ, Osborn G, Lazarus JE, Holzbaur EL. End-binding proteins recruit dynactin to the microtubule plus-end through CLIP-170 for efficient transport initiation. In press at J Neurosci.

Zhang J, Twelvetrees AE, Lazarus JE, Blasier KR, Yao X, Inamda NA, Holzbaur EL, Pfister K, Xiang X. Establishing a novel transgenic mouse line for studying neuronal cytoplasmic dynein under normal and pathogenic conditions. Cytoskeleton. 2013 Apr;70(4):215-27.

Hendricks AG*, Lazarus JE*, Perlson, E, Gardner M, Odde D, Tokito M, Goldman YE, Holzbaur EL. Dynein tethers and stabilizes dynamic microtubule plus ends. Current Biology. 2012 Apr 10;22 (7): 632-7. * Denotes equal contribution.

Hendricks AG, Lazarus JE, Holzbaur EL. Dynein at odd angles? Nat Cell Biol. 2010 Dec;12(12):1126-8.

Dixit R, Barnett B, Lazarus JE, Tokito M, Goldman YE, Holzbaur EL. Microtubule plus-end tracking by CLIP-170 requires EB1. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):492-7.

Vaites LP, Lee EK, Lian Z, Barbash O, Roy D, Wasik M, Klein-Szanto AJ, Rustgi AK, Diehl JA. The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation. Mol Cell Biol. 2011 Nov;31(22):4513-23. 

Barbash O, Lee EK, Diehl JA. Phosphorylation-dependent regulation of SCFFbx4dimerization and activity involves a novel component, 14-3-3ε. Oncogene. 2011 Apr 28;30(17):1995-2002.

Lee EK, Diehl JA. Breast cancer go sMAD: Cyclin towards aggressive phenotypes. Cell Cycle.2011 Jan 15;10(2):187. 

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Schaller T, Ocwieja KE, Rasaiyaah J, Price AJ, Brady TL, Roth SL, Hué S, Fletcher AJ, Lee K, Kewalramani VN, Noursadeghi M, Jenner RG, James LC, Bushman FD, Towers GJ. HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency. PLoS Pathog. 2011 7(12): e1002439.

Gijsbers R, Vets S, De Rijck J, Ocwieja KE, Ronen K, Malani N, Bushman FD, Debyser Z. Role of the PWWP domain of lens epithelium-derived growth factor(LEDGF/p75) in lentiviral integration targeting. J Biol Chem. 2011 286(48): 41812-25.

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Abt MC, Osborne LC, Monticelli LA, Doering TA, Alenghat T, Sonnenberg GF, Paley MA, Antenus M, Williams KL, Erikson J, Wherry EJ, Artis D.Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity. 2012 Jul 27;37(1):158-70

Kao C, Oestreich KJ, Paley MA, Crawford A, Angelosanto JM, Ali MA, Intlekofer AM, Boss JM, Reiner SL, Weinmann AS, Wherry EJ. Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nat Immunol. 2011 May 29;12(7):663-71.

Banerjee A, Gordon SM, Intlekofer AM, Paley MA, Mooney EC, Lindsten T, Wherry EJ, Reiner SL. Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche. J Immunol. 2010 Nov 1;185(9):4988-92. 

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Tsai V, Parker WE, Orlova KA, Baybis M, Chi AW, Berg BD, Birnbaum JF, Estevez J, Okochi K, Sarnat HB, Flores-Sarnat L, Aronica E, Crino PB. Fetal Brain mTOR Signaling Activation in Tuberous Sclerosis Complex. Cereb Cortex. 2012 Oct 18.

Hardesty DA, Sanborn MR, Parker WE, Storm PB. Perioperative seizure incidence and risk factors in 223 pediatric brain tumor patients without prior seizures. J Neurosurg Pediatr. 2011 Jun;7(6):609-15.

Parker WE, Orlova KA, Heuer GG, Baybis M, Aronica E, Frost M, Wong M, Crino PB.Enhanced epidermal growth factor, hepatocyte growth factor, and vascular endothelial growth factor expression in tuberous sclerosis complex. Am J Pathol. 2011 Jan;178(1):296-305.

Orlova KA, Parker WE, Heuer GG, Tsai V, Yoon J, Baybis M, Fenning RS, Strauss K, Crino PB. STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice. J Clin Invest. 2010 May;120(5):1591-602.

Parker ZF, Iyer SS, Wilen CB, Parrish NF, Chikere KC, Lee FH, Didigu CA, Berro R, Klasse PJ, Lee B, Moore JP, Shaw GM, Hahn BH, Doms RW. Transmitted/Founder and Chronic HIV-1 Envelope Proteins Are Distinguished by Differential Utilization of CCR5. J Virol. 2013 Mar;87(5):2401-11. 

Pandrea I, Parrish NF, Raehtz K, Gaufin T, Barbian HJ, Ma D, Kristoff J, Gautam R, Zhong F, Haret-Richter GS, Trichel A, Shaw GM, Hahn BH, Apetrei C. Mucosal simian immunodeficiency virus transmission in African green monkeys: susceptibility to infection is proportional to target cell availability at mucosal sites. J Virol. 2012 Apr;86(8):4158-68.

Parrish NF, Wilen CB, Banks LB, Iyer SS, Pfaff JM, Salazar-Gonzalez JF, Salazar MG, Decker JM, Parrish EH, Berg A, Hopper J, Hora B, Kumar A, Mahlokozera T, Yuan S, Coleman C, Vermeulen M, Ding H, Ochsenbauer C, Tilton JC, Permar SR, Kappes JC, Betts MR, Busch MP, Gao F, Montefiori D, Haynes BF, Shaw GM, Hahn BH, Doms RW. Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7. PLoS Pathog. 2012;8(5):e1002686. 

Choo AM, Geddes-Klein DM, Hockenberry A, Scarsella D, Mesfin MN, Singh P, Patel TP, Meaney DF.  NR2A and NR2B subunits differentially mediate MAP kinase signaling and mitochondrial morphology following excitotoxic insult. Neurochem Int. 2012 Apr;60(5):506-16.

Singh P, Doshi S, Spaethling JM, Hockenberry AJ, Patel TP, Geddes-Klein DM, Lynch DR, Meaney DF. N-methyl-D-aspartate receptor mechanosensitivity is governed by C terminus of NR2B subunit. J Biol Chem. 2012 Feb 3;287(6):4348-59.

Patel TP, Ventre SC, Meaney DF. Dynamic changes in neural circuit topology following mild mechanical injury in vitro.Ann Biomed Eng. 2012 Jan;40(1):23-36.

Volpicelli-Daley LA, Luk KC, Patel TP, Tanik SA, Riddle DM, Stieber A, Meaney DF, Trojanowski JQ, Lee VM. Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron. 2011 Oct 6;72(1):57-71.

Liu Z, Yang M, Peterfreund GL, Tsou AM, Selamoglu N, Daldal F, Zhong Z, Kan B, Zhu J. Vibrio cholerae anaerobic induction of virulence gene expression is controlled by thiol-based switches of virulence regulator AphB. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):810-5 

Higa M, Petersen JE, Hooper J, Doms RW. Efficient Production of Hantaan and Puumala Pseudotypes for Viral Tropism and Neutralization Studies. Virology. 2012 Feb 20;423(2):134-42.

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Okeoma CM, Petersen J, Ross SR. Expression of Murine APOBEC3 Alleles in Different Mouse Strains and Their Effect on Mouse Mammary Tumor Virus Infection.  J Virol. 2009 Apr;83(7):3029-38.

Wise DR, Ward PS, Shay JE, Cross JR, Gruber JJ, Sachdeva UM, Platt JM, DeMatteo RG, Simon MC, Thompson CB. Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. PNAS 2011 Dec 6;108(49). 

Rawnsley DR, Xiao J, Lee JS, Liu X, Mericko-Ishizuka P, Kumar V, He J, Basu A, Lu M, Lynn FC, Pack M, Gasa R, Kahn ML.  The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development.  J Biol Chem.  2013 Aug 23; 288(34): 24429-40.  PMCID: PMC3750143

Langham M, Englund E, Mohler E, Li C, Rodgers Z, Floyd T, and Wehrli FW. Integrated MRI Evaluation of Age- and Peripheral Artery Disease-related Vascular Functional Deficits. J Cardiov Magn Reson 2013, 15(17).

Finnberg NK, Hart LS, Dolloff NG, Rodgers ZB, Dicker DT, El-Deiry WS. High-resolution Imaging and Antitumor Effects of GFP(+) Bone Marrow-Derived Cells Homing to Syngeneic Mouse Colon Tumors.  Am J Pathol. 2011 Nov;179(5):2169-76.

Hasson D*, Panchenko T*, Salimian KJ*, Salman MU, Sekulic N, Alonso A, Warburton PE, Black BE: The octamer is the major form of CENP-A nucleosomes at human centromeres. Nature Structural and Molecular Biology. 2013; 20(6): 687-695. (*These authors contributed equally and are listed in alphabetical order)

Salimian KJ, Ballister ER, Smoak EM, Wood S, Panchenko T, Lampson MA, Black BE. Feedback control in sensing chromosome biorientation by the aurora B kinase. Curr Biol. 2011 Jul 12;21(13):1158-65

Bassett EA, Wood S, Salimian KJ, Ajith S, Foltz DR, Black BE. Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors. J Cell Biol. 2010 Jul 26;190(2):177-85. 

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Kirino Y, Vourekas A, Sayed N, de Lima Alves F, Thomson T, Lasko P, Rappsilber J, Jongens TA, Mourelatos Z. Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization. RNA. 2010 Jan;16(1):70-8.

Guo L, Jamiolkowski R, Li Y, Shaffer S, Naji A.  Islet Cell Transplantation in Type I Diabetes.  Yale Journal of Biology and Medicine.  2012 Mar; 85(1): 37-43. 

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Mucaj, V.1Shay, J.E.S.1, and Simon, M.C. Effects of hypoxia and HIFs on cancer metabolism. Intl J Hematology. 2012 May;95(5):464-70  Review paper.

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Spencer SP, Belkaid Y. Curr Opin Immunol. Dietary and commensal derived nutrients: shaping mucosal and systemic immunity. Review paper. 2012 Aug 24;(4):379-84. PMCID: PMC3431603

Hall JA, Grainger JR, Spencer SP, Belkaid Y.  The role of retinoic Acid in tolerance and immunity. Immunity. 2011 Jul 22;35(1):13-22.

Saenz SA, Siracusa MC, Perrigoue JG, Spencer SP, Urban JF Jr, Tocker JE, Budelsky AL, Kleinschek MA, Kastelein RA, Kambayashi T, Bhandoola A, Artis D.  IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses. Nature. 2010 Apr 29;464(7293):1362-6.

Stern AM, Liu B, Bakken LR, Shapleigh JP, and Zhu J. A novel protein protect bacterial iron dependent metabolism from nitric oxide. J Bacteriol  2013 Oct;195(20):4702-4708. PMCID: PMCID In Process

Yang M, Liu Z, Hughes C, Stern AM, Wang H, Zhong Z, Kan B, Fenical W, and Zhu J. (2013) Bile salt induced intermolecular disulfide bond formation activates Vibrio cholerae virulence. Proc Natl Acad Sci USA 110(6):2348-2350. PMCID: PMC3568309

Stern AM, Hay AJ, Liu Z, Desland FA, Zhang J, Zhong Z, and Zhu J. The NorR regulon is critical for Vibrio cholerae resistance to nitric oxide and sustained colonization of the intestines. MBio. 2012 Apr 17;3(2):e00013-12.

Stern AM, Hsiao A, and Zhu J. (2011) Negative regulation during bacterial infection. In Vasil M and Darwin A (Ed.), Regulation of Bacterial Virulence. American Society for Microbiology Press: Washington, DC. Book chapter (In press)

Xu X*, Stern AM*, Liu Z, Kan B, and Zhu J. Virulence regulator AphB enhances toxR transcription in Vibrio cholerae. BMC Microbiol. 2010 Jan 6;10:3.

Du W, Jiang P, Mancuso A,Stonestrom A, Brewer MD, Minn AJ, Mak TW, Wu M, Yang X. TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nat Cell Biol. 2013 Aug;15(8):991-000

Zaitsev S, Kowalska MA, Neyman M, Carnemolla R, Tliba S, Ding BS, Stonestrom A, Spitzer D, Atkinson JP, Poncz M, Cines DB, Esmon CT, Muzykantov VR. Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis. Blood. 2012 May 17;119(20):4779-85.

Mei Y, Stonestrom A, Hou YM, Yang X. Apoptotic regulation and tRNA. Protein Cell. 2010 Sep;1(9):795-801. Review.

Mei Y, Yong J, Stonestrom A, Yang X. tRNA and cytochrome c in cell death and beyond. Cell Cycle. 2010 Aug 1;9(15):2936-9. Review.

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Ai D, Baez JM, Jiang H, Conlon DM, Hernandez-Ono A, Frank-Kamenetsky M, Milstein S, Fitzgerald K, Murphy AJ, Woo WH, Strong A, Ginsberg HN, Tabas I, Rader DJ, Tall AR. Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice. J Clin Invest. 2012 May 1;122(5):1677-87

Strong A, Rader DJ. Clinical Implications of Lipid Genetics for Cardiovascular Disease. Curr Cardiovasc Risk Rep. 2010 Oct;4(6):461-468.

Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, Morales CR, Lund-Katz S, Phillips MC, Wong J, Cantley W, Racie T, Ejebe KG, Orho-Melander M, Melander O, Koteliansky V, Fitzgerald K, Krauss RM, Cowan CA, Kathiresan S, Rader DJ. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus.Nature. 2010 Aug 5;466(7307):714-9.

Sundararaman SA, Liu W, Keele BF, Learn GH, Bittinger K, Mouacha F, Ahuka-Mundeke S, Manske M, Sherrill-Mix S, Li Y, Malenke JA, Delaporte E, Laurent C, Mpoudi Ngole E, Kwiatkowski DP, ShawGM, Rayner JC, Peeters M, Sharp PM, Bushman FD, Hahn BH. Plasmodium falciparum-like parasites infecting wild apes in southern Cameroon do not represent a recurrent source of human malaria. Proc Natl Acad Sci U S A.2013 Apr 23;110(17):7020-5. 

Zou Z, Enis DR, Bui H, Khandros E, Kumar V, Jakus Z, Thom C, Yang Y, Dhillon V, Chen M, Lu M, Weiss MJ, Kahn ML. The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood. 2013 April 18;121(16):3228-36.

Khandros E, Thom CS, D’Souza J, Weiss MJ. Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia. Blood. 2012 May 31;119(22):5265-75.

Qing G, Li B, Vu A, Skuli N, Walton ZE, Liu X, Mayes PA, Wise DR, Thompson CB, Maris JM, Hogarty MD, Simon MC. ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.  Cancer Cell. 2012 Nov 13;22(5):631-44. 

Finley LW, Zhang J, Ye J, Ward PS, Thompson CB. Snapshot: cancer metabolism pathways. Cell Metab. 2013 Mar 5;17(3):466-466.e2.

Ward PS, Lu C, Cross JR, Abdel-Wahab O, Levine RL, Schwartz GK, Thompson CB.The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization. J Biol Chem. 2013 Feb 8;288(6):3804-15.

Ward PS, and Thompson CB. Signaling in control of cell growth and metabolism. Cold Spring Harb Perspect Biol. 2012 Jul 1;4(7):a006783.

Ward PS, Cross JR, Lu C, Weigert O, Abel-Wahab O, Levine RL, Weinstock DM, Sharp KA, Thompson CB..** Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production.  Oncogene. 2012 May 10;31(19):2491-8

Ye J, Mancuso A, Tong X, Ward PS, Fan J, Rabinowitz JD, Thompson CB.** Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.  Proc Natl Acad Sci U S A. 2012 May 1;109(18):6904-9. 

Ward PS, Thompson CB.** Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate. Cancer Cell. 2012 Mar 20;21(3):297-308.

Turcan S*, Rohle D*, Goenka A*, Walsh LA, Fang F, Yilmaz E, Campos C, Fabius AWM, Lu C, Ward PS, Thompson CB, Kaufman A, Guryanova O, Levine R, Heguy A, Viale A, Morris LGT, Huse JT, Mellinghoff, IK, Chan TA.** IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature. 2012 Feb 15;483(7390):479-83.

Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, Edwards CR, Khanin R, Figueroa ME, Melnick A, Wellen KE, O'Rourke DM, Berger SL, Chan TA, Levine RL, Mellinghoff IK, Thompson CB. (2012). IDH mutation impairs histone demethylation and results in a block to cell differentiation.  Nature. 2012 Feb 15;483(7390):474-8.

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Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Löwenberg B, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A.Leukemic IDH1 and IDH2 mutations results in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.  Cancer Cell. 2010 Dec 14;18(6):553-67.

Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB.** The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.  Cancer Cell. 2010 Mar 16;17(3):225-34.

Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM.** Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009 Dec 10;462(7274):739-44.

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