Highlights

Boram Kim, Bailey Mikytuck, Eunran Suh, Garrett S. Gibbons, Vivianna M. Van Deerlin, Sanjeev N.  Vaishnavi, Meredith A. Spindler, Lauren Massimo, Murray Grossman, John Q. Trojanowski, David J. Irwin, Edward B. Lee. Tau immunotherapy is associated with glial responses in FTLD-tau. Acta Neuropathologica, 142, 243-257 (2021).

 

Creekmore BC, Chang YW, Lee EB.  The cryo-EM effect: Structural biology of neurodegenerative disease aggregates.  JNEN, 80(6): 514-529 (2021).

 

Creekmore BC, Chang YW, Lee EB.  The cryo-EM effect: Structural biology of neurodegenerative disease proteostasis factors.  JNEN, 80(6): 494-513 (2021).

 

Nasrallah MP, Mourelatos Z, Lee EB. Neuropathology associated with SARS-CoV-2 infection.  Lancet. 2021 Jan 23;397(10271):277.

 

Darwich NF, Phan JM, Kim B, Suh E, Papatriantafyllou JD, Changolkar L, Nguyen AT, O'Rourke CM, He Z, Porta S, Gibbons GS, Luk KC, Papageorgiou SG, Grossman M, Massimo L, Irwin DJ, McMillan CT, Nasrallah IM, Toro C, Aguirre GK, Van Deerlin VM, Lee EB. Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau.  Science. 2020 Nov 20;370(6519):eaay8826. pdf reprint

 

Liu EY, Russ J, Lee EB. Neuronal transcriptome from C9orf72 repeat expanded human tissue is associated with loss of C9orf72 function.  Free Neuropathol. 2020;1:23.

 

Nguyen AT, Wang K, Hu G, Wang X, Miao Z, Azevedo JA, Suh E, Van Deerlin VM, Choi D, Roeder K, Li M, Lee EB. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease.  Acta Neuropathol. 2020 Oct;140(4):477-493.

 

Cali CP, Park DS, Lee EB. Targeted DNA methylation of neurodegenerative disease genes via homology directed repair.  Nucleic Acids Res. 2019 Dec 16;47(22):11609-11622.

 

Cali CP, Patino M, Tai YK, Ho WY, McLean CA, Morris CM, Seeley WW, Miller BL, Gaig C, Vonsattel JPG, White CL 3rd, Roeber S, Kretzschmar H, Troncoso JC, Troakes C, Gearing M, Ghetti B, Van Deerlin VM, Lee VM, Trojanowski JQ, Mok KY, Ling H, Dickson DW, Schellenberg GD, Ling SC, Lee EB. C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy.  Acta Neuropathol. 2019 Nov;138(5):795-811.

 

Lee EB, Kinch K, Johnson VE, Trojanowski JQ, Smith DH, Stewart W. Chronic traumatic encephalopathy is a common co-morbidity, but less frequent primary dementia in former soccer and rugby players.  Acta Neuropathol. 2019 Sep;138(3):389-399.

 

Liu EY, Russ J, Cali CP, Phan JM, Amlie-Wolf A, Lee EB. Loss of nuclear TDP-43 is associated with decondensation of LINE retrotransposons.  Cell Rep. 2019 Apr 30;27(5):1409-1421.e6.

 

Lee EB.  Integrated neurodegenerative disease autopsy diagnosis.  Acta Neuropathol. 2018 Apr;135(4):643-646.

 

Liu EY, Cali CP, Lee EB. RNA metabolism in neurodegenerative disease. Disease Models & Mechanisms, 10: 509-518, 2017.

 

Lee EB*, Porta S, Baer GM, Xu Y, Suh E, Kwong LK, Elman L, Grossman M, Lee VM-Y, Irwin DJ, VanDeerlin VM, Trojanowski JQ. Expansion of the classification of FTLD-TDP: Distinct pathology associated with rapidly progressive frontotemporal degeneration. Acta Neuropathologica, Jul, 2017. *Corresponding author

 

Amlie-Wolf A, Ryvkin P, Tong R, Dragomir I, Suh E, Xu Y, Van Deerlin VM, Gregory BD, Kwong LK, Trojanowski JQ, Lee VMY, Wang LS, Lee EB. Transcriptomic changes due to cytoplasmic TDP-43 expression reveal dysregulation of histone transcripts and nuclear chromatin. PLoS One. 10(10): e0141836, 2015.

 

Suh E*, Lee EB*, Neal D, Wood EM, Toledo JB, Rennert L, Irwin DJ, McMillan CT, Krock B, Elman LB, McCluskey LF, Grossman M, Xie SX, Trojanowski JQ, Van Deerlin VM. Semi-automated quantification of C9orf72 expansion size reveals inverse correlation between hexanucleotide repeat number and disease duration in frontotemporal degeneration. Acta Neuropathologica, 130(3): 363-72, 2015. *Co-lead authors

 

McMillan CT, Russ J, Wood EM, Irwin DJ, Grossman M, McCluskey L, Elman L, Van Deerlin V, Lee EB. C9orf72 promoter hypermethylation is neuroprotective: Neuroimaging and neuropathologic evidence. Neurology. 84(16): 1622-30, 2015.

 

Russ J, Liu EY, Wu K, Neal D, Suh E, Irwin DJ, McMillan CT, Harms MB, Cairns NJ, Wood EM, Xie SX, Elman L, McCluskey L, Grossman M, Van Deerlin VM, Lee EB. Hypermethlation of repeat expanded C9orf72 is a clinical and molecular disease modifier. Acta Neuropathologica. 129(1): 39-52, 2015.

 

Liu EY, Russ J, Wu K, Neal D, Suh E, McNally AG, Irwin DJ, Van Deerlin VM, Lee EB. C9orf72 hypermethylation protects against repeat expansion associated pathology in ALS/FTD. Acta Neuropathologia. 128(4): 542-41, 2014.

 

Lee EB*, Russ J, Jung H, Elman LB, Chahine LM, Kremer D, Miller BL, Coslett HB, Trojanowski JQ, Van Deerlin VM, McCluskey LF. Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U. Acta Neuropathologica Communications. 1:9, May 2013. *Corresponding author

 

Lee Edward B, Lee Virginia M.-Y. and Trojanowski John Q. Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nature reviews neuroscience 13(1): 38-50, Nov 2011.

 

Igaz Lionel M*, Kwong Linda K*, Lee Edward B*, Chen-Plotkin Alice, Swanson Eric, Unger Travis, Malunda Joe, Xu Yan, Winton Matthew J, Trojanowski John Q, Lee Virginia M-Y: Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. The Journal of clinical investigation 121(2): 726-38, Feb 2011. PMCID: PMC3026736 *Co-lead authors