Active Research

The HD Center at Penn works very hard to develop treatments and, eventually, a cure to Huntington's Disease by being part of clinical trials and research studies.

To learn more about the research studies being conducted at the HD Center at Penn, as well as information about opportunities and requirements for participation, scroll down:

(Click on the toggle to see enrollment status and point of contact!)

HD DatabaseHuntington's Disease Society of America logo

We will utilize an electronic research database to manage demographic and clinical information collected from patients seen at the HDSA Center of Excellence at Pennsylvania Hospital. The data will be used to develop and conduct research aimed at establishing best practices aimed at improving the care for families living with HD. Participants must be patients at the Center and able to give consent directly, by proxy or assent to participate.

Enrollment Status: ENROLLING!

Contact for More Information:
Jennifer Klapper, MSN, RN, CNS-BC at 215-829-5176

Enroll-HDEnroll HD logo

Enroll-HD is a prospective observational multicenter multi-national cohort study to be conducted in multiple native languages. Study procedures include annual assessments conducted during study visits that may coincide with regularly scheduled clinic visits. The study does not include interventional procedures outside of normal clinical care, nor does it include experimental therapies. Any member of a family with HD can take part.

Enrollment StatusENROLLING!

Contact for More Information:

Jennifer Klapper, MSN, RN, CNS-BC at 215-829-5176

The Visual System in HDvision

This observational study is aimed to characterize the extent to which HD affects vision and to identify risk factors for greater visual impairment in people with HD. Patients with genetically confirmed symptomatic and pre-symptomatic HD and their unaffected relatives will undergo three tests of vision.

Enrollment Status: CLOSED

Contact for More Information:
Jennifer Klapper, MSN, RN, CNS-BC at 215-829-5176

Wearable Sensors in HD

The purpose of this study is to determine whether sensor-derived movement data can discriminate between healthy controls, prodromal HD patients, symptomatic HD patients, and patients with ataxia, as well as whether sensor data can detect treatment response in patients who are started on medication for clinical purposes to reduce chorea.
 
This observational study measures abnormal movements in individuals who have tested positive for the HD gene mutation (in people with or without symptoms) and in patients with ataxia. Sensors will be worn at a baseline clinic visit, at home, and a second follow-up clinic visit for subjects started on medication to reduce chorea.

Enrollment StatusENROLLING!

Contact for More Information:

Jennifer Klapper, MSN, RN, CNS-BC at 215-829-5176