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Zev Binder, M.D., Ph.D.
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Research Assistant Professor of Neurosurgery
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Scientific Director, Adult Brain Tumor Tissue Bank
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Department: Neurosurgery
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Contact information
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3600 Hamilton Walk
30 Stemmler Hall
Philadelphia, PA 19104
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30 Stemmler Hall
Philadelphia, PA 19104
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Office: 215-573-0837
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Graduate Group Affiliations
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Publications
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Links
e2 Search PubMed for articles
6d O'Rourke Laboratory Website
93 University of Pennsylvania's Center for Cellular Immunotherapies
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e2 Search PubMed for articles
6d O'Rourke Laboratory Website
93 University of Pennsylvania's Center for Cellular Immunotherapies
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Education:
21 7 BS 19 (Biochemistry) c
38 University of California, Davis, 2004.
21 9 M.D. c
4a Pennsylvania State University College of Medicine, 2008.
21 a Ph.D. 32 (Chemical and Biomolecular Engineering) c
31 Johns Hopkins University, 2014.
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21 7 BS 19 (Biochemistry) c
38 University of California, Davis, 2004.
21 9 M.D. c
4a Pennsylvania State University College of Medicine, 2008.
21 a Ph.D. 32 (Chemical and Biomolecular Engineering) c
31 Johns Hopkins University, 2014.
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Post-Graduate Training
24 38 Postdoctoral Researcher, Department of Neurosurgery 2d Johns Hopkins University School of Medicine 1b , 2008-2009.
24 42 Postdoctoral Researcher, Physical Sciences on Oncology Center 21 Institute for NanoBioTechnology 33 Johns Hopkins University, 2009-2011.
24 3d Senior Research Investigator, Department of Neurosurgery 1d Perelman School of Medicine 35 University of Pennsylvania, 2015-2018.
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Permanent link24 38 Postdoctoral Researcher, Department of Neurosurgery 2d Johns Hopkins University School of Medicine 1b , 2008-2009.
24 42 Postdoctoral Researcher, Physical Sciences on Oncology Center 21 Institute for NanoBioTechnology 33 Johns Hopkins University, 2009-2011.
24 3d Senior Research Investigator, Department of Neurosurgery 1d Perelman School of Medicine 35 University of Pennsylvania, 2015-2018.
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Description of Research Expertise
204 Dr. Binder is a Research Assistant Professor, working with Dr. O'Rourke since 2015. He received a B.S. degree in Biochemistry from the University of California at Davis, an M.D. from Pennsylvania State University, and a Ph.D. in Chemical and Biomolecular Engineering from Johns Hopkins University. Dr. Binder's research focuses on translational GBM research with an emphasis on immuno-oncology. He also works on GBM model development, characterization, and incorporation into the ongoing research.e 29
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22b Elizabeth J Li, Adam Kraya, Pedro Costa-Pinheiro, Joshua Scheuermann, Anthony J Young, Erin Schubert, Mariam Aboian, Robert Doot, Jeffrey B Ware, Austin R Pantel, Zev A Binder, Phillip B Storm, Adam C Resnick, Nduka M Amankulor, Donald M O'Rourke, Arati Desai, MacLean P Nasrallah, Steven Brem, Stephen J Bagley, David Mankoff, Ali Nabavizadeh: Metabolic Imaging and Molecular Signatures Reveal Metabolic Phenotypes in Recurrent Glioblastoma. Journal of Nuclear Medicine March 2026.
102 Zev A. Binder, Stephen J. Bagley, Jessica B. Foster & Donald M. O’Rourke: The development of CAR T cells for patients with CNS malignancies. Nature Reviews Clinical Oncology Dec 2025.
21d Kyosuke Shishikura, Jiasong Li, Yiming Chen, Nate R. McKnight, Thomas P. Keeley,Katelyn A. Bustin, Eric W. Barr, Snehil R. Chilkamari, Mahaa Ayub, Sun Woo Kim,Zongtao Lin, Ren- Ming Hu, Kelly Hicks, Xie Wang, Donald M. O’Rourke,J. Martin Bollinger Jr., Zev A. Binder, William H. Parsons, Kirill A. Martemyanov,Aimin Liu, Megan L. Matthews: Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma. Science Advances 11(42), Oct 2025.
253 Erica L Carpenter, Jacob E Till, Dominique Ballinger, Camilla Macia, Carlos Leche, Melinda Yin, Arati S Desai, Timothy Prior, Maikel Mansour, Emily McCoy, Thara Patel, Shivani Shah, H Isaac Chen, Eric Zager, Christina Jackson, Steven Brem, Zev A Binder, Donald M O'Rourke, Nduka Amankulor, Nike Beaubier, Stephen J Bagley: Next-Generation Sequencing of Intraoperatively Acquired Cerebrospinal Fluid and Matched Tumor Tissue in Patients Undergoing Surgical Resection for Glioblastoma. JCO Precision Oncology September 2025.
2f6 Benjamin Lin, Abigail K. Shelton, Erin Smithberger, Julia Ziebro, Kasey R. Skinner, Ryan E. Bash, Richard Kirkman, Allie Stamper, Madison Butler, Alex Flores, Steven P. Angus, Michael P. East, Timothy F. Cloughesy, David A. Nathanson, Michael E. Berens, Jann N. Sarkaria, Zev A. Binder, Donald M. O’Rourke, Timothy C. Howton, Brittany N. Lasseigne, Christopher D. Willey, Gary L. Johnson, Anita B. Hjelmeland, Frank B. Furnari & C. Ryan Miller: Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma. Acta Neuropathologica Communications June 2025 Notes: DOI https://doi.org/10.1186/s40478-025-02068-y.
369 Stephen J. Bagley, Arati S. Desai, Joseph A. Fraietta, Dana Silverbush, Daniel Chafamo, Nelson F. Freeburg, Gayathri Konanur Gopikrishna, Andrew J. Rech, Ali Nabavizadeh, Linda J. Bagley, Jungmin Park, Danuta Jarocha, Rene Martins, Nicolas Sarmiento, Eileen Maloney, Lester Lledo, Carly Stein, Amy Marshall, Rachel M. Leskowitz, Julie K. Jadlowsky, Shane Mackey, Shannon Christensen, Bike Su Oner, Gabriela Plesa, Andrea Brennan, Vanessa Gonzalez, Fang Chen, David Barrett, Robert Colbourn, MacLean P. Nasrallah, Zissimos Mourelatos, Wei-Ting Hwang, Cecile Alanio, Donald L. Siegel, Carl H. June, Elizabeth O. Hexner, Zev A. Binder & Donald M. O’Rourke: Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial. Nature Medicine June 2025.
1f8 Fathi Kazerooni A, Akbari H, Hu X, Bommineni V, Grigoriadis D, Toorens E, Sako C, Mamourian E, Ballinger D, Sussman R, Singh A, Verginadis II, Dahmane N, Koumenis C, Binder ZA, Bagley SJ, Mohan S, Hatzigeorgiou A, O'Rourke DM, Ganguly T, De S, Bakas S, Nasrallah MP, Davatzikos C. : The radiogenomic and spatiogenomic landscapes of glioblastoma and their relationship to oncogenic drivers. Communications Medicine 5(1), March 2025.
f8 Sabrina L. Begley, Donald M. O’Rourke, and Zev A. Binder: CAR T cell therapy for glioblastoma: A review of the first decade of clinical trials. Molecular Therapy March 2025.
244 Sun Y, Wang X, Zhang DY, Zhang Z, Bhattarai JP, Wang Y, Park KH, Dong W, Hung YF, Yang Q, Zhang F, Rajamani K, Mu S, Kennedy BC, Hong Y, Galanaugh J, Sambangi A, Kim SH, Wheeler G, Gonçalves T, Wang Q, Geschwind DH, Kawaguchi R, Viaene AN, Helbig I, Kessler SK, Hoke A, Wang H, Xu F, Binder ZA, Isaac Chen H, Pai EL, Stone S, Nasrallah MP, Christian KM, Fuccillo M, Toni N, Wu Z, Cheng HJ, O'Rourke DM, Ma M, Ming GL, Song H. : Brain-wide neuronal circuit connectome of human glioblastoma. Nature Jan 2025.
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Selected Publications
24e Sabra K Salim, Muhammad Vaseem Shaikh, Jeffrey Wei, William T Maich, Alisha Anand, Oliver Y Tang, Minomi K Subapanditha, Zahra Alizada, Yujin Suk, Manoj Singh, Kui Zhai, Aapti Khanna, Benjamin Brakel, Vassil Dimitrov, Zoya Tabunshchyk, Katie Chan, Kevin R Brown, Parvez Vora, Donald M O'Rourke, Zev A Binder, Chitra Venugopal, Jason Moffat, Sheila K Singh: Generation of Allogeneic CAR-T Circumvents Functional Deficits in Patient-Derived Autologous Product for Glioblastoma. International Journal of Cancer Apr 2026.22b Elizabeth J Li, Adam Kraya, Pedro Costa-Pinheiro, Joshua Scheuermann, Anthony J Young, Erin Schubert, Mariam Aboian, Robert Doot, Jeffrey B Ware, Austin R Pantel, Zev A Binder, Phillip B Storm, Adam C Resnick, Nduka M Amankulor, Donald M O'Rourke, Arati Desai, MacLean P Nasrallah, Steven Brem, Stephen J Bagley, David Mankoff, Ali Nabavizadeh: Metabolic Imaging and Molecular Signatures Reveal Metabolic Phenotypes in Recurrent Glioblastoma. Journal of Nuclear Medicine March 2026.
102 Zev A. Binder, Stephen J. Bagley, Jessica B. Foster & Donald M. O’Rourke: The development of CAR T cells for patients with CNS malignancies. Nature Reviews Clinical Oncology Dec 2025.
21d Kyosuke Shishikura, Jiasong Li, Yiming Chen, Nate R. McKnight, Thomas P. Keeley,Katelyn A. Bustin, Eric W. Barr, Snehil R. Chilkamari, Mahaa Ayub, Sun Woo Kim,Zongtao Lin, Ren- Ming Hu, Kelly Hicks, Xie Wang, Donald M. O’Rourke,J. Martin Bollinger Jr., Zev A. Binder, William H. Parsons, Kirill A. Martemyanov,Aimin Liu, Megan L. Matthews: Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma. Science Advances 11(42), Oct 2025.
253 Erica L Carpenter, Jacob E Till, Dominique Ballinger, Camilla Macia, Carlos Leche, Melinda Yin, Arati S Desai, Timothy Prior, Maikel Mansour, Emily McCoy, Thara Patel, Shivani Shah, H Isaac Chen, Eric Zager, Christina Jackson, Steven Brem, Zev A Binder, Donald M O'Rourke, Nduka Amankulor, Nike Beaubier, Stephen J Bagley: Next-Generation Sequencing of Intraoperatively Acquired Cerebrospinal Fluid and Matched Tumor Tissue in Patients Undergoing Surgical Resection for Glioblastoma. JCO Precision Oncology September 2025.
2f6 Benjamin Lin, Abigail K. Shelton, Erin Smithberger, Julia Ziebro, Kasey R. Skinner, Ryan E. Bash, Richard Kirkman, Allie Stamper, Madison Butler, Alex Flores, Steven P. Angus, Michael P. East, Timothy F. Cloughesy, David A. Nathanson, Michael E. Berens, Jann N. Sarkaria, Zev A. Binder, Donald M. O’Rourke, Timothy C. Howton, Brittany N. Lasseigne, Christopher D. Willey, Gary L. Johnson, Anita B. Hjelmeland, Frank B. Furnari & C. Ryan Miller: Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma. Acta Neuropathologica Communications June 2025 Notes: DOI https://doi.org/10.1186/s40478-025-02068-y.
369 Stephen J. Bagley, Arati S. Desai, Joseph A. Fraietta, Dana Silverbush, Daniel Chafamo, Nelson F. Freeburg, Gayathri Konanur Gopikrishna, Andrew J. Rech, Ali Nabavizadeh, Linda J. Bagley, Jungmin Park, Danuta Jarocha, Rene Martins, Nicolas Sarmiento, Eileen Maloney, Lester Lledo, Carly Stein, Amy Marshall, Rachel M. Leskowitz, Julie K. Jadlowsky, Shane Mackey, Shannon Christensen, Bike Su Oner, Gabriela Plesa, Andrea Brennan, Vanessa Gonzalez, Fang Chen, David Barrett, Robert Colbourn, MacLean P. Nasrallah, Zissimos Mourelatos, Wei-Ting Hwang, Cecile Alanio, Donald L. Siegel, Carl H. June, Elizabeth O. Hexner, Zev A. Binder & Donald M. O’Rourke: Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial. Nature Medicine June 2025.
1f8 Fathi Kazerooni A, Akbari H, Hu X, Bommineni V, Grigoriadis D, Toorens E, Sako C, Mamourian E, Ballinger D, Sussman R, Singh A, Verginadis II, Dahmane N, Koumenis C, Binder ZA, Bagley SJ, Mohan S, Hatzigeorgiou A, O'Rourke DM, Ganguly T, De S, Bakas S, Nasrallah MP, Davatzikos C. : The radiogenomic and spatiogenomic landscapes of glioblastoma and their relationship to oncogenic drivers. Communications Medicine 5(1), March 2025.
f8 Sabrina L. Begley, Donald M. O’Rourke, and Zev A. Binder: CAR T cell therapy for glioblastoma: A review of the first decade of clinical trials. Molecular Therapy March 2025.
244 Sun Y, Wang X, Zhang DY, Zhang Z, Bhattarai JP, Wang Y, Park KH, Dong W, Hung YF, Yang Q, Zhang F, Rajamani K, Mu S, Kennedy BC, Hong Y, Galanaugh J, Sambangi A, Kim SH, Wheeler G, Gonçalves T, Wang Q, Geschwind DH, Kawaguchi R, Viaene AN, Helbig I, Kessler SK, Hoke A, Wang H, Xu F, Binder ZA, Isaac Chen H, Pai EL, Stone S, Nasrallah MP, Christian KM, Fuccillo M, Toni N, Wu Z, Cheng HJ, O'Rourke DM, Ma M, Ming GL, Song H. : Brain-wide neuronal circuit connectome of human glioblastoma. Nature Jan 2025.
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