All Publications

Lee EB. John Q. Trojanowski: neuropathology icon. Acta Neuropathol. 2022 Apr; 143(4):419-425.

 

Luk KC, Mourelatos Z, Lee EB.  John Q. Trojanowski (1946-2022).  Neuron. 2022 April 06; 110(7): 1095-1096.

 

Lee EB.  John Q. Trojanowski. Nat Rev Neurol. 2002 Mar 22, online ahead of print.

 

Franzmeier N, Brendel M, Beyer L, Slemann L, Kovacs GG, Arzberger T, Kurz C, Respondek G, Lukic MJ, Biel D, Rubinski A, Frontzkowski L, Hummel S, Müller A, Finze A, Palleis C, Joseph E, Weidinger E, Katzdobler S, Song M, Biechele G, Kern M, Scheifele M, Rauchmann BS, Perneczky R, Rullman M, Patt M, Schildan A, Barthel H, Sabri O, Rumpf JJ, Schroeter ML, Classen J, Villemagne V, Seibyl J, Stephens AW, Lee EB, Coughlin DG, Giese A, Grossman M, McMillan CT, Gelpi E, Molina-Porcel L, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Xie SX, Irwin DJ, Roeber S, Herms J, Simons M, Bartenstein P, Lee VM, Trojanowski JQ, Levin J, Höglinger G, Ewers M. Tau deposition patterns are associated with functional connectivity in primary tauopathies. Nat Commun. 2022 Mar 15;13(1):1362.

 

Feng T, Luan L, Katz II, Ullah M, Van Deerlin VM, Trojanowski JQ, Lee EB, Hu F. TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss. Acta Neuropathol Commun. 2022 Mar 14;10(1):33.

 

Steinkellner T, Conrad WS, Kovacs I, Rissman RA, Lee EB, Trojanowski JQ, Freyberg Z, Roy S, Luk KC, Lee VM, Hnasko TS. Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease. Brain. 2021 Nov 19, online ahead of print.

 

Chen M, Ohm DT, Phillips JS, McMillan CT, Capp N, Peterson C, Xie E, Wolk DA, Trojanowski JQ, Lee EB, Gee J, Grossman M, Irwin DJ. Divergent Histopathological Networks of Frontotemporal Degeneration Proteinopathy Subytpes. J Neurosci. 2022 Mar 21, online ahead of print.

 

Brown AL, Wilkins OG, Keuss MJ, Hill SE, Zanovello M, Lee WC, Bampton A, Lee FCY, Masino L, Qi YA, Bryce-Smith S, Gatt A, Hallegger M, Fagegaltier D, Phatnani H; NYGC ALS Consortium, Newcombe J, Gustavsson EK, Seddighi S, Reyes JF, Coon SL, Ramos D, Schiavo G, Fisher EMC, Raj T, Secrier M, Lashley T, Ule J, Buratti E, Humphrey J, Ward ME, Fratta P. TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A. Nature. 2022 Mar;603(7899):131-137

 

Bellenguez C et al., New insights into the genetic etiology of Alzheimer's disease and related dementias. Nat Genet. 2022 Apr 4, online ahead of print.

 

Burke SE, Phillips JS, Olm CA, Peterson CS, Cook PA, Gee JC, Lee EB, Trojanowski JQ, Massimo L, Irwin DJ, Grossman M. Phases of volume loss in patients with known frontotemporal lobar degeneration spectrum pathology. Neurobiol Aging. 2022 Feb 24, online ahead of print.

 

Tisdall MD, Ohm DT, Lobrovich R, Das SR, Mizsei G, Prabhakaran K, Ittyerah R, Lim S, McMillan CT, Wolk DA, Gee J, Trojanowski JQ, Lee EB, Detre JA, Yushkevich P, Grossman M, Irwin DJ. Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology.  Neuroimage Clin 2022; 33: 102913.

 

Ohm DT, Cousins KAQ, Xie SX, Peterson C, McMillan CT, Massimo L, Raskovsky K, Wolk DA, Van Deerlin VM, Elman L, Spindler M, Deik A, Trojanowski JQ, Lee EB, Grossman M, Irwin DJ. Signature laminar distributions of pathology in frontotemporal lobar degeneration. Acta Neuropathol. 2022 Mar; 143(3):363-382

 

Uemura MT, Robinson JL, Cousins KAQ, Tropea TF, Kargilis DC, McBride JD, Suh E, Xie SX, Xu Y, Porta S, Uemura N, Van Deerlin VM, Wolk DA, Irwin DJ, Brunden KR, Lee VM, Lee EB, Trojanowski JQ. Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease. Acta Neuropathologica 2022 Jan; 143(1): 15-31.

 

Kurt Farrell, et al., Genome-wide association study and functional validation implicates JADE1 in tauopathy.  Acta Neuropathologica. 2022 Jan; 143(1): 33-53.

Kim BJ, Lee V, Lee EB, Saludades A, Trojanowski JQ, Dunaief JL, Grossman M, Irwin DJ. Retina tissue validation of optical coherence tomography determined outer nuclear layers loss in FTLD-tau. Acta Neuropathol Commun 2021 Nov 18; 91(1): 184.

 

Hu J, Li X, Coleman K, Schroeder A, Ma N, Irwin DJ, Lee EB, Shinohara RT, Li M. SpaGCN: Integrating gene expression, spatial location and histology to identify spatial domains and spatially variable genes by graph convolutional network.  Nat Methods. 2021 Nov 18, 18(11): 1342-1351.

 

NeuroLINCS Consortium, et al., An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients. iScience 2021 Oct 12; 24(11): 103221.

 

Sadhana Ravikumar, Laura E. M. Wisse, Sydney Lim, Ranjit Ittyerah, Long Xie, Madigan L. Bedard, Sandhitsu R. Das, Edward B. Lee, M. Dylan Tisdall, Karthik Prabhakaran, Jacqueline Lane, John A. Detre, Gabor Mizsei, John Q. Trojanowski, John L. Robinson, Theresa Schuck, Murray Grossman, Emilio Artacho-Pérula, Maria Mercedes Iñiguez de Onzoño Martin, María del Mar Arroyo Jiménez, Monica Muñoz, Francisco Javier Molina Romero, Maria del Pilar Marcos Rabal, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa Prieto, Marta Córcoles Parada, David J. Irwin, David A. Wolk, Ricardo Insausti & Paul A. Yushkevich. Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology.  Acta Neuropathologica Communications. 2021 Oct 24; 9: 173.

 

Thomas Steinkellner, William S. Conrad, Imre Kovacs, Robert A. Rissman, Edward B. Lee, John Q. Trojanowski, Mark H. Tuszynski, Zachary Freyberg, Subhojit Roy, Kelvin Luk, Virginia M.-Y. Lee, Thomas S. Hnasko. Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease. Brain, in press.

 

Iida MA, Farrell K, Walker JM, Richardson TE, Marx GA, Bryce CH, Purohit D, Ayalon G, Beach TG, Bigio EH, Cortes EP, Gearing M, Haroutunian V, McMillan CT, Lee EB, Dickson DW, McKee AC, Stein TD, Trojanowski JQ, Woltjer RL, Kovacs GG, Kofler JK, Kaye J, White CL 3rd, Crary JF. Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study.  Acta Neuropathol Commun. 2021 Aug 5; 9(1): 134.

 

Laura Wisse, Sadhana Ravikumar, Ranjit Ittyerah, Sydney Lim, Jacqueline Lane, Madigan Bedard, Long Xie, Sandhitsu Das, Theresa Schuck< Murray Grossman, Edward Lee, M Tisdall, Karthik Prabhakaran, John Detre, Gabor Mizsei, John Trojanowski, Emilio Artacho, Mercedes Iñiguez de Onzono, Maria Del Mar Arroyo, Monica Munoz, Francisco Molina Romero, Maria Del Pilar Marcos, Sandra Cebada Sanchez, Jose Delgado Gonzalez, Carlos De la Rosa Prieto, Marta Corcoles Parada, David Wolk, David Irwin, Ricardo Insausti, Paul Yushkevich. Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions.  Acta Neuropathologica Communications, 2021 Jul 21; 9(1): 128.

 

Paul A. Yushkevich, Mónica Muñoz López, Maria Mercedes Iñiguez de Onzoño Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L. Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, Salena Cui, Lauren McCollum, John L. Robinson, Theresa Schuck, Robin de Flores, Murray Grossman, M. Dylan Tisdall, Karthik Prabhakaran, Gabor Mizsei, Sandhitsu R. Das, Emilio Artacho-Pérula, María del Mar Arroyo Jiménez, María Pilar Marcos Rabal, Francisco Javier Molina Romero, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa-Prieto, Marta Córcoles Parada, Edward B. Lee, John Q. Trojanowski, Daniel T. Ohm, Laura E.M. Wisse, David A. Wolk, David J. Irwin, Ricardo Insausti. 3D mapping of neurofibrillary tangle burden in the human medial temporal lobe.  Brain, 2021 Oct, 144(9): :2784-2797.

 

Mao F, Robinson JL, Unger T, Posavi M, Amado DA, Elman L, Grossman M, Wolk DA, Lee EB, Van Deerlin VM, Porta S, Lee VMY, Trojanowski JQ, Chen-Plotkin AS. TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy.  Acta Neuropathologica, 2021, Aug; 24(8): 1077-1088.

 

Yen-Chen Lin, Meenakshi Sundaram Kumar, Nandini Ramesh, Eric N. Anderson, Aivi T. Nguyen, Boram Kim, Simon Cheung, Justin A. McDonough, William C. Skarnes, Rodrigo Lopez-Gonzalez, John E. Landers, Nicolas L. Fawzi, Ian R. A. Mackenzie, Edward B. Lee, Jeffrey A. Nickerson, David Grunwald, Udai B. Pandey & Daryl A. Bosco. Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway. Nat Neurosci, 2021 Aug; 24(8): 1077-1088.

 

Wan Yun Ho, Jer-Cherng Chang, Kenneth Lim, Amaury Cazenave-Gassiot, Aivi Nguyen, Juat Chin Foo, Sneha Muralidharan, Ashley Viera-Ortiz, Sarah Ong, Jin Hui Hor, Ira Agrawal, Shawn Hoon, Olubankole Aladesuyi Arogundade, Maria Rodriguez, Su Min Lim, Seung Huyn Kim, John Ravits, Shi-Yan Ng, Markus Wenk, Edward Lee, Greg Tucker-Kellogg, and Shuo-Chien Ling. TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination. JCB, 2021 Sep 6; 220(9): e201910213.

 

Porta S, Xu Y, Lehr T, Zhang B, Meymand E, Olufemi M, Steiber A, Lee EB, Trojanowski JQ, Lee VM.-Y. Distinct brain-deritved TDP-43 strains from FTLD-TDP subtypes induce diverse morphological TDP-43 aggregates and spreading patterns in vitro and in vivo. Neuropathol Appl Neurobiol, 2021 Dec, 47(7): 1033-1049.

 

Katheryn A.Q. Cousins, Jessica Bove, Lucia A.A. Giannini, Nikolas G. Kinney, Yvonne R. Balgenorth, Katya Rascovsky, Edward B. Lee, John Q. Trojanowski, Murray Grossman, and David J. Irwin. Longitudinal naming and repetition relates to AD pathology and burden in autopsy-confirmed primary progressive aphasia. Alzheimer's & Dementia; Translational Research & Clinical Interventions, 2021 Aug 7(1): e12188.

 

Boram Kim, Bailey Mikytuck, Eunran Suh, Garrett S. Gibbons, Vivianna M. Van Deerlin, Sanjeev N.  Vaishnavi, Meredith A. Spindler, Lauren Massimo, Murray Grossman, John Q. Trojanowski, David J. Irwin, Edward B. Lee. Tau immunotherapy is associated with glial responses in FTLD-tau. Acta Neuropathologica, 2021 Aug 152(2): 243-257.

 

Creekmore BC, Chang YW, Lee EB.  The cryo-EM effect: Structural biology of neurodegenerative disease aggregates.  JNEN, 2021 Jun 80(6): 514-529.

 

Creekmore BC, Chang YW, Lee EB.  The cryo-EM effect: Structural biology of neurodegenerative disease proteostasis factors.  JNEN, 2021 Jun 80(6): 494-513.

 

Zhang JV, Irwin DJ, Blennow K, Zetterberg H, Lee EB, Shaw LM, Rascovsky K, Massimo L, McMillan CT, Chen-Plotkin A, Elman L, Lee VM, McCluskey L, Toledo JB, Weintraub D, Wolk D, Trojanowski JQ, Grossman M. Neurofilament light chain related to longitudinal decline in frontotemporal lobar degeneration. Neurol Clin Pract. 2021 Apr;11(2):105-116.

 

Soares AC, Ferreira A, Mariën J, Delay C, Lee E, Trojanowski JQ, Moechars D, Annaert W, De Muynk L. PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding. J Biol Chem. 2021. Jan-Jun 296: 100636.

 

Smith DH, Dollé JP, Ameen-Ali KE, Bretzin A, Cortes E, Crary JF, Dams-O'Connor K, Diaz-Arrastia R, Edlow BL, Folkerth R, Hazrati LN, Hinds SR, Iacono D, Johnson VE, Keene CD, Kofler J, Kovacs GG, Lee EB, Manley G, Meaney D, Montine T, Okonkwo DO, Perl DP, Trojanowski JQ, Wiebe DJ, Yaffe K, McCabe T, Stewart W. COllaborative Neuropatholgoy NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI).  Acta Neuropathol Commun. 2021 Mar 1;9(1):32.

 

Klionsky DJ, et al.  Guildeines of the use and interpretation of assays for monitoring autophagy (4th edition).  Autophagy. 2021 Feb 8:1-382.

 

Giannini LAA, Peterson C, Ohm D, Xie SX, McMillan CT, Raskovsky K, Massimo L, Suh E, Van Deerlin VM, Wolk DA, Trojanowski JQ, Lee EB, Grossman M, Irwin DJ. Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology.  Acta Neuropathol Commun. 2021 Feb 23;9(1):30.

 

Nasrallah MP, Mourelatos Z, Lee EB. Neuropathology associated with SARS-CoV-2 infection.  Lancet. 2021 Jan 23;397(10271):277.

 

Robinson JL, Richardson H, Xie SX, Suh E, Van Deerlin VM, Alfaro B, Loh N, Porras-Paniagua M, Nirschl JJ, Wolk D, Lee VM, Lee EB, Trojanowski JQ. The development and convergence of co-pathologies in Alzheimer's disease.  Brain. 2021;144:953-962.

 

Neumann M, Lee EB, Mackenzie IR. Frontotemporal lobar degeneration TDP-43-immunoreactive pathological subtypes: Clinical and mechanistic significance.  Adv Exp Med Biol. 2021;1281:201-217.

 

Attems J, Toledo JB, Walker L, Gelpi E, Gentleman S, Halliday G, Hortobagyi T, Jellinger K, Kovacs GG, Lee EB, Love S, McAleese KE, Nelson PT, Neumann M, Parkkinen L, Polvikoski T, Sikorska B, Smith C, Grinberg LT, Thal DR, Trojanowski JQ, McKeith IG. Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study.  Acta Neuropathol. 2021 Feb;141(2):159-172.

 

Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, Cortes E, Dickson DW, Fischer P, Flanagan ME, Franklin E, Gearing M, Glass J, Hansen LA, Haroutunian V, Hof PR, Honig L, Kawas C, Keene CD, Kofler J, Kovacs GG, Lee EB, Lutz MI, Mao Q, Masliah E, McKee AC, McMillan CT, Mesulam MM, Murray M, Nelson PT, Perrin R, Pham T, Poon W, Purohit DP, Rissman RA, Sakai K, Sano M, Schneider JA, Stein TD, Teich AF, Trojanowski JQ, Troncoso JC, Vonsattel JP, Weintraub S, Wolk DA, Woltjer RL, Yamada M, Yu L, White CL, Crary JF. Early selective vulnerability of the CA2 hippocampal subfiled in primary age-related tauopathy.  J Neuropathol Exp Neurol. 2021 Jan 20;80(2):102-111.

 

Placek K, Benatar M, Wuu J, Rampersaud E, Hennessy L, Van Deerlin VM, Grossman M, Irwin DJ, Elman L, McCluskey L, Quinn C, Granit V, Statland JM, Burns TM, Ravits J, Swenson A, Katz J, Pioro EP, Jackson C, Caress J, So Y, Maiser S, Walk D, Lee EB, Trojanowski JQ, Cook P, Gee J, Sha J, Naj AC, Rademakers R; CReATe Consortium, Chen W, Wu G, Paul Taylor J, McMillan CT. Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis.  EMBO Mol Med. 2021 Jan 11;13(1):e12595.

 

Dewan R, et al.  Pathogenic huntingtin repeat expansions in patients with frontotemporal dementia and amyotrophic lateral sclerosis.  Neuron. 2021 Feb 3;109(3):448-460.e4.

Arena JD, Johnson VE, Lee EB, Gibbons GS, Smith DH, Trojanowski JQ, Stewart W. Astroglial tau pathology alone preferentially concentrates at sulcal depths in chronic traumatic encephalopathy.  Brain Commun. 2020 Dec 3;2(2):fcaa210.

 

Cousins KAQ, Phillips JS, Irwin DJ, Lee EB, Wolk DA, Shaw LM, Zetterberg H, Blennow K, Burke SE, Kinney NG, Gibbons GS, McMillan CT, Trojanowski JQ, Grossman M. ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration.  Alzheimers Dement. 2020 Nov 23.

 

Spotorno N, Coughlin DG, Olm CA, Wolk D, Vaishnavi SN, Shaw LM, Dahodwala N, Morley JF, Duda JE, Deik AF, Spindler MA, Chen-Plotkin A, Lee EB, Trojanowski JQ, McMillan CT, Weintraub D, Grossman M, Irwin DJ. Tau pathology associated with in vivo cortical thinning in Lewy body disorders.  Ann Clin Transl Neurol. 2020 Dec;7(12):2342-2355.

 

Darwich NF, Phan JM, Kim B, Suh E, Papatriantafyllou JD, Changolkar L, Nguyen AT, O'Rourke CM, He Z, Porta S, Gibbons GS, Luk KC, Papageorgiou SG, Grossman M, Massimo L, Irwin DJ, McMillan CT, Nasrallah IM, Toro C, Aguirre GK, Van Deerlin VM, Lee EB. Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau.  Science. 2020 Nov 20;370(6519):eaay8826.

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Coughlin DG, Phillips JS, Roll E, Peterson C, Lobrovich R, Rascovsky K, Ungrady M, Wolk DA, Das S, Weintraub D, Lee EB, Trojanowski JQ, Shaw LM, Vaishnavi S, Siderowf A, Nasrallah IM, Irwin DJ, McMillan CT; Alzheimer’s Disease Neuroimaging Initiative. Multimodal in vivo and postmortem assessments of tau in Lewy body disorders.  Neurobiol Aging. 2020 Dec;96:137-147.

 

Liu EY, Russ J, Lee EB. Neuronal transcriptome from C9orf72 repeat expanded human tissue is associated with loss of C9orf72 function.  Free Neuropathol. 2020;1:23.

 

Nguyen AT, Wang K, Hu G, Wang X, Miao Z, Azevedo JA, Suh E, Van Deerlin VM, Choi D, Roeder K, Li M, Lee EB. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease.  Acta Neuropathol. 2020 Oct;140(4):477-493.

 

Robinson JL, Porta S, Garrett FG, Zhang P, Xie SX, Suh E, Van Deerlin VM, Abner EL, Jicha GA, Barber JM, Lee VM, Lee EB, Trojanowski JQ, Nelson PT. Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration.  Brain. 2020 Sep 1;143(9):2844-2857.

 

Ohm DT, Peterson C, Lobrovich R, Cousins KAQ, Gibbons GS, McMillan CT, Wolk DA, Van Deerlin V, Elman L, Spindler M, Deik A, Siderowf A, Trojanowski JQ, Lee EB, Grossman M, Irwin DJ. Degeneration of the locus coeruleus is a common feature of tauopathies and distinct from TDP-43 proteinopathies in the frontotemporal lobar degeneration spectrum.  Acta Neuropathol. 2020 Nov;140(5):675-693.

 

Katsumata Y, Abner EL, Karanth S, Teylan MA, Mock CN, Cykowski MD, Lee EB, Boehme KL, Mukherjee S, Kauwe JSK, Kryscio RJ, Schmitt FA, Fardo DW, Nelson PT. Distinct clinicopathologic clusters of persons with TDP-43 encephalopathy.  Acta Neuropathol. 2020 Nov;140(5):659-674.

 

Dai DL, Tropea TF, Robinson JL, Suh E, Hurtig H, Weintraub D, Van Deerlin V, Lee EB, Trojanowski JQ, Chen-Plotkin AS. ADNC-RS, a clinical-genetic risk score, predicts Alzheimer's pathology in autopsy-confirmed Parkinson's disease and Dementia with Lewy bodies. Acta Neuropathol. 2020 Oct;140(4):449-461.

 

Cornblath EJ, Robinson JL, Irwin DJ, Lee EB, Lee VM, Trojanowski JQ, Bassett DS. Defining and predicting transdiagnostic categories of neurodegenerative disease.  Nat Biomed Eng. 2020 Aug;4(8):787-800.

 

Cousins KAQ, Irwin DJ, Wolk DA, Lee EB, Shaw LMJ, Trojanowski JQ, Da Re F, Gibbons GS, Grossman M, Phillips JS. ATN status in amnestic and non-amnestic Alzheimer's disease and frontotemporal lobar degeneration.  Brain. 2020 Jul 1;143(7):2295-2311.

 

Arena JD, Smith DH, Lee EB, Gibbons GS, Irwin DJ, Robinson JL, Lee VM, Trojanowski JQ, Stewart W, Johnson VE. Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer's disease.  Brain. 2020 May 1;143(5):1572-1587.

 

Kovacs GG, Lukic MJ, Irwin DJ, Arzberger T, Respondek G, Lee EB, Coughlin D, Giese A, Grossman M, Kurz C, McMillan CT, Gelpi E, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Roeber S, Xie SX, Lee VM, Trojanowski JQ, Höglinger GU. Distribution patterns of tau pathology in progressive supranuclear palsy.  Acta Neuropathol. 2020 Aug;140(2):99-119.

 

Johnson ECB, Dammer EB, Duong DM, Ping L, Zhou M, Yin L, Higginbotham LA, Guajardo A, White B, Troncoso JC, Thambisetty M, Montine TJ, Lee EB, Trojanowski JQ, Beach TG, Reiman EM, Haroutunian V, Wang M, Schadt E, Zhang B, Dickson DW, Ertekin-Taner N, Golde TE, Petyuk VA, De Jager PL, Bennett DA, Wingo TS, Rangaraju S, Hajjar I, Shulman JM, Lah JJ, Levey AI, Seyfried NT. Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reeals early changes in energy metabolism associated with microglia and astrocyte activation.  Nat Med. 2020 May;26(5):769-780. doi: 10.1038/s41591-020-0815-6.

 

Robinson JL, Yan N, Caswell C, Xie SX, Suh E, Van Deerlin VM, Gibbons G, Irwin DJ, Grossman M, Lee EB, Lee VM, Miller B, Trojanowski JQ. Primary tau pathology, not copathology, correlates with clinical symptoms in PSP and CBD.  J Neuropathol Exp Neurol. 2020 Mar 1;79(3):296-304.

 

Viaene AN, Lee EB, Nasrallah MP. Intraoperative cytology of pituicytomas.  Diagn Cytopathol. 2020 Apr;48(4):342-349.

Cali CP, Park DS, Lee EB. Targeted DNA methylation of neurodegenerative disease genes via homology directed repair.  Nucleic Acids Res. 2019 Dec 16;47(22):11609-11622.

 

Tam OH, Rozhkov NV, Shaw R, Kim D, Hubbard I, Fennessey S, Propp N; NYGC ALS Consortium, Fagegaltier D, Harris BT, Ostrow LW, Phatnani H, Ravits J, Dubnau J, Gale Hammell M. Postmortem cortex samples identify distinct molecular subtypes of ALS: Retrotransposon activation, oxidative stress, and activated glia.  Cell Rep. 2019 Oct 29;29(5):1164-1177.e5.

 

Spotorno N, Hall S, Irwin DJ, Rumetshofer T, Acosta-Cabronero J, Deik AF, Spindler MA, Lee EB, Trojanowski JQ, van Westen D, Nilsson M, Grossman M, Nestor PJ, McMillan CT, Hansson O. Diffusion tensor MRI to distinguish progressive supranuclear palsy from alpha-synucleinopathies.  Radiology. 2019 Dec;293(3):646-653.

 

Caswell C, McMillan CT, Xie SX, Van Deerlin VM, Suh E, Lee EB, Trojanowski JQ, Lee VM, Irwin DJ, Grossman M, Massimo LM. Genetic predictors of survival in behavioral variant frontotemporal degeneration.  Neurology. 2019 Oct 29;93(18):e1707-e1714.

 

Giannini LAA, Xie SX, Peterson C, Zhou C, Lee EB, Wolk DA, Grossman M, Trojanowski JQ, McMillan CT, Irwin DJ. Empiric methods to account for pre-analytical variability in digital histopathology in frontotemporal lobar degeneration.  Front Neurosci. 2019 Jul 3;13:682.

 

Cali CP, Patino M, Tai YK, Ho WY, McLean CA, Morris CM, Seeley WW, Miller BL, Gaig C, Vonsattel JPG, White CL 3rd, Roeber S, Kretzschmar H, Troncoso JC, Troakes C, Gearing M, Ghetti B, Van Deerlin VM, Lee VM, Trojanowski JQ, Mok KY, Ling H, Dickson DW, Schellenberg GD, Ling SC, Lee EB. C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy.  Acta Neuropathol. 2019 Nov;138(5):795-811.

 

Lee EB, Kinch K, Johnson VE, Trojanowski JQ, Smith DH, Stewart W. Chronic traumatic encephalopathy is a common co-morbidity, but less frequent primary dementia in former soccer and rugby players.  Acta Neuropathol. 2019 Sep;138(3):389-399.

 

Phillips JS, Da Re F, Irwin DJ, McMillan CT, Vaishnavi SN, Xie SX, Lee EB, Cook PA, Gee JC, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M. Longitudinal progression of grey matter atrophy in non-amnestic Alzheimer's disease.  Brain. 2019 Jun 1;142(6):1701-1722.

 

Viaene AN, Lee EB, Rosenbaum JN, Nasrallah IM, Nasrallah MP. Histologic, immunohistochemical, and molecular features of pituicytomas and atypical pituicytomas.  Acta Neuropathol Commun. 2019 May 2;7(1):69.

 

Liu EY, Russ J, Cali CP, Phan JM, Amlie-Wolf A, Lee EB. Loss of nuclear TDP-43 is associated with decondensation of LINE retrotransposons.  Cell Rep. 2019 Apr 30;27(5):1409-1421.e6.

 

Giannini LAA, Xie SX, McMillan CT, Liang M, Williams A, Jester C, Rascovsky K, Wolk DA, Ash S, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ. Divergent patterns of TDP-43 and tau pathologies in primary progressive aphasia.  Ann Neurol. 2019 May;85(5):630-643.

 

Stewart W, Allinson K, Al-Sarraj S, Bachmeier C, Barlow K, Belli A, Burns MP, Carson A, Crawford F, Dams-O'Connor K, Diaz-Arrastia R, Dixon CE, Edlow BL, Ferguson S, Fischl B, Folkerth RD, Gentleman S, Giza CC, Grady MS, Helmy A, Herceg M, Holton JL, Howell D, Hutchinson PJ, Iacono D, Iglesias JE, Ikonomovic MD, Johnson VE, Keene CD, Kofler JK, Koliatsos VE, Lee EB, Levin H, Lifshitz J, Ling H, Loane DJ, Love S, Maas AI, Marklund N, Master CL, McElvenny DM, Meaney DF, Menon DK, Montine TJ, Mouzon B, Mufson EJ, Ojo JO, Prins M, Revesz T, Ritchie CW, Smith C, Sylvester R, Tang CY, Trojanowski JQ, Urankar K, Vink R, Wellington C, Wilde EA, Wilson L, Yeates K, Smith DH. Primum non nocere: a call for balance when reporting on CTE.  Lancet Neurol. 2019 Mar;18(3):231-233.

 

Pottier C, et. al.  Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FLTD.  Acta Neuropathol. 2019 Jun;137(6):879-899.

 

Coughlin D, Xie SX, Liang M, Williams A, Peterson C, Weintraub D, McMillan CT, Wolk DA, Akhtar RS, Hurtig HI, Branch Coslett H, Hamilton RH, Siderowf AD, Duda JE, Rascovsky K, Lee EB, Lee VM, Grossman M, Trojanowski JQ, Irwin DJ. Cognitive and pathological influences of tau pathology in Lewy body disorders.  Ann Neurol. 2019 Feb;85(2):259-271.

 

Placek K, Baer GM, Elman L, McCluskey L, Hennessy L, Ferraro PM, Lee EB, Lee VMY, Trojanowski JQ, Van Deerlin VM, Grossman M, Irwin DJ, McMillan CT. UNC13A polymorphism contributes to frontotemporal disease in sporadic amyotrophic lateral sclerosis.  Neurobiol Aging. 2019 Jan;73:190-199.

 

Alcolea D, Irwin DJ, Illán-Gala I, Muñoz L, Clarimón J, McMillan CT, Fortea J, Blesa R, Lee EB, Trojanowski JQ, Grossman M, Lleó A. Elevated YKL-40 and low sAPPß:YKL-40 ratio in antemortem cerebrospinal fluid of patients with pathologically confirmed FTLD.  J Neurol Neurosurg Psychiatry. 2019 Feb;90(2):180-186.

Porta S, Xu Y, Restrepo CR, Kwong LK, Zhang B, Brown HJ, Lee EB, Trojanowski JQ, Lee VM. Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo.  Nat Commun. 2018 Oct 11;9(1):4220.

 

Brettschneider J, Suh E, Robinson JL, Fang L, Lee EB, Irwin DJ, Grossman M, Van Deerlin VM, Lee VM, Trojanowski JQ. Converging patterns of alpha-synuclein pathology in multiple system atrophy.  J Neuropathol Exp Neurol. 2018 Nov 1;77(11):1005-1016.

 

McMillan CT, Lee EB, Jefferson-George K, Naj A, Van Deerlin VM, Trojanowski JQ, Wolk DA. Alzheimer's genetic risk is reduced in primary age-related tauopathy: a potential model of resistance?  Ann Clin Transl Neurol. 2018 Jun 19;5(8):927-934.

 

Conlon EG, Fagegaltier D, Agius P, Davis-Porada J, Gregory J, Hubbard I, Kang K, Kim D; New York Genome Center ALS Consortium, Phatnani H, Shneider NA, Manley JL.   Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism.  Elife. 2018 Jul 13;7:e37754.

 

Kovacs GG, Xie SX, Robinson JL, Lee EB, Smith DH, Schuck T, Lee VM, Trojanowski JQ. Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain.  Acta Neuropathol Commun. 2018 Jun 11;6(1):50.

 

Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C, Caswell C, Van Deerlin VM, Yan N, Yousef A, Hurtig HI, Siderowf A, Grossman M, McMillan CT, Miller B, Duda JE, Irwin DJ, Wolk D, Elman L, McCluskey L, Chen-Plotkin A, Weintraub D, Arnold SE, Brettschneider J, Lee VM, Trojanowski JQ.  Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE-associated.  Brain. 2018 Jul 1;141(7):2181-2193.

 

Pottier C., et. al.  Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.  Lancet Neurol. 2018 Jun;17(6):548-558.

 

Shi M, Tang L, Toledo JB, Ginghina C, Wang H, Aro P, Jensen PH, Weintraub D, Chen-Plotkin AS, Irwin DJ, Grossman M, McCluskey L, Elman LB, Wolk DA, Lee EB, Shaw LM, Trojanowski JQ, Zhang J.   Cerebrospinal fluid alpha-synuclein contributes to the differentiate diagnosis of Alzheimer's disease.  Alzheimers Dement. 2018 Aug;14(8):1052-1062.

 

Nicolas A, et. al.  Genome-wide analyses identify KIF5A as a novel ALS gene.  Neuron. 2018 Mar 21;97(6):1268-1283.e6.

 

Lleó A, Irwin DJ, Illán-Gala I, McMillan CT, Wolk DA, Lee EB, Van Deerlin VM, Shaw LM, Trojanowski JQ, Grossman M. A 2-step cerebrospinal fluid algorithm for the selection of frontotemporal lobar degeneration subtypes.  JAMA Neurol. 2018 Jun 1;75(6):738-745.

 

Lee EB.  Integrated neurodegenerative disease autopsy diagnosis.  Acta Neuropathol. 2018 Apr;135(4):643-646.

 

Irwin DJ, Xie SX, Coughlin D, Nevler N, Akhtar RS, McMillan CT, Lee EB, Wolk DA, Weintraub D, Chen-Plotkin A, Duda JE, Spindler M, Siderowf A, Hurtig HI, Shaw LM, Grossman M, Trojanowski JQ. CSF tau and ß-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders.  Neurology 90(12): e1038-e1046, March 20, 2018.

 

Irwin DJ, McMillan CT, Xie SX, Rascovsky K, Van Deerlin VM, Coslett HB, Hamilton R, Aguirre G, Lee EB, Lee VMY, Trojanowski JQ, Grossman M. Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia. Brain, 2018.

 

Phillips JS, Da Re F, Dratch L, Xie SX, Irwin DJ, McMillan CT, Vaishnavi SN, Ferrarese C, Lee EB, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M. Neocortical origins and progression of gray matter atrophy in nonamnestic Alzheimer's disease. Neurobiol Aging 63: 75-87, 2018.

 

Kovacs Gabor G, Kwong Linda K, Grossman Murray, Irwin David J, Lee Edward B, Robinson John L, Suh Eunran, Van Deerlin Vivianna M, Lee Virginia M, Trojanowski John Q: Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain Pathology, 28(2): 274-283, Mar, 2018. PMCID: PMC28019685

Wang L, Hubbard RA, Walker RL, Lee EB, Larson EB, Crane PK. Assessing robustness of hazard ratio estimates to outcome misclassification in longitudinal panel studies with application to Alzheimer's disease. PLoS One, 12(12): E0190107, 2017.


Yousef A, Robinson JL, Irwin DJ, Byrne MD, Kwong LK, Lee EB, Xu Y, Xie SX, Rennert L, Suh E, Van Deerlin VM, Grossman M, Lee VM, Trojanowski JQ. Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration. Acta Neuropathologica Communications 5(1): 68, 2017.

 

Irwin DJ, Lleo A, Xie SX, McMillan CT, Wolk DA, Lee EB, Van Deerlin VM, Shaw LM, Trojanowski JQ, Grossman M. Ante mortem cerebrospinal fluid tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration. Ann Neurol 82(2): 247-258, 2017.

 

Paolicelli RC, Jawaid A, Henstridge CM, Valeri A, Merlini M, Robinson JL, Lee EB, Rose J, Appel S, Lee VM, Trojanowski JQ, Spires-Jones T, Schulz PE, Rajendran L. TDP-43 depletion in microglia promotes amyloid clearance but also induces synapse loss. Neuron 95(2): 297-308, 2017.

 

Kovacs GG et al., Multisite assessment of aging-related tau astrogliopathy (ARTAG). JNEN, 76(7): 605-619, 2017.

 

Giannini LAA, Irwin DJ, McMillan CT, Ash S, Rascovsky K, Wolk DA, Van Deerlin VM, Lee EB, Trojanowski JQ, Grossman M. Clinical markers for Alzheimer disease pathology in logopenic primary progressive aphasia. Neurology, 2017.

 

Bonini NM, Lee EB, Wasco W, Roses AD. Editorial overview: Molecular & genetic basis of disease. Curr Opin Genet Dev, 2017.

 

Liu EY, Cali CP, Lee EB. RNA metabolism in neurodegenerative disease. Disease Models & Mechanisms, 10: 509-518, 2017.

 

Kovacs GG, Robinson JL, Xie SX, Lee EB, Grossman M, Wolk DA, Irwin DJ, Weintraub D, Kim CF, Schuck T, Yousef A, Wagner ST, Suh E, Van Deerlin VM, Lee VM, Trojanowski JQ. Evaluating the patterns of aging-related tau astrogliopathy unravels novel insights into brain aging and neurodegenerative diseases. JNEN, 76(4): 270-788, 2017.

 

Jefferson-George KS, Wolk DA, Lee EB, McMillan CT. Cognitive decline associated with pathological burden in primary age-related tauopathy. Alzheimers Dement, Sep, 2017.

 

Lee EB*, Porta S, Baer GM, Xu Y, Suh E, Kwong LK, Elman L, Grossman M, Lee VM-Y, Irwin DJ, VanDeerlin VM, Trojanowski JQ. Expansion of the classification of FTLD-TDP: Distinct pathology associated with rapidly progressive frontotemporal degeneration. Acta Neuropathologica, Jul, 2017. *Corresponding author

 

Spotorno N, McMillan CT, Irwin DJ, Clark R, Lee EB, Trojanowski JQ, Weintraub D, Grossman M. Decision-making deficits associated with amyloidosis in Lewy body disorders. Front Hum Neurosci, 10: 693, 2017

 

Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX, Lee EB, Van Deerlin VM, Lopez OL, Kofler JK, Nelson PT, Jicha GA, Woltjer R, Quinn JF, Kaye J, Leverenz JB, Tsuang D, Longfellow K, Yearout D, Kukull W, Keene CD, Montine TJ, Zabetian CP, Trojanowski JQ. Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. Lancet Neurology, 16(1): 55-65, 2017.

McMillan CT, Irwin DJ, Nasrallah I, Phillips JS, Spindler M, Rascovsky K, Ternes K, Jester C, Wolk DA, Kwong LK, Lee VM, Lee EB, Trojanowski JQ, Grossman M. Multimodal evaluation demonstrates in vivo 18F-AV-1451 uptake in autopsy-confirmed coritcobasal degeneraion. Acta Neuropathologica, 132(6): 935-937, 2016.

 

Placek K, Massimo L, Olm C, Ternes K, Firn K, Van Deerlin V, Lee EB, Trojanowski JQ, Lee VM, Irwin D, Grossman M, McMillan CT. Congitive reserve in frontotemporal degeneration: Neuroanatomic and neuropsychological evidence. Neurology, 87(17): 1813-1819, 2016.

 

McMillan CT, Boyd C, Gross RG, Weinstein J, Firn K, Toledo JB, Rascovsky K, Shaw L, Wolk DA, Irwin DJ, Lee EB, Trojanowski JQ, Grossman M. Multimodal imaging evidence of pathology-mediated distribution in corticobasal syndrome. Neurology, 87(12): 1227-34, 2016.

 

Toledo JB, Gopal P, Raible K, Irwin DJ, Brettschneider J, Sedor S, Waits K, Boluda S, Grossman M, Van Deerlin VM, Lee EB, Arnold SE, Duda JE, Hurtig H, Lee VM, Adler CH, Beach TG, Trojanowski JQ. Pathological alpha-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology. Acta Neuropathologica, 131(3): 393-409, 2016.

 

Kovacs GG, et al. Aging-related tau astrogliopathy (ARTAG): Harmonized evaluation strategy. Acta Neuropathologica. 131(1): 87-102, 2016.

 

Irwin DJ, Brettschneider J, McMillan CT, Cooper F, Olm C, Arnold SE, Van Deerlin VM, Seeley WW, Miller BL, Lee EB, Lee VM, Grossman M, Trojanowski JQ. Deep clinical and neuropathological phenotyping of Pick's disease. Annals of Neurology, 79(2): 272,87, 2016.

 

Montine TJ, Monsell SE, Beach TG, Bigio EH, Bu Y, Cairns NJ, Frosch M, Henriksen J, Kofler J, Kukull WA, Lee EB, Nelson PT, Schantz AM, Schneider JA, Sonnen JA, Trojanowski JQ, Vinters HV, Zhou XH, Hyman BT. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimers Dement 12(2): 164-9, 2016.

 

Iwrin DJ, Byrne MD, McMillan CT, Cooper F, Arnold SE, Lee EB, Van Deerlin VM, Xie SX, Lee VM, Grossman M, Trojanowski JQ. Semi-automated image analysis of Pick's disease and TDP-43 proteinopathy. J Histochem Cytochem. 64(1): 54-66, 2016.

O'Rourke JG, Bogdanik L, Muhammad AKMG, Gendron TF, Kim KJ, Austin A, Day J, Liu EY, Zarrow J, Grant S, Ho R, Bell S, Carmona S, Simpkinson M, Lall D, Wu K, Daughrity L, Dickson DW, Harms MB, Petrucelli L, Lee EB, Lutz CM, Baloh RH. C9orf72 BAC transgenic mice display typical pathologic features of ALS/FTD. Neuron. 88(5): 892-901, 2015.

 

Amlie-Wolf A, Ryvkin P, Tong R, Dragomir I, Suh E, Xu Y, Van Deerlin VM, Gregory BD, Kwong LK, Trojanowski JQ, Lee VMY, Wang LS, Lee EB. Transcriptomic changes due to cytoplasmic TDP-43 expression reveal dysregulation of histone transcripts and nuclear chromatin. PLoS One. 10(10): e0141836, 2015.

 

Montine TJ, Monsell SE, Beach TG, Bigio EH, Bu Y, Cairns NJ, Frosch M, Henriksen J, Kofler J, Kukull WA, Lee EB, Nelson PT, Schantz AM, Schneider JA, Sonnen JA, Trojanowski JQ, Vinters HV, Zhou XH, Hyman BT. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimers Dement. In press, 2015.

 

Robinson JL, Suh E, Wood EM, Lee EB, Coslett HB, Raible K, Lee VM, Trojanowski JQ, Van Deerlin VM. Common neuropathological features underlie distinct clinical presentations in three siblings with hereditary diffuse leukoencephalopathy with spheroids caused by CFS1R p.Arg782His. Acta Neuropathol Commun. 3(1): 42, 2015.

 

Suh E*, Lee EB*, Neal D, Wood EM, Toledo JB, Rennert L, Irwin DJ, McMillan CT, Krock B, Elman LB, McCluskey LF, Grossman M, Xie SX, Trojanowski JQ, Van Deerlin VM. Semi-automated quantification of C9orf72 expansion size reveals inverse correlation between hexanucleotide repeat number and disease duration in frontotemporal degeneration. Acta Neuropathologica, 130(3): 363-72, 2015. *Co-lead authors

 

McMillan CT, Russ J, Wood EM, Irwin DJ, Grossman M, McCluskey L, Elman L, Van Deerlin V, Lee EB. C9orf72 promoter hypermethylation is neuroprotective: Neuroimaging and neuropathologic evidence. Neurology. 84(16): 1622-30, 2015.

 

Irwin DJ, Cairns NJ, Grossman M, McMillan CT, Lee EB, Van Deerlin VM, Lee VM, Trojanowski JQ. Frontotemporal lobar degeneration: defining phenotyping diversity thorugh personalized medicine. Acta Neuropathologica. 129(4): 469-91, 2015.

 

Russ J, Liu EY, Wu K, Neal D, Suh E, Irwin DJ, McMillan CT, Harms MB, Cairns NJ, Wood EM, Xie SX, Elman L, McCluskey L, Grossman M, Van Deerlin VM, Lee EB. Hypermethlation of repeat expanded C9orf72 is a clinical and molecular disease modifier. Acta Neuropathologica. 129(1): 39-52, 2015.

McGurk L, Lee VM, Trojanowski JQ, Van Deerlin VM, Lee EB, Bonini NM. Poly-A binding protein-1 localization to a subset of TDP-43 inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72. Journal of Neuropathology and Experimental Neurology. 73(9): 837-45, 2014.

 

Yarchoan M, Toledo JB, Lee EB, Arvanitakis Z, Kazi H, Han LY, Louneva N, Lee VM, Kim SF, Trojanowski JQ, Arnold SE. Abnormal serine phosphorylation of insulin receptor substrate-1 is associated with tau pathology in Alzheimer's disease and tauopathies. Acta Neuropathologica. 128(5): 679-89, 2014.

 

Robinson JL, Molina-Porcel L, Corrada MM, Raible K, Lee EB, Lee VM, Kawas CH, Trojanowski JQ. Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old. Brain. 137(9): 2578-87, 2014.

 

Boluda S, Toledo JB, Irwin DJ, Raible KM, Byrne MD, Lee EB, Lee VM, Trojanowski JQ. A comparison of Abeta amyloid pathology staging systems and correlation with clinical diagnosis. Acta Neuropathologica. 128(4): 543-50, 2014.

 

BrettschneiderJ, Arai K, Del Tredici K, Toledo JB, Robinson JL, Lee EB, Kuwabara S, Shibuya K, Irwin DJ, Fang L, Van Deerlin VM, Elman L, McCLuskey L, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. TDP-43 pathology and neuron loss in amyotrophic lateral sclerosis spinal cord. Acta Neuropathologica. 128(3): 423-37, 2014.

 

Liu EY, Russ J, Wu K, Neal D, Suh E, McNally AG, Irwin DJ, Van Deerlin VM, Lee EB. C9orf72 hypermethylation protects against repeat expansion associated pathology in ALS/FTD. Acta Neuropathologia. 128(4): 542-41, 2014.

 

Brettschneider J, Del Tredici K, Irwin DJ, Gromssan M, Robinson JL, Toledo JB, Lee EB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathologica. 127(3): 423-39, 2014.

 

Lee EB, Mattson MP. The neuropathology of obesity: insights from human disease. Acta Neuropathologica. 127(1): 3-28, 2014.

Wood EM, Falcone D, Suh E, Irwin DJ, Chen-Plotkin AS, Lee EB, Xie S, Van Deerlin VM, Grossman M. Development and validation of pedigree classification for frontotemporal lobar degeneration. JAMA Neurology. 70(11): 1411-7, 2013.

 

Arnold SE, Toledo JB, Appleby DH, Xie SX, Wang LS, Baek Y, Wolk DA, Lee EB, Miller BL, Lee VM, Trojanowski JQ. A comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases. J Comp Neurol. 521(18): 4339-55, 2013.

 

Toledo JB, Van Deerlin VM, Lee EB, Suh E, Baek Y, Robinson JL, Xie SS, McBride J, Wood EM, Schuck T, Irwin D, Gross RG, Hurtig H, McCluskey L, Elman L, Karlawish J, Schellenberg G, Chen-Plotkin A, Wolk D, Grossman M, Arnold SE, Shaw LM, Lee VM-Y, Trojanowski JQ. A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank. Alzheimer's and Dementia. 10(4): 477-87, 2013.

 

Brettschneider J, Tredicki, KD, Toledo JB, Robinson JL, Irwin DJ, Grossman M, Suh E, Van Deerlin VM, Wood EM, Baek Y, Kwong L, Lee EB, Elman L, McCluskey L, Fang L, Feldengut S, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Stages of pTDP-43 pathology in amyotrophic lateral sclerosis. Ann Neurol. 74(1): 20-38, 2013.

 

Lee EB*, Russ J, Jung H, Elman LB, Chahine LM, Kremer D, Miller BL, Coslett HB, Trojanowski JQ, Van Deerlin VM, McCluskey LF. Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U. Acta Neuropathologica Communications. 1:9, May 2013. *Corresponding author

Yarchoan M, Xie SX, Kling MA, Toledo JB, Wolk DA, Lee EB, Van Deerlin V, Lee VM.-Y., Trojanowski JQ, Arnold SE. Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias. Brain. 135(12): 3749-56, Dec 2012.

 

Brettschneider J, van Deerlin V, Robinson J, Kwong L, Lee Edward B, Ali YO, Safren N, Monteiro M, Toledo JB, Elman L, McCluskey L, Irwin DJ, Grossman M, Molina L, Lee VMY, Trojanowski JQ.  Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion.  Acta Neuropathologica. 123(6): 825-39, Jun 2012.

 

Patel S, Lee EB, Xie SX, Law A, Jackson EM, Arnold SE, Clark CM, Shaw LM, Grady MS, Trojanowski JQ, Hamilton RH. Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus. Fluids Barriers CNS. 9(1): 7, Mar 2012.

 

Wang Sumei, Kim Sungheon, Zhang Yu, Wang Lu, Lee Edward B., Syre Peter, Poptani Harish, Melhem Elias R., Lee John Y.K.: Grading and subtyping of meningiomas using histogram analysis of diffusion tensor imaging. Radiology 262(2): 584-92, Feb 2012.

 

Lee Edward B and Ahima Rexford S. Alteration of hypothalamic cellular dynamics in obesity. The journal of clinical investigation. 122(1): 22-5, Jan 2012.

Hamilton Roy, Patel Sunil, Lee Edward B, Jackson Eric M, Lopinto Joanna, Arnold Steven E, Clark Christopher M, Basil Anuj, Shaw Leslie M, Xie Sharon X, Grady M Sean, Trojanowski John Q: Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology. Annals of neurology 68(4): 535-40, Oct 2010. PMCID: PMC2964442

 

Prasad Sashank, Lee Edward B, Woo John H, Alavi Abass, Galetta Steven L: Photo essay. MRI and positron emission tomography findings in Heidenhain variant Creutzfeldt-Jakob disease. Journal of neuro-ophthalmology 30(3): 260-2, Sep 2010. PMCID: PMC2964442

 

Arnold Steven E, Lee Edward B, Moberg Paul J, Stutzbach Lauren, Kazi Hala, Han Li-Ying, Lee Virginia M Y, Trojanowski John Q: Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease. Annals of neurology 67(4): 462-9, Apr 2010. PMCID: PMC2864948

 

Turkeltaub Peter E, Guzman Miguel A, Lee Edward B, Galetta Steven L: Idiopathic eosinophilic meningoencephalomyelitis following Well syndrome. Neurology 73(23): 2037-9, Dec 2009. PMCID: PMC2790232

 

Ranalli Nathan J, Huang Jason H, Lee Edward B, Zhang Paul J L, Siegelman Evan S, Zager Eric L: Hemangiomas of the brachial plexus: a case series. Neurosurgery 65(4 Suppl): A181-8, Oct 2009. PMCID: PMC2864948

 

Kim A K, Lee E B, Bagley L J, Loevner L A: Retained surgical sponges after craniotomies: imaging appearances and complications. AJNR. American journal of neuroradiology 30(6): 1270-2, Jun 2009. PMCID: PMC2790232

 

Lee Edward B, Tihan Tarik, Scheithauer Bernd W, Zhang Paul J, Gonatas Nicholas K: Thyroid transcription factor 1 expression in sellar tumors: a histogenetic marker? Journal of neuropathology and experimental neurology 68(5): 482-8, May 2009. PMCID: PMC2790232

 

Ko Melissa W, Turkeltaub Peter E, Lee Edward B, Gonatas Nicholas K, Volpe Nicholas J, Moster Mark L, Galetta Steven L: Primary diffuse leptomeningeal gliomatosis mimicking a chronic inflammatory meningitis. Journal of the neurological sciences 278(1-2): 127-31, Mar 2009. PMCID: PMC2790232

 

Neumann Manuela, Kwong Linda K, Lee Edward B, Kremmer Elisabeth, Flatley Andrew, Xu Yan, Forman Mark S, Troost Dirk, Kretzschmar Hans A, Trojanowski John Q, Lee Virginia M-Y: Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta neuropathologica 117(2): 137-49, Feb 2009. PMCID: PMC2693625

Prasad S, Moss H E, Lee E B, Glisson C C, Galetta S L: Clinical reasoning: a 42-year-old man with sequential monocular visual loss. Neurology 71(17): e43-9, Oct 2008. PMCID: PMC2693625

 

Lee Edward B, Lee Virginia M-Y, Trojanowski John Q, Neumann Manuela: TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system. Acta neuropathologica 115(3): 305-11, Mar 2008. PMCID: PMC2693625

 

Lee Edward B and Lee Virginia M.-Y.: Biology and molecular neuropathology of ß-amyloid protein. Neurobiology of Alzheimer's Disease, 3rd edition. Dawbarn D and Allen SJ (eds.). 2007.

 

Prasad Sashank, Ko Melissa W, Lee Edward B, Gonatas Nicholas K, Stern Matthew B, Galetta Steven: Supranuclear vertical gaze abnormalities in sporadic Creutzfeldt-Jakob disease. Journal of the neurological sciences 253(1-2): 69-72, Feb 2007. PMCID: PMC269362

Lee Edward B, Leng Lewis Z, Zhang Bin, Kwong Linda, Trojanowski John Q, Abel Ted, Lee Virginia M-Y: Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. The Journal of biological chemistry 281(7): 4292-9, Feb 2006. PMCID: PMC2693625

 

Lee Edward B, Leng Lewis Z, Lee Virginia M-Y, Trojanowski John Q: Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis. FEBS letters 579(12): 2564-8, May 2005. PMCID: PMC2693625

 

Lazarov Orly, Morfini Gerardo A, Lee Edward B, Farah Mohamed H, Szodorai Anita, DeBoer Scott R, Koliatsos Vassilis E, Kins Stefan, Lee Virginia M-Y, Wong Philip C, Price Donald L, Brady Scott T, Sisodia Sangram S: Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. The Journal of neuroscience 25(9): 2386-95, Mar 2005.

 

Zhang Bin, Maiti Arpita, Shively Sharon, Lakhani Fara, McDonald-Jones Gaye, Bruce Jennifer, Lee Edward B, Xie Sharon X, Joyce Sonali, Li Chi, Toleikis Philip M, Lee Virginia M-Y, Trojanowski John Q: Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proceedings of the National Academy of Sciences of the United States of America 102(1): 227-31, Jan 2005. PMCID: PMC544048

 

Lee Edward B, Zhang Bin, Liu Kangning, Greenbaum Eric A, Doms Robert W, Trojanowski John Q, Lee Virginia M-Y: BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo. The Journal of cell biology 168(2): 291-302, Jan 2005. PMCID: PMC2171598

Sung Syaun, Yang Hengxuan, Uryu Kunihiro, Lee Edward B, Zhao Lei, Shineman Diana, Trojanowski John Q, Lee Virginia M-Y, Pratic? Domenico: Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. The American journal of pathology 165(6): 2197-206, Dec 2004. PMCID: PMC1618710

 

Watson Deborah J, Longhi Luca, Lee Edward B, Fulp Carl T, Fujimoto Scott, Royo Nicolas C, Passini Marco A, Trojanowski John Q, Lee Virginia M Y, McIntosh Tracy K, Wolfe John H: Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury. Journal of neuropathology and experimental neurology 62(4): 368-80, Apr 2003. PMCID: PMC1618710

 

Lee Edward B, Skovronsky Daniel M, Abtahian Farhad, Doms Robert W, Lee Virginia M-Y: Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons. The Journal of biological chemistry 278(7): 4458-66, Feb 2003. PMCID: PMC1618710

 

Passini Marco A, Lee Edward B, Heuer Gregory G, Wolfe John H: Distribution of a lysosomal enzyme in the adult brain by axonal transport and by cells of the rostral migratory stream. The Journal of neuroscience 22(15): 6437-46, Aug 2002. PMCID: PMC1618710