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Liu Laboratory

Yilu Zhou, Ph.D.

Postdoctoral Fellow 

Hometown

Jiangxi, China

Education

Ph.D., Mechanical Engineering, 2018, University of Delaware

M.S., Precision Instrument and Machinery, 2011, Shanghai Jiao Tong University, China

B.S., Measurement & Control Technology and Instrument, 2008, Hefei University of Technology, China

Hobbies

Chaos theory, game theory, deep learning, big data, quantum physics, Marathon running, table tennis

Research areas of interest

Bone and cartilage biomechanics, osteoarthritis mechanisms, intracellular calcium signaling

Honors and Awards

ASBMR Travel Award, 2014

ASBMR Muscle Symposium Young Investigator Travel Grant, 2013

3rd prize in Network Security Competition in Shanghai Jiao Tong University, 2008

Outstanding Graduates Awards in Anhui Province, China, 2008

Outstanding Student Awards in Jiangxi Province, China, 2004

2nd prize in National Physics Competition, 2003

Publications

  1. Fung A, Shetye S, Li Y, Zhou Y, Liu X, Soslowsky LJ. Pregnancy and Lactation Impair Subchondral Bone Leading to Reduced Rat Supraspinatus Tendon Failure [published online ahead of print, 2020 Jun 25]. J Biomech Eng. 2020;10.1115/1.4047629. doi:10.1115/1.4047629
  2. Lv, M., Zhou, Y., Chen, X., Han, L., Wang, L. and Lu, X.L., 2018. Calcium signaling of in situ chondrocytes in articular cartilage under compressive loading: Roles of calcium sources and cell membrane ion channels. Journal of Orthopaedic Research, 36(2), pp.730-738.
  3. Wang, K., Ma, J., Wang, F., Wang, Z., Yan, G. and Zhou, Y., 2017. Full-driving soft robotic colonoscope in compliant colon tissue. Journal of medical engineering & technology, 41(8), pp.662-669.
  4. Jia, H., Ma, X., Tong, W., Doyran, B., Sun, Z., Wang, L., Zhang, X., Zhou, Y., Badar, F., Chandra, A. and Lu, X.L., 2016. EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation. Proceedings of the National Academy of Sciences, 113(50), pp.14360-14365.
  5. Chen, X., Zhou, Y., Wang, L., Santare, M.H., Wan, L.Q. and Lu, X.L., 2016. Determining tension–compression nonlinear mechanical properties of articular cartilage from indentation testing. Annals of biomedical engineering, 44(4), pp.1148-1158.
  6. Zhou, Y., David, M.A., Chen, X., Wan, L.Q., Duncan, R.L., Wang, L. and Lu, X.L., 2016. Effects of osmolarity on the spontaneous calcium signaling of in situ juvenile and adult articular chondrocytes. Annals of biomedical engineering, 44(4), pp.1138-1147.
  7. Zhou, Y., Park, M., Cheung, E., Wang, L. and Lu, X.L., 2015. The effect of chemically defined medium on spontaneous calcium signaling of in situ chondrocytes during long-term culture. Journal of biomechanics, 48(6), pp.990-996.
  8. Zimmerman, B.K., Bonnevie, E.D., Park, M., Zhou, Y., Wang, L., Burris, D.L. and Lu, X.L., 2015. Role of interstitial fluid pressurization in TMJ lubrication. Journal of dental research, 94(1), pp.85-92.
  9. Zhou, Y., Yan, G., Wang, Z., Gao, P., Liu, H. and Jiang, P., 2011. Design of Mobile Robot System for Pipe Trench Inspection in Nuclear Industry. Measurement & Control Technology, 3, p.016.
  10. Gao, P., Yan, G., Wang, Z., Wang, K., Jiang, P. and Zhou, Y., 2011. A robotic endoscope based on minimally invasive locomotion and wireless techniques for human colon. The International Journal of Medical Robotics and Computer Assisted Surgery, 7(3), pp.256-267.
  11. Wang, K., Wang, Z., Zhou, Y. and Yan, G., 2010, December. Squirm robot with full bellow skin for colonoscopy. In Robotics and Biomimetics (ROBIO), 2010 IEEE International Conference on (pp. 53-57). IEEE.

Abstracts

  1. Yihan Li; Yilu Zhou; Chantal de Bakker; Hongbo Zhao; Luqiang Wang; Leilei Zhong; Ling Qin; X. Sherry Liu. Effects Of Reproduction And Lactation On Osteogenic And Adipogenic Differentiation Potentials Of Bone Marrow Mesenchymal Stem Cells. Orthopaedic Research Society Annual Meeting; February 12-16, 2021.
  2. Yilu Zhou, Yihan Li, Zachary Davis, Wenzheng Wang, Ashley K. Fung, Snehal S. Shetye, Andrew F. Kuntz, Jiang, Nathaniel Dyment, Louis J. Soslowsky, X. Sherry Liu. Structural and Cellular Responses of Supraspinatus Tendon Enthesis and Subchondral Bone to Pregnancy, Lactation, and Post-Weaning Recovery. Orthopaedic Research Society Annual Meeting; February 8-11, 2020.
  3. Yilu Zhou, Tiange Zhang, Mengxi Lv, Tong Li, Earl M. Bampo, Megan E. Hoerrner, Mary P. Watson, X. Lucas Lu. From French Paradox to Osteoarthritis Treatment: Hierarchical Chondro-protective Actions of Resveratrol. Orthopedic Research Society Annual Meeting, New Orleans, LA 2018 (Selected as Poster Teaser)
  4. Tiange Zhang, Yilu Zhou, Mengxi Lv, Cynthia Wang, Liyun Wang, X. Lucas Lu. Short- and Long-term Effects of Antioxidants on the Calcium Signaling of Chondrocytes. Orthopedic Research Society Annual Meeting, New Orleans, LA 2018
  5. Mengxi Lv, Yilu Zhou, Tiange Zhang, Liyun Wang, X. Lucas Lu. Chondro-protective Mechanism of Statin. Orthopedic Research Society Annual Meeting, New Orleans, LA 2018
  6. Mengxi Lv, Yilu Zhou, X. Lucas Lu. Chondro‐Protective Function of Statin Is Related to the Inhibition of Small GTPase Activities. ORS 47th International Musculoskeletal Biology Workshop at Sun Valley, ID 2017.
  7. Mengxi Lv, Yilu Zhou, Shongshan Fan, Olivia Smith, X. Lucas Lu. Statin Attenuates the Inflammatory Damage on Cartilage by Inhibiting Rho Activity in Chondrocytes. Summer Biomechanics, Bioengineering, and Biotransport Conference, Tucson, AZ 2017
  8. Mengxi Lv, Yilu Zhou, Shongshan Fan, Olivia Smith, X. Lucas Lu. Statin Attenuates the Inflammatory Damage on Chondrocytes by Inhibiting Rho Activity. OARSI 2017 World Congress, Las Vegas, NV 2017
  9. Shongshan Fan, Mengxi Lv, Yilu Zhou, X. Lucas Lu. Tracking in vitro Cartilage Degeneration and Biosynthesis Based on Bioorthogonal Chemistry. Orthopedic Research Society Annual Meeting, San Diego, CA 2017
  10. Mengxi Lv, Yilu Zhou, Shongshan Fan, Kalani Picho, X. Lucas Lu. Inhibition of Mevalonate Pathway in Chondrocytes Attenuates IL-1 Induced Cartilage Degeneration. Orthopedic Research Society Annual Meeting, San Diego, CA 2017
  11. Mengxi Lv, Yilu Zhou, Shongshan Fan, Shawn Polson, Liyun Wang, X. Lucas Lu. Transcriptional Changes of In Situ Chondrocytes Damaged by Interleukin-1. Orthopedic Research Society Annual Meeting, San Diego, CA 2017
  12. Jessica Kerns, Mengxi Lv, Yilu Zhou, Shongshan Fan, X. Lucas Lu. Antioxidant EGCG Protects Cartilage from Inflammatory Attack. Orthopedic Research Society Annual Meeting, San Diego, CA 2017
  13. Yilu Zhou, Mengxi Lv, Liyun Wang, X. Lucas Lu. Chondro-Protective Function of Bisphosphonate and The Inhibition of Mevalonate Pathway, Orthopedic Research Society Annual Meeting, San Diego, CA 2017
  14. Yilu Zhou, Mengxi Lv, Shongshan Fan, Liyun Wang, X. Lucas Lu. Bisphosphonate Rescues Articular Cartilage from Trauma Damage. BMES Annual Meeting, Minneapolis, MN 2016
  15. Yilu Zhou, Mengxi Lv, Marisa Bisram, Joshua A. Blotnick, Liyun Wang, X. Lucas Lu. Bisphosphonate can Rescue the Damaged Articular Cartilage in vitro. Summer Biomechanics, Bioengineering, and Biotransport Conference, National Harbor, MD 2016 (podium)
  16. Mengxi Lv, Yilu Zhou, Shongshan Fan, Liyun Wang, X. Lucas Lu. Chondro-Protective Effect Of Zoledronate On In Situ Chondrocytes Damaged By Interleukin-1. Summer Biomechanics, Bioengineering, and Biotransport Conference, National Harbor, MD 2016
  17. Yilu Zhou, Carolyn Hall, Mengxi Lv, Grace Gong, Kalani Picho, X. Lucas Lu. Intracellular Calcium Signaling of In Situ Chondrocytes could be Correlated with Tissue Stiffness. Orthopedic Research Society Annual Meeting, Orlando, FL 2016
  18. Mengxi Lv, Yilu Zhou, Kalani Picho, Grace Gong, Liyun Wang, X. Lucas Lu. Chondro-protective effect of bisphosphonate on in situ chondrocytes exposed to IL-1β. Orthopedic Research Society Annual Meeting, Orlando, FL 2016
  19. Mengxi Lv, Yilu Zhou, Liyun Wang, X. Lucas Lu. Calcium Signaling Of In Situ Chondrocytes under Unconfined Compression. BMES Annual Meeting, Tampa, FL, 2015
  20. Xingyu Chen, Yilu Zhou, Brandon K. Zimmerman, Liyun Wang, Michael H. Santare, Leo Q. Wan, X. Lucas Lu.  Determining Tension-Compression Nonlinear Mechanical Properties of Articular Cartilage from Indentation Testing. BMES Annual Meeting, Tampa, FL, 2015
  21. Yilu Zhou, Miri Park, Liyun Wang, Enoch Cheung, X. Lucas Lu. Bisphosphonate Gives Trauma Damaged Chondrocytes a New Life via Inhibition of Mevalonate Pathway, 2015 Summer Biomechanics, Bioengineering and Biotransport Conference, SB3C2015‑5702015, Snowbird, UT (podium)
  22. Yilu Zhou, Miri Park, Jie Ma, X. Lucas Lu. Bisphosphonate Rescues Cartilage from Traumatic Damage Is Related to the Inhibition of Chondrocyte Mevalonate Pathway, ICRS 2015 - 12th World Congress of the International Cartilage Repair Society, Chicago, USA
  23. Yilu Zhou, Miri Park, Liyun Wang, X. Lucas Lu. Bisphosphonates Rescue Articular Cartilage from Trauma Damage, 2015 NEBEC at Rensselaer Polytechnic Institute, NY
  24. Yilu Zhou, Miri Park, Monideepa Chatterjee, Jie Ma, Lea Fang, Liyun Wang, X. Lucas Lu. Chondro-protective Effects of Bisphosphonate for PTOA Could Attribute to the Inhibition of Chondrocyte Mevalonate Pathway, Orthopedic Research Society Annual Meeting, Las Vegas, NV, 2015
  25. Zhou, Yilu; David, Michael A.; Ma, Jie; Wang, Liyun; Lu, X. Lucas. Effect of Osmotic Stress on Intracellular Calcium Signaling of In Situ Juvenile and Mature Chondrocytes, Orthopedic Research Society Annual Meeting, Las Vegas, NV, 2015
  26. Ma, Jie; Zhou, Yilu; Wang, Liyun; Lu, X. Lucas. Metabolic Activities in Mevalonate Pathway could affect the Intracellular Calcium Signaling of In Situ Chondrocytes, Orthopedic Research Society Annual Meeting, Las Vegas, NV, 2015
  27. Yilu Zhou, Jie Ma, Liyun Wang, X. Lucas Lu. Spontaneous Calcium Signaling of in situ Chondrocytes, 7th World Congress of Biomechanics, Boston, MA, 2014
  28. Miri Park, Yilu Zhou, Liyun Wang, X. Lucas Lu. Bisphosphonate Rescues Articular Cartilage from Trauma Damage, 7th World Congress of Biomechanics, Boston, MA, 2014
  29. Zhou Y, Park M, Wang L, Lu XL. Bisphosphonate Can Rescue Cartilage from Trauma Damage by Regulating the Metabolic Activities of Chondrocytes, Bone Research Society Annual Meeting, Sheffield, UK, 2014 (ASBMR Travel Award)
  30. Yilu Zhou, Liyun Wang, X. Lucas Lu. Bisphosphonate prevents post-traumatic osteoarthritis by promoting the spontaneous calcium signaling in chondrocytes, OARSI World Congress on Osteoarthritis, Paris, France, 2014
  31. Yilu Zhou, Jie Ma, Liyun Wang, X. Lucas Lu. Spontaneous Calcium Response of in situ Chondrocyte and Related Pathways, Orthopedic Research Society Annual Meeting, New Orleans, LA, 2014
  32. Miri Park, Yilu Zhou, Liyun Wang, Christopher Price, X. Lucas Lu. Bisphosphonate Rescues Cartilage from Trauma Damage by Promoting Mechanical Sensitivity and Calcium Signaling in Chondrocytes, Orthopedic Research Society Annual Meeting, New Orleans, LA, 2014
  33. Yilu Zhou, Lauren Resutek, Liyun Wang, X. Lucas Lu. Bisphosphonate prevents post-traumatic osteoarthritis by promoting the spontaneous calcium signaling in chondrocytes, 5th Biennial Northeast Regional IDeA Conference, Newark, DE, 2013
  34. Yilu Zhou, Lauren Resutek, Liyun Wang, X. Lucas Lu. Bisphosphonate rescues cartilage from trauma damage by promoting the spontaneous calcium signaling in chondrocytes, American Society for Bone and Mineral Research Annual Meeting, Baltimore, MD, 2013 (selected as ASBMR Muscle Symposium 2013 Young Investigator Travel Award; Final list of President’s Poster Competition)
  35. Yilu Zhou, Wen Li, Liyun Wang, Christopher Price, X. Lucas Lu. Bisphosphonate Rescue Post-Traumatic Osteoarthritis by Promoting the Calcium Signaling in Chondrocytes, The 5th Sino-American Workshop on Biomedical Engineering and China-Oversea Joint Workshop on Biomechanics, Beijing, China, 2013
  36. Yilu Zhou, Lauren Resutek, Liyun Wang, X. Lucas Lu. In Situ Calcium Signaling Of Chondrocytes Under Non-Serum And Serum Culture, Summer Bioengineering Conference, Sunriver, OR, 2013
  37. Yilu Zhou, Lauren Resutek, Liyun Wang, X. Lucas Lu. Effects Of Bisphosphonate On Long-Term Culture Of Cartilage Allografts, Summer Bioengineering Conference, Sunriver, OR, 2013
  38. Yilu Zhou, Lauren Resutek, Liyun Wang, X. Lucas Lu, In Situ Calcium Signaling Of Chondrocytes Under Serum-Free And Serum Culture, OARSI World Congress on Osteoarthritis, Philadelphia, PA, 2013
  39. Yilu Zhou, Enoch Cheung, X. Lucas Lu, Ex Vivo Spontaneous Calcium Signaling of Chondrocytes in Juvenile and Mature Cartilage, Orthopedic Research Society Annual Meeting, San Antonio, TX, 2013
  40. Yilu Zhou, Enoch Cheung, X. Lucas Lu, In Situ Calcium Signaling of Chondrocytes in Serum-free Culture, Orthopedic Research Society Annual Meeting, San Antonio, TX, 2013
  41. Miri Park, Anna Sung, Brandon Zimmerman, Enoch Cheung, Yilu Zhou, X. Lucas Lu, In Vitro Simulation of Microfracture in a Cartilage-Bone Explant Model, Orthopedic Research Society Annual Meeting, San Antonio, TX, 2013
  42. Miri Park, Yilu Zhou, Anna Sung, Enoch Cheung, X. Lucas Lu, Biphasic Effects of Zoledronic Acid on The Calcium Signaling of Chondrocytes, Orthopedic Research Society Annual Meeting, San Antonio, TX, 2013
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