The Translational Neuropathology Research Laboratory seeks to understand the molecular causes of age-related neurodegenerative diseases, in particular frontotemporal degeneration (FTD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Trauma-Related Neurodegeneration (TReND). We use an interdisciplinary approach to address the mechanisms of neurodegeneration, including molecular, biochemical, histologic, physiologic and behavioral methods. We are also interested in using and developing cutting-edge techniques including multi-spectral confocal imaging, single cell RNA sequencing, spatial transcriptomics, CRISPR editing, and cryo-electron microscopy. The laboratory is comprised of a collaborative group of inquisitive researchers, led by Eddie Lee, Associate Professor in the Division of Neuropathology in the Department of Pathology and Laboratory Medicine, and Associate Director of the Penn Alzheimer's Disease Research Center. It is our mission to understand the root causes of human neurodegenerative diseases so that our discoveries can translate into specific disease-modifying therapies.