MSTP trainers directory

Welcome to the Penn MSTP Faculty Trainer Directory

Each of the Penn faculty members included in this directory has made an explicit commitment to good mentorship practices in the training of future physician-scientists in Penn’s MD/PhD and VMD/PhD programs. The directory exists to assist recently-arrived students identify potential mentors for research rotations and thesis projects. The directory is also here to help applicants to the MSTP learn more about Penn and the faculty who work here. Many of the faculty included in the directory either have or have had MD/PhD and VMD/PhD students as part of their research teams. Others would very much like to, but not every Penn faculty member who would make a splendid thesis mentor is currently included. Current students should use this directory in combination with other sources of information and advice, especially from their graduate programs. Faculty updates should be sent to Hope Charney (Hope.Charney@Pennmedicine.upenn.edu). Penn faculty who are not currently listed but would like to be should contact Skip Brass and check out the MSTP or VMD/PhD website for more information about the program, the students who are in it, and the careers of our alumni.

- Skip Brass, MD, PhD, Associate Dean and Director of the Penn MSTP (brass@pennmedicine.upenn.edu)

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Geoffrey K. Aguirre, MD, PhD

Primary Department: Neurology

Faculty Rank: Professor

Degrees:

BA (Politics), Princeton University, 1992. PhD (Neuroscience), University Of Pennsylvania, 1999. MD, University Of Pennsylvania, 2000. Neurology Residency, Hospital of the University of Pennsylvania, 2004.

Research Interests:

I relate human perception to the structure and function of the visual pathway. We make use of quantitative modeling of retinal and brain imaging, with applications to ophthalmologic  and neurologic disease.

Clinical Specialties:

Behavioral neurology.

Keywords: Vision, visual cortex, functional MRI, retina


Office Address:
512 Goddard Building
3710 Hamilton Walk
Philadelphia PA, 19104
Email
GKAguirre Lab

Unconscious Bias Trained

Grad Group Affiliations: NGG, Psychology

Languages Spoken: English

Steven M. Albelda, MD

Primary Department: Pulmonary, Allergy and Critical Care

Faculty Rank: Professor

Degrees:

B.A. (Chemistry), Williams College, 1975. M.D., University Of Pennsylvania, 1979.

Research Interests:

1.  CAR T Cells Targeting Fibroblast Activation Protein
2.  Augmentation of CAR T cells Targeting Mesothelin
3.  Development of an augmented "off the shelf" NK Cell CAR Line
4.  Development of human-based models of immunotherapy (pleural effusions, tissue slices)
5.  Generating predictors of response to checkpoint therapy in Lung Cancer 
6.  Immunobiology of Mesothelioma and Lung 

Keywords: lung cancer, mesothelioma, tumor immunology, CAR T cells


Office Address:
228 Stemmler Hall
3450 Hamilton Walk
Philadelphia PA, 19104
(215) 573-9933
Email
Albelda Lab

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Stewart A. Anderson, MD

Primary Department: Psychiatry

Faculty Rank: Professor

Degrees:

BA (Neuroscience And Psychology), Amherst College, Amherst, MA, 1984. MD (Medicine), University Of Connecticut, Storrs, CT, 1989.

Research Interests:

Our main focus is the neurobiological underpinnings of schizophrenia, autism, and epilepsy. We study these underpinnings using mouse models of brain development as well as human stem cell derived excitatory and inhibitory neurons, astrocytes, microglia, and blood brain barrier-like cells. Recently, we have been study the role of mitochondrial energetics in variable penetrance for schizophrenia in the 22q11.2 deletion syndrome. We also have numerous collaborations, including sodium channel mutation related epilepsy, energetics of synaptic vesicle cycling in human neurons, interneuron-cell based therapy for glioblastoma, role of blood brain barrier in neuropsychiatric illness, and the interaction of cannabinoids with HIV in human stem cell derived microglia.

Keywords: Stem cells, Forebrain Development, Schizophrenia, Mitochondria, Interneurons


Office Address:
Abramson Pediatric Research Center
3615 Civic Center Blvd
Philadelphia, PA 19104
(215) 590-6527
Email
Anderson Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English, Spanish

Montserrat C. Anguera, Ph.D

Primary Department: SVM - Biomedical Science

Faculty Rank: Associate Professor

Degrees:

B.A (Environmental Chemistry) University of California, San Diego, 1998. Ph.D (Biochemistry, Molecular and Cellular Biology) Cornell University, 2004

Research Interests:

Epigenetics, X-Chromosome Inactivation, Xist RNA, female-biased autoimmunity, epigenetic analyses using female lymphocytes, allele-specific analyses, RNA/DNA FISH, microscopy, long noncoding RNAs

Keywords: X-chromosome Inactivation, Xist RNA, epigenetics, heterochromatin, female-biased autoimmunity, B cell development, B cell quiescence and activation, T cell quiescence and activation.


Office Address:
Penn Vet
3800 Spruce St, 390EB
Philadelphia, PA 19104

Email
Anguera Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English, Spanish

Zoltan Pierre Arany, MD, PhD

Primary Department: Cardiovascular Medicine

Faculty Rank: Professor

Degrees:

BA (Biochemical Sciences (Summa Cum Laude), Harvard College, 1989. PhD (Biological And Biomedical Sciences)Harvard Graduate School, 1995. MD (Medicine), Harvard Medical School, 1998.

Research Interests:

The Arany lab focuses on cardiovascular metabolism. Such unfocused focus has led us to study a wide range of projects in the heart, liver, fat, and many other tissues, and has led us to use all techniques we can get out hands on, including human genetics, genetically engineered mouse models, cell culture, metabolomics, in vivo isotope metabolic tracing, and many more. In essence, the lab aims to ask fundamental questions within the (wide) space of cardiovascular metabolism, and leverages all available state-of-the-art approaches to do so.

Clinical Specialties:

Cardiology.

Keywords: Metabolomics, heart failure, peripartum cardiomyopathy, genetics, diabetes, vascular biology, NAFLD/NASH, cardiac metabolism, senescence


Office Address:
Smilow 11-106
3400 Civic Center Boulevard
Philadelphia PA, 19104
Email
Arany Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English, French, Spanish

Michael Atchison, PhD

Primary Department: SVM - Biomedical Science

Faculty Rank: Professor

Degrees:

B.S. (Biology) SUNY at Albany, 1977. Ph.D. (Cell and Molecular Biology) New York University School of Medicine, 1983.

Research Interests:

The Atchison laboratory studies the molecular mechanisms responsible for transcriptional regulation, epigenetic processes, and the control of B and T cell lineage development.

Keywords: Transcription, Epigenetics, Lineage Development, Long distance DNA interactions.


Office Address:
142 Rosenthal Building
3800 Spruce Street
Philadelphia PA, 19104
(215) 898-6428
Email
Atchison Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

Will Bailis, PhD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Assistant Professor

Degrees:

B.A. (Biochemistry) Vassar College, Poughkeepsie, NY, 2008. Ph.D. (Immunology) University Of Pennsylvania, Philadelphia, PA, 2014.

Research Interests:

The Bailis lab aims aims to understand how metabolism underlies immunology and disease, by controlling the biochemistry of cells and tissues. We do so using in vitro and in vivo CRISPR engineering of primary human and mouse immune cells. Together with next generation sequencing and metabolomics, this permits us to fully interrogate how metabolic networks control immune cell function. The long term goal of our work is to develop diet and metabolite based therapies.

Keywords: immunology, metabolism, T cell, epigenetics, post-transcriptional gene regulation, malnutrition, host-pathogen


Office Address:
1211B Abramson Research Center
3615 Civic Center Blvd
Philadelphia, PA 19104
Email
Bailis Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

Amit Bar-Or, MD

Primary Department: Neurology

Faculty Rank: Professor

Degrees:

BSc (Biology And Psychology), McMaster University, 1988. MD (Medicine), McGill University, 1993. Medicine Internship and Neurology Residency, MGH, Harvard University, 1997 Neuroimmunology fellowship, Harvard/MIT, 2000

Research Interests:

Cellular immunology
Immune regulation
Immune neural and immune glial interactions
Immune therapies 
Biomarker development 

Clinical Specialties:

MS and related disorders.

Keywords: Neuroinflammation, Neuroimmunology, immune regulation, immune-neural interactions, multiple sclerosis and related disorders


Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: NGG (Neuroscience Graduate Group)

Languages Spoken: English

Yoseph Barash, PhD

Primary Department: Genetics

Faculty Rank: Associate Professor

Degrees:

B.Sc. (Computer Science And Physics) Hebrew University, Jerusalem, Israel., 1998. Ph.D. (Machine Learning, Computational Biology) School Of Computer Science & Engineering Hebrew University, Jerusalem, Israel, 2006.

Research Interests:

The lab develops machine learning algorithms that integrate high-throughput data (RNASeq, CLIPSeq , WGS, etc.) to infer RNA biogenesis and function as these relate to human disease, followed by experimental verifications of inferred mechanisms. Research projects in the lab involve a mix of comp methods development, Genomics analysis, new assay tech development, and biochemical wet lab experiments.

Keywords: computational biology, machine learning, probabilistic graphical models, RNA processing, alternative-splicing, post-transcriptional regulation, genomics, high-throughput sequencing analysis.


Office Address:
Richards Medical Research Laboratories, D205
3700 Hamilton Walk
Philadelphia PA, 19104
Email
BioCiphers

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology)

Languages Spoken: English

Marisa S. Bartolomei, PhD

Primary Department: Cell and Development Biology

Faculty Rank: Professor

Degrees:

B.S. (Biochemistry) University Of Maryland, College Park, MD, 1982. Ph.D. (Biochemistry) Johns Hopkins University School Of Medicine, Cellular & Molecular Biology Training Program (Dr. Jeffry Corden), 1987.

Research Interests:

The research in my laboratory focuses on the study of genomic imprinting and X inactivation in mice.

Keywords: genomic imprinting, X inactivation, DNA methylation, epigenetics, environment.


Office Address:
Smilow Center for Translational Research, 9-122
3400 Civic Center Boulevard
Philadelphia PA, 19104
(215) 898-9063
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Danielle S. Bassett, PhD

Primary Department: SEAS - Bioengineering

Faculty Rank: Professor

Degrees:

Ph.D., University of Cambridge (2009) C.P.G.S., University of Cambridge (2005) B.S., Pennsylvania State University, Schreyer Honors College (2004)

Research Interests:

Cognitive Neuroscience
Computational Modeling
Control of Action
Decision Processes
Memory and Learning


Email
https://complexsystemsupenn.com

Mentor Training Completed

Grad Group Affiliations: BE (Bioengineering)

Languages Spoken: English

Paul Bates, PhD

Primary Department: Microbiology

Faculty Rank: Professor

Degrees:

B.S. (Biochemistry) Pennsylvania State University, 1979. Ph.D. (Biochemistry) Michigan State University, 1985.

Research Interests:

The Bates lab is interested in the interactions between viruses and their host cells. We use a combination of molecular, cell biological, and genetic tools to understand how viruses invade host cells and evade host defenses with emphasis on emerging viral pathogens. We also use technologies such as modified mRNA and recombinant viruses to generate vaccines for highly pathogenic viruses.

Keywords: Virus entry, virus-host interactions, ebolavirus, hantavirus, SARS, Tetherin, mRNA vaccines


Office Address:
303A Johnson Pavilion
3610 Hamilton Walk
Philadelphia PA, 19104
(215) 573-3509
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Gregory Beatty, MD, PhD

Primary Department: Hematology/Oncology

Faculty Rank: Associate Professor

Degrees:

BS Bucknell University, 1995. PhD University Of Pennsylvania, 2000. MD University Of Pennsylvania, 2004.

Research Interests:

The Beatty Laboratory incorporates both basic science research and clinical investigation to define strategies for leveraging the immune system for the treatment of cancer. Our mission is to define mechanisms of resistance and response to immunotherapy in an effort to design effective strategies to condition tumors and patients for enhanced therapeutic responsiveness.

Clinical Specialties:

Medical Oncology with a focus on clinical trials related to pancreatic cancer.

Keywords: cancer immunotherapy, tumor microenvironment, T cells, macrophages, pancreatic cancer, liver biology


Office Address:
PCAM South Pavilion, Rm 8-107
3400 Civic Center Blvd
Philadelphia, PA 19104
Email
Beatty Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

Ed Behrens, MD

Primary Department: Pediatrics, Rheumatology

Faculty Rank: Associate Professor

Degrees:

BA (Biology) The Johns Hopkins University, 1997. MD (Medicine) The University Of Pennsylvania School Of Medicine, 2002.

Research Interests:

The Behrens Laboratory is mainly focused on the understanding the pathogenesis of Cytokine Storm Syndrome, a common pathologic endpoint of a heterogeneous group of initiating diseases. Cytokine Storm Syndrome results in multi-organ failure and a stereotypical immune response including increased serum ferritin and Interferon gamma that leads to the organ failure itself. The lab is interested in dissecting the initiating, propagating, and regulatory factors that determine the pace and outcome of cytokine storm. This is done using a number of different murine models including perforin deficient mice, repeated TLR9 agonist injections, and other murine systems of systemic inflammation. The ultimate goal of these investigations is to improve the lives of patients that suffer from cytokine storm syndromes by developing strategies for treatment and prevention.

Clinical Specialties:

Pediatric Rheumatology

Keywords: Dendritic Cell, Toll-like receptor, Macrophage Activation Syndrome, Hemophagocytic Lymphohistiocytosis, Antigen Presentation


Office Address:
Room 1107A ARC
3615 Civic Center Blvd
Philadelphia, PA 19107
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

Shelley Berger, PhD

Primary Department: Biology, Cell and Development Biology

Faculty Rank: Professor

Degrees:

B.S. (Biology), University Of Michigan, Ann Arbor, MI, 1982. PhD (Cell & Molecular Biology), University Of Michigan, Ann Arbor, MI, 1987.

Roles:

Daniel S. Och University Professor

Research Interests:

Epigenetics and chromatin structure/function in genomic regulation; Post-translational modifications of histones and transcription factors; Biological problems: chromatin regulation of transcription; neuroepigenetics and behavioral epigenetics (human, mouse, ant); chromatin regulation in disease including cancer, senescence and aging, and neurodegeneration (cell models, mouse, human).

Keywords: epigenetics, chromatin, transcription, histone post-translational modifications, genome structure, p53 tumor suppressor


Office Address:
Smilow Center for Translational Research, Room 9-125
400 Civic Center Boulevard
Philadelphia PA, 19104

(215) 746-3106
Email
Berger Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: Biology, BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology), NGG (Neuroscience Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Elizabeth Bhoj, MD, PhD

Primary Department: Pediatrics

Faculty Rank: Assistant Professor

Degrees:

BS (Biology And Philosophy) The College Of New Jersey, 2002. PhD (Genetics) University Of Texas Southwestern Medical Center At Dallas, 2010. MD University Of Texas Southwestern Medical Center At Dallas, 2010. MTR (Translational Research ) University Of Pennsylvania, 2016.

Research Interests:

Our lab works in translational genetics to improve diagnosis and treatment through the discovery, mechanistic understanding, and targeted treatment of novel human syndromes.

Clinical Specialties:

Pediatrics, Clinical Genetics, Molecular Genetics.

Keywords: genetics, genomics, clinical genetics, molecular genetics, exome sequening, genome sequencing, RNAseq, gene discovery, neurogenetics, histone, mTOR, RAS, targeted therapeutics


Office Address:
Abramson Pediatric Research Center, 1016D
3615 Civic Center Blvd
Philadelphia, PA 19104
(215) 300-3215
Email
Bhoj Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Ben Black, PhD

Primary Department: Biochemistry and Biophysics

Faculty Rank: Professor

Degrees:

B.A. (Biology) Carleton College, 1997. PhD (Biochemistry And Molecular Genetics) University Of Virginia, 2002.

Research Interests:

The longest standing goal of my lab has been to understand how particular proteins direct accurate chromosome segregation at mitosis and meiosis. In humans, the chromosomal element-the centromere-that directs this process is not defined by a particular DNA sequence. Rather, the location of the centromere is dictated by an epigenetic mark generated by one or more resident proteins. These centromeric proteins interact directly with the DNA to create a specialized chromatin compartment that is distinct from any other part of the chromosome. By taking biophysical, biochemical, genetic, epigenomic, and cell biological approaches, our work is to define the composition and physical characteristics of the protein and protein/DNA complexes that epigenetically mark the location of the centromere on the chromosome. This work involves building centromeric chromatin from its component parts for analysis of its physical characteristics, developing biochemical assays to reconstitute steps in the process of establishing and maintaining the epigenetic mark, exploiting emerging genomic and epigenomic technologies to investigate the structure of centromeric chromatin, and using cell and organismal approaches to study the behavior of proteins involved in centromere inheritance and other essential aspects related to chromosome segregation at cell division. We are using the understanding gained from this work to advance technologies for building synthetic chromosomes for applications in research and medicine. An exciting area of interest for my group to emerge in the last several years has been with the enzyme PARP-1: a key component for signaling DNA damage and an important clinical target for small molecule inhibition. Our work with PARP-1 has defined the allosteric network that potently activates the enzyme upon binding to a DNA break. Most recently, we have discovered that clinical PARP inhibitor (PARPi) compounds fall into three distinct types, depending on their allosteric modulation of DNA binding affinity. Our collaborative team is using this understanding to develop 'designer' PARPi compounds where the allosteric effects they confer are tuned for either strong DNA retention (i.e. potent for cancer cell killing) or strong DNA release (i.e. for inhibiting PARP-1 activity in neuroinflammatory and cardiovascular disease where preserving cell viability is the goal). 

Keywords: Chromosomes, epigenetics, structural biology, chromatin, DNA repair, synthetic biology


Office Address:
Stellar - Chance Laboratories
422 Curie Boulevard
Philadelphia PA, 19104
(215) 898-5039
Email
Black Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology)

Languages Spoken: English

Gerd Blobel, MD, PhD

Primary Department:

Faculty Rank: Professor

Degrees:

MD - Ruprecht-Karls University, Heidelberg, Baden-Württemberg, Germany. PhD in Molecular Oncology - Rockefeller University, New York, NY

Research Interests:

Higher order chromatin structure, gene expression, epigenetics, globin genes, sickle cell disease, therapeutics

Keywords: Epigenetics, chromatin architecture, gene expression, cell division, epigenetic memory, globin gene expression, hematologic diseases.


Office Address:
Abramson Pediatric Research Center, 316H
3615 Civic Center Blvd
Philadelphia, PA 19104
Email
Blobel Laboratory

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology), IGG (Immunology Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Nancy Bonini, PhD

Primary Department: Biology

Faculty Rank: Professor

Degrees:

AB (Biology) Princeton University, 1981. PhD (Neuroscience) University Of Wisconsin-Madison, 1987.

Research Interests:

Molecular genetics of neurodegenerative disease and brain aging; molecular mechanisms of risk factors for neurodegenerative disease

Keywords: Neurodegeneration; suppressor mechanisms; human disease; Alzheimer's, Parkinson's and Huntington's diseases; Amyotrophic Lateral Sclerosis and Frontotemporal Dementia; Ageing; microRNAs; RNA binding proteins; stress response


Office Address:
204G Lynch Laboratory
433 South University Avenue
Philadelphia PA, 19104
(215) 573-9267
Email
SAS Biology Faculty Page

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Donita Brady, PhD

Primary Department: Cancer Biology

Faculty Rank: Associate Professor

Degrees:

B.S. (Chemistry) Radford University, Radford, VA, 2003. Ph.D. (Pharmacology) University Of North Carolina At Chapel Hill, 2008.

Research Interests:

The research interests of our laboratory lie at the intersection of cancer biology, signal transduction, and metal homeostasis.

Keywords: Cancer Biology, Metal Homeostasis, Signal Transduction, Kinases, Small GTPases, Pharmacologic Interventions, Genetically Engineered Mouse Models


Office Address:
BRB II/III, Room 612
421 Curie Blvd.
Philadelphia, PA 19104
(215) 573-9705
Email
Brady Lab

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Lawrence (Skip) Brass, MD, PhD

Primary Department: Hematology/Oncology

Faculty Rank: Associate Dean, Director, Professor

Degrees:

A.B. (Chemistry), Harvard College, 1970. Ph.D. (Biochemistry) Case Western Reserve University, 1975. M.D. Case Western Reserve, 1977.

Roles:

  • Professor of Medicine
  • Professor of Systems Pharmacology and Translational Therapeutics
  • Attending Physician, Hospital of the University of Pennsylvania
  • PI, Hematology Fellowship Training Grant, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
  • Associate Dean and Director, Combined Degree and Physician Scholar Programs, University of Pennsylvania, Perelman School of Medicine

Research Interests:

Mechanisms of hemostasis and thrombosis.

Keywords: platelets, coagulation, vascular biology, signal transduction, systems biology, proteomics, transgenic mice, megakaryocytes, intravital microscopy


Office Address:
815 BRB-II/III
421 Curie Blvd
Philadelphia, PA 19104
(215) 573-3540
Email
Brass Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Igor E. Brodsky, AB, PhD

Primary Department: SVM - Pathobiology

Faculty Rank: Associate Professor

Degrees:

AB (Molecular Biology) Princeton University, 1997. PhD (Microbiology and Immunology) Stanford University, 2004.

Research Interests:

Bacterial pathogens, Bacteriology, Infectious Disease, Inflammasome, Innate Immune Defense, Immunology.

The Brodsky lab values diversity in all its forms. We seek to provide a rigorous and supportive training environment that enables individuals from all backgrounds to pursue their love of discovery and advancement of biomedical knowledge while being their authentic selves.

Keywords: Inflammasome; Caspase-1; Caspase-8; Yersinia; Salmonella; Mucosal Immunity; Macrophages; Monocytes; Apoptosis; Sepsis


Office Address:
3800 Spruce St.
390EE Rosenthal
Philadelphia, PA 19104
(215) 746-8426
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: MVP (Microbiology, Virology and Parasitology)

Languages Spoken: English, Russian

Frederic D. Bushman, PhD

Primary Department: Microbiology

Faculty Rank: Professor

Degrees:

B.A. (Biology And English) Amherst College, 1980. Ph.D. (Cellular And Developmental Biology) Harvard University, 1988.

Research Interests:

SARS-CoV-2, HIV, human microbiome and virome, human gene therapy.

Keywords: microbiome, gene therapy, SARS-CoV-2, virome, HIV, integration, DNA modifying enzyme, virology.


Email
Bushman Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology)

Languages Spoken: English

Michael Cancro, PhD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Professor

Degrees:

B.S. (Zoology) University Of Maryland College Park, 1973. Ph.D. (Zoology/Genetics) University Of Maryland College Park, 1976. Postdoc (Immunology) University Of Pennsylvania, 1977.

Research Interests:

B lymphocyte development, selection, and homeostasis; immunobiology of aging.

Keywords: B lymphocytes, immunity, autoimmunity


Office Address:
284 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: IGG (Immunology Graduate Group)

Languages Spoken: English

Ricardo Castillo-Neyra, PhD, DVM, MSPH

Primary Department: Epidemiology

Faculty Rank: Assistant Professor

Degrees:

BSc (Veterinary Medicine), Universidad Nacional Mayor De San Marcos, 2006. DVM (Veterinary Medicine), Universidad Nacional Mayor De San Marcos, 2007. PhD (Epidemiology), Johns Hopkins. Bloomberg School Of Public Health, 2014. MSPH (International Health) Johns Hopkins Bloomberg School Of Public Health, 2014.

Research Interests:

I study the eco-epidemiology of tropical diseases. My current research uses canine rabies as a model system to understand how the social and spatial features of urban areas influence the emergence and persistence of infectious diseases.

Keywords: Global health, Tropical diseases, Zoonotic diseases, Epidemiology, Outbreaks, One Health


Office Address:
Room 715, Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
Email
DBEI Profile

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: GGEB (Epidemiology and Biostatistics)

Languages Spoken: English, Spanish

Yi-Wei Chang, PhD

Primary Department: Biochemistry and Biophysics

Faculty Rank: Assistant Professor

Degrees:

B.S. (Mechanical Engineering ) Chung Hua University, Taiwan, 2004. Ph.D. (Structural Biology ) Academia Sinica & National Tsing Hua University, Taiwan, 2010.

Research Interests:

Structural biology; Cryo-electron microscopy; Cryo-electron tomography; Correlative light and electron microscopy; Cellular imaging; Microbiology; Host-pathogen interaction

Clinical Specialties:

913B Stellar Chance Laboratories
422 Curie Boulevard
Philadelphia PA, 19104


Office Address:
913B Stellar Chance Laboratories
422 Curie Boulevard
Philadelphia PA, 19104
(215) 898-7789
Yi-Wei Chang Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology)

Languages Spoken: English

Alice Chen-Plotkin, MD

Primary Department: Neurology

Faculty Rank: Professor

Degrees:

AB (English) Harvard-Radcliffe College, 1996. MSc (Biology) University Of Oxford, 1998. MD Harvard Medical School, 2003.

Research Interests:

The over-arching goal of our research is to better understand the mechanisms of neurodegenerative disease in order to intervene in these disease processes.

Our general approach is to use unbiased genomic- or proteomic-scale screens in human-derived materials to generate leads, which are then followed mechanistically in relevant systems including neuronal culture and in vivo animal models. The pace of technology development is allowing us to acquire more data, faster, than ever before, but this does not always translate into biological understanding. We believe that to unlock the true potential of leads generated in this way, computational methods must work hand-in-hand with bench-based manipulative experiments. We are looking for new ways to do this all the time. 

Clinical Specialties:

Neurology.

Keywords: Neurodegeneration, Parkinson's disease, dementia, Genomics Biomarkers


Email
Chen-Plotkin Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Sara Cherry, PhD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Professor

Degrees:

B.S. (Chemistry) U.C. Berkeley, 1994. Ph.D. (Biology) MIT, 2000.

Research Interests:

Genetic and mechanistic studies of viral-host interactions.

Keywords: virus, genomics, RNAi, genetics, Drosophila, innate, immunity, therapeutics, and antivirals


Office Address:
472A Stemmler Hall
3450 Hamilton Walk
Philadelphia PA, 19104
(215) 746-2384
Email
Cherry Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology), IGG (Immunology Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Lewis A. Chodosh, MD, PhD

Primary Department: Cancer Biology

Faculty Rank: Professor

Degrees:

B.S. (Molecular Biophysics & Biochemistry) Yale University, 1981. Ph.D. (Biochemistry) Massachusetts Institute Of Technology, 1988. M.D. Harvard Medical School, 1989.

Research Interests:

The Chodosh laboratory uses genetically engineered mouse models, patient samples and bioinformatics to understand the mechanisms by which cancers develop, progress to more aggressive states, and ultimately contribute to cancer mortality. A broad array of basic and translational research approaches are used to address problems of fundamental clinical importance to cancer patients by elucidating pathways and principles common to human cancers. These approaches encompass genetics, genomics, molecular biology, biochemistry, cell biology, computational biology, functional imaging, animal studies, preclinical trials and clinical investigation. Particular areas of interest include: pathways regulating cancer development, metastasis, tumor dormancy and recurrence; the use of genomics and computational approaches to understand genetic programs in cancer; the impact of obesity on cancer recurrence; the mechanisms by which pregnancy protects against breast cancer; and the use of non-invasive imaging approaches to study tumor biology.

Keywords: Cancer biology, breast cancer, tumor dormancy, metastatic recurrence, therapy resistance, cancer genetics, genomics, computational biology, oncogenes, targeted therapy, functional imaging, development.The Chodosh laboratory uses genetically engineered mouse models, patient samples and bioinformatics to understand the mechanisms by which cancers develop, progress to more aggressive states, and ultimately contribute to cancer mortality. A broad array of basic and translational research approaches are used to address problems of fundamental clinical importance to cancer patients by elucidating pathways and principles common to human cancers. These approaches encompass genetics, genomics, molecular biology, biochemistry, cell biology, computational biology, functional imaging, animal studies, preclinical trials and clinical investigation. Particular areas of interest include: pathways regulating cancer development, metastasis, tumor dormancy and recurrence; the use of genomics and computational approaches to understand genetic programs in cancer; the impact of obesity on cancer recurrence; the mechanisms by which pregnancy protects against breast cancer; and the use of non-invasive imaging approaches to study tumor biology.


Office Address:
614 BRB II/III
421 Curie Blvd
Philadelphia, PA 19104
(215) 898-1321
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Peter Choi, PhD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Assistant Professor

Degrees:

B.S. (Biology), Cornell University, 2002. Ph.D. (Immunology), Stanford University, 2012.

Research Interests:

Our laboratory is interested in the genetics of cancer and in particular, how genetic alterations affecting processes such as RNA splicing drive cancer and expose potential therapeutic vulnerabilities.

Keywords: Cancer biology; Genetics; Genome editing; RNA splicing; Next-generation sequencing; Synthetic lethality


Office Address:
3501 Civic Center Blvd
4010 Colket Translational Research Building
Philadelphia, PA 19104
Email
The Choi Lab

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Brian Chow, PhD

Primary Department: SEAS - Bioengineering

Faculty Rank: Associate Professor

Degrees:

B.S. in Chemistry from Stanford University. Ph.D. from M.I.T. in 2008

Research Interests:

The Chow Laboratory invents optical technologies to manipulate and monitor cellular physiology, and applies them to understanding how cells make decisions in response to external cues.

Keywords: Optogenetics, Synthetic Biology, Photosensory Biology, GTPase signaling.


Chow Lab

Grad Group Affiliations: BE (Bioengineering), BMB (Biology and Molecular Biophysics), MSE (Materials Science and Engineering), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Diego Contreras, MD, PhD

Primary Department:

Faculty Rank: Professor

Degrees:

M.D. University Autonoma Of Madrid, Spain, 1988. Ph.D. Laval University, Quebec, Canada, 1996.

Research Interests:

Representation of information in thalamocortical networks. Epilepsy.

Keywords: Neocortex, thalamus, optical imaging, information, coding, epilepsy


Email

Unconscious Bias Trained

Grad Group Affiliations: NGG (Neuroscience Graduate Group)

Languages Spoken: English, French, Spanish

George Cotsarelis, MD

Primary Department: Dermatology

Faculty Rank: Professor

Degrees:

B.A. (Bio Basis Of Behavior) University Of Pennsylvania, 1983. M.D. (Medicine) University Of Pennsylvania, 1987.

Research Interests:

Stem cells; hair follicle; wounding; aging skin.

Clinical Specialties:

Alopecia.

Keywords: skin, stem cells, regeneration, alopecia, wound healing


Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English, Greek

Douglas A. Coulter, PhD

Primary Department: Pediatrics

Faculty Rank: Professor

Degrees:

B.S. (Biology With Honors) Trinity College, Hartford, CT, 1980. M.S. (Zoology) University Of Rhode Island, 1983. Ph.D. (Biology) Boston University Marine Program, Marine Biological Laboratory, Woods Hole, MA, 1986.

Research Interests:

Epilepsy, neuronal excitability, CNS rhythm generation, circuit imaging, GABA receptors, development of neurotransmitter receptors and ion channels, synaptic function

Keywords: epilepsy, hippocampus, circuit imaging, GABA receptors, thalamus


Email

Unconscious Bias Trained

Grad Group Affiliations: NGG (Neuroscience Graduate Group)

Languages Spoken: English

Qi N. Cui, MD, PhD

Primary Department: Ophthalmology

Faculty Rank: Assistant Professor

Degrees:

BS (Molecular & Cellular Biology And Psychology) University Of Arizona, 2002. MD/PhD (Neurobiology And Anatomy) University Of Rochester School Of Medicine And Dentistry, 2011.

Research Interests:

Understanding glaucoma pathogenesis and identifying effective treatments for a neurodegenerative disease affecting the retina and the optic nerve.

Dr. Cui can be found on Twitter @CuiLab

Clinical Specialties:

Glaucoma

Keywords: ophthalmology; glaucoma; neuroprotection; neurodegeneration; GLP-1 receptor agonists; iron chelation; mitochondria; retinal ganglion cells; optic nerve; intraocular pressure


Office Address:
302/303 Stellar-Chance
422 Curie Blvd.
Philadelphia, PA 19103
Email
Cui Lab

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English, Mandarin Chinese

Beverly Davidson, PhD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Professor

Degrees:

B.S. (Biology Major/Chemistry Minor; High Distinction) Nebraska Wesleyan University, 1981. Ph.D. (Biological Chemistry) University Of Michigan, 1987.

Research Interests:

Research in the Davidson Laboratory is focused on inherited genetic diseases that cause central nervous system dysfunction, with a focus on: i) recessive, childhood onset neurodegenerative disease, such as the lysosomal storage diseases mucopolysaccharidoses and Battens disease; ii) dominant genetic diseases, specifically the CAG repeat disorders, Huntington's disease and Spinocerebellar ataxia; iii) understanding how changes in the transcriptome impact neural development and neurodegenerative disease processes.

Keywords: Neurodegenerative diseases; Gene therapy; Vector development; Animal models


Office Address:
5060 CTRB
3501 Civic Cntr Blvd
Philadelphia, PA 19104
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), GTV (Gene Therapy and Vaccines), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Kate Davis, MD, MSc

Primary Department: Neurology

Faculty Rank: Associate Professor

Degrees:

BSc (Neuroscience) Brown University, 1999. MD Yale University School of Medicine, 2004. MSTR (Masters in Translational Research) University of Pennsylvania, 2011.

Research Interests:

Dr. Davis' research centers around utilizing both the advancing fields of invasive neurophysiology and neuroimaging to better localize epileptic networks in medication refractory epilepsy patients. She hopes that improving localization will enable epileptologists to better localize epileptic networks and assign individual patients to the most efficacious therapy, for example, seizure control devices, resective surgery, or continued medical management.

Clinical Specialties:

Epilepsy.

Keywords: Neuroimaging, electrophysiology, epilepsy, network neuroscience


Office Address:
301 Hayden Hall
240 South 33rd Street
Philadelphia, PA 19104
Email
Davis Lab

Mentor Training Completed

Grad Group Affiliations: BE (Bioengineering), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Sharlene Day, MD

Primary Department: Cardiovascular Medicine

Faculty Rank: Associate Professor

Degrees:

BS (Biology) Massachusetts Institute of Technology, 1991. M.D. (Medicine) New York University School of Medicine, 1995.

Research Interests:

The Day lab is interested in genetic heart muscle diseases. Our research program integrates translational and clinical science, with a primary focus on hypertrophic cardiomyopathy. We want to understand the full spectrum of disease evolution and progression, from the primary effects of sarcomere gene mutations in cardiac muscle cells to the phenotypic expression and predictors of adverse outcomes in patients.

Clinical Specialties:

Hypertrophic cardiomyopathy and cardiovascular genetic heart conditions.

Keywords: Cardiomyopathy, cardiovascular genetics, hypertrophic cardiomyopathy, molecular chaperones, protein quality control, translational


Office Address:
Smilow Center for Translational Research, 11-102
3400 Civic Center Boulevard
Philadelphia PA, 19104
(734) 548-0394
Email
Sharlene Day Lab

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Cesar de la Fuente, PhD

Primary Department: Psychiatry

Faculty Rank: Professor

Degrees:

M.Sc. (Biotechnology) University of Leon, 2009. Ph.D. (Microbiology & Immunology) University of British Columbia, 2014.

Roles:

Presidential Assistant Professor

Research Interests:

My lab's goal is to combine the power of machines and biology to understand, prevent, and treat infectious diseases.

Keywords: Machine biology; Synthetic biology; infectious diseases; computational biology; microbiology


Office Address:
Robert Wood Johnson Pavilion, 303C
3610 Hamilton Walk
Philadelphia PA, 19104
(215) 746-6083
Email
de la Fuente Lab

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology), NGG (Neuroscience Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English, Spanish

Horace M. Delisser, MD

Primary Department: Pulmonary, Allergy and Critical Care

Faculty Rank: Associate Professor

Degrees:

BA Temple University , 1981. M.D. University Of Pennsylvania, 1985.

Roles:

I am the Associate Dean for Diversity and Inclusion, directing the school’s efforts to promote medical student inclusion and diversity. I have also been involved in promoting graduate medical trainee and faculty diversity at the University of Pennsylvania through various institutional mentoring programs.

Research Interests:

[1] Endothelial Cell Adhesion and Motility
[2] Angiogenesis
[3] Tumor Metastasis
[4] Pulmonary Hypertension


Email

Grad Group Affiliations: BGS (Biomedical Graduate Studies)

Languages Spoken: English

Roberto Dominguez, Ph.D.

Primary Department: Physiology

Faculty Rank: Professor

Degrees:

M.S. (Theoretical Physics & Mathematics), Faculty Of Physics, Odessa State University (Former USSR), 1987. Ph.D. (Protein Crystallography And Biochemistry), Pasteur Institute & Paris-Sud University, Paris, France, 1996

Research Interests:

My laboratory studies the proteins that control the actin cytoskeleton and cytoskeleton-membrane connections, as well as the signaling pathways that regulate their activities. We use interdisciplinary approaches, spanning structural biology, biochemistry and cell biology, allowing us to correlate the functional mechanisms of proteins to their cellular activities

Keywords: Structural biology (x-ray crystallography, cryo-EM), Biochemistry & Biophysics applied to the study of the cellular cytoskeleton


Office Address:
415 Curie Blvd (CRB 728)
Philadelphia, PA 19104-6085
(215) 573-4559
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology)

Languages Spoken: English, French, Russian, Spanish

Nadia Dowshen, MD

Primary Department: Pediatrics

Faculty Rank: Associate Professor

Degrees:

BA (Urban Studies) University Of Pennsylvania, 1999. MD University Of Pennsylvania School Of Medicine, 2004. MSHP University Of Pennsylvania, 2016.

Clinical Specialties:

Pediatrics/Adolescent Medicine. Medical Director of Adolescent HIV Clinic and Gender and Sexuality Development Program.

Keywords: HIV/AIDS, mHealth, digital health, transgender health, LGBT health, adolescent health, health equity


PolicyLab Faculty Profile

Unconscious Bias Trained

Grad Group Affiliations: GGEB (Epidemiology and Biostatistics)

Languages Spoken: English

Joshua L. Dunaief, MD, PhD

Primary Department: Ophthalmology

Faculty Rank: Professor

Degrees:

B.A. (Biology) Harvard University (Magna Cum Laude), 1987. PhD (Microbiology) Columbia University, 1994. MD Columbia University, 1996.

Research Interests:

We study the pathogenesis of age-related macular degeneration of the retina, focusing on oxidative stress and inflammation. More broadly, we are interested in mechanisms of aging and therapeutic approaches to prevent age-related diseases. One therapy currently showing promise is oral administration of an oxidation-resistant fatty acid. We are also testing iron-specific chelation and antioxidant gene therapy in mouse models of macular degeneration. Multimodal in vivo retinal imaging in mice and functional testing with electroretinography greatly accelerate discovery.

Clinical Specialties:

Medical retina. Stopped seeing patients in 2019 to focus on research.

Keywords: retinal degeneration, retina biology, neurodegeneration, oxidative stress, antioxidants, iron transport, apoptosis, aging, inflammation, transcriptomics, gene therapy, pharmacotherapy, cell biology, histology


Office Address:
305 Stellar-Chance Laboratories
422 Curie Boulevard
Philadelphia PA, 19104
(215) 898-5235
Email
Dunaief Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Laurence C. Eisenlohr, VMD, PhD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Professor

Degrees:

BS (Biology) Haverford College , 1979. VMD (Veterinary Medicine) University of Pennsylvania, 1983. PhD (Immunology) University of Pennsylvania, 1988.

Research Interests:

Dr. Eisenlohr studies the fundamental aspects of host defense, primarily against virus infections such as influenza and HIV.

Keywords: antigen processing and presentation, viral immunity, T cell responses and memory, influenza, poxviruses, HIV, beta-coronavirus


Office Address:
1107B Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104
(215) 590-0952
Email
Pathology and Laboratory Medicine Faculty Profile

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

Kojo S. J. Elenitoba-Johnson, MD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Professor

Degrees:

MD (Medicine), College Of Medicine, University Of Lagos And Lagos University Teaching Hospital, 1988.

Roles:

Peter C. Nowell, M.D. Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania 
Director, Center for Personalized Diagnostics
Director, Division of Precision and Computational Diagnostics

Clinical Specialties:

Genomic sequencing of primary human cancers for oncologic diagnostics.

Keywords: Genomics, Proteomics, Molecular mechanisms of lymphomagenesis


Office Address:
422 Curie Boulevard
609 Stellar Chance Laboratories
Philadelphia, PA 19104
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations:

Languages Spoken: English

Michal A. Elovitz, MD

Primary Department: Obstetrics and Gynecology

Faculty Rank: Professor

Degrees:

BA (History/Pre-med) University of Texas at Austin, Texas (with honors), 1990. MD (Medicine) Albert Einstein College of Medicine Bronx, New York, 1994.

Research Interests:

Dr. Elovitz brings the clinical and research world together to advance pregnancy health.  She has been actively involved in translational and clinical research for the over 20 years. Her research is or has been funded by the March of Dimes, Burroughs Wellcome Fund, National Institute of Child Health and Development, National Institute for Nursing Research, the National Institute of Mental Health and the National Institute for Allergy and Infectious Diseases. Dr. Elovitz supports, fosters, participates and advocates for collaborative research, from the bench to the bedside, to advance the mission of improving health outcomes for women and their children.  She has been very successful at growing a multidisciplinary research team that will undoubtedly push forward the needle on women's health. Her own research program has focused on understanding the mechanisms and consequences of adverse pregnancy outcomes both for the pregnancy of interest and for implications for the long-term health of the mother and child. Her research integrating immunology and microbiology into pregnancy health has led to novel discoveries in preterm birth. Dr. Elovitz is unique in that her research expertise spans the bench to the bedside. She has developed mouse models relevant to human pregnancy conditions, create unique in vitro systems and has implemented translational research that has created large biobanks of specimens with rigorous clinical metadata.

Clinical Specialties:

Maternal Fetal Medicine.

Keywords: Microbiome, immunome, reproductive health, maternal health; preterm birth, exposome,


Office Address:
1354 BRB 2/3
421 Curie Blvd
Philadelphia, PA 19104
Email
Elovitz Lab

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Jonathan A. Epstein, MD

Primary Department: Cell and Development Biology

Faculty Rank: Professor

Degrees:

A.B. (Biochemistry) Harvard College, 1983. M.D. (Medicine) Harvard Medical School, 1988.

Research Interests:

Epigenetic regulation of stem cell biology, developmental biology, nuclear architecture and cardiovascular medicine.  We also have an interest in the use of mRNA and lipid nanoparticles to create CART cells to treat fibrosis.

Clinical Specialties:

Cardiovascular medicine, though no longer seeing patients.

Keywords: Nuclear architecture, Cardiac development, Neural crest, Transcription, Epigenetics, Stem cells, CAR T, Fibrosis, Hopx


Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

David Fajgenbaum, MD, MSC, MBA

Primary Department: Translational Medicine and Human Genetics

Faculty Rank: Assistant Professor

Degrees:

BS (Human Sciences With Distinction, Magna Cum Laude) Georgetown University, Washington, DC, 2007. MSc (Public Health) University Of Oxford, Oxford, UK, 2008. MD (Medicine) University Of Pennsylvania Perelman School Of Medicine, 2013. MBA (Health Care Management Program) Wharton School Of Business, University Of Pennsylvania, 2015.

Roles:

Founding Director, Center for Cytokine Storm Treatment & Laboratory (CSTL)

Associate Director, Patient Impact of the Penn Orphan Disease Center

Co-Founder/President of the Castleman Disease Collaborative Network (CDCN)

Research Interests:

1) Elucidating the etiology, dysregulated cell types, signaling pathways, and effector cytokines in idiopathic multicentric Castleman disease (iMCD) and related cytokine storm disorders
iMCD is a poorly-understood and deadly hematologic disorder. A proinflammatory cytokine storm and reactive lymphoproliferation occur for an unknown etiology. The poor understanding of etiology and pathogenesis has limited the development of effective treatments and contributed to the significant morbidity and mortality associated with iMCD (55-77% 5-year overall survival). Currently, we leverage a variety of techniques to study the etiology and pathogenesis of iMCD. In addition, we leverage a biobank (CastleBank) to collect samples to fuel our translational research.

2) Identifying effective treatments for iMCD patients
The poor understanding of iMCD pathogenesis has slowed the development of treatment approaches. Currently, there is only one FDA-approved treatment for iMCD, which is effective in approximately one-third or patients. We run an international Natural History Study of Castleman Disease (ACCELERATE) to collect in-depth data on patients around the world to identify effective treatment approaches currently being used off-label.

3) PI3K/Akt/mTOR signaling in iMCD
Proteomic, flow cytometric, and immunostaining studies revealed upregulation of Vascular Endothelial Growth Factor (VEGF), activated CD8+ T cells, and uncontrolled PI3K/Akt/mTOR signaling in iMCD. Whole genome sequencing of an iMCD patient and both parents revealed rare compound heterozygous missense mutations in both alleles of a negative regulator of T cell activation and a candidate etiological mechanism. These novel findings led to the first-ever use of sirolimus in iMCD and a prolonged remission for a refractory patient (manuscript in submission). Drawing upon the world's largest collection of iMCD patients and their biospecimens in ACCELERATE, we are employing whole genome sequencing, transcriptomics, proteomics, flow cytometry and phospho-flow, and cellular signaling assays to continue to elucidate the role of PI3K/Akt/mTOR signaling in iMCD. As there are no animal models, we are also performing extensive correlative studies to quantify changes in VEGF, T cell activation, PI3K/Akt/mTOR signaling, and other immunological markers following in vivo sirolimus administration to patients and documenting treatment efficacy.

4) Investigating the role of stromal cells and chemokines in iMCD
Quantification of 1,129 plasma proteins in iMCD revealed highly up-regulated acute phase reactants and chemokines. The chemokines that were most upregulated are essential for normal lymph node morphology/function and typically produced by lymph node stromal cells. The most up-regulated chemokine, CXCL13, is responsible for homing B cells into the germinal center. This is interesting, because the pathological hallmark of iMCD is dysmorphic lymph node germinal centers with either too few (atrophic) or too many B cells (hyperplastic). Immunohistochemistry confirmed significantly increased germinal center expression of CXCL13. We are exploring the mechanisms of lymph node stromal cell activation and chemokine signaling.

5) Methods for accelerating drug development and drug repurposing

I am looking for motivated MD, PhD, and MD/PhD students to join my lab to help advance understanding of mechanisms involved in hyperinflammation/cytokine storm and translate these findings into novel treatment approaches for cytokine storm disorders.

 

Keywords: Castleman disease, cytokine storm, drug repurposing, IL-6, PI3K/Akt/mTOR


Office Address:
3620 Hamilton Walk
214/215 Anatomy/Chemistry Building
Philadelphia, PA 19104
(215) 614-0936
Email
PSOM Faculty Listing

Unconscious Bias Trained

Grad Group Affiliations: IGG (Immunology Graduate Group)

Languages Spoken: English

Bruce D. Freedman, VMD, PhD

Primary Department: SVM - Pathobiology

Faculty Rank: Associate Professor

Degrees:

B.S. Dickinson College, 1980 M.S. Pennsylvania State University, 1983 V.M.D. University of Pennsylvania, 1987 Ph.D. University of Pennsylvania, 1992

Research Interests:

Calcium, Calcium channels, Calcium Signaling, Signal transduction in lymphocytes and macrophages, calcium dependent mechanisms of viral entry and egress in cells. Calcium regulation of gene expression in lymphocytes

Keywords: Cell Signaling, Signal transduction, B lymphocytes, T lymphocytes, NF-kB, Calcium signaling


Office Address:
368E Old Vet Bldg
3800 Spruce Street
Philadelphia PA, 19104
(215) 573-8218
Email

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), GTV (Gene Therapy and Vaccines), IGG (Immunology Graduate Group)

Languages Spoken: English

Marc V. Fuccillo, MD, PhD

Primary Department: Neurology

Faculty Rank: Assistant Professor

Degrees:

B.A. (Molecular and Cellular Biology, Music Performance (Violin)) Brown University, 1998. Ph.D. (Developmental Genetics) New York University School of Medicine, 2007. M.D. New York University School of Medicine, 2008.

Research Interests:

The synaptic and circuit mechanisms of behavioral control.

Keywords: Synaptic transmission, striatal circuits, inhibition, mouse genetics, in vitro electrophysiology, in vivo imaging, goal-directed behavior, motor control, neuropsychiatric disease modeling


Office Address:
415 Curie Blvd
Clinical Research Building
Room 226
Philadelphia, PA 19104
(215) 898-8744
Fuccillo Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Terence Gade, MD, PhD

Primary Department: Radiology

Faculty Rank: Assistant Professor

Clinical Specialties:

Interventional Radiology.

Keywords: image-guided interventions, molecular imaging, cancer biology


Office Address:
652 BRB II/III
421 Curie Blvd
Philadelphia, PA 19104
(215) 573-9756
Email
Pigi Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), CAMB (Cell and Molecular Biology)

Languages Spoken: English

James Gee, PhD

Primary Department: Radiology

Faculty Rank: Professor

Degrees:

B.S. (Electrical Engineering) University of Washington, 1987. B.S. (Computer Science) University of Washington, 1987. M.S. (Electrical Engineering) University of Washington, 1989. Ph.D. (Computer and Information Science) University of Pennsylvania, 1996.

Research Interests:

Dr. Gee's research interests are broadly in the field of biological and medical image analysis and computing. Toward this end, the group he directs, the Penn Image Computing and Science Laboratory (PICSL), conducts basic and applied research in mathematical, computational and statistical methods for extracting, analyzing and integrating information from imaging and ancillary data. Of particular interest to the lab are methods for detecting, quantifying and modeling the ways in which anatomy and physiology can vary in nature, over time, or as a consequence of disease or therapy. PICSL is well known internationally for its long track record of methodological innovation in nearly every area of the field, and for its commitment to translating research accomplishments into highly acclaimed open-source software that directly underpin hundreds of published imaging studies across the world every year. The group's large portfolio of interdisciplinary collaborations spans different model systems and the major modalities in biological and medical imaging of various organ systems in health and disease.

Keywords: Biological and medical image analysis and computing; Digital atlases; Computational anatomy; Open-source software


Office Address:
Richards Medical Research Laboratories, D067
3700 Hamilton Walk
Philadelphia PA, 19104
Email
Penn Image Computing & Science Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: AMCS (Applied Mathematics and Computational Science), BE (Bioengineering), CIS (Computer and Information Science)

Languages Spoken: English

Maria Neimark Geffen, PhD

Primary Department: Otorhinolaryngology

Faculty Rank: Associate Professor

Degrees:

A.B. (Molecular Biology) Princeton University, 2001. Ph.D. (Biophysics) Harvard University, 2006.

Research Interests:

Dr. Geffen is a leader in the field of auditory neuroscience. She is interested in the way the brain encodes information about the world and how our perception is shaped by our emotional state and experience. She combines computational and biological approaches to study the mechanisms behind dynamic auditory perception, memory and learning.

Dr. Geffen first became interested in systems neuroscience through her undergraduate thesis under mentorship of John Hopfield at Princeton University, in which she explored the mechanics of whisking in rats. She studied texture encoding in the somatosensory system with Christopher Moore at MIT during her first two years of graduate school at Harvard. She completed her Ph.D. in the laboratory of Markus Meister at Harvard University, where she discovered a novel retinal circuit for processing moving images. After her Ph.D., she was a fellow at the Center for Physics and Biology at Rockefeller University, where she worked under mentorship of Dr. Marcelo Magnasco, exploring the dynamics of natural sounds.

Dr. Geffen has been directing the Laboratory for Auditory Coding at the University of Pennsylvania since 2010. She was promoted to Associate Professor in 2018. Dr. Geffen's recent discoveries include: identifying a novel cell type that supports hearing of unexpected sounds; establishing the connection between emotional learning and sound perceptual acuity; and elucidating the neuronal code for representation of communication signals in the brain. Her scientific results are regularly published in well-recognized journals, including Nature Neuroscience, eLife and PLoS Biology. Her research accomplishments have been recognized with prestigious awards, including the Burroughs Wellcome Career Award at the Scientific Interface, the Klingenstein Foundation Award in Neurosciences, the Human Frontiers in Science Foundation Young Investigator Award, the Auditory Neurophysiology Young Investigator Spotlight Award and the Kaufman Foundation New Initiative Grant. Her research is supported by multiple grants from the NIH, including NIDCD and the BRAIN Initiative, as well as by private and international foundations. She serves as a permanent member on an NIH review panel, and has served as the general chair and workshop director for multiple national and international meetings. She currently serves as a co-director of the Cajal Course in Computational Neuroscience, and an organizer of the E.A.R.S. seminar series. Dr. Geffen is a dedicated mentor and her trainees have won the Brain Research Foundation Young Investigator Award, multiple Ruth L. Kirschstein National Research Service Awards from the NIH and the Saul Winegrad Award for Outstanding Dissertation.

Keywords: neuroscience, computational neuroscinece, auditory neuroscience, imaging, electrophysiology, auditory system, systems neuroscience


Office Address:
Stemmler Hall G14A
3460 Hamilton Walk
University of Pennsyvlania
Philadelphia, PA 19104
Email
Laboratory of Auditory Coding

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), NGG (Neuroscience Graduate Group), Psychology

Languages Spoken: English

Saar Gill, MD, PhD

Primary Department: Hematology/Oncology

Faculty Rank: Associate Professor

Degrees:

MBBS (Medicine) University Of Melbourne, 1999. PhD (Immunology) University Of Melbourne, 2011.

Research Interests:

Tumor Immunology; Chimeric Antigen Receptor T cells; Mouse Models of Human Leukemia; Murine Xenografts; Adoptive Cellular Therapy; Genetic Engineering of T cells; Flow Cytometry.

Clinical Specialties:

Hematology-oncology (leukemia, bone marrow transplantation and cell therapies).


Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Ethan Goldberg, MD, PhD

Primary Department: Neurology

Faculty Rank: Assistant Professor

Degrees:

B.A. (Neurobiology) Harvard University, 1999. Ph.D. (Physiology & Neuroscience) New York University School of Medicine, 2006. M.D. (Medicine) New York University School of Medicine, 2008.

Roles:

Pediatric neurology; neurogenetics.

Research Interests:

The lab studies mechanisms of cerebral cortex circuit function and circuit dysfunction in neurodevelopmental disorders towards the development of mechanistically-informed, targeted therapies. 

Keywords: Epilepsy; neurodevelopment; electrophysiology; ion channels; human neurogenetics.


Office Address:
The Children's Hospital of Philadelphia
Abramson Research Center
Room 502A
3615 Civic Center Boulevard
Philadelphia, PA 19104
(215) 590-6894
Email
Goldberg Neruo Lab

Unconscious Bias Trained

Grad Group Affiliations: NGG (Neuroscience Graduate Group)

Languages Spoken: English

Robert C. Gorman, MD

Primary Department: Surgery

Faculty Rank: Professor

Degrees:

B.S.Ch.E. (Chemical Engineering) Newark College Of Engineering, New Jersey Institute Of Technology, Newark, NJ , 1984. MD (Medicine) Robert Wood Johnson Medical School/University Of Medicine And Dentistry Of New Jersey, Piscataway, NJ, 1989.


Email
Gorman Cardiovascular Research Group

Mentor Training Completed

Grad Group Affiliations: BE (Bioengineering)

Languages Spoken: English

Roger A. Greenberg, MD, PhD

Primary Department: Cancer Biology

Faculty Rank: Professor

Degrees:

BA (Chemistry) Haverford College, 1991. Ph.D. (Microbiology And Immunology) Albert Einstein College Of Medicine, 2000. M.D. Albert Einstein College Of Medicine, 2000. Residency in Clinical Pathology, Brigham and Women's Hospital 2003.

Research Interests:

This laboratory is devoted to understanding basic mechanisms of DNA repair and their impact on genome integrity, cancer etiology and response to targeted therapies. To investigate these interrelationships, we are devoted to elucidating BRCA1- and BRCA2- dependent homologous recombination mechanisms in breast and ovarian cancer, telomere length maintenance mechanisms that rely on a specialized form of homologous recombination, and DNA damage induced activation of immune responses to cancer. We utilize a myriad of approaches to investigate these areas, which include biochemistry, structural biology, cell biology, and genetically engineered mouse models.

Keywords: BRCA1, BRCA2, DNA repair, Homologous Recombination, Telomeres, Epigenetics, Breast Cancer, Ovarian Cancer, cytokines, immune therapy.


Office Address:
BRB II/III, Rm 513
421 Curie Boulevard
Philadelphia PA, 19104
(215) 746-2738
Email

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology)

Languages Spoken: English

Elizabeth Grice, PhD

Primary Department: Dermatology

Faculty Rank: Associate Professor

Degrees:

B.A. (Biology) Luther College, 2001. Ph.D. (Human Genetics) Johns Hopkins University, 2006.

Research Interests:

Genomic and metagenomic approaches to understand cutaneous host-microbe interactions in health and disease.

Keywords: host-microbe interactions, skin microbiome, metagenomics, wound healing, chronic wounds


Office Address:
BRB II/III, Rm 1015
421 Curie Boulevard
Philadelphia PA, 19104
(215) 898-3179
Email
Grice Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology)

Languages Spoken: English

Malay Haldar, MD, PhD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Assistant Professor

Degrees:

MBBS (Medicine) B.J. Medical College, University Of Pune, Pune, Maharashtra, India, 2001. PhD (Human Genetics) University Of Utah, Salt Lake City, UT, 2007.

Clinical Specialties:

Molecular Diagnostics; Diagnostic Pathology.

Keywords: Tumor Immunology, Macrophage, Dendritic Cells, Monocytes, Sarcoma


Office Address:
BRB II/III, Rm 413
421 Curie Boulevard
Philadelphia PA, 19104
Email
Haldar Lab

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Scott D. Halpern, MD, PhD, MBe

Primary Department: Pulmonary, Allergy and Critical Care

Faculty Rank: Professor

Degrees:

B.S. (Psychology And Economics) Duke University, 1995. M.S.C.E. (Epidemiology) University Of Pennsylvania, 2001. Ph.D. (Epidemiology) University Of Pennsylvania, 2002. M.Be (Bioethics) University Of Pennsylvania, 2002. M.D. (Medicine) University Of Pennsylvania, 2003.

Clinical Specialties:

Critical care medicine.

Keywords: End-of-Life; Epidemiology; Health Services Research; Medical Ethics


Email
Palliative and Advanced Illness Research Center

Unconscious Bias Trained

Grad Group Affiliations: GGEB (Epidemiology and Biostatistics)

Languages Spoken: English

Kathryn Hamilton, PhD

Primary Department: Pediatrics

Faculty Rank: Assistant Professor

Degrees:

BA (Biology) Assumption College, 2003. PhD (Cell And Molecular Physiology) University Of North Carolina Chapel Hill, 2010.

Research Interests:

The gut epithelium acts as an arbiter between harmful substances in the external environment and the human body. Our laboratory specializes in understanding mechanisms regulating the gut epithelium in health and disease. We use in vivo models and mouse/human 3D enteroid and colonoid (organoid) lines to understand the molecular basis of intestinal regeneration and inflammatory bowel disease (IBD). Within these contexts, we are interested in how RNA binding proteins impart global, post-transcriptional regulation of key pathways in normal physiology and pathophysiology.

Keywords: gastrointestinal stem cell biology, epithelial regeneration, inflammatory bowel disease (IBD), organoid models of disease, in vivo models of disease, patient tissue-derived organoids


(267) 426-5266
Email
Hamilton Laboratory

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Roy Hamilton, MD, MS

Primary Department: Neurology

Faculty Rank: Associate Professor

Degrees:

B.A. (Psychology, magna cum laude) Harvard University, 1995. M.S. (Health Sciences and Technology) Massachusetts Institute of Technology , 2001. M.D. (Medicine, cum laude) Harvard Medical School, 2001.

Roles:

Assistant Dean for Cultural Affairs and Diversity, PSOM
Vice Chair for Inclusion and Diversity, Department of Neurology

Research Interests:

My research focus is on the characteristics and limits of functional neuroplasticity in the adult human brain. I investigate how the brain reorganizes itself in response to injury, and whether or not it is possible to enhance the brain's potential for reorganization in order to speed rehabilitation using noninvasive electrical or magnetic brain stimulation. A second area of interest for me is on the use of noninvasive brain stimulation to elucidate and enhance mechanisms of cognition in healthy individuals, and the biological, social, and ethical implications of neural enhancement.

The Laboratory for Cognition and Neural Stimulation (LCNS)

Clinical Specialties:

Cognitive and behavioral neurology.

Keywords: Transcranial Magnetic Stimulation, Aphasia, Transcranial Direct Current Stimulation, Cognitive Neuroscience, Neuromodulation


Office Address:
Goddard Laboratories, 518
3710 Hamilton Walk
Philadelphia, PA 19104
Email
brainSTIM

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: NGG (Neuroscience Graduate Group)

Languages Spoken: English

Ronald N. Harty, PhD

Primary Department: SVM - Pathobiology

Faculty Rank: Professor

Degrees:

BS (Biology) University of Lowell, Massachusetts, 1985 Ph.D. (Microbiology/Virology) Louisiana State University Medical Center, 1991 Postdoc (Virology) Mount Sinai School of Medicine, New York, 1993

Research Interests:

Antiviral immune responses, Ebola, Marburg, Rabies, VSV, Lassa Fever, Junin, Innate immunity, Innate Immune Defense, Virus-host interaction, Zoonotic diseases, Antiviral therapeutics

Keywords: Antiviral immune responses, Ebola, Marburg, Rabies, VSV, Lassa Fever, Junin, Innate immunity, Innate Immune Defense, Virus-host interaction, Zoonotic diseases, Antiviral therapeutics


Office Address:
School of Veterinary Medicine
3800 Spruce Street
University of Pennsylvania
Philadelphia, PA 19104
(215) 573-4485
PennVet Faculty Page

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Jorge Henao-Mejia, MD, PhD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Associate Professor

Degrees:

M.D. (Medicine) University Of Antioquia, Colombia, 2005. Ph.D. (Microbiology And Immunology) Indiana University, 2009.

Keywords: Immunology, gene expression, host metabolism


Office Address:
Biomedical Research Building II/III, Room 312
421 Curie Boulevard
Philadelphia PA, 19104
(215) 898-2212
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English, Spanish

Sarah Henrickson, MD, PhD

Primary Department: Pediatrics

Faculty Rank: Assistant Professor

Degrees:

AB in Biochemical Sciences Harvard University, 2001. PhD in Immunology Harvard Medical School, 2008. MD Harvard Medical School, 2011.

Research Interests:

Human Immunology; Immune Dysregulation; Mouse models of disease; Primary Immune Deficiency; Asthma; Obesity.

Clinical Specialties:

Allergy Immunology.

Keywords: Immune dysregulation, T cell function, chronic inflammation (obesity, asthma), primary immune deficiency


Office Address:
ARC Allergy Immunology
34th and Center Boulevard
Philadelphia Children's Hospital
Philadelphia, PA 19104-4399
Email
Henrickson Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

Scott E. Hensley, PhD

Primary Department: Microbiology

Faculty Rank: Professor

Degrees:

BA (Biology) University of Delaware, 2000. PhD (Cell and Molecular Biology) University of Pennsylvania, 2006.

Research Interests:

Influenza virus; SARS-CoV-2; antibodies; antigenic drift; vaccines.

Keywords: Influenza virus, SARS-CoV-2, antigenic drift, viral pathogenesis, viral receptors, antibody specificity, vaccines


Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

De'Broski R. Herbert, Ph

Primary Department: SVM - Pathobiology

Faculty Rank: Associate Professor

Degrees:

BS (Microbiology) Xavier University of Louisiana, 1994. PhD (Immunology) Thomas Jefferson University, 2000.

Research Interests:

Regulatory networks, Immunity, Inflammation, Tissue repair, Mucosal interface, Helminth infection, Lung and intestinal injury, Transgenic mice.

Keywords: Type 2 immunity, mucosal inflammation, parasite infection


Office Address:
3800 Spruce St.
Rm 367 OVQ Bldg.
School of Veterinary Medicine
Philadelphia, PA19130
(215) 898-9151
Email
Herbert Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: IGG (Immunology Graduate Group), MVP (Microbiology, Virology and Parasitology)

Languages Spoken: English

Robert O. Heuckeroth, MD, PhD

Primary Department: Pediatrics

Faculty Rank: Professor

Degrees:

B.S. (Chemistry, Summa Cum Laude With High Honors In Chemistry) University Of Maryland, 1983. Ph.D. (Biochemistry) Washington University School Of Medicine, St. Louis, 1990. M.D. Washington University School Of Medicine, St. Louis, 1990.

Research Interests:

We are interested in developing new ways to diagnose, treat and cure bowel motility disorders. Bowel motility is controlled by a complex nervous system within the bowel wall called the "enteric nervous system" (ENS), by pacemaker cells and by bowel smooth muscle among other cell types. Our work is a mixture of developmental biology, genetics, cell biology, biochemistry, stem cell biology, imaging, and includes translational studies focused on the ENS and smooth muscle. These reviews written by MSTP students in my lab are a good introduction to the field:

Hashmi SK, Ceron RH, Heuckeroth RO. (2021) Visceral myopathy: clinical syndromes, genetics, pathophysiology, and fall of the cytoskeleton. Am J Physiol Gastrointest Liver Physiol. 2021 Jun 1;320(6):G919-G935. doi: 10.1152/ajpgi.00066.2021. Epub 2021 Mar 17.
Schneider S, Wright CM, Heuckeroth RO. (2019) Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function. Annu Rev Physiol. 2019 Feb 10;81:235-259. doi: 10.1146/annurev-physiol-021317-121515. Epub 2018 Oct 31.

Clinical Specialties:

Pediatric gastroenterology with a focus on bowel motility disorders.

Keywords: Enteric nervous system, Hirschsprung disease, ACTG2, Visceral myopathy, Chronic intestinal pseudo-obstruction, Bowel motility disorders, Neural crest


Office Address:
Abramson Research Center, 1116i
3615 Civic Center Boulevard
Philadelphia, PA 19104
Email
Heuckeroth Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group)

Languages Spoken: English

David Hill, MD, PhD

Primary Department: Pediatrics

Faculty Rank: Assistant Professor

Degrees:

BS (Biological Sciences, With Honors) Carnegie Mellon University, 2005. PhD (Cell And Molecular Biology) Perelman School Of Medicine, University Of Pennsylvania, David Artis Lab, 2011. MD (Medicine) Perelman School Of Medicine, University Of Pennsylvania, 2013.

Roles:

Our research group seeks to understand how the immune system contributes to the two most common chronic diseases of childhood: allergy and obesity. We use clinical and epidemiological information to guide basic and translational research aimed at understanding the genetic, molecular, and immunologic basis of these diseases. By studying disease mechanisms in our lab, we are poised to lead the development of new preventative and therapeutic approaches for these important conditions.

Clinical Specialties:

Pediatric Allergy and Immunology.

Keywords: Allergy, Obesity, Obesity Associated Asthma, Food allergy


Office Address:
Abramson Pediatric Research Center, Room 1208B
3615 Civic Center Blvd.
Philadelphia, PA 19104
(267) 425-2124
Email
Hill Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

Blanca E. Himes, Ph.D.

Primary Department: Biostatistics and Epidemiology

Faculty Rank: Associate Professor

Degrees:

BS (Physics With Specialization In Computational Physics), University Of California, San Diego (UCSD),2001. PhD (Medical Physics And Bioinformatics), Massachusetts Institute Of Technology (MIT), 2007.

Research Interests:

My work has focused on using biomedical informatics approaches to study asthma and other pulmonary diseases. I began asthma genetics and pharmacogenetics research by participating in genome-wide association studies (GWAS) as a lead investigator and as part of large collaborations. Although promising loci were identified via these studies, I realized that translation of findings into insights that would have an impact on understanding disease pathophysiology was a difficult challenge that required novel research strategies. I have addressed this challenge by leveraging my background in biomedical informatics to generate novel genome-scale datasets and to integrate novel and publicly available datasets using creative approaches. Specifically, my lab has studied asthma and response to β2-agonists and glucocorticoids, commonly used asthma drugs, by obtaining and integrating omics-level data corresponding to in vitro and human studies. My lab also uses Electronic Health Record (EHR)-derived data to understand characteristics of real life populations with asthma and COPD, incorporating social, economic and environmental factor data obtained from secondary sources, and leveraging Biobank cohorts to perform genomics studies. I am the Director of the Exposure Biology Informatics Core of the Center of Excellence in Environmental Toxicology (CEET), where I lead efforts to analyze data and create informatics tools related to our environmental health studies.

Keywords: asthma, EHR, genomics


Office Address:
402 Blockley Hall
423 Guardian Dr
Philadelphia, PA 19104
(215) 573-3282
Email
Himes Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: GCB (Genomics and Computational Biology), GGEB (Epidemiology and Biostatistics)

Languages Spoken: English, Spanish

John Holmes, PhD, PhD, FACE, FACMI

Primary Department: Biostatistics and Epidemiology

Faculty Rank: Professor

Degrees:

A.B. (Sociology) University Of Pennsylvania, 1976. M.S. (Information Systems) Drexel University, 1987. Ph.D. (Information Science) Drexel University, 1996.

Research Interests:

Medical informatics; data mining; evolutionary computation; machine learning; artificial intelligence; database design and implementation for clinical research; medical decision making.

Keywords: Epidemiology, Injury, Social determinants of disease, Machine learning, Biomedical informatics (not bioinformatics), Agent-based modeling, Social network analysis


Office Address:
Blockley Hall, Rm 401
423 Guardian Drive
Philadelphia PA, 19104
(215) 898-4833
Email
DBEI Profile

Unconscious Bias Trained

Grad Group Affiliations: GCB (Genomics and Computational Biology), GGEB (Epidemiology and Biostatistics)

Languages Spoken: English, Italian

Erika L.F. Holzbaur, PhD

Primary Department: Physiology

Faculty Rank: Professor

Degrees:

B.S. (Chemistry/History) College Of William And Mary, 1982. Ph.D. (Biochemistry) Pennsylvania State University, 1987.

Research Interests:

Our lab studies the dynamics of organelle motility along the cellular cytoskeleton, driven by the microtubule motors cytoplasmic dynein and kinesin. We are interested in the mechanisms leading to coordinated motor activity, required  to drive organelle transport over distance of up to 1 meter in neuronal axons. We also investigate the cellular mechanisms leading to neurodegeneration, including the dynamics of autophagy and mitophagy in neurons. Our work was the first to identify a key role for optineurin in the clearance of damaged mitochondria via mitophagy, downstream of PINK1 kinase and the E3 ubiquitin ligase parkin. As mutations in optineurin and the associated kinase TBK1 cause familial ALS, and mutations in PINK1 and parkin cause familial Parkinson's disease, this discovery demonstrates that the failure to clear damaged mitochondria is likely to contribute to the pathogenesis observed in multiple forms of neurodegeneration, a hypothesis currently under investigation in our lab. Together, we have developed a significant record of contributions to neuronal cell biology, focusing on the cellular and biophysical analysis of molecular motors, the mechanistic analysis of organelle trafficking, the elucidation of pathways for autophagy and mitophagy in neurons, and an improved understanding of pathogenic mechanisms leading to neurodegenerative disease.

Keywords: Cytoplasmic dynein, dynactin, kinesin, microtubules, autophagy, mitophagy, neurodegeneration.


Office Address:
Department of Physiology
University of Pennsylvania Perelman School of Medicine
638A Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104-6085
(215) 573-3257
Email
Holzbaur Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Alex Hughes, PhD

Primary Department: SEAS - Bioengineering

Faculty Rank: Assistant Professor

Degrees:

BE (Chemical & Materials Engineering) University of Auckland, 2008. BSc (Pharmacology) University of Auckland, 2008. PhD (Bioengineering) University of California, Berkeley, 2013.

Research Interests:

Our lab works to bring developmental processes that operate in vertebrate embryos and regenerating organs under an engineering control framework, so that we can build better tissues. We study how cells conspire to create complex structures, so that we can build models of human disease, reconstituted tissues for regenerative medicine, and new types of biological machines.

Keywords: Developmental engineering, epithelial morphogenesis, microfluidics, mechanics of development, kidney organogenesis.


Email
Hughes Lab

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), CAMB (Cell and Molecular Biology)

Languages Spoken: English

Christopher Hunter, PhD

Primary Department: SVM - Pathobiology

Faculty Rank: Professor

Degrees:

B.Sc (Zoology, specializing in Parasitology) University of Glasgow, 1985 Ph.D. University of Glasgow, 1989

Research Interests:

Infectious Disease, Toxoplasma gondii, Zoonotic diseases, Host-pathogen interactions, Immunology, Parasites, Parasitology, Transgenic parasites, Inflammatory responses.

Keywords: Cytokine, infection, brain, inflammation, gut, T cells


(215) 573-7772
Email

Mentor Training Completed

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

David Issadore, PhD

Primary Department: SEAS - Bioengineering

Faculty Rank: Associate Professor

Degrees:

PhD (Applied Physics,) Harvard.

Research Interests:

Our lab combines microelectronics, microfluidics, nanomaterials, and machine learning to solve big problems in healthcare. We create miniaturized platforms for the diagnosis of disease, we develop new platforms to manufacture micro and nanomaterials, and we dip our toes into an assortment of other areas where we can leverage our engineering training to improve healthcare. This work requires an interdisciplinary approach in which engineers, scientists, and physicians work together to solve high impact problems in healthcare. 

Keywords: microfluidics, exosomes, medical diagnostics, microparticles, nanoparticles, drug formulations.


Office Address:
Hayden Hall, Rm 312
3320 Smith Walk
Philadelphia PA, 19104
issadore@seas.upenn.edu
Email
SEAS Profile

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), CBE (Chemical and Biomolecular Engineering), ESE (Electrical and Systems Engineering), MEAM (Mechanical Engineering and Applied Mechanics)

Languages Spoken: English

Rajan Jain, MD

Primary Department: Cardiovascular Medicine

Faculty Rank: Assistant Professor

Degrees:

BA (Molecular And Cellular Biology) University Of California, Berkeley, 2001. MD New York University School Of Medicine, 2005.

Research Interests:

We are interested in how genome organization shapes organogenesis.

Clinical Specialties:

Cardiology.

Keywords: Nuclear architecture, gene regulation, chromatin, epigenetics, 3D genome organization, heart development, stem cell biology


Office Address:
09-102 Smilow TRC
3400 Civic Center Blvd
Philadelphia, PA 19104
Email
Jain Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

F. Bradley Johnson, MD, PhD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Professor

Degrees:

B.S. (Molecular Biophysics & Biochemistry) Yale University , 1987. M.D. Stanford University School of Medicine, 1995. Ph.D. (Biochemistry) Stanford University School of Medicine , 1995.

Research Interests:

Molecular biology of aging, cell senescence, telomeres, dyskeratosis congenita, pulmonary fibrosis, colon cancer, neurodegeneration, transplantation.

Clinical Specialties:

Transplant Immunology (HLA and Histocompatibility)

Keywords: Aging, telomeres, cell senescence, dyskeratosis congenita, pulmonary fibrosis, colon cancer, neurodegeneration, transplantation.


Office Address:
Stellar-Chance Laboratories, 405A
422 Curie Blvd
Philadelphia, PA 19104-6100
(610) 906-4198
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology)

Languages Spoken: English

Michelle Johnson, PhD

Primary Department: Physical Medicine and Rehabilitation, SEAS - Bioengineering

Faculty Rank: Associate Professor

Degrees:

BS (Mechanical Engineering And Applied Mechanics) University Of Pennsylvania, 1990. MS (Mechanical Engineering (Emphasis In Robot Mechanical System) University Of California, Irvine, 1994. PhD (Mechanical Engineering (Emphasis In Robotics, Design, Controls And Mechatronics) Stanford University, 2002.

Research Interests:

My research is mainly in the area of robot-mediated rehabilitation. I am focused on the investigation and rehabilitation of dysfunction due to aging, neural disease, and neural injury. I am particularly interested in 1) exploring the relationships between brain plasticity and behavioral/motor control using robotics; 2) quantifying motor/cognitive impairment effects on motor control of the upper limb in real world tasks; 3) defining methods to maintain therapeutic effectiveness while administering local and remote, robot-mediated interventions in high and low resource settings; 4) global and affordable technology-mediated interventions after brain injury.

GRASP Lab Faculty Page

Keywords: Robotics, stroke rehabilitation, brain injury and recovery, HIV, motor and cognitive impairment, upper limb


(215) 893-2665
Email
The Rehabilitation Robotics Lab

Unconscious Bias Trained

Grad Group Affiliations: NGG (Neuroscience Graduate Group)

Languages Spoken: English

Eric Joyce, PhD

Primary Department: Genetics

Faculty Rank: Assistant Professor

Degrees:

B.A. (Genetics And Microbiology) Rutgers University, 2004. Ph.D. (Microbiology And Molecular Genetics) Rutgers University, 2010.

Research Interests:

The Joyce lab studies how chromosomes are functionally organized and folded in 3-D space and time. Our primary goal is to understand how the structure and position of chromosomes within the nucleus is established and inherited across cell divisions, and how dysfunctional organization contributes to genome instability. To this end, we develop and utilize technologies to visualize chromosomes and subchromosomal regions at single-cell resolution and in a high-throughput fashion. Our research takes advantage of both Drosophila and mammalian systems as models for chromosome function, which allows us to directly address the conservation and health relatedness of the mechanisms we discover.


Office Address:
Clinical Research Building, Rm 564
415 Curie Boulevard
Philadelphia PA, 19104
Email
Eric Joyce Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology)

Languages Spoken: English

Kellie Jurado, PhD

Primary Department: Microbiology

Faculty Rank: Assistant Professor

Degrees:

B.S. (Biology, Microbiology) New Mexico State University, 2011. Ph.D. (Medical Sciences) Harvard University, 2015.

Research Interests:

Our research group focuses on delineating disease pathogenesis of emerging viruses in order to uncover mechanisms of immune control. We primarily focus on emerging viral pathogens that present with unknown mechanisms of disease in the nervous system or placenta. Both regions of infection have interfaces (maternal-fetal and blood-brain) that provide extra protection to an essential organ or allogenic fetus. These interfaces necessitate a delicate balance of initiating an effective antiviral response while also ensuring that there is limited damage and tolerance is maintained. In order to achieve this balance, immune responses in these regions have evolved intricate layers of distinct control which are only now beginning to be fully appreciated.


Email
Jurado Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

Michael J. Kahana, PhD

Primary Department: SAS - Psychology

Faculty Rank: Professor

Degrees:

BA, Case Western Reserve University. Ph.D., Psychology, University of Toronto

Roles:

Edmund J. and Louise W. Kahn Term Professor of Psychology

Research Interests:

Memory, learning, neuromodulation.

Keywords: Behavioral Neuroscience; Cognitive Neuroscience; Memory and Learning


Email
Computational Memory Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: NGG (Neuroscience Graduate Group)

Languages Spoken: English

Mark L. Kahn, MD

Primary Department: Cardiovascular Medicine

Faculty Rank: Professor

Degrees:

B.A. (Biology) Brown University, 1984. M.D. (Medicine) Brown University School of Medicine, 1987.

Research Interests:

The Kahn Lab investigates signaling pathways in endothelial cells and other cell types in the cardiovascular system. We investigate mechanisms of disease related to both the blood and lymphatic vascular networks as well as those connecting vascular biology and thrombosis.

Keywords: vascular biology, cardiovascular disease, vascular signaling pathways


Office Address:
Smilow Center for Translational Research, 11-123
3400 Civic Center Blvd
Philadelphia PA 19104
(215) 898-9007
Email
Kahn Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English, Italian

Taku Kambayashi, MD, PhD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Associate Professor

Degrees:

B.S. (Biomedical Engineering), Johns Hopkins University, Baltimore, MD, 1993 Ph.D. (Immunology), Emory University, Atlanta, GA, 2002 M.D. (Medicine), Emory University, Atlanta, GA, 2004.

Research Interests:

Regulation of T cell responses; regulatory T cell expansion and homeostasis; Regulation of skin barrier function; cell signaling.

Clinical Specialties:

Transfusion Medicine

Keywords: CD8+ T cells, CD4+ T cells, Regulatory T cells, NK cells, Signal Transduction, Cellular Immunology, Antigen Presentation


Office Address:
John Morgan Building, Rm 288
3620 Hamilton Walk
Philadelphia PA, 19104
(610) 850-4152
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: IGG (Immunology Graduate Group)

Languages Spoken: English, Japanese

Matthew Kayser, MD, PhD

Primary Department: Psychiatry

Faculty Rank: Assistant Professor

Degrees:

ScB (Neuroscience) Brown University, 2000. MD, PhD (Neuroscience) University of Pennsylvania School of Medicine, 2009.

Research Interests:

We study how neural circuits give rise to complex behaviors, and how dysfunction of neural processes can cause mental illness. Our particular focus is in understanding how sleep -- a highly conserved behavior whose core function remains a mystery -- contributes to sculpting brain circuits during development and in other times of life.

Clinical Specialties:

Psychiatry; sleep mental health

Keywords: sleep, synapse, development, drosophila, psychiatry, behavior


Office Address:
Clinical Research Building, Rm 320
415 Curie Boulevard
Philadelphia PA, 19104
Email
Kasyer Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Max B. Kelz, MD, PhD

Primary Department: Anesthesia

Faculty Rank: Professor

Degrees:

MS (Molecular Biophysics And Biochemistry) Yale University, 1993. BS (Molecular Biophysics And Biochemistry) Yale University, 1993. PhD (Neuroscience) Yale University, 1999. MD (Medicine) Yale University, 2000.

Research Interests:

Molecular Mechanisms of Anesthetic Action; Neurobiology of Sleep; Wake Regulation; Mouse Genetics; Molecular Biology; Anesthetic pharmacology.

Keywords: Sleep, Impaired Arousal, Sedation, Hypnosis, Hypothalamic Neurobiology


Office Address:
John Morgan Building, Rm 334
3620 Hamilton Walk
Philadelphia PA, 19104
(215) 573-8208
Email
Kelz Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), NGG (Neuroscience Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Peter S. Klein, MD, PhD

Primary Department: Hematology/Oncology

Faculty Rank: Professor

Degrees:

B.A. (Biochemistry) Harvard College, 1980. M.D. (Medicine) Johns Hopkins University School of Medicine, 1988. Ph.D. (Biological Chemistry) Johns Hopkins University School of Medicine, 1988.

Research Interests:

Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neural stem cells and neurogenesis, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3).

Clinical Specialties:

Hematology

Keywords: Wnt, embryo, signaling, signal transduction, developmental biology, lithium, chromatin, epigenetic, hematopoiesis, stem cell, GSK-3, mTOR, behavior, affective disorders.


Office Address:
Smilow Center for Translational Research, 9-103
3400 Civic Center Boulevard
Philadelphia PA, 19104
(215) 898-2179

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Rahul M. Kohli, MD, PhD

Primary Department: Infectious Diseases

Faculty Rank: Associate Professor

Degrees:

B.S. (Biochemistry) University Of Michigan, 1998. M.D. Harvard Medical School, 2004. Ph.D. (Biochem & Mol Pharm) Harvard Medical School, 2004.

Research Interests:

Our laboratory focuses on the DNA modifying enzymes that provide an added layer of complexity to the genome. These enzymes can be involved in the purposeful introduction of mutations or in the chemical modification of nucleobases, making DNA a remarkably dynamic entity. Many of these processes are at the heart of the battle between the immune system and pathogens or are central to epigenetics.

Our research program aims to understand diversity generating enzymes and pathways in vitro, to perturb their function in physiological settings, and to harness the biotechnological potential of these diversity-generating pathways.

Keywords: Genome Engineering, Epigenetics, DNA modification, Antibiotic Resistance, Bacterial Pathogens


Office Address:
Johnson Pavilion, Rm 502B
3610 Hamilton Walk
Philadelphia PA, 19104
(215) 573-7523
Email
Kohli Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Mitchell A. Lazar, MD, PhD

Primary Department: Endocrinology, Diabetes & Metabolism

Faculty Rank: Professor

Degrees:

S.B. (Chemistry) Massachusetts Institute Of Technology, 1976. Ph.D. (Neuroscience) Stanford Univerity, 1981. M.D. Stanford Univerity, 1982.

Research Interests:

Epigenomic regulation of transcription and metabolism by nuclear receptors; mechanism of obesity-associated insulin resistance and diabetes; circadian regulation of metabolism.

Keywords: diabetes, endocrinology, epigenomics, nuclear receptors, circadian rhythms


Office Address:
Institute for Diabetes, Obesity, and Metabolism
University of Pennsylvania Perelman School of Medicine
12-102 Smilow Center for Translational Research
3400 Civic Center Boulevard
Philadelphia, PA 19104 USA

(215) 898-0198
Email
Lazar Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Edward B. Lee, MD, PhD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Associate Professor

Degrees:

BS (Biological Sciences), Stanford University, 1997. PhD (Neuroscience), University of Pennsylvania School of Medicine, 2004. MD University of Pennsylvania School of Medicine, 2005.

Research Interests:

Alzheimer's disease, Frontotemporal lobar degeneration, Amyotrophic lateral sclerosis.

Clinical Specialties:

Neuropathology

Keywords: Neurodegenerative Disease, Frontotemporal Dementia, Alzheimer's Disease, Tau, TDP-43, VCP


Office Address:
Stellar-Chance Laboratories, Rm 613A
422 Curie Blvd
Philadelphia, PA 19104
(215) 898-0908
Email
Translational Neuropathology Research Laboratory

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Christopher Lengner, PhD

Primary Department: SVM - Biomedical Science

Faculty Rank: Associate Professor

Degrees:

B.S. (Biotechnology) Worcester Polytechnic Institute, 1998. Ph.D. (Cell and Molecular Biology) University of Massachusetts Medical School, 2004

Research Interests:

Intestinal epithelial stem cell biology and tissue regeneration, Colorectal cancer initiation, progression, and metastasis, organoid models of human telomere disorders, genetic tool development (evolving barcode systems, CRISPR-Cas9 forward genetic screening, mouse genetic models).

Keywords: Cancer, stem cells, lineage tracing, CRISPR-Cas9, mouse genetics, organoids.


Office Address:
School of Veterinary Medicine
Rosenthal 390EA
3800 Spruce Street
(215) 746-8425
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Michael Z. Levy, PhD

Primary Department: Biostatistics and Epidemiology

Faculty Rank: Associate Professor

Degrees:

B.A. (Interdisciplinary Major (Philosophy And Biology)) Amherst College, 1998. PhD (Population Biology, Ecology And Evolution) Emory University, 2007.

Research Interests:

I study insects and human health.

Keywords: Chagas disease, vector control, disease ecology, insect declines


Office Address:
Blockley Hall, Rm 714
423 Guardian Drive
Philadelphia PA, 19104
(215) 746-8131
Email
UPENN- UPCH Zoonotic Disease Research Center

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: Biology, GCB (Genomics and Computational Biology), GGEB (Epidemiology and Biostatistics)

Languages Spoken: English, Spanish

Mingyao Li, PhD

Primary Department: Biostatistics and Epidemiology

Faculty Rank: Professor

Degrees:

B.S. (Mathematics) Nankai University, China, 1996. M.S. (Mathematics) Nankai University, China, 1999. M.S. (Biostatistics) University Of Michigan, Ann Arbor, 2002. Ph.D. (Biostatistics) University Of Michigan, Ann Arbor, 2005.

Research Interests:

Identification of disease genes for human diseases; Development of statistical and computational methods for genomics data

Keywords: single-cell genomics, spatial transcriptomics, spatial metabolomics, digital pathology


Office Address:
Blockley Hall, Rm 213
423 Guardian Drive
Philadelphia, PA 19104
Email
Laboratory for Statistical and Translational Genomics

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: GCB (Genomics and Computational Biology), GGEB (Epidemiology and Biostatistics)

Languages Spoken: English

Brian Litt, MD

Primary Department: Neurology, SEAS - Bioengineering

Faculty Rank: Professor

Degrees:

A.B. Harvard University Cum Laude, Engineering And Applied Sciences, 1982. M.D. Johns Hopkins University School Of Medicine, 1986.

Research Interests:

Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Brain Stimulation, Implantable devices, network neuroscience, deep brain stimulation, functional imaging, neuroengineering, Biomedical engineering, computational neuroscience.

Clinical Specialties:

Neurology and epilepsy

Keywords: Epilepsy, EEG, Neuroengineering, Brain-Computer Interface, Neuroimaging, Neurodevices, neurosurgery, neurology


Office Address:
Hayden Hall, Rm 301
University of Pennsylvania
240 South 33rd Street
Philadelphia, PA 19104
(215) 746-4850
Email
Litt Lab

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), NGG (Neuroscience Graduate Group)

Languages Spoken: English, French, Hebrew

Vincent Lo Re, MD, MSCE

Primary Department: Infectious Diseases

Faculty Rank: Assistant Professor

Degrees:

B.S. (Chemistry) Georgetown University, 1992. M.D. (Medicine) University Of Pennsylvania, 1997. M.S.C.E. (Pharmacoepidemiology) University Of Pennsylvania, 2005.

Research Interests:

  • Hepatic and non-hepatic outcomes of chronic hepatitis B and C, particularly among patients with HIV infection
  • Adherence to hepatitis C virus therapy
  • Hepatotoxicity of medications
  • Evaluation of clinical outcomes
  • Population-based and administrative databases 

 

Clinical Specialties:

Hepatitis B, hepatitis C, hepatitis delta, HIV/viral hepatitis coinfection

Keywords: HIV/viral hepatitis coinfection; hepatitis B; hepatitis C; HIV/AIDS; epidemiology; clinical outcomes; pharmacoepidemiology


Office Address:
Blockley Hall, Rm 836
423 Guardian Drive
Philadelphia, PA 19104
(215) 573-5964
Email
Lo Re Research Group

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: GGEB (Epidemiology and Biostatistics)

Languages Spoken: English

Wenqin Luo, MD, PhD

Primary Department: Neuroscience

Faculty Rank: Associate Professor

Degrees:

MD (Medicine) Hunan Medical University, 1996. MS (Molecular Biology And Biochemistry) Peking Union Medical College, 1999. PhD (Neuroscience) Johns Hopkins University School Of Medicine, 2005.

Research Interests:

Development and Function of Mammalian somatosensory system, pathological pain and itch conditions

Keywords: Development, Function, Touch Sensation, pain, itch, DRG, brain, Mouse Genetics, human tissue


Office Address:
Johnson Pavilion, Rm 146
3610 Hamilton Walk
Philadelphia PA, 19104
(215) 573-7281
Email
Luo Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Minghong Ma, PhD

Primary Department:

Faculty Rank: Professor

Degrees:

B.S. in Biophysics, Peking University, 1988. M.S. in Biophysics, Chinese Academy of Sciences, 1991. Ph.D. in Neurobiology and Behavior, Columbia University, 1997.

Research Interests:

We are interested in how the brain perceives external sensory information and responds appropriately using the mouse olfactory system as a model. Rodents primarily use olfactory cues to guide their behaviors (e.g., locating food, communicating with conspecifics, and avoiding danger). Odor detection relies on a large family (~1200 in mice) of G-protein coupled odorant receptors (ORs) expressed in olfactory sensory neurons (OSNs) in the nose. OSNs transmit sensory information to the olfactory bulb, which relays the information to several olfactory cortical and subcortical regions. Some OSNs serve dual functions as odor detectors and mechanical sensors, thus the olfactory system carries both odor and nasal breathing signals into the brain. Our current investigation focuses on how the olfactory system interacts with non-olfactory regions (e.g., the prefrontal cortex and striatum) to influence the brain activity and behavioral output. Since olfactory dysfunction is manifested in neuropsychiatric and neurodegenerative disorders, we are also interested in analyzing the olfactory system and related circuits in diseased states.

Keywords: Sensory and behavioral neuroscience, neural circuits, respiration, brain rhythms, and olfaction


Email
Minghong Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Ivan Maillard, MD, PhD

Primary Department: Hematology/Oncology

Faculty Rank: Professor

Degrees:

BA, Gymnase De Chamblandes, 1986. MD (Medicine), University Of Lausanne And Zurich, 1993. MD-PhD (Medicine) Swiss Academy Of Medical Sciences, 1997.

Research Interests:

My laboratory investigates the regulation of normal and malignant hematopoiesis, bone marrow transplantation and T cell alloimmunity. A central focus of our studies is the role of Notch signaling in T cell development, differentiation and function, as well as in other aspects of hematopoiesis and lymphoid homeostasis. Using mouse models of bone marrow transplantation, we discovered essential functions for Notch receptors and ligands in graft-versus-host disease with a high fundamental and translational impact. We also identified specialized stromal niches that represent the critical sources of Notch ligands in secondary lymphoid organs. 

Clinical Specialties:

Hematology/Oncology

Keywords: Hematopoiesis, bone marrow transplantation, T cell immunology, B cell immunology, Notch signaling.


Office Address:
BRB II/III, Rm 451
421 Curie Blvd
Philadelphia, PA 19104
(215) 746-2929
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English, French, German, Portuguese

Nicola Mason, BVetMed, DACVIM PhD

Primary Department: SVM - Clinical Sciences & Advanced Medicine

Faculty Rank: Professor

Degrees:

BVetMed (Veterinary Medicine ) University of London , 1992. PhD (Immunology) University of Pennsylvania , 2004.

Research Interests:

Chimeric Antigen Receptor T cells, Chimeric Auto-Antigen Receptor T cells, Adoptive Cell Therapies, Listeria based vaccines, Canine hematopoietic cancers, Canine osteosarcoma, Canine Urothelial Carcinoma, Canine Soft Tissue Sarcomas.

Keywords: Spontaneous models of cancer, Adoptive cell therapies, Chimeric antigen receptor T cells, Allogeneic and xenogenic CAR-T cells, Clinical trials in pet dogs with spontaneous cancer


(215) 898-3996
Email
PennVet Faculty Page

Mentor Training Completed

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

Robert L. Mauck, PhD

Primary Department: Orthopaedic Surgery

Faculty Rank: Professor

Degrees:

B.A. (Biochemistry) Columbia University, 1998. B.S. (Biomedical Engineering) Columbia University, 1998. MS (Biomedical Engineering) Columbia University, 2000. Ph.D. (Biomedical Engineering) Columbia University, 2003.

Research Interests:

The goals of our research program in soft tissue mechanobiology and tissue engineering are to understand the physiologic and patho-physiologic processes that regulate the formation, maturation, and adult function of soft connective tissues.  We believe that such an understanding will better direct our efforts to generate functional tissue replacements and regenerative strategies, with a particular focus on articular cartilage and the knee meniscus. Our program utilizes various mechanical and biological testing modalities, scaffold fabrication techniques, and bioreactor culture conditions to explore these issues in both animal and human model systems.

Keywords: Regenerative Medicine, Musculoskeletal Biology and Bioengineering, Stem Cells, Biomaterials


Office Address:
Stemmler Hall, Rm 308A
3450 Hamilton Walk
Philadelphia PA, 19104
Email
Mauck Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), CAMB (Cell and Molecular Biology)

Languages Spoken: English

Kara N. Maxwell, MD, PhD

Primary Department: Hematology/Oncology

Faculty Rank: Assistant Professor

Degrees:

BS (Genetics, Biochemistry) University Of Wisconsin-Madison, 1998. PhD (Molecular And Cellular Biology) Rockefeller University, 2006. MD (Medicine) Weill Cornell Medical College, 2007.

Research Interests:

I am a Medical Oncologist with postdoctoral training in Cancer Genetics and PhD training in molecular and cellular biology. My research interests are in the genetics of human disease, particularly familial breast and prostate cancers, and in determinants of disease penetrance.

Clinical Specialties:

Medical Oncology

Keywords: Cancer genetics, cancer genomics, Li Fraumeni Syndrome, TP53, inherited cancer syndromes, bioinformatics, sequencing


Email
Maxwell Lab

Mentor Training Completed

Grad Group Affiliations: CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology)

Languages Spoken: English

Michael J. May, PhD

Primary Department: SVM - Biomedical Science

Faculty Rank: Associate Professor

Degrees:

B. Sc. (Immunology) University of Glasgow, UK, 1988. M.Sc. (Immunology) University of Manchester, UK, 1992. Ph.D. (Vascular Biology) King's College London, UK., 1996.

Research Interests:

NF-kB signaling in immunity and inflammation with a primary focus on the role of this pathway in controlling the phenotype and function of vascular and lymphatic endothelial cells. 

Keywords: Inflammation, Signaling, NF-kB, Lymphatics, Lymph Nodes, vascular biology


Office Address:
School of Veterinary Medicine, OVH200E
3800 Spruce Street
Philadelphia, PA 19104
(215) 573-0940
Email
PennVet Faculty Page

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

Michael C. Milone, MD, PhD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Associate Professor

Degrees:

B.S (Chemical Biology) Stevens Institute Of Technology, 1993. M.D. (Medical Doctor) UMDNJ- New Jersey Medical School, 1999. Ph.D (Experimental Pathology/ Immunology) UMDNJ - Graduate School Of Biomedical Sciences, 1999.

Research Interests:

Research in my laboratory is focused on T cell biology and applications of genetically-engineered T cells to the treatment of disease.

Clinical Specialties:

Clinical Pathology

Keywords: T cells, immunology, cancer, gene therapy


Office Address:
Perelman Center for Advanced Medicine, SPE 8-101
3400 Spruce Street
Philadelphia, PA 19104
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Jonathan J. Miner, MD, PhD

Primary Department: Medicine

Faculty Rank: Associate Professor

Degrees:

B.S. (Zoology) BYU, 2002. B.A. (Russian) BYU, 2002. Ph.D. (Biochemistry and Molecular Biology) University of Oklahoma, 2008. M.D. (Medicine) University of Oklahoma, 2010.

Research Interests:

The Miner laboratory studies the intersection of autoimmunity and antiviral immunity. This includes studies of rare rheumatic diseases caused by mutations in genes that regulate immune responses to viruses, such as the TREX1, cGAS, STING, RIG-I, and STAT1 genes. The Miner laboratory is also developing novel therapeutics for rare diseases, and is conducting whole-genome CRISPR/Cas9 screens to discover novel regulators of these pathways.


Email
Miner Lab

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Guo-li Ming, MD, PhD

Primary Department:

Faculty Rank: Professor

Degrees:

M.D. (Medicine (OBGYN)) Tongji Medical University, P. R. China, 1994. Ph.D. (Biology) University Of California At San Diego, California, 2002.

Research Interests:

Neurobiology of mental disorders Neural development human induced pluripotent stem cells cell signalling cell and molecular biology.

Keywords: human iPSCs, Neurodevelopment, Psychiatric disorders. brain organoids


Office Address:
Clinical Research Building, 111A
415 Curie Boulevard
Philadelphia PA, 19104
(215) 746-6686
Email
Ming Lab

Unconscious Bias Trained

Grad Group Affiliations: NGG (Neuroscience Graduate Group)

Languages Spoken: Chinese, English

Ed Morrisey, PhD

Primary Department: Cardiovascular Medicine

Faculty Rank: Professor

Degrees:

B.S. (Microbiology) University Of Illinois Urbana-Champaign, 1986. Ph.D. (Molecular Biology) Northwestern University, Evanston, IL, 1994.

Research Interests:

The Morrisey Lab is comprised of a group of researchers dedicated to investigating cell fate decisions that occur in the lung during development, tissue homeostasis, and regeneration. We utilize cutting edge technologies including sing cell -omics, novel transgenic mouse models, advanced imaging techniques, and custom bioinformatics platforms to expand our understanding of how the respiratory system responds to acute and chronic disease and injury.

Our lab is composed of a highly collaborative team of graduate students, postdocs, physician-scientists, technicians, staff scientists, and a bioinformatics team.  Former Morrisey lab trainees are emerging as the next generation of leaders in pulmonary research and medicine. We invite you to view our webpage and learn more about us.

Keywords: Lung regeneration, lung development, organoid, tissue repair


Office Address:
Smilow Center for Translational Research, Rm 11-124
3400 Civic Center Boulevard
Philadelphia, PA 19104-5129
(215) 573-3010
Email
Morrisey Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Ilya Nasrallah, MD, PhD

Primary Department: Radiology

Faculty Rank: Assistant Professor

Degrees:

BA Cornell University, 1998. PhD University Of Pennsylvania, 2004. MD University Of Pennsylvania, 2005.

Research Interests:

Development of new PET radiotracers for neurodegenerative disease and neuroinflammation.
Application of quantitative neuroimaging and pattern analysis/machine learning methods to multi site neuroimaging studies to understand mechanisms and phenotypes of brain aging and neurodegenerative disease.
 

Clinical Specialties:

Radiology and Nuclear Medicine

Keywords: Molecular imaging, PET, MRI, quantitative neuroimaging, machine learning, neurodegenerative disease, Alzheimer's disease, cerebrovascular disease


Office Address:
Hospital of the University of Pennsylvania
Donner Building, Rm 1023
3400 Spruce Street
Philadelphia PA, 19104
Email
MIND Lab

Grad Group Affiliations: BE (Bioengineering)

Languages Spoken: English

Audrey R. Odom John, MD, PhD

Primary Department: Pediatrics

Faculty Rank: Associate Professor

Degrees:

BS (Major Biology/Minor Chemistry), Duke University, 1996. PhD (Biochemistry), Duke University School Of Medicine, 2002. MD, Duke University School Of Medicine, 2003.

Roles:

Chief of Infectious Diseases at CHOP; Penn MSTP, Steering and admissions committees; Co-advisor for AWSM (association of women student MD-PhDs)

Research Interests:

Dr. Odom John studies the malaria parasite, Plasmodium falciparum, to understand its basic molecular and cellular biology and functions of its specific metabolic pathways--what the parasite needs to make and why it needs to make it--to identify new antimalarial drug targets and develop new diagnostics. More recently, our work has expanded into new "breathalyzer" diagnostics for pediatric SARS-CoV-2 and the post-coronavirus syndrome MIS-C.

Clinical Specialties:

Pediatric Infectious Diseases.

Keywords: Microbiology, malaria, Plasmodium, parasitology, SARS-CoV-2, metabolism, drug discovery, diagnostics, breathprinting


Office Address:
Clinical and Translational Research Center, Rm 10006
3400 Civic Center Blvd
Philadelphia, PA 19104
(215) 590-2457
Email
John Laboratory

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), MVP (Microbiology, Virology and Parasitology)

Languages Spoken: English

Paula M. Oliver, PhD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Associate Professor

Degrees:

BS (Zoology), North Carolina State University, 1989 PhD (Pathology), University of North Carolina at Chapel Hill, 1998

Research Interests:

Our focus is on defining new mechanisms that regulate immune cell activation and protective immune responses. Our goal is to use this information to design therapies with which to treat the immune-mediated pathologies found in autoimmune and allergic disease. 

Keywords: Immune cell function, autoimmune disease, allergy, ubiquitin biology


Office Address:
Children's Hospital of Philadelphia
816F ARC, 3615 Civic Center Blvd.
Philadelphia, PA 19104
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

Jennifer L. Orthmann Murphy, MD, PhD

Primary Department: Neurology

Faculty Rank: Assistant Professor

Degrees:

B.A. (Biological Basis Of Behavior With Distinction (History Minor)) University Of Pennsylvania, 2001. Ph.D. (Neuroscience) University Of Pennsylvania Perelman School Of Medicine, 2007. M.D. (Combined Degree Program) University Of Pennsylvania Perelman School Of Medicine, 2010.

Research Interests:

The Orthmann-Murphy laboratory studies the dynamic role of glial cells in acquired and inherited demyelinating disease.

Keywords: Glia, myelin, multiple sclerosis, demyelination, remyelination


Email

Mentor Training Completed

Grad Group Affiliations: NGG (Neuroscience Graduate Group)

Languages Spoken: English

Xilma Ortiz-Gonzalez, MD, PhD

Primary Department: Neurology

Faculty Rank: Assistant Professor

Degrees:

BS (Chemistry) University of Puerto Rico, Cayey, 1997. PhD (Neuroscience) University of Minnesota, 2004. MD (Medicine) Univeristy of Minnesota Medical School, Minneapolis, 2006.

Research Interests:

The Ortiz-Gonzalez lab is interested in pediatric neurodegenerative disorders and how these rare genetic disorders inform our knowledge of neurobiology and pathways critical for maintaining brain health. We focus on the role mitochondrial dysfunction in neurodegenerative phenotypes.

Clinical Specialties:

Pediatric Neurogenetics.

Keywords: Mitochondria, induced pluripotent stem cells, pediatric neurodegeneration


Email
Ortiz-Gonzalez Laboratory

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group)

Languages Spoken: English, Portuguese, Spanish

Michael Parmacek, MD

Primary Department: Cardiovascular Medicine

Faculty Rank: Professor

Degrees:

B.S. (Biology/Psychology) Tufts University, 1977. M.D. Northwestern University Medical School, 1981.

Research Interests:

Transcriptional programs that regulate cardiovascular development.

Clinical Specialties:

Cardiology

Keywords: Smooth muscle cell, cardiac myocyte, GATA, myocardin, transcription, notch


Office Address:
PCAM South Pavilion, Rm 6-631
3400 Civic Center Blvd.
Philadelphia, PA 19104
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Aimee S. Payne, MD, PhD

Primary Department: Dermatology

Faculty Rank: Professor

Degrees:

BS (Biology) Stanford University, 1993. MD, PhD (Molecular And Cellular Biology) Washington University School Of Medicine, 2001.

Research Interests:

Genetic and functional characterization of human anti-desmoglein B cell repertoires; Precision cellular immunotherapies for pemphigus and other autoantibody-mediated diseases.

Keywords: Autoimmunity, human immunology, CAR T cells, cell therapy, precision medicine, cell adhesion, dermatology, skin, B cell


Office Address:
Biomedical Research Building, Rm 1009
421 Curie Boulevard
Philadelphia, PA 19104
Email
Payne Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

Adriana Petryna, PhD

Primary Department: SAS - Anthropology

Faculty Rank: Professor

Degrees:

Ph.D. Anthropology, University of California, Berkeley; M.A. Anthropology & M.Arch., University of California, Berkeley; B.S. Architecture, University of Michigan, Ann Arbor.

Research Interests:

Adriana Petryna is Professor in Anthropology at the University of Pennsylvania. She directs the MD-PhD program in Anthropology and the undergraduate concentration in Medical Anthropology and Global Health. In her ethnographic studies in Eastern Europe and the United States, she probes the socio-political nature of science, how populations are enrolled in experimental knowledge-production, and what becomes of citizenship and ethics in that process. She is the author of the award-winning books, including Life Exposed: Biological Citizens after Chernobyl and When Experiments Travel: Clinical Trials and the Global Search for Human Subjects, and is co-editor of Global Pharmaceuticals: Ethics, Markets, Practices and When People Come First: Critical Studies in Global Health. A recently named Guggenheim Fellow, Petryna's research has been supported by the National Science Foundation, the National Endowment for the Humanities, the Wenner-Gren Foundation, the Social Science Research Council, and the School for Advanced Research. She was a Member of the School of Social Science at the Institute for Advanced Study and a Faculty Fellow at Princeton University's Center for Human Values. 

Keywords: Medical anthropology; anthropological theory and methods; humanistic medicine; global health; social studies of science and technology; environmental disaster; clinical trials and medical resource access; pharmaceuticals and global health; United States, Eastern Europe and Eurasia, and Brazil.


Office Address:
University Museum, Rm 334
University of Pennsylvania, School of Arts and Sciences
3260 South Street, Philadelphia, PA 19104
Email
Anthropology Faculty Page

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: Anthropology

Languages Spoken: English

Jennifer E. Phillips-Cremins, PhD

Primary Department: Genetics

Faculty Rank: Associate Professor

Degrees:

B.S. (Chemical Engineering) Clarkson University, 1999. Ph.D. (Biomedical Engineering) Georgia Institute Of Technology, 2007.

Research Interests:

The Cremins Lab focuses on higher-order genome folding and how classic epigenetic modifications work through long-range, spatial mechanisms to govern synaptic plasticity in healthy and diseased neural circuits. Much is already known regarding how transcription factors work in the context of the linear genome to regulate brain development. Yet, severe limitations exist in our ability to engineer chromatin in neural circuits to correct synaptic defects in vivo. At the lab's inception, it remained unclear whether and how genome folding could functionally influence cell type-specific gene expression. We have developed and applied new molecular and computational technologies to discover that nested subTADs and long-range loops undergo marked reconfiguration during neural lineage commitment, somatic cell reprogramming, neuronal activity stimulation, and in repeat expansion disorders. We demonstrated that loops induced by neural circuit activation, engineered through synthetic architectural proteins, and miswired in fragile X syndrome were tightly connected to transcription, thus providing early insight into the genome's structure-function relationship. We will now focus on a fundamental mystery in neuroscience: how memory is encoded over decades despite rapid turnover of synaptic proteins/RNAs. We hypothesize that the 3D genome integrates molecular traces of synaptic plasticity written on chromatin to store long-term memory in neural circuits. We will employ single-cell genomics and imaging technologies to dissect how individual synaptic inputs create 3D epigenetic traces. We will perform genome-wide CRISPR screens to identify specific loops and epigenetic modifications important for synaptic plasticity. We will also re-direct technologies used for genome architecture mapping to create molecular activity-dependent neural connectome maps. Finally, we will study how, when, and why pathologic genome misfolding leads to synaptic dysfunction. Addressing this knowledge gap will provide an essential foundation for our long-term goal to engineer the 3D genome to reverse pathologic synaptic defects in debilitating neurological diseases.

Keywords: Higher-order chromatin architecture, 3D genome, synaptic plasticity, genome instability, repeat expansion disorders, neurodegenerative disease, neural connectome, epigenetics


Email
Cremins Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology), NGG (Neuroscience Graduate Group)

Languages Spoken:

Paul Planet, MD, PhD

Primary Department: Infectious Diseases, Pediatrics

Faculty Rank: Assistant Professor

Degrees:

BS (Molecular Biophysics & Biochemistry And Anthropology) Yale University, New Haven, CT, 1996. Ph.D (Integrated Program For Cellular, Molecular, And Biophysical Studies) Columbia University College Of Physicians & Surgeons, New York, NY , 2003. MD Columbia University College Of Physicians & Surgeons, New York, NY, 2004.

Research Interests:

Dr. Planet's research program focuses on the evolution and ecology of infectious disease. His current interests include the evolution and spread of antibiotic resistant strains, particularly community acquired MRSA, and the impact of the pulmonary microbiome in cystic fibrosis. Other organisms studied in teh Planet lab include nontuberculous mycobacteria and Prevotella melaninogenica. Dr. Planet's laboratory uses whole genome phylogenetics, high-throughput sequencing, and bioinformatics to generate hypotheses that are then tested with bench-based microbiology and molecular techniques.

Clinical Specialties:

Pediatric Infectious Disease

Keywords: Microbial Evolution, Phylogenetics, Antimicrobial Resistance, Global Spread of Infectious Disease, Host-Pathogen Interactions, Respiratory Microbiome, Genomics


Office Address:
Abramson Research Center 1202A
3615 Civic Center Blvd
Philadelphia, PA, 19104
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English, Spanish

Michael Povelones, PhD

Primary Department: SVM - Pathobiology

Faculty Rank: Assistant Professor

Degrees:

BA (Chemistry) Columbia University, 1995. PhD (Developmental Biology) Stanford University School of Medicine, 2004.

Research Interests:

Host-pathogen interactions, Vector biology, Malaria, Complement, Innate immunity.

Keywords: Host parasite interactions; mosquito; innate immunity; malaria; filariae


Office Address:
School of Veterinary Medicine, Rm 390 ED
3800 Spruce St.
Philadelphia PA, 19104
(215) 898-4144
Email
Povelones Laboratory

Mentor Training Completed

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group), MVP (Microbiology

Languages Spoken: English

Ben Prosser, PhD

Primary Department: Physiology

Faculty Rank: Associate Professor

Degrees:

BS (Health And Exercise Science) Wake Forest University, 2005. Ph.D (Molecular Medicine) University Of Maryland School Of Medicine, 2009.

Research Interests:

The lab is broadly interested in understanding the role of the cardiac cytoskeleton as a novel target for the treatment of heart disease. A second arm of the lab, inspired by Dr. Prosser's daughter, is focused on genetic neurodevelopmental disorders, and designing RNA-based therapeutics for their treatment.  

Keywords: Cardiac physiology; cytoskeleton; heart failure; neurodevelopmental disorders; RNA therapeutics


(215) 746-1488
Email
Prosser Lab

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology)

Languages Spoken: English

Daniel J. Rader, MD

Primary Department: Medicine

Faculty Rank: Professor

Degrees:

BA, Lehigh University, 1981. MD, Medical College Of Pennsylvania, 1984.

Research Interests:

Our laboratory is focused on: 1) human genetics to identify novel genes and pathways involved in cardiometabolic diseases and traits; 2) experimental approaches to understanding the mechanisms by which these genes and pathways influence these phenotypes; 3) translational therapeutics for cardio metabolic diseases; 4) implementation science regarding the application of genomic medicine approaches in clinical practice. A variety of computational genomics methods, basic cell and molecular laboratory techniques, mouse models, and translational research approaches are used in addressing these questions.

Clinical Specialties:

I see patients with lipid disorders, including extreme high and low cholesterol, triglycerides, and HDL cholesterol, familial lipodystrophy, other inherited disorders of lipid metabolism, and premature atherosclerotic cardiovascular disease.

Keywords: Human genetics, metabolism, lipids, lipoproteins, cardiovascular disease, translational science


Office Address:
Smilow Center for Translational Research, Rm 11-125
3400 Civic Center Blvd.
Philadelphia, PA 19104
(215) 573-4176
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology), PGG (Pharmacology Graduate Group)

Languages Spoken: English

David Raizen, MD, PhD

Primary Department: Neurology

Faculty Rank: Associate Professor

Degrees:

BA (Biochemistry) University of Texas at Austin, 1989. PhD (Neuroscience) University of Texas Southwestern, 1997. MD (Medicine) University of Texas Southwestern, 1997.

Research Interests:

(1) The regulation and function of sleep
(2) Mechanism of fatigue during sickness

Clinical Specialties:

Neurology and Sleep Medicine

Keywords: Sleep, ecdysis, molting, behavior, amyloid, neuropeptides, wake, fatigue, sickness


Office Address:
Clinical Research Building, Rm 347B
415 Curie Blvd.
Philadelphia, PA 19104
Email
Raizen Lab

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Arjun Raj, PhD

Primary Department: Genetics, SEAS - Bioengineering

Faculty Rank: Professor

Degrees:

BA (Physics And Mathematics) University Of California, Berkeley, 2000. PhD (Mathematics) Courant Institute Of Mathematical Sciences, New York University, 2006.

Research Interests:

Single cell, systems biology, cancer, development.

Keywords: Single cell, systems biology, cancer, development


Email
Raj Lab for Systems Biology

Mentor Training Completed

Grad Group Affiliations: BE (Bioengineering), BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology)

Languages Spoken: English

Peter Reese, MD, MSCE

Primary Department: Medicine

Faculty Rank: Associate Professor

Degrees:

B.A. (Anthropology) Princeton University, 1993. (Post-Baccalaureate Year) University Of Washington, 1994. M.D. Johns Hopkins University School Of Medicine, 1999. M.S.C.E. University Of Pennsylvania, 2007.

Research Interests:

His research focuses on: a) developing effective strategies to increase access to kidney transplantation, b) improving the process of selecting and caring for live kidney donors, c) determining outcomes of health policies on vulnerable populations with renal disease, including the elderly, and d) testing strategies to improve important health behaviors such as medication adherence.


Email

Grad Group Affiliations: GGEB (Epidemiology and Biostatistics)

Languages Spoken: English

Marylyn Ritchie, PhD

Primary Department: Genetics

Faculty Rank: Professor

Degrees:

BS (Biology) University Of Pittsburgh At Johnstown, 1999. MS (Applied Statistics) Vanderbilt University, 2002. PhD (Statistical Genetics) Vanderbilt University, 2004.

Research Interests:

Computational Genomics; Bioinformatics; Epistasis; Pharmacogenomics; Big Data; Evolutionary Computation; Genetic Epidemiology; Statistical Genetics; Systems Genomics; Computational Biology; Translational Informatics; Cardiovascular Disease

Keywords: translational bioinformatics, pharmacogenomics, human genetics


Office Address:
Richards Medical Research Laboratory, A301
3700 Hamilton Walk
Philadelphia PA, 19104
Email
Ritchie Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology)

Languages Spoken: English

Erle S. Roberston, Ph.D.

Primary Department: Otorhinolaryngology

Faculty Rank: Professor

Degrees:

B.Sc. (Microbiology), Howard University, Washington, DC, Dean's List For Entire Period, 1987. PhD (Microbiology And Molecular Genetics), Wayne State University, Detroit, MI Mentor: Allan Nicholson, Ph.D., 1992. MS (Honorary Masters), University Of Pennsylvania, 2003.

Research Interests:

Mechanisms of Viral Associated Cancers.

Keywords: oncogenesis, viruses and cancer, viral oncology, Tumor Virology, Gene therapy, Kaposi's Sarcoma, Epstein-Barr Virus, Lymphoproliferative disease, Lymphomas, Microbiome and Cancer.


(215) 746-0114
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Theodore D. Satterthwaite, MD, MA

Primary Department: Psychiatry

Faculty Rank: Associate Professor

Degrees:

B.A. (Psychology: Neuroscience) Williams College, 2000. M.A. (Biology: Neuroscience) Washington University in St. Louis, 2006. M.D. (Medicine) Washington University in St. Louis, 2006.

Research Interests:

My research uses multi-modal neuroimaging to describe both normal and abnormal patterns of brain development, in order to better understand the origins of neuropsychiatric illness. To do this, we use large-scale neuroimaging datasets, with an emphasis on neuroinformatics, network science, and machine learning.  

Clinical Specialties:

Psychiatry

Keywords: Neuroimaging, brain development, network science, adolesence, psychiatric neuroscience, neuroinformatics


Office Address:
Richards Medical Laboratories, A509
3700 Hamilton Walk
Philadelphia PA, 19104
Email
Lifespan Informatics & Neuroimaging Center

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: NGG (Neuroscience Graduate Group)

Languages Spoken: English

Mitch Schnall, MD, PhD

Primary Department: Radiology

Faculty Rank: Professor

Degrees:

B.S. (Physics) University of Pennsylvania, 1981. M.D. University of Pennsylvania, 1986. Ph.D. (Biophysics) University of Pennsylvania, 1986.

Research Interests:

My research focuses on the application of innovative imaging approaches to cancer diagnosis and treatment.  My specific expertise is in the development of now approaches to MRI signal acquisition and analysis. 

Clinical Specialties:

Body Imaging/Radiology

Keywords: Imaging, cancer


Office Address:
Department of Radiology
1 Silverstein Pavilion
3400 Spruce Street
(215) 200-2189
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering)

Languages Spoken: English

Patrick Seale, PhD

Primary Department: Cell and Development Biology

Faculty Rank: Associate Professor

Degrees:

B.Sc. (Biology) McMaster University, Ontario, Canada, 1997. Ph.D. (Biology) McMaster University, Ontario, Canada, 2003.

Research Interests:

1. Obesity pathogenesis, including insulin resistance and susceptibility to type 2 diabetes.
2. Adipose (fat) tissue biology
3. Adipocyte development
4. Mesenchymal stem cells and fibrosis responses.

Keywords: Stem Cells, Embryonic development, Adipocyte progenitors, Obesity, Type 2 diabetes, Brown adipose tissue, White adipose tissue, Mesenchymal stem cells, PRDM16, PPARgamma


Office Address:
Smilow Center for Translational Research
12th Floor, Room 105
3400 Civic Center Blvd
Email
Seale Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Amita Sehgal, PhD

Primary Department:

Faculty Rank: Professor

Degrees:

B.S. Delhi University, New Delhi, India, 1980. M.S. Jawaharlal Nehru University, New Delhi, India, 1982. Ph.D. (Cell Biology And Genetics, Adviser: Moses Chao) Graduate School Of Medical Sciences, Cornell University, 1988.

Research Interests:

Molecular basis of behavior.

Keywords: Circadian rhythms, sleep, genetics, metabolism, aging


Office Address:
Smilow Center for Translational Research, 10-135
3400 Civic Center Boulevard
Philadelphia PA, 19104
Email
Sehgal Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English, Hindi

Mark Sellmyer, MD, PhD

Primary Department: Radiology

Faculty Rank: Assistant Professor

Degrees:

BS (Chemistry) Massachusetts Institute Of Technology , 2004. PhD (Chemical And Systems Biology) Stanford Medical School, 2012. MD Stanford Medical School, 2012.

Research Interests:

Molecular Imaging; Chemical Biology; Synthetic Biology; Radiology; Nuclear Imaging and Therapy

Clinical Specialties:

Nuclear Radiology


Office Address:
Stellar-Chance Labs,
813A (Office), 815 (Lab)
422 Curie Boulevard
Philadelphia PA, 19104
(215) 573-3212
Email
Sellmyer Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), BMB (Biology and Molecular Biophysics), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Sydney M. Shaffer, MD, PhD

Primary Department: Pathology & Laboratory Medicine, SEAS - Bioengineering

Faculty Rank: Assistant Professor

Degrees:

B.S. (Chemical And Biomolecular Engineering) Georgia Institute Of Technology , 2010. Ph.D. (Bioengineering) University Of Pennsylvania, 2017. M.D. (Medicine) Perelman School Of Medicine, University Of Pennsylvania, 2018.

Keywords: Systems biology, cancer systems biology, single-cell analysis


Email
Syd Shaffer Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology)

Languages Spoken: English

Ophir Shalem, PhD

Primary Department: Genetics

Faculty Rank: Assistant Professor

Degrees:

B.Sc. (Computer Science And Biology, Bioinformatics Track In The Computer Science Department) Ben Gurion University Of The Negev, Beer Sheva, Israel, 2004. M.Sc. (Bioinformatics, Advisors: Tzachi Pilpel And Eran Segal) The Weizmann Institue Of Science, 2007. Ph.D. (Biology And Computer Science, Advisors: Tzachi Pilpel And Eran Segal) The Weizmann Institue Of Science, 2012.

Research Interests:

Our lab is interested in functional genomics, approaches that are aimed at understanding gene function by following the effects of direct perturbations at a large scale, we are developing novel perturbation and functional genomics approaches and applying them together with additional genomics approaches to study a range of human diseases including early and late onset neurodegenerative diseases.

Keywords: Functional genomics, protein quality control


Email
Shalem Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Junwei Shi, PhD

Primary Department: Cancer Biology

Faculty Rank: Assistant Professor

Degrees:

B.S. (Biotechnology) Sun Yat-Sen University (China), 2008. Ph.D. (Molecular And Cellular Biology) Stony Brook University, SUNY, 2016.

Research Interests:

We have a wide range of interests, but we primarily focus on the molecular biology of cancer using CRISPR gene editing technology. 

Keywords: CRISPR, acute myeloid leukemia, epigenetics, transcription regulation, gene editing, high-throughput screening


Office Address:
BRB II/III, Rm 610
421 Curie Blvd.
Philadelphia, PA 19104
Email
Shi Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Sunny Shin, PhD

Primary Department: Microbiology

Faculty Rank: Assistant Professor

Degrees:

B.S. (Biology, Advisor: Hidde Ploegh) Massachusetts Institute of Technology, 1998. Ph.D. (Microbiology and Immunology, Advisor: Yueh-hsiu Chien) Stanford University School of Medicine, 2004.

Research Interests:

Our research is focused on understanding mechanisms of immune defense against bacterial pathogens, including Legionella pneumophila, Coxiella burnetii, Salmonella Typhimurium, and Yersinia spp., and in turn, how these pathogens subvert host immunity. 

Keywords: Innate immunity; bacterial pathogenesis


Office Address:
Johnson Pavilion, 201B
3610 Hamilton Walk
Philadelphia PA, 19104
(215) 746-8410
Email
Microbiology Faculty Page

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Michael Silverman, MD, PhD

Primary Department: Pediatrics

Faculty Rank: Assistant Professor

Degrees:

BS (Biology) Cornell University, 1998. MD, PhD (Medicine And Immunology) University Of Pennsylvania School Of Medicine, 2007.

Research Interests:

The Silverman Lab aims to understand the mechanisms of immune system variation and to discover novel approaches to predict and prevent immune-mediated diseases, specifically the microbial and developmental factors that lead to T1D. Current research studies in the lab involve the genetic and microbiota impacts on T1D; pediatric gnotobiotic mouse model; and selective IgA deficiency (SIgAD).

Specifically, transgenic expression of the MHCII E molecule in NOD mice (Eα16/NOD)completely prevents T1D, mirroring dominant HLA protection from T1D in humans. Using these Eα16/NOD mice as a model of dominant genetic protection from T1D, the Silverman Lab demonstrated that protection from autoimmunity operates by the immune system shaping the early-life commensal microbiota. The lab's ongoing project in this area aims to discover the mechanisms by which the host immune system impacts the development of commensal microbiota, and further, how commensal microbes educate the immune system to prevent autoimmunity. Modeling of HLA class II dominant protection from T1D supports the lab's long-term goal of developing early-life microbiota-based therapies to prevent T1D in humans

The Silverman Lab has collaborated with Paul Planet, MD, PhD, attending physician in the Division of Infectious Diseases at CHOP, to generate the first gnotobiotic mouse model of the pediatric microbiome, which we call Pediatric Community or "PedsCom." PedsCom is a consortium of 8 bacterial strains isolated from the intestine of pre-weaning diabetes-protected Eα16/NOD mice. These mice are unique and powerful tools to define the "rules of engagement" between the host and their commensal microbes.

Finally, the lab has recently defined the microbiome from pediatric patents lacking IgA. The team's ongoing research aims to determine the mechanism for the increased incidence of autoimmune disease in patients with SIgAD.  The lab developed a technique (mFLOW-SEQ) to tag microbes with a patient's own serum IgG antibodies followed by metagenomic sequencing to define those microbes which activate, and in some cases, over-activate their immune systems.

Clinical Specialties:

Pediatric infectious disease

Keywords: Microbiome, Immunology, HLA, MHC, antibiotics, intestinal immune system, autoimmune (type I) diabetes, IgA deficiency, Graft-vs-host disease


Office Address:
Abramson Research Center, 1205G
3615 Civic Center Blvd
Philadelphia, PA, 19104
Email
Silverman Laboratory

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

M. Celeste Simon, PhD

Primary Department: Cell and Development Biology

Faculty Rank: Professor

Degrees:

B.A. (Microbiology) Miami University, 1977. M.S. (Microbiology) Ohio State University, 1980. Ph.D. (Molecular Biology) The Rockefeller University, 1985.

Research Interests:

Our laboratory studies cancer cell metabolism, tumor immunology, metastasis, and cellular responses to oxygen deprivation.

Keywords: Hypoxia; cancer metabolism; immunology; metastasis; in vivo and ex vivo models of pancreatic, liver, and renal cancer; and sarcoma.


Office Address:
BRB II/III, 456
421 Curie Blvd.
Philadelphia, PA 19104
(215) 746-5532
Email
Faculty Listing

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Hongjun Song, PhD

Primary Department:

Faculty Rank: Professor

Degrees:

B.S. (Biology) Peking University, P.R. China, 1992. MA, M Phil (Biology) Columbia University, New York, 1995. Ph.D. (Biology) University Of California At San Diego, La Jolla, 1998.

Research Interests:

Research in Dr. Hongjun Song's laboratory focuses on two core topics: (1) neural stem cell regulation and neurogenesis in the developing and adult mammalian brain and how these processes affect neural function; (2) epigenetic and epitranscriptomic mechanisms and their functions in the mammalian nervous system. The lab is also interested in addressing how dysfunction of these mechanisms may be involved in brain disorders.

Keywords: Neural development, neural stem cells, epigenetics, RNA modifications, brain organoids, brain disorders


Office Address:
Clinical Research Building, 111B
415 Curie Boulevard
Philadelphia PA, 19104
(215) 573-2449
Email
Song Lab

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Louis Soslowsky, PhD

Primary Department: Orthopaedic Surgery

Faculty Rank: Professor

Degrees:

Diploma East Brunswick High School , 1982. B.S. (Engineering Mechanics) Columbia University, 1986. M.S. (Engineering Mechanics) Columbia University, 1987. M.Phil Columbia University, 1989. Ph.D. (Engineering Mech./Biomechanics, Mentor: Van C. Mow) Columbia University, 1991. Cert. (Academic Medicine Leadership Program) Wharton School Of The University Of Pennsylvania , 2008.

Research Interests:

The overall goals of our research program are to determine fundamental relationships and mechanisms of tendon and ligament injury, healing, repair, and regeneration and to use this information to develop and evaluate potential treatment modalities.

Orthopaedic research, orthopaedic biomechanics and tissue engineering, tendons and ligaments, shoulder and elbow.

Keywords: Orthopaedic research, orthopaedic biomechanics and tissue engineering, tendons and ligaments, rotator cuff, Achilles


Office Address:
Stemmler Hall, 307A
3450 Hamilton Walk
Philadelphia PA, 19104
Email
Soslowsky Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), MEAM (Mechanical Engineering and Applied Mechanics)

Languages Spoken: English

Nancy A. Speck, PhD

Primary Department: Cell and Development Biology

Faculty Rank: Professor

Degrees:

B.A. Western Maryland College, Westminster, MD, 1977. Ph.D. Northwestern University, Evanston IL, 1983.

Research Interests:

Hematopoietic stem cells and leukemia using mouse models.

Keywords: Hematopoietic stem cells, leukemia, core binding factors, transcription, small molecule inhibitors


Office Address:
BRB II/III, Room 554
421 Curie Boulevard
Philadelphia, PA 19104
Email
Speck Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

Ben Stanger, MD, PhD

Primary Department: Gastroenterology

Faculty Rank: Professor

Degrees:

SB (Life Sciences) Massachusetts Institute Of Technology, 1988. MD (Medicine) Harvard Medical School, 1997. PhD (Genetics) Harvard Medical School, 1997.

Research Interests:

Metastasis, Pancreatic Cancer, Tumor Immunology, Cell Plasticity.

Clinical Specialties:

Gastroenterology.

Keywords: Cell Plasticity; Pancreatic Cancer; Tumor Immunology; Metastasis; Liver Regeneration


Office Address:
BRB II/III, 512
421 Curie Blvd
Philadelphia, PA 19104
Email
BGS Faculty Profile

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Boris Striepen, PhD

Primary Department: SVM - Pathobiology

Faculty Rank: Professor

Degrees:

PhD (Biochemistry, Cell Biology and Genetics) Philipps-Universität, Marburg, Germany, 1995.

Research Interests:

We study the cell and molecular biology of parasites and how they interact with their mammalian host.
In recent years we have focused on the apicomplexan Cryptosporidium, a distant cousin to the parasite that cause malaria. Cryptosporidium is an important pathogen for which neither prophylaxis nor effective treatment are available. Cryptosporidium was first recognized in the 1980s as an AIDS-defining opportunistic infection, however, immunocompetent individuals are susceptible, and today Cryptosporidium accounts for 50% of all U.S. waterborne disease outbreaks.
Most recently, Cryptosporidium was identified as a leading cause of diarrheal disease and death in infants. Beyond acute disease, asymptomatic cryptosporidiosis causes stunting and environmental enteropathy with lasting impact on the development and health of children. Malnutrition and cryptosporidiosis are intimately linked. Cryptosporidium has long been difficult to study, but a series of recent advances has made the organism and the disease tractable. We developed genetic manipulation of the parasite and mouse infection models which has opened this important pathogen to sophisticated mechanistic studies.
Currently our research is exploring three areas of Cryptosporidium biology: 1) how does the parasite invade and manipulate the intestinal epithelial cells in which it develops, 2) how does the sexual part of the parasite’s lifecycle unfold and 3) how does the host immune system recognize and restrict Cryptosporidium infection?
Trainees in the lab use a broad range of modern approaches including single cell sequencing, super-resolution and live-cell microscopy, genetic engineering, flow cytometry, cryo-electron tomography and a variety of cell, organoid and animal model systems.


Email
Striepen Laboratory

Mentor Training Completed

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

Kai Tan, PhD

Primary Department: Pediatrics

Faculty Rank: Professor

Degrees:

B.S. (Biochemistry) Beloit College, 1997. Ph.D. (Computational Biology) Washington University In St. Louis, 2004.

Research Interests:

Gene regulation plays a fundamental role in cellular development and cancer. Our lab uses genomics and systems biology approaches to understand the gene regulatory factors underlying cellular processes. We take snapshots of the regulatory systems using bulk and single-cell omics and imaging assays, and develop computational algorithms to integrate data and generate testable models of gene regulatory pathways in model systems.

Keywords: Systems biology, cancer genomics, immunotherapy, single-cell biology, computational biology


Office Address:
Colket Translational Research Building, 4004
3501 Civic Center Blvd
Philadelphia, PA 19104
(267) 425-0050
Email
Tan Laboratory

Unconscious Bias Trained

Grad Group Affiliations: AMCS (Applied Mathematics and Computational Science), BE (Bioengineering), CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology), GGEB (Epidemiology and Biostatistics), IGG (Immunology Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Christoph Thaiss, PhD, MSc

Primary Department: Microbiology

Faculty Rank: Assistant Professor

Degrees:

B.S. University of Bonn, Germany. M.S. Yale University & Swiss Federal Institute of Technology (ETH) Zurich, Switzerland. Ph.D. (Immunology) Weizmann Institute of Science, Rehovot, Israel, 2017.

Research Interests:

We study the impact of environmental factors (the "exposome") on human disease, including inflammatory, metabolic, and neurological diseases.

Keywords: Microbiome, neuroscience, immunology, gut-brain axis, metabolism


Office Address:
Johnson Pavilion, 301B
3610 Hamilton Walk
Philadelphia, PA 19104
Email
Thaiss Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology), IGG (Immunology Graduate Group), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Deborah A. Thomas, PhD

Primary Department: SAS - Anthropology

Faculty Rank: Professor

Roles:

R. Jean Brownlee Professor of Anthropology

Research Interests:

Political Anthropology; Sovereignty; Violence; The Afterlives of Imperialism; Transnationalism and Diaspora; Race and Gender; Performance and Popular Culture; Culture and Political Economy; Popular Culture; the Caribbean.

Keywords: Caribbean, Multi-Modality, Anthropology


Office Address:
Penn Museum, 335
3260 South Street
Philadelphia, PA 19104
(215) 746-0435
Email
Center for Experimental Ethnography

Unconscious Bias Trained

Grad Group Affiliations: Comparative Literature, English

Languages Spoken: English, French, Portuguese

Andrew Tsourkas, PhD, MS

Primary Department: SEAS - Bioengineering

Faculty Rank: Professor

Degrees:

B.S. (Mechanical Engineering) Cornell University, 1997. M.S. (Mechanical Engineering) Johns Hopkins University, 1999. Ph.D. (Biomedical Engineering) Georgia Institute Of Technology/Emory University, 2004.

Research Interests:

Developing targeted imaging and therapeutic agents designed to improve the detection and treatment of cancer. Specific research interests include (i) developing new nanoformulations that are capable of carrying extremely high payloads of drugs, radiosensitizing agents, and/or contrast agents; (ii) investigating new targeting strategies that maximize specificity and sensitivity; and (iii) developing new bioconjugation techniques that enable the highly efficient, site-specific labeling of antibodies and other targeting ligands.

Keywords: Molecular imaging, contrast agents, magnetic resonance, fluorescence, bioluminescence, protein engineering, antibody conjugates, bispecific antibodies, bioconjugate chemistry.


Office Address:
Hayden Hall, 110
3320 Smith Walk
Philadelphia PA, 19104
(215) 898-8167
Email
Tsourkas Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Gregory D. Van Duyne, PhD

Primary Department: Biochemistry and Biophysics

Faculty Rank: Professor

Degrees:

B.S. (Chemistry) Cornell University, 1983. Ph.D. (Biophysical Chemistry) Cornell University, 1988.

Research Interests:

We are interested in understanding on a structural and biochemical level how DNA and RNA molecules are maintained and processed by living cells. In addition to the mechanisms and regulation of genome replication and transcription, this includes processes such as DNA repair, site-specific and homologous recombination, transposition, condensation of chromosomes, chromosome pairing and segregation, and RNA trafficking and splicing. Our approach is to establish three-dimensional models of macromolecular assemblies relating to a particular biological question using X-ray diffraction methods and to then develop mechanistic and functional models that can be tested experimentally.


Office Address:
Stellar-Chance Laboratories, Rm 809
422 Curie Boulevard
Philadelphia PA, 19104
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics)

Languages Spoken: English

Susan W. Volk, VMD, PhD

Primary Department: SVM - Clinical Sciences & Advanced Medicine

Faculty Rank: Associate Professor

Degrees:

B.A. University of Pennsylvania College of Arts and Sciences, 1991 V.M.D. University of Pennsylvania, 1995 Ph.D. University of Pennsylvania, 1998 Diplomate, American College of Veterinary Surgeons

Research Interests:

The goals of the Volk laboratory are to understand regulatory mechanisms governing dynamic interactions between cells and their surrounding extracellular matrix in the wound healing-fibrosis-cancer progression triad and to apply this knowledge to develop innovative regenerative and oncologic therapies for veterinary and human patients.

Clinical Specialties:

Small animal surgery.

Keywords: Wound repair and regeneration Extracellular Matrix Scar formation and fibrosis Regenerative medicine Cell-based therapies Tumor microenvironment


Office Address:
University of Pennsylvania School of Veterinary Medicine
312 Hill Pavilion
380 S. University Ave
Philadelphia PA 19104-4539
(215) 898-0635
Email
Volk Laboratory

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering)

Languages Spoken: English

Robert H. Vonderheide, MD, DPhil

Primary Department: Hematology/Oncology

Faculty Rank: Professor

Degrees:

BSc (Chemical Engineering) University Of Notre Dame, 1985. DPhil (Immunology) Oxford University, 1989. MD Harvard Medical School, 1993.

Research Interests:

The Vonderheide laboratory combines efforts in both basic research and clinical investigation to advance the understanding of tumor immunology and to develop novel immunotherapies for cancer. The chief hypothesis is that successful approaches in tumor immunotherapy will need to (a) optimize target antigens with regard to clinical applicability and risk of antigen loss, (b) repair host immuno-incompetence in antigen presentation and T cell function, and (c) circumvent immuno-suppressive factors of the tumor and tumor microenvironment.

Clinical Specialties:

Medical oncology.

Keywords: Tumor immunology, CD40, pancreatic cancer


Office Address:
Smilow Center for Translational Research, 12th Floor
3400 Civic Center Boulevard
Philadelphia PA, 19104
(215) 662-3929
Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English

Douglas C. Wallace, PhD

Primary Department: Pediatrics

Faculty Rank: Professor

Degrees:

B.S. (Genetics, Developmental Biology) Cornell University, Ithaca, NY, 1968. M. Phil. (Microbiology And Human Genetics) Yale University, New Haven CT, 1972. PhD (Microbiology And Human Genetics) Yale University, New Haven CT, 1975.

Research Interests:

The role of mtDNA and nDNA mitochondrial genetic variation in all aspects of human biology including clinical genetics,  neuropsychiatric disoreders, SARS-CoV-2 pathophysiology, cancer, immunology, population biology, animal models, and genetic and metabolic therapeutics.

Keywords: Mitochondria, DNA, mtDNA, epigenome, mitochondrial medicine, SARS-CoV-2 & COVID-19, metabolic and neuropsychiatric diseases including autism, gene therapy, metabolic therapy, mouse models, cancer genetics and immunobiology


Office Address:
Colket Translational Research Building, Rm 6060
Center for Mitochondrial and Epigenomic Medicine
3501 Civic Center Blvd.
Philadelphia, PA 19104
(267) 425-3034
Email

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Felix W. Wehrli, PhD

Primary Department: Radiology

Faculty Rank: Professor

Degrees:

M.S. (Chemistry) Swiss Federal Institute of Technology, Zurich, Switzerland. PhD (Chemistry) Swiss Federal Institute of Technology, Switzerland. 

Research Interests:

Quantitative imaging approaches using MRI.

Keywords: Medical Imaging, Translational Research, Quantitative MRI, Musculoskeletal, Oxygen Metabolism, Solid State Imaging


Office Address:
Department of Radiology
1st Floor Founders Building
MRI Education Center
3400 Spruce Street
Philadelphia, PA 19104-4283
(215) 662-7951
Email
Laboratory for Structural Physiologic and Functional Imaging

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), BMB (Biology and Molecular Biophysics)

Languages Spoken: English, French, German, Italian

David Weiner, PhD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Professor

Degrees:

B.S. (Biology) SUNY At Stony Brook, NY, 1978. M.S. (Biology) University Of Cincinnati, Cincinnati, OH, 1985. Ph.D. (Developmental Biology Graduate Program) University Of Cincinnati College Of Medicine, 1986.

Research Interests:

DNA vaccines for infectious diseases or cancers, T cell immunity, Active immunization. Development of novel strategies for invivo biologic production, Self assembly invivo of designed vaccine antigens. 

Keywords: Nucleic Acid Vaccines, Rapid Responses to Emerging Infectious Disease, Coronaviruses, HIV, Influenza, AMR, Cancer Immunotherapy, dMABs for treatment, T cells, humoral immunity, Genetic adjuvants.


Office Address:
Wistar Institute, 6th Floor
3601 Spruce Street
Philadelphia, PA 19104
(215) 898-0381
Email

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), GTV (Gene Therapy and Vaccines), IGG (Immunology Graduate Group), MVP (Microbiology, Virology and Parasitology), PGG (Pharmacology Graduate Group)

Languages Spoken: English

Susan Weiss, PhD

Primary Department: Microbiology

Faculty Rank: Professor

Degrees:

B.A. (Biology) Brandeis University, 1971. Ph.D. (Microbiology And Molecular Genetics) Harvard University, 1975.

Research Interests:

Murine coronavirus pathogenesis, central nervous system, liver and lung - Pathogenesis of human coronaviruses including MERS-CoV, SARS-CoV-2 and other nonlethal human respiratory viruses - Activation and antagonism of the OAS-RNase L pathway in human and bat cells - Viral and cellular phosphodiesterases - Interaction of viruses with dsRNA induced innate immune pathways - Zika virus pathogenesis - Endogenous dsRNA induced pathogenesis

Keywords: Murine coronavirus, SARS-CoV MERS-CoV, human respiratory coronavirus, viral pathogenesis, interferon antagonist, OAS-RNase L, endogenous double-stranded (ds)RNA


Office Address:
Johnson Pavilion, 203A
3610 Hamilton Wak
Philadelphia, PA 19104
(215) 898-8013
Email
Microbiology Faculty Page

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Matthew Weitzman, PhD

Primary Department: Pathology & Laboratory Medicine

Faculty Rank: Professor

Degrees:

B.Sc. (Honours Degree In Genetics) University Of Leeds, UK, 1987. Ph.D. (Molecular Virology) Oxford Polytechnic And The Institute Of Virology And Environmental Microbiology Of The Natural Environment Research Council (NERC), Oxford, UK, 1991.

Research Interests:

Our lab aims to understand cellular host responses to virus infection, and the environment encountered and manipulated by viruses. We study multiple viruses in an integrated experimental approach that combines biochemistry, molecular biology, genetics and cell biology. We have chosen viral models that provide tractable systems to investigate the dynamic interplay between viral genetic material and host defense strategies. The pathways illuminated are key to fighting diseases of both viral infection and genome instability, and our studies have significant implications for the development of efficient viral vectors for gene therapy.

Keywords: Virology, Virus Replication, DNA Damage and Repair, Genome Instability, Viral Vectors


Office Address:
Colket Translational Research Building, 4050
3501 Civic Center Blvd
Philadelphia, PA 19104
Email
CHOP Faculty Page

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group)

Languages Spoken: English, Hebrew

Kathryn Wellen, PhD

Primary Department: Cancer Biology

Faculty Rank: Associate Professor

Degrees:

B.S. (Biological Psychology, Summa Cum Laude) The College Of William And Mary, 2000. Ph.D. (Biological Sciences, Genetics & Complex Diseases) Harvard University, School Of Public Health, 2006.

Research Interests:

My lab is studying cellular metabolism, including mechanisms of metabolic adaptation to nutrient availability and mechanisms of metabolic regulation of gene expression in cancer and metabolic disease.

Keywords: Metabolism, cancer, diabetes, acetylation, nutrient-sensing


Office Address:
BRB II/III, Room 653
421 Curie Blvd.
Philadelphia, PA 19104
(215) 746-8599
Email
Wellen Lab

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), NGG (Neuroscience Graduate Group)

Languages Spoken: English

E. John Wherry, PhD

Primary Department: Systems Pharmacology and Translational Therapeutics

Faculty Rank: Professor

Degrees:

BS (Science) Pennsylvania State University, 1993. PhD (Immunology) Thomas Jefferson University, 2000.

Research Interests:

T Cell Exhaustion, Immunotherapy, T Cell Memory, Viral Immunity, Immune Oncology, Immune Health.

Keywords: T cell exhaustion, PD-1, T cell memory, Chronic infection, Cancer Immunotherapy, Checkpoint Blockade, Memory T cell differentiation, T Follicular Helper Cells.


Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology), IGG (Immunology Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English

James Wilson, MD, PhD

Primary Department: Translational Medicine and Human Genetics

Faculty Rank: Professor

Degrees:

B.A. (Chemistry) Albion College, 1977. Ph.D. (Biological Chemistry) University Of Michigan Medical School, 1984. M.D. University Of Michigan Medical School, 1984.

Research Interests:

Dr. Wilson's laboratory focuses on the development of gene transfer vectors and their application in the treatment of inherited and acquired diseases. Characterization of these novel viral isolates has yielded important insights into basic virology. More importantly, recombinant versions of these viruses have proven to be useful as improved gene transfer vehicles to a variety of targets such as the liver, cardiac and skeletal muscle, and the brain.

Keywords: Adeno-associated virus (AAV), gene therapy, gene transfer, gene editing, gene delivery, route of administration.


215-573-9020
Email
Gene Therapy Program

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: CAMB (Cell and Molecular Biology)

Languages Spoken: English

Walter Witschey, PhD

Primary Department: Radiology

Faculty Rank: Associate Professor

Degrees:

B.S. (Physics) University Of Virginia, 2004. Ph.D (Biochemistry And Molecular Biophysics) University Of Pennsylvania, 2009.

Research Interests:

The research focus of the Advanced Cardiovascular Imaging Lab is the development of next generation imaging technologies for cardiovascular disease. As an interdisciplinary team of Radiologists, Physicists, Computational Scientists, and Engineers, we solve complex problems and develop new tools, to improve our scientific understanding of cardiovascular disease and clinical care of patients.

Keywords: Machine learning, artificial intelligence, magnetic resonance imaging, magnetic resonance spectroscopy, computed tomography, image reconstruction, autonomous systems, cardiovascular disease, metabolic imaging, electrodynamics, computer vision, arrhythmias, ischemia heart disease, heart attack, image-derived phenotypes, bioinformatics


Office Address:
PCAM South Pavilion, 11-155
3400 Civic Center Blvd.
Philadelphia, PA 19104
(215) 662-2310
Email
Advanced Cardiovascular Imaging Lab

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics)

Languages Spoken: English

David Wolk, MD

Primary Department: Neurology

Faculty Rank: Professor

Degrees:

BA (Psychology) Dartmouth College, 1994. MD (Medicine) Johns Hopkins University School Of Medicine, 1998

Research Interests:

Episodic Memory, neuroimaging, MRI, PET imaging, Alzheimer's Disease, Dementia, Memory Disorders, Cognitive Neurology, Aging.

Penn Memory Center 

Clinical Specialties:

Cognitive neurology.

Keywords: Alzheimer's disease, Memory, Aging, Medial Temporal Lobe, neuroimaging, amyloid PET, tau PET


(215) 573-7495
Email
Penn Alzheimer's Disease Research Center

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering), NGG (Neuroscience Graduate Group)

Languages Spoken: English

Mark Yim, PhD

Primary Department: SEAS - Mechanical Engineering and Applied Mechanics

Faculty Rank: Professor

Degrees:

BS (Engineering Mechanics) Johns Hopkins University, 1989. MS (Mechanical Engineering) Stanford University, 1989. PhD (Mechanical Engineering) Stanford University, 1995

Roles:

Director of the GRASP Lab

Research Interests:

Steerable needles.

Keywords: Robotics


Email
Modular Robotics Lab (ModLab)

Grad Group Affiliations: BE (Bioengineering), CIS (Computer and Information Science), ESE (Electrical and Systems Engineering), MEAM (Mechanical Engineering and Applied Mechanics)

Languages Spoken: English

Paul Yushkevich, PhD

Primary Department: Radiology

Faculty Rank: Professor

Degrees:

B.S. (Computer Science And Mathematics) University Of North Carolina At Charlotte, 1996. M.S. (Computer Science) University Of North Carolina Chapel Hill, 2000. Ph.D. (Computer Science) University Of North Carolina Chapel Hill, 2003.

Research Interests:

I am a computational biomedical image analysis scientist whose program combines theoretical work on image segmentation, registration, and statistical morphometry with applied and translational research, primarily in the area of brain MRI analysis.  I lead a research program focused on using detailed imaging and image analysis of the medial temporal lobe (MTL) to derive effective and informative biomarkers for neurodegenerative diseases. My group is widely recognized one of the leaders in the detailed MTL neuroimaging field, particularly, as the main provider of advanced computational algorithms. Our major research products include the first ex vivo 3D computational atlas of the human hippocampus that combined ex vivo MRI and histology; the best-performing software for hippocampal subfield and MTL subregion segmentation in in vivo MRI (ASHS, in use by ADNI3); winning performance in general image segmentation challenges at MICCAI 2012 and 2013; and the demonstration of the efficacy of MTL subregional measures in detecting granular changes associated with early AD. My group is also heavily invested into open-source software development, including our flagship tool ITK-SNAP, which has tens of thousands of users.

Keywords: Medical image analysis, Alzheimer's disease


Office Address:
Richards Hall, D605
3700 Hamilton Walk
Philadelphia PA 19104
Email
Penn Image Computing and Science Laboratory

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BE (Bioengineering)

Languages Spoken: English, Russian, Spanish

Nancy Zhang, PhD

Primary Department: Wharton - Statistics

Faculty Rank: Professor

Degrees:

Stanford University, Bachelors in Mathematics, 2001. Stanford University, Masters in Computer Science, 2001. Stanford University, Doctorate of Philosophy in Statistics, 2005.

Research Interests:

Genomics, change-point methods, empirical bayes estimation, model and variable selection, scan statistics, statistical modeling.

Keywords: Genomics, change-point methods, empirical bayes estimation, model and variable selection, scan statistics, statistical modeling


Email

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: GCB (Genomics and Computational Biology), PNGCB (Penn Neurodegeneration Genomics Center)

Languages Spoken: Chinese, English

Zhaolan (Joe) Zhou, PhH

Primary Department: Genetics

Faculty Rank: Professor

Degrees:

B.S. (Bioengineering) Nankai University, 1991; Ph.D. (Molecular And Cellular Biology) Harvard University, 2001.

Research Interests:

Genetics and Epigenetic Control of Genome Function in Brain Development and Disease.

Keywords: Epigenetics, Neuroepigenetics, DNA methylation, Chromatin Organization, Genomic Editing, CRISPR, MeCP2, CDKL5, Neurexin, Rett Syndrome, Autism, Major Depression


Office Address:
Department of Genetics
452A Clinical Research Building
415 Curie Blvd
Philadelphia, PA 19104-6145
(215) 746-5025
Email
PSOM Faculty Listing

Mentor Training Completed

Unconscious Bias Trained

Grad Group Affiliations: BMB (Biology and Molecular Biophysics), CAMB (Cell and Molecular Biology), GCB (Genomics and Computational Biology), NGG (Neuroscience Graduate Group), PGG (Pharmacology Graduate Group)

Languages Spoken: English

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