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Steven Brem, M.D.

Professor of Neurosurgery at the Hospital of the University of Pennsylvania
Chair, Neuro-TCE, Hospital of the University of Pennsylvania
Chief, Neurosurgical Oncology, Hospital of the University of Pennsylvania
Co-Director, Brain Tumor Center, Hospital of the University of Pennsylvania
Program Leader, Neuro-Onc Service Line, Abramson Cancer Center at the Hospital of the University of Pennsylvania
Department: Neurosurgery

Contact information
3400 Spruce Street, 3rd Floor Silverstein
Department of Neurosurgery
Philadelphia, PA 19104
Office: (215) 662-7854
Education:
BA (Magna Cum Laude)
Rutgers University, 1968.
MD (Medicine - Cum Laude)
Harvard Medical School, 1972.
Post-Graduate Training
Surgery , Massachusetts General Hospital - Intership , 1972-1973.
Neurosurgery, Massachusetts General Hospital - Residency , 1973-1981.
Clinical Associate, Oncology, Laboratory of Pathophysiology, National Cancer Institute - Postdoctoral Research, 1974-1976.
Neurosurgery, New York Hospital, Cornell Medical Center - Fellowship , 1979-1980.
Certifications
National Board of Medical Examiners, 1973.
Province of Quebec, Neurosurgery , 1982.
Royal College of Physicians and Surgeons of Canada, Neurosurgery Fellowship , 1982.
American Board of Neurological Surgery, 1983.
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Description of Clinical Expertise

Complex Brain Tumor Surgery; Surgery of Intrinsic and Metastatic Brain Tumors; Pituitary Tumors; Acoustic Neuromas; Meningiomas; Skull Base Surgery; Brain Mapping; Health Outcomes; Evidence-Based Medicine;

Description of Research Expertise

Angiogenesis, Neuro-Oncology, Translational Drug Discovery, Personalized Medicine, Genomics, Biomarkers, Experimental Therapeutics, Brain Mapping, Health Outcomes, Brain Metastases, Clinical Guidelines, Clinical Pathways, Glioma Invasion, Targeted Brain Tumor Therapies

Selected Publications

O’Rourke DM, Nasrallah MP, Morrissette J, Melenhorst JJ, Lacey SF, Mansfield K, Martinez-Lage M, Desai A, Brem S, Maloney E, Mohan S, Wang S, Verma G, Navenot J-M, Shen A, Zheng Z, Levine BL, Okada H, June CH, Maus M: Phase I study of T cells redirected to EGFRvIII with a chimeric antigen receptor in patients with EGFRvIII+ glioblastoma. AACR Annual Meeting April 2016.

Brem S, Wong E, Desai A, Fan Y, Pan E: Angiogenesis and brain tumors. Youmans and Winn Neurological Surgery 2016.

Thawani JP, Brem S: The story of glioblastoma: History and modern correlates. Glioblastoma 2016.

Abdullah KG, Miller JA, Brem S: Recurrent glioblastoma. Glioblastoma. Elsevier, 2016.

Abdullah KG, Brem S: The molecular pathogenesis of glioblastoma. Glioblastoma. Elsevier, 2016.

Verma G, Poptani H, Nasrallah M, Thomas A, Brem S, Mohan S. : Chemical Shift Imaging (CSI) for detection of 2-hydroxyglutarate (2HG) in human gliomas at 3T. Radiol Soc North Amer (RSNA) November 2015.

Verma G, Mohan S, Nasrallah M, Thomas MA, Desai A, Desiderio L, Poptani H. : Two-dimensional localized correlated spectroscopy (2D L-COSY) at 7T for detection of 2-hydroxyglutarate in gliomas with IDH mutations. Radiol Soc North Amer (RSNA) November 2015.

O’Rourke DM, Desai A, Morrissette JD, Martinez-Lage M, Nasrallah M, Brem S, Maloney E, Shen A, Mohan S, Wang S, Verma G, Lacey S, Melenhorst J, Navenot J-M, Zheng Z, Levine BL, Okada H, June C, Maus M. : IMCT-15*Pilot study of T cells redirected to EGFRvIII with a chimeric antigen receptor in patients with EGFRvIII+ glioblastoma. Neuro-Oncology October 2015.

Alonso-Basanta M, Lee J, Miller D, Kurtz K, Dorsey J, Kolker J, Nagda S, Geiger G, Brem S, O’Rourke D, Zager E: Novel prognostic scores for survival and intracranial failure in patients treated with radiosurgery alone to melanoma brain metastases. American Society of Therapeutic Radiology and Oncology (ASTRO) October 2015.

Ulyanova A, Lee J-H, Brem S, Lucas T, O’Rourke D, Grovola M, Wang J, Na Y, Singh J, Smith D, Kim J, Eberwine J, Sul J-Y, Grady S, Wolf J: Electrophysiological phenotyping of human neurons in slices and dissociated culture. National Neurotrauma Society June 2015.

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Last updated: 07/14/2016
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