Research Collaborations
The HD Center serves to catalyze the formation of an Academic HD Group across the University of Pennsylvania and the Children’s Hospital of Philadelphia.
This includes:
(Click on the toggle to see the leaders of these groups)
This group provides deep phenotyping of HD subjects in support of clinical studies.
Led by:
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Dr. Tim Lucas (neurosurgeon)
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Dr. Allison Willis (movement disorder neurologist and neuroepidemiologist)
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Dr. Hamedani (neuro-ophthalmologist)
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The HD Clinic at Penn
This team is currently devoted to the development of novel devices for therapeutic application in HD subjects, led by Dr. Flavia Vitale, and the use of novel biosensors to better phenotype HD subjects in the clinic and at home, using novel technologies for data integration and large-scale analysis.
Led by:
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Dr. Brian Litt, a neurologist and the director of the Center for Neuroengineering and Therapeutics.
This team aims to identify novel MRI-based functional endpoints in subjects with HD.
Another project, led by Dr. Dylan Tisdall, is to apply motion correction techniques to eliminate artifactual findings in HD subjects.
Led by:
Located at the Raymond G. Perelman Center for Cell & Molecular Therapeutics at the Children’s Hospital of Philadelphia, where Dr. Gonzalez-Alegre also directs a translational research laboratory.
This laboratory has projects focused on gaining a better understanding of the neurobiological bases of HD and a strong focus on the development of novel therapeutic approaches.
Led by:
KidsHD Study
The HD Center also maintains a very active research collaboration with the HDSA Center of Excellence at the University of Iowa, specifically on the KidsHD study.