Frederick (Fritz) Lewy & Parkinson's Disease Neuropathology:
Lewy FH. Paralysis agitans. 1. Pathologische Anatomie. In: Lewandowsky M, editor. Handbuch der Neurologie, Dritter Band, Spezielle Neurologie I. Berlin: Julius Springer; 1912. pp. 920–933.
Lewy FH. Zur pathologischen Anatomie der Paralysis agitans. Dtsch Ztschr Nervenheilkunde. 1914;50:50–55.
Lewy FH. Die Lehre vom Tonus und der Bewegung Zugleich Systematische Untersuchungen zur Klinik, Physiologie, Pathologie und Pathogenese der. Paralysis agitans. Berlin: Julius Springer; 1923.
Foundational Neuropathology:
Lee VM, Balin BJ, Otvos Jr L, Trojanowski JQ. A68: a major subunit of paired helical filaments and derivatized forms of normal tau. Science. 1991 Feb 8;251(4994):675-8.
Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. Alpha-synuclein in Lewy bodies. Nature 1997 Aug 28;388(6645):839-40.
Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, Feiden W, Kretzschmar HA, Trojanowski JQ, Lee VM. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science. 2006 Oct 6;314(5796):130-3.
Fluid and Neuroimaging Biomakers & Neuropathology:
Shaw LM, Vanderstichele H, Knapik-Czajka M, Clark CM, Aisen PS, Petersen RC, Blennow K, Soares H, Simon A, Lewczuk P, Dean R, Siemers E, Potter W, Lee VMY, Trojanowski JQ, ADNI. Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects. Ann Neurol. 2009 Apr;65(4):403-413.
Skovronsky DM, Zhang B, Kung MP, Kung HF, Trojanowski JQ, Lee VM. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease. PNAS. 2000 Jun 20;97(13):7609-14.
Genetics & Neuropathology: Vacuolar Tauopathy and Small Molecule VCP Activators:
Zarley BD. 4 people in the world have a mysterious dementia. Could it hold a key to Alzheimer's. Freethink. 2020.
Darwich NF, Phan JM, Kim B, Suh E, Papatriantafyllou JD, Changolkar L, Nguyen AT, O'Rourke CM, He Z, Porta S, Gibbons GS, Luk KC, Papageorgiou SG, Grossman M, Massimo L, Irwin DJ, McMillan CT, Nasrallah IM, Toro C, Aguirre GK, Van Deerlin VM, Lee EB. Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. Science. 2020 Nov 20;370(6519):eaay8826. pdf reprint
Phan JM, Creekmore BC, Nguyen AT, Bershadskaya DD, Darwich NF, Mann CN, Lee EB. VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models. J Clin Invest. 2024 May 23;134(15):e169039.
Environmental Neuropathology:
Kim B, Yannatos I, Blam K, Wiebe D, Xie SX, McMillan CT, Mechanic-Hamilton D, Wolk DA, Lee EB. Neighborhood disadvantage reduces cognitive reserve independent of neuropathologic change. Alzheimers Dement 2024 Apr;20(4):2707-2718.
Kim B, Blam K, Elser H, Xie SX, Van Deerlin VM, Penning TM, Weintrab D, Irwin DJ, Massimo LM, McMillan CT, Mechanic-Hamilton D, Wolk DA, Lee EB. Alzheimer's disease neuropathologic change mediates the relationship between ambient air pollution and dementia severity. medRxiv. 2024.
Structural Neuropathology:
Creekmore BC, Kixmoeller K, Black BE, Lee EB, Chang Y-W. Ultrastructure of human brain tissue vitrified from autopsy revealed by cryo-ET with cryo-plasma FIB milling. Nature Communications. 2024 Mar 26;15(1):2660.
