Joeng Laboratory

Bonhyeock Koo

Postdoctoral Fellow

Contact Information

Department of Orthopaedic Surgery
School of Medicine, University of Pennsylvania
360 Stemmler Hall,
36th Street and Hamilton Walk
Philadelphia, PA 19104

BonHyeock.Koo@Pennmedicine.upenn.edu

EDUCATION

PhD in Kangwon National University Chuncheon, Korea 2018~2022

Master digree in Kangwon National University Chuncheon, Korea 2016~2018

Bachelor in Kangwon National University Chuncheon, Korea 2011~2016

 

PUBLICATIONS

1. Koo BH, Won MH, Kim YM, Ryoo S (2021)

Arginase II protein regulates Parkin-dependent p32 degradation that contributes to Ca2+-dependent eNOS activation in endothelial cells. Cardiovascular Research/ IF: 10.787

2. Koo BH, Hong D, Hong HD, Lim HK, Hoe KL, Won MH, Kim YM, Berkowitz DE, Ryoo S (2019) 

Arginase II activity regulates cytosolic Ca2+ level in a p32-dependent manner that contributes to Ca2+- dependent vasoconstriction in native low-density lipoprotein-stimulated vascular smooth muscle cells. Experimental & molecular medicine 51: 1-12/ IF: 8.718

3. Koo BH, Lee J, Jin Y, Lim HK, Ryoo S (2021)

Arginase inhibition by rhaponticin increases L-arginine concentration that contributes to Ca2+-dependent eNOS activation. BMB reports 54: 516/ IF: 4.778

4. Koo BH, Won MH, Kim YM, Ryoo S (2020)

p32-Dependent p38 MAPK activation by arginase II downregulation contributes to endothelial nitric oxide synthase activation in HUVECs. Cells 9: 392/ IF: 6.600

5. Koo BH, Yi BG, Jeong MS, Kwon SH, Hoe KL, Kwon YG, Won MH, Kim YM, Ryoo S (2018a)

Arginase II inhibition prevents interleukin-8 production through regulation of p38MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs. Experimental & molecular medicine 50: e438-e438/ IF: 8.718

6. Koo BH, Yi BG, Wang WK, Ko IY, Hoe KL, Kwon YG, Won MH, Kim YM, Lim HK, Ryoo S (2018b) 

Arginase inhibition suppresses native low-density lipoprotein-stimulated vascular smooth muscle cell proliferation by NADPH oxidase inactivation. Yonsei medical journal 59: 366-375/ IF: 2.759

7. Koo BH, Hwang HM, Yi BG, Lim HK, Jeon BH, Hoe KL, Kwon YG, Won MH, Kim YM, Berkowitz DE,

Ryoo S (2018) Arginase II Contributes to the Ca2+/CaMKII/eNOS Axis by Regulating Ca2+ Concentration Between the Cytosol and Mitochondria in a p32‚ÄźDependent Manner. Journal of the American Heart Association 7: e009579/ IF: 5.501

8. Choi CI, Koo BH, Hong D, Kwon HJ, Hoe KL, Won MH, Kim YM, Lim HK, Ryoo S (2019)

Resveratrol is an arginase inhibitor contributing to vascular smooth muscle cell vasoconstriction via increasing cytosolic calcium. Molecular medicine reports 19: 3767-3774/ IF: 2.952

9. Choi K, Koo BH, Yoon BJ, Jung M, Yun HY, Jeon BH, Won MH, Kim YM, Mun JY, Lim HK, Ryoo S (2020)

Overexpressed p32 localized in the endoplasmic reticulum and mitochondria negatively regulates calcium-dependent endothelial nitric oxide synthase activit. Molecular medicine reports 22: 2395-2403/ IF: 2.952

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