A strength of the BBCB program is its broad combination of faculty interests and disciplines. Faculty members are drawn from many departments in the Perelman School of Medicine, from other schools in the University, and from affiliated local research institutes. The faculty are unified by research that is quantitative, mechanistic, molecular; That is founded on principles of chemistry and physics; By the development of advanced biophysical, biochemical and chemical methods and instrumentation; By the training of graduate students in these areas of research and that more broadly aligns with the mission of BBCB.



Control of Gene Expression, Cellular Programming
Baur Berger Bernstein Blanco, A. Blanco, K. Bonasio Brass Busino Cherry Conn Dreyfuss Gardini Greenberg Grishchuk Gupta Jordan-Sciutto Kohli Lakadamyali Lazar Lewis Lin Little Liu Lorenzo Lynch Marmorstein Modzelewski Murakami Murray Raj Shaffer Shi Shorter Song, Y Song, H Taabazuing Tian Trauner Van Duyne Wan Wang Wellen Zaret Zhou, Z.

Cell Signaling, Intracellular Trafficking
Berger Black Brady Brass Brown Busino Chanaday Conn Dominguez Dreyfuss Goulian Greenberg Grishchuk Holzbaur Hua Kohli Lakadamyali Lampson Lee, E. Lee, V. M. Lorenzo Lynch Marks Pohlschroder Prosser Radhakrishnan Salzberg Shi Song, H Song, Y Taabazuing Titchenell Wan Zhou, Z.

Chemical Biology, Structural Biology
Baumgart Black Boesze-Battaglia Bowman Brady Brown Burslem Chenoweth de la Fuente Dominguez Dunbrack Goldman Greenberg Gupta Kohli Kulp Marmorstein Matthews Moiseenkova-Bell Murakami Ostap Patel Penning Petersson Radhakrishnan Rhoades Rubin Saven Sellmyer Sharp Sgourakis Shorter Skordalakes Song, H Trauner Van Duyne Zhou, Lijun

Bioenergetics, Metabolism, Membranes
Bartman Baumgart Baur Goldman Lazar Lorenzo Lu Ostap Penning Radhakrishnan Rhoades Pohlschroder Salzberg Sharp Song, Y Titchenell Weljie Wellen Witschey Zhou, Lijun

Biophysical Instrumentation, Techniques, Nanotechnology, Microscopies and Imaging
Black Busch Chanaday Chang Cormode Farwell Greenberg Johnson, A.C. Lakadamyali Lampson Lu Mir Ostap Patel Reddy Rhoades Sellmyer Sgourakis Timperman Tsourkas Vinogradov Wehrli Weisel Witschey Zhou, Lijun

Molecular Immunology
Bartman Escolano Kulp Lynch Sellmyer Sgourakis Taabazuing Tian

Caroline Bartman, Ph.D, Metabolic flux, metabolomics, isotope tracing, cancer, immunology
Tobias Baumgart, Ph.D, Biomembrane function: thermodynamics, dynamics and mechanics
Joseph A. Baur, Ph.D Molecular mechanisms of aging and caloric restriction
Shelley L. Berger, Ph.D, Role of adaptors in regulation of transcriptional activation in yeast and humans
Kara Bernstein, Ph.D DNA damage, repair and tumorigenesis
Ben E. Black, Ph.D, Chromosome segregation; chromatin structure; epigenetic centromere specification; hydrogen/deuterium exchange
Andres Blanco, Ph.D, Epigenetics in normal and pathological (eg. cancerous) cells
Kahlilia Blanco, Ph.D , epigenetics, mitochondrial properties, stroke pathophysiology
Kathleen Boesze-Battagalia, Ph.D, Degradative processes, phagocytosis and autophagy, cell homeostasis
Roberto Bonasio, Ph.D, Noncoding RNAs in chromatin biology and epigenetics.
Greg Bowman, Ph.D, Protein folding, structure and dynamics, simulations
Donita C. Brady, Ph.D, Cancer biology, signal transduction, and metal homeostasis.
Lawrence Brass, MD, Ph.D, Molecular basis for intracellular signaling in vascular biology
Eric J. Brown, Ph.D, Mechanisms that maintain genome stability during DNA replication
George Burslem, Ph.D Protein Engineering, Chemical Biology, Post-translational Modifications
Theresa Busch, Ph.D, Photodynamic therapy, tumor microenvironment
Luca Busino, Ph.D, Mechanisms of protein ubiquitylation and degradation
Natali Chanaday Communication in neurons, Neurotransmitters
Yi-Wei Chang Cyro-EM tomogrophy of cells
David Chenoweth, Ph.D, Development and application of synthetic methods for creating molecules that mimic or interact with biomolecules.
Sara Cherry, Ph.D, Genetic and mechanistic studies of viral-host interactions
Crystal Conn, Ph.D Cancer Biology, Adaptive Stress Responses, mRNA Translation, Drug targeting, Protein Homeostasis
David Cormode, Ph.D, Medical imaging, nanoparticles, contrast agents, cardiovascular disease

Cesar de la Fuente, Ph.D, Machine Biology, Synthetic Biology, Computational Biology, Microbiology, Bioengineering.
Roberto Dominguez, Ph.D, Actin cytoskeleton, structural biology
Roland L. Dunbrack, Jr. Ph.D, Methods and applications of protein structure prediction
Amelia Escolano, Ph.D, Immunology, antibody affinity maturation, rational design of vaccines
Michael Farwell, MD, Developing new imaging tools, oncological applications of imaging
Alessandro Gardini, Ph.D, Understanding the role of enhancers and noncoding RNAs in transcriptional regulation in mammals.
Mark Goulian, Ph.D, Two-component signaling, bacterial regulatory circuits
Roger Greenberg, MD, Ph.D, Basic DNA repair mechanisms that impact cancer etiology and therapy
Ekaterina L. Grishchuk, Ph.D Mechanisms that drive and control chromosome motions in mitosis
Kushol Gupta, Ph.D, Structural biology of large macromolecular assemblies that regulate genetic information; X-ray crystallography; small-angle scattering.
Erika Holzbaur, Ph.D, Molecular motor-driven dynamics of organelles along the cellular cytoskeleton
Xianxin Hua, Ph.D, Signaling and epigenetic regulation of cell homeostasis and tumorigenesis
Paul A. Janmey, Ph.D, Cytoskeleton, biopolymer mechanics, phosphoinositides
A. Charlie Johnson, Ph.D, Nanomaterials, biosensors for disease diagnosis.
Kelly Jordan-Sciutto, Ph.D, Integrated Stress Response, Molecular mechanisms underlying neuronal loss in neurodegenerative disorders.
Rahul M. Kohli, MD, Ph.D, Enzymatic basis for diversity in the immune system and pathogens; enzyme mechanisms, chemical biology, protein evolution
Daniel Kulp, Ph.D,rational vaccine and therapeutic antibody design
Melike Lakadamyali, Ph.D We study cytoskeleton and nuclear organization with super-resolution microscopy.
Michael Lampson, Ph.D, Chromosome segregation in mitosis and meiosis, biosensors for mitotic kinase
Mitchell Lazar, MD, Ph.D, Nuclear receptors and the transcriptional regulation of metabolism
Edward B. Lee, MD, Ph.D, Neuropathology Alzheimer's, ALS disease
Virginia M.-Y. Lee, Ph.D, Pathobiology of Alzheimer's and Parkinson's disease
Mitchell Lewis, D.Phil. , Gene regulation; protein crystallography; structural basis of recognition
Lan Lin, Ph.D RNA modifications (a.k.a "epitranscriptomics") in human diseases
Shawn C. Little, Ph.D, Transcription bursting dynamics; single molecule measurements; cell fate specification
Kathy Fange Liu, Ph.D, The nature and mechanism of mRNA modification and its role in disease
Damaris Lorenzo, Ph.D Molecular mechanisms of diseases of the nervous system, metabolic disorders
Zhe Lu, MD, Ph.D, Structure-function relationship of ion channels; molecular mechanisms of protein-protein interactions
Kristen W. Lynch, Ph.D, Mechanism and consequences of regulated alternative splicing
Michael S. Marks, Ph.D, Molecular mechanisms of intracellular protein transport and organelle biogenesis
Ronen Marmorstein, Ph.D, Epigenetics, Protein acetylation, MAPK signaling, Metabolism, Structural Biology, Enzymology, Inhibitor Development
Megan Matthews, Ph.D Chemical biology and enzymology.
Mustafa Mir, Ph.D Imaging, single molecule dynamics of gene expression
Andrew Modzelewski, Ph.D , Retrotransposon activity, Endogenous Retroviruses
Vera Moiseenkova-Bell, Ph.D, Cryo-EM, structure and function of transient receptor potential channels.
Kenji Murakami, Ph.D, Transcription initiation and regulation in eukaryote.
Maureen E. Murphy, Ph.D Tumor suppressor proteins, Cancer
John I. Murray, Ph.D., Embryonic transcriptional regulation; fate specification; cell lineages; C. elegans; microscopy
E. Michael Ostap, Ph.D, Biochemistry of contractile proteins, biophysics of cell motility, and characterization of unconventional myosins
Amish Patel, Ph.D Predictive computational framework for characterizing biomolecular hydration, interactions and assemblies
Trevor M. Penning, Ph.D, Structure-function of aldo-keto reductases; role in steroid hormone action and chemical carcinogenesis
E. James Petersson, Ph.D., Semi-synthesis of labeled proteins to probe and control conformation
Mecky Pohlschroder Prokaryotic Cell Surface Biogenesis and Function.
Benjamin L. Prosser, Ph.D., Mechano-signaling in the heart, Therapies for neurodevelopmental disorders.
Ravi Radhakrishnan, Ph.D, Computational structural biology, cell membrane mediated trafficking; targeted drug delivery; cancer signaling
Arjun Raj, Ph.D, Systems biology; developmental biology; non-coding RNA
Ravinder Reddy, Ph.D, Sodium and oxygen-17 MR methods; multiple quantum and polarization transfer MR techniques
Rhoades, Elizabeth. Functional and dysfunctional mechanisms of intrinsically disordered proteins
Harvey Rubin, MD, Ph.D, Pathogenesis of dormancy in mycobacterium tuberculosis; biomolecular computation, and enzymology
Brian M. Salzberg, Ph.D, Multiple-site optical recording; excitation-secretion coupling; neural networks
Jeffery G. Saven, Ph.D, Theory, simulation and design of proteins and folding molecules
Mark Sellmyer, MD, Ph.D Molecular Imaging, chemical biology, synthetic biology
Nikolaos Sgourakis, Ph.D Chemical and structural biology. Biomedical imaging, nanotechnology and supramolecular assemblies
Sydney Shaffer, MD, Ph.D Study of single cell phenotypes in development and disease
Kim A. Sharp, Ph.D Theory and simulation of protein and nucleic acid structure and function
Junwei Shi, Ph.D, Hepatocellular Carcinoma, epigenetic regulators, signal transduction
James Shorter, Ph.D, Regulation of neuropathogenic prions and amyloids by protein-remodeling factors, molecular chaperones
Hongjun Song, Ph.D, Neurogenesis and Epigenetic/Epitranscriptomic Mechanisms in the Nervous System
Yuanquan Song, Ph.D, Studying the formation, maintenance and function of neural circuits
Bin Tian, Ph.D RNA processing and metabolism in cancer and immunity.
Cornelius Taabazuing, Ph.D Innate immunity. Molecular mechanisms of cell death.
Aaron Timperman, Ph.D, Microfluidics, Nanofluidics, Proteomics, Lab on a chip
Paul M. Titchenell, Ph.D, Molecular mechanisms of insulin signaling and insulin resistance.
Dirk Trauner, Ph.D Chemical Biology, Optigenetic Control
Andrew Tsourkas, Ph.D Molecular imaging, drug delivery, nanotechnology, and biotherapeutics
Gregory D. Van Duyne, Ph.D, Structural biology; protein-protein interactions; x-ray crystallography
Sergei A. Vinogradov, Ph.D, Functional macromolecules, optical imaging probes, chemical biology, oxygen microscopy and tomography
Liling Wan, Ph.D , Chromatin and its regulatory network, cancer biology and epigenetics.
Kai Wang, Ph.D , Genomics and bioinformatics methods to treat rare diseases.
Felix W. Wehrli, Ph.D, MRI of biomaterials microstructure, mathematical modeling, image processing
Aalim Weljie, Ph.D, Circadian, sleep, environmental and cancer metabolism via metabolomics profiling
Kathryn E. Wellen, Ph.D, Cancer cell metabolism, nutrient sensing
Walter Witschey, Ph.D. Study of cardiovascular disease using imaging and computational biology.
Xiaolu Yang, Ph.D, Molecular mechanisms of apoptosis and how they may relate to cancer and other diseases.
Kenneth S. Zaret, Ph.D, Investigating transcription factor interactions with chromatin
Lijun Zhou, Ph.D, Nucleic Acid Chemistry, Non-Natural Nucleic Acids, Structural Biology, Artificial Cells
Zhaolan (Joe) Zhou, Ph.D, Epigenetic control of genome function in brain development and disease

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