Mourkioti Laboratory

Publications

 

Stanley A., Tichy ED, Kocan J, Roberts DW, Shore EM, Mourkioti F. Dynamics of skeletal muscle-resident stem cells during myogenesis in fibrodysplasia ossificans progressiva. NPJ Regen Med 2021, Accepted for publication.

Tichy ED,  Mourkioti F. Telomere length assessments of muscle stem cells in rodents and human skeletal muscle sections. Star Protocols 2021,  Sep 14;2(4):100830. doi: 10.1016/j.xpro.2021.100830. eCollection 2021 Dec 17. PMID: 34585163. 

Tichy ED, Ma N., Sidibe D., Loro E., Kocan J., Chen DZ., Khurana TS., Hasty P., Mourkioti F. Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening Cell Reports 2021 35 (6), 109098, May 11, 2021 doi:https://doi.org/10.1016/j.celrep.2021.109098. PMID: 33979621.

Yao L, Tichy ED, Zhong L, Mohanty S, Ai E, Yang S, Mourkioti F*, Qin L*. Gli1 defines a subset of fibroadipogenic progenitors that promote skeletal muscle regeneration with less fat accumulation * co-corresponding authors. J Bone Miner Res. 2021 Feb 2.  doi: 10.1002/jbmr.4265. PMID: 33529374.

Das S, Browne KD, Laimo FA, Maggiore JC, Himan MC, Kaiser H, Aguilar CA, Ali ZS, Mourkioti F, Cullen DK. Pre-innervated tissue engineered muscle promotes a pro-regenerative microenvironment following volumetric muscle loss. Communications Biology-Nature, 2020  Jun 25;3(1):330. doi: 10.1038/s42003-020-1056-4. PMID: 32587337.

Das S, Gordián-Vélez WJ, Ledebur HC, Mourkioti F, Rompolas P, Chen HI, Serruya MD, Cullen DK. Innervation: the missing link for biofabricated tissues and organs. NPJ Regen Med.-Nature 2020 Jun 5;5:11. doi: 10.1038/s41536-020-0096-1. eCollection 2020. PMID: 32550009. 

 

Stanley A, Heo SJ, Mauck RL, Mourkioti F, Shore EM. Elevated BMP and mechanical signaling through YAP1/RhoA Poises FOP Mesenchymal Progenitors for Osteogenesis. J Bone Miner Res. 2019 May 20. doi: 10.1002/jbmr.3760. [Epub ahead of print] PMID: 31107558

Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, Discher DE. Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest. Dev Cell. 2019 Jun 17;49(6):920-935.e5. doi: 10.1016/j.devcel.2019.04.020. Epub 2019 May 16. PMID: 31105008

Haupt J, Stanley A, McLeod CM, Cosgrove BD, Culbert AL, Wang L, Mourkioti F, Mauck RL, Shore EM. ACVR1R206H FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification. Mol Biol Cell. 2019 Jan 1;30(1):17-29. doi: 10.1091/mbc.E18-05-0311. Epub 2018 Oct 31. PMID: 30379592

Haupt J, Stanley A, McLeod CM, Cosgrove BD, Culbert AL, Wang L, Mourkioti F, Mauck RL, Shore EM.ACVR1R206H FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification. Mol Biol Cell. 2018 Oct 31:mbcE18050311. doi: 10.1091/mbc.E18-05-0311. [Epub ahead of print] PMID: 30379592

Tichy ED, Mourkioti F. Human Skeletal Stem Cells: The Markers Provide Some Clues in the Hunt for Hidden Treasure. Cell Stem Cell. 2018 Oct 4;23(4):462-463. doi: 10.1016/j.stem.2018.09.006. PMID:30290174.

Ho PP, Lahey LJ, Mourkioti F, Kraft PE, Filareto A, Brandt M, Magnusson KEG, Finn EE, Chamberlain JS, Robinson WH, Blau HM, Steinman L. Engineered DNA plasmid reduces immunity to dystrophin while improving muscle force in a model of gene therapy of Duchenne dystrophy. Proc Natl Acad Sci U S A. 2018 Sep 4. pii: 201808648. doi: 10.1073/pnas.1808648115. [Epub ahead of print] PMID:30181272.

Tichy ED, Sidibe DK, Greer CD, Oyster NM, Rompolas P, Rosenthal NA, Blau HM, Mourkioti F. A robust Pax7EGFP mouse that enables the visualization of dynamic behaviors of muscle stem cells. Skelet Muscle. 2018 Aug 24;8(1):27. doi: 10.1186/s13395-018-0169-7. PMID: 30139374.

 

Tichy ED, Sidibe DK, Tierney MT, Stec MJ, Sharifi-Sanjani M, Hosalkar H, Mubarak S, Johnson FB, Sacco A, Mourkioti F. Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles. Stem Cell Reports. 2017 Aug 30. pii: S2213-6711(17)30360-0. doi: 10.1016/j.stemcr.2017.08.003. [Epub ahead of print] PMID: 28890163.

Sharifi-Sanjani M, Oyster NM, Tichy ED, Bedi KC, Harel O, Margulies KB, Mourkioti F. Cardiomyocyte-Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans. J Am Heart Assoc. 2017 Sep 7;6(9). pii: e005086. doi: 10.1161/JAHA.116.005086. PMID:28882819

Sharifi-Sanjani M, Meeker AK, Mourkioti F. Evaluation of telomere length in human cardiac tissues using cardiac quantitative FISH. Nat Protoc. 2017 Sep;12(9):1855-1870. doi: 10.1038/nprot.2017.082. Epub 2017 Aug 17. PMID: 28817123

Theodoris CV, Mourkioti F, Huang Y, Ranade SS, Liu L, Blau HM, Srivastava D. Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency.   J Clin Invest. 2017 May 1;127(5):1683-1688. doi: 10.1172/JCI90338. Epub 2017 Mar 27. PMID: 28346225.

Tichy ED, Mourkioti F. A new method of genotyping MDX4CV mice by PCR-RFLP analysis. Muscle Nerve. 2017 Jan 7. doi: 10.1002/mus.25566. [Epub ahead of print] PMID:28063157.

Frederick DW, Loro E, Liu L, Davila A Jr, Chellappa K, Silverman IM, Quinn WJ 3rd, Gosai SJ, Tichy ED, Davis JG, Mourkioti F, Gregory BD, Dellinger RW, Redpath P, Migaud ME, Nakamaru-Ogiso E, Rabinowitz JD, Khurana TS, Baur JA. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metab. 2016 Aug 9;24(2):269-82. doi: 10.1016/j.cmet.2016.07.005. PMID: 27508874

Cosgrove BD, Gilbert PM, Porpiglia E, Mourkioti F, Lee SP, Corbel SY, Llewellyn ME, Delp SL, Blau HM. Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nat Med. 2014 Mar;20(3):255-64. doi: 10.1038/nm.3464. Epub 2014 Feb 16. PMID: 24531378.

 

Mourkioti F, Kustan J, Kraft P, Day JW, Zhao MM, Kost-Alimova M, Protopopov A, DePinho RA, Bernstein D, Meeker AK, Blau HM. Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy. Nat Cell Biol. 2013 Aug;15(8):895-904. doi: 10.1038/ncb2790. Epub 2013 Jul 7. PMID: 23831727

This paper was highlighted in Nature under “Research Highlights: Disease Research” section: (2013) Short Telomeres Damage Heart. Nature, 499:129.

Sacco, A*., Mourkioti, F*., Tran, R., Choi, J., Llewellyn, M., Kraft, P., Shkreli, M., Delp , S., Pomerantz, JH., Artandi, SE., Blau HM. (2010) Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice. Cell, 143(7):1059-71. Epub 2010 Dec 9. *Authors contributed equally.

This paper was highlighted under Faculty 1000

Kratsios, P., Catela, C., Salimova, E., Huth, M., Berno, V., Rosenthal, N., and Mourkioti, F. (2010) Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart. Circ. Res.,106(3):559-72. Epub 2009 Dec 10.

Kratsios, P., Huth, M., Temmerman, L., Salimova, E., Al Banchaabouchi, M., Sgoifo, A., Manghi, M., Suzuki, K., Rosenthal, N., and Mourkioti, F**. (2010)Antioxidant amelioration of dilated cardiomyopathy caused by conditional deletion of NEMO/IKKgamma in cardiomyocytes. Circ Res., 106(1):133-44. Epub 2009 Oct. 22. ** corresponding author.

This paper was highlighted in Circulation Research under “Editorials” section: Nemchenko, A., Hill, J.A. (2010) NEMO nuances NF-kappaB. Circ. Res. 106(1):10-2.

Ruffell D*, Mourkioti F*, Gambardella A*, Kirstetter P, Lopez RG, Rosenthal N, Nerlov C. A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17475-80. doi: 10.1073/pnas.0908641106. Epub 2009 Sep 24. PMID:19805133. * authors contributed equally.

Mourkioti F, Slonimsky E, Huth M, Berno V, Rosenthal N. Analysis of CRE-mediated recombination driven by myosin light chain 1/3 regulatory elements in embryonic and adult skeletal muscle: a tool to study fiber specification. Genesis. 2008 Aug;46(8):424-30. doi: 10.1002/dvg.20419. PMID:18693277.

Mourkioti F, Rosenthal N.NF-kappaB signaling in skeletal muscle: prospects for intervention in muscle diseases. J Mol Med (Berl). 2008 Jul;86(7):747-59. doi: 10.1007/s00109-008-0308-4. Epub 2008 Feb 2. Review. PMID:18246321. 

Lara-Pezzi E, Winn N, Paul A, McCullagh K, Slominsky E, Santini MP, Mourkioti F, Sarathchandra P, Fukushima S, Suzuki K, Rosenthal N.A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration. J Cell Biol. 2007 Dec 17;179(6):1205-18. PMID: 18086917.

Mourkioti F, Kratsios P, Luedde T, Song YH, Delafontaine P, Adami R, Parente V, Bottinelli R, Pasparakis M, Rosenthal N. Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration. J Clin Invest. 2006 Nov;116(11):2945-54. Erratum in: J Clin Invest. 2007 Jan;117(1):277.  PMID: 17080195.

This paper was highlighted in Journal of Clinical Investigation under “Commentaries” section: Karin, M. Role for IKK2 in muscle: waste not, want not. J. Clin. Invest. 116(11):2866-8.

Mourkioti F, Rosenthal N. IGF-1, inflammation and stem cells: interactions during muscle regenerationTrends Immunol. 2005 Oct;26(10):535-42. Review. PMID: 16109502.

Peter A, Schöttler P, Werner M, Beinert N, Dowe G, Burkert P, Mourkioti F, Dentzer L, He Y, Deak P, Benos PV, Gatt MK, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demaille J, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Borkova D, Miñana B, Kafatos FC, Bolshakov S, Sidén-Kiamos I, Papagiannakis G, Spanos L, Louis C, Madueño E, de Pablos B, Modolell J, Bucheton A, Callister D, Campbell L, Henderson NS, McMillan PJ, Salles C, Tait E, Valenti P, Saunders RD, Billaud A, Pachter L, Klapper R, Janning W, Glover DM, Ashburner M, Bellen HJ, Jäckle H, Schäfer U. Mapping and identification of essential gene functions on the X chromosome of Drosophila. EMBO Rep. 2002 Jan;3(1):34-8. Epub 2001 Dec 19. PMID: 11751581.

Benos PV, Gatt MK, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demaille J, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Borkova D, Miñana B, Kafatos FC, Bolshakov S, Sidén-Kiamos I, Papagiannakis G, Spanos L, Louis C, Madueño E, de Pablos B, Modolell J, Peter A, Schöttler P, Werner M, Mourkioti F, Beinert N, Dowe G, Schäfer U, Jäckle H, Bucheton A, Callister D, Campbell L, Henderson NS, McMillan PJ, Salles C, Tait E, Valenti P, Saunders RD, Billaud A, Pachter L, Glover DM, Ashburner M.  From first base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. Genome Res. 2001 May;11(5):710-30. PMID: 11337470.

Benos PV, Gatt MK, Ashburner M, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demailles J, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Borkova D, Minana B, Kafatos FC, Louis C, Sidén-Kiamos I, Bolshakov S, Papagiannakis G, Spanos L, Cox S, Madueño E, de Pablos B, Modolell J, Peter A, Schöttler P, Werner M, Mourkioti F, Beinert N, Dowe G, Schäfer U, Jäckle H, Bucheton A, Callister DM, Campbell LA, Darlamitsou A, Henderson NS, McMillan PJ, Salles C, Tait EA, Valenti P, Saunder RD, Glover DM. From sequence to chromosome: the tip of the X chromosome of D. melanogaster. Science. 2000 Mar 24;287(5461):2220-2. PMID: 10731137.

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