Scientific Director, Penn Institute for Regenerative Medicine
CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
CVI Research Description:
The Morrisey Lab focuses on the molecular pathways that regulate cardiovascular and lung development. Currently, our interests include the role of forkhead and GATA transcription factors in cardiac, smooth muscle and lung epithelial development and the role of Wnt signaling in cardiovascular and lung development. We utilize in vivo loss and gain of function techniques including mouse knock-outs to define how these factors and pathways regulate developmental processes. We are also interested in how these transcription factors and signaling pathways regulate cardiovascular and pulmonary homeostasis and injury repair. Our long term goal is to define the molecular mechanisms underlying cardiovascular and pulmonary development and determine whether these mechanisms are recapitulated in adult disease.
Selected Publications
Lepore, J.J., Cappola, T.P., Mericko, P.A., Morrisey, E.E., and Parmacek, M. S. : GATA-6 regulates genes promoting synthetic functions in vascular smooth muscle cells. Arteriorsclerosis Thrombosis and Vascular Biology 25(2): 309-14, February 2005.
Zhao,R., Watt, A.J., Li,J., Luebke-Wheeler, J., Morrisey, E.E., and Duncan, S.A.: GATA6 is essential for embryonic development of the liver but dispensable for early heart development. Molecular and Cellular Biology 25(7): 2622-2631, April 2005.
Lepore, J.J., Cheng, L., Lu, M.M., Mericko, P.A., Morrisey, E.E., and Parmacek, M.S.: High efficiency somatic mutagenesis in smooth muscle cells and cardiac myocytes in SM22α-cre transgenic mice. Genesis 41(4): 179-184, April 2005.
Shu,W., Cho,J., Jiang,Y., Zhang,M., Haroutunian,V., Weisz,D., Perl,D., Morrisey, E.E*., and Buxbaum, J. D*: Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene. Proceedings of the National Academy of Sciences 102: 9643-9648, 2005 Notes: * these laboratories contributed equally to these studies.
Shu,W., Wang,Z., Lu, M.M., Whitsett, J.A., Millar, S.E., and Morrisey, E.E. : Wnt/β-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Developmental Biology 283(1): 226-239, July 2005.
Wang,Z., Shu,W., Lu, M.M., Millar S.E., and Morrisey, E.E. : Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Molecular and Cellular Biology 25(12): 5022-5030, June 2005.
Rath,N., Wang,Z., Lu, M.M., and Morrisey, E.E. : LMCD1/dyxin is a novel transcriptional co-factor that restricts GATA6 function by inhibiting DNA binding. Molecular and Cellular Biology 25(20): 8864-8873, October 2005.
Lobov,I.B., Rao,S., Carroll,T.J., Vallance,J.E., Ito,M., Ondr,J.K., Kurup, S., Glass,D.A., Pate,M.S., Shu,W., Morrisey,E.E., McMahon,A.P., Karsenty, G. and Lang,R.A. : WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 437(7057): 417-421, September 2005.
Li, S., Weidenfeld, J., and Morrisey, E.E. : Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic proteins interactions. Molecular and Cellular Biology 24(2): 809-822, January 2004.
Haesler, S., Wada, K., Nshdejan,A., Morrisey,E.E., Lints, E.K.T., Jarvis, E.D., and Scharff, C. : Foxp2 expression in avian vocal learners and non-learners. Journal of Neuroscience 24(13): 3164-3175, March 2004.
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Last updated: 09/21/2016
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