McKay Orthopaedic Research Laboratory

Sung-Han Jo, Ph.D.

Post-Doctoral Fellow 
University of Pennsylvania

Hometown

Busan, South Korea

Education

Ph.D. Biomedical Engineering, Pukyong National University 2024

M.S., Biomedical Engineering Pukyong National University 2020

B.S., Biomedical Engineering Pukyong National University 2018

Areas of Special Interest

I’m interested in the use of exosomes in regenerative medicine and pathological analysis, particularly extracellular matrix-anchored exosomes. I'm also interested in natural polymer chemistry with ECM-based self-healing materials and bioorthogonal injectable delivery systems. In my free time, I like watching movies and traveling.

Publications

• Iman Gholamali, Sung-Han Jo, Won Han, Juhee Lim, Ali Rizwan, Sang-Hyug Park, Kwon Taek Lim: The Diels-Alder Cross-Linked Gelatin/Dextran Nanocomposite Hydrogels with Silver Nanoparticles for Wound Healing Applications: Synthesis, Characterization, and In Vitro Evaluation. Gels 2024, 10, 408.
• Iman Gholamali, Trung Thang Vu, Sung-Han Jo, Sang-Hyug Park, Kwon Taek Lim: Exploring the Progress of Hyaluronic Acid Hydrogels: Synthesis, Characteristics, and Wide-Ranging Applications. Materials 2024, 17, 2439.
• Viswanathan Karthika*, Sung‐Han Jo*, Sonyabapu Yadav, Obireddy Sreekanth Reddy, Hae Gyun Lim, Won‐Ki Lee, Sang‐Hyug Park, Kwon Taek Lim: Self‐Signal‐Triggered Drug Delivery System for Tumor Therapy Using Cancer Cell Membrane‐Coated Biocompatible Mn3O4 Nanocomposites. Advanced Biology 2024, 2300375. (*: Equal contributions as first authors)
• Trung Thang Vu*, Sung-Han Jo*, Seon-Hwa Kim, Byeong Kook Kim, Sang-Hyug Park, Kwon Taek Lim: Injectable and Multifunctional Hydrogels Based on Poly (N-Acryloyl Glycinamide) and Alginate Derivatives for Antitumor Drug Delivery. ACS Applied Materials & Interfaces 2024, 16, 15322–15335. (*: Equal contributions as first authors)
• Israr Ali, Ali Rizwan, Trung Thang Vu, Sung-Han Jo, Chul-Woong Oh, Yong Hyun Kim, Sang-Hyug Park, Kwon Taek Lim: NIR-Responsive Carboxymethyl-Cellulose Hydrogels Containing Thioketal-Linkages for on-Demand Drug Delivery System. International Journal of Biological Macromolecules 2024, 260, 129549.
• Ali Rizwan, Israr Ali, Sung-Han Jo, Trung Thang Vu, Yeong-Soon Gal, Yong Hyun Kim, Sang-Hyug Park, Kwon Taek Lim: Facile Fabrication of NIR-Responsive Alginate/CMC Hydrogels Derived through IEDDA Click Chemistry for Photothermal–Photodynamic Anti-Tumor Therapy. Gels 2023, 9, 961.
• Jeong-Woo Seo, Sung-Han Jo, Seon-Hwa Kim, Byeong-Hoon Choi, Hongsik Cho, James J Yoo, Sang-Hyug Park: Application of Cartilage Extracellular Matrix to Enhance Therapeutic Efficacy of Methotrexate. Tissue Engineering and Regenerative Medicine 1–13 (2023).
• Byeong-Hoon Choi, Sung-Han Jo, Sang-Hyug Park: Characterization of Sea Urchin Gonad-Derived Extracellular Vesicles and Study of Their Effects on Nerve Cells. Journal of Biomedical Engineering Research 2024, 45, 20–25.
• Trung Thang Vu, Sonyabapu Yadav, Obireddy Sreekanth Reddy, Sung-Han Jo, Soo-Bin Joo, Byeong Kook Kim, Eun Ju Park, Sang-Hyug Park, Kwon Taek Lim: Reduction-Responsive Chitosan-Based Injectable Hydrogels for Enhanced Anticancer Therapy. Pharmaceuticals 16, 841 (2023).
• Ali Rizwan, Muhammad Gulfam, Sung-Han Jo, Jeong-Woo Seo, Israr Ali, Trung Thang Vu, Soo-Bin Joo, Sang-Hyug Park, Kwon Taek Lim: Gelatin-based NIR and reduction-responsive injectable hydrogels cross-linked through IEDDA click chemistry for drug delivery application. European Polymer Journal 191, 112019 (2023).
• Trung Thang Vu, Muhammad Gulfam, Sung-Han Jo, Ali Rizwan, Soo-Bin Joo, Bonggi Lee, Sang-Hyug Park, Kwon Taek Lim: The effect of molecular weight and chemical structure of cross-linkers on the properties of redox-responsive hyaluronic acid hydrogels. International Journal of Biological Macromolecules 238, 124285 (2023).
• Sonyabapu Yadav, Kalyan Ramesh, Obireddy Sreekanth Reddy, Viswanathan Karthika, Parveen Kumar, Sung-Han Jo, Seong II Yoo, Sang-Hyug Park, Kwon Taek Lim: Redox-Responsive Comparison of Diselenide and Disulfide Core-Cross-Linked Micelles for Drug Delivery Application. Pharmaceutics 15, 1159 (2023).
• Muhammad Gulfam, Sung-Han Jo, Trung Thang Vu, Israr Ali, Ali Rizwan, Soo-Bin Joo, Sang-Hyug Park, Kwon Taek Lim: NIR-degradable and biocompatible hydrogels derived from hyaluronic acid and coumarin for drug delivery and bio-imaging. Carbohydrate Polymers 120457 (2022).
• Parveen Kumar, Seon-Hwa Kim, Sonyabapu Yadav, Sung-Han Jo, Seong Yoo, Sang-Hyug Park, Kwon Taek Lim: Redox-Responsive Core-Cross-Linked Micelles of Miktoarm Poly (ethylene oxide)-b-poly (furfuryl methacrylate) for Anticancer Drug Delivery. ACS Applied Materials & Interfaces (2023).
• Alka Ashok Singh, Sung‐Han Jo, Anley Teferra Kiddane, Irvine Niyonizigiye, Gun‐Do Kim: Indole‐3‐carbinol induces apoptosis in AGS cancer cells via mitochondrial pathway. Chemical Biology & Drug Design (2023).
• Sang-Hun Lee, Sung-Han Jo, Seon-Hwa Kim, Chang-Su Kim, Sang-Hyug Park: Anti-Osteoarthritic Effects of Cartilage-Derived Extracellular Matrix in a Rat Osteoarthritis Model. Tissue Engineering and Regenerative Medicine 20, 83–92 (2023).
• Seon-Hwa Kim, Sung-Han Jo, Byeong Kook Kim, Sang-Hyug Park: Tissue Engineered Mini-Cornea Model for Eye Irritation Test. Tissue Engineering and Regenerative Medicine 1–11 (2022).
• Muhammad Gulfam*, Sung-Han Jo*, Sung-Woo Jo, Trung Thang Vu, Sang-Hyug Park, Kwon Taek Lim: Highly porous and injectable hydrogels derived from cartilage acellularized matrix exhibit reduction and NIR light dual-responsive drug release properties for application in antitumor therapy. NPG Asia Materials 14, 1–17 (2022). (*: Equal contributions as first authors)
• Israr Ali, Muhammad Gulfam, Sung-Han Jo, Jeong-Woo Seo, Ali Rizwan, Sang-Hyug Park, Kwon Taek Lim: Reduction-responsive and bioorthogonal carboxymethyl cellulose based soft hydrogels cross-linked via IEDDA click chemistry for cancer therapy application. International Journal of Biological Macromolecules 219, 109–120 (2022).
• Soo-Bin Joo, Muhammad Gulfam, Sung-Han Jo, Yi-Jun Jo, Trung Thang Vu, Sang-Hyug Park, Yeong-Soon Gal, Kwon Taek Lim: Fast Absorbent and Highly Bioorthogonal Hydrogels Developed by IEDDA Click Reaction for Drug Delivery Application. Materials 15, 7128 (2022).
• Huong Thi Hoang, Trung Thang Vu, Viswanathan Karthika, Sung-Han Jo, Yi-Jun Jo, Jeong-Woo Seo, Chul-Woong Oh, Sang-Hyug Park, Kwon Taek Lim: Dual cross-linked chitosan/alginate hydrogels prepared by Nb-Tz ‘click’reaction for pH responsive drug delivery. Carbohydrate Polymers 288, 119389 (2022).
• Kalyan Ramesh, Sonyabapu Yadav, Avnish Kumar Mishra, Sung‐Han Jo, Sang‐Hyug Park, Chul‐Woong Oh, Kwon Taek Lim: Interface‐cross‐linked micelles of poly (D, L‐lactide)‐b‐poly (furfuryl methacrylate)‐b‐poly (N‐acryloylmorpholine) for near‐infrared‐triggered drug delivery application. Polymers for Advanced Technologies 33, 2137–2148 (2022).
• Yi-Jun Jo, Muhammad Gulfam, Sung-Han Jo, Yeong-Soon Gal, Chul-Woong Oh, Sang-Hyug Park, Kwon Taek Lim: Multi-stimuli responsive hydrogels derived from hyaluronic acid for cancer therapy application. Carbohydrate Polymers 286, 119303 (2022).
• Sonyabapu Yadav, Parveen Kumar, Sung-Han Jo, Sang-Hyug Park, Won-Ki Lee, Seong II Yoo, Kwon Taek Lim: Redox-responsive properties of core-cross-linked micelles of poly (ethylene oxide)-b-poly (furfuryl methacrylate) for anticancer drug delivery application. Reactive and Functional Polymers 175, 105271 (2022).
• Trung Thang Vu, Muhammad Gulfam, Sung-Han Jo, Sang-Hyug Park, Kwon Taek Lim: Injectable and biocompatible alginate-derived porous hydrogels cross-linked by IEDDA click chemistry for reduction-responsive drug release application. Carbohydrate Polymers 118964 (2021).
• Tae‐Hee Kim, Seong‐Yeong Heo, Gun‐Woo Oh, Won Sun Park, Il‐Whan Choi, Hyun Wook Kang, Hyun‐Woo Kim, Young‐Mog Kim, Sung‐Han Jo, Sang‐Hyug Park, Won‐Kyo Jung: A phlorotannins‐loaded homogeneous acellular matrix film modulates post‐implantation inflammatory responses. Journal of Tissue Engineering and Regenerative Medicine 16, 51–62 (2022).
• Sonyabapu Yadav, Kalyan Ramesh, Parveen Kumar, Sung-Han Jo, Seong II Yoo, Yeong-Soon Gal, Sang-Hyug Park, Kwon Taek Lim: Near-Infrared Light-Responsive Shell-Crosslinked Micelles of Poly (d, l-lactide)-b-poly ((furfuryl methacrylate)-co-(N-acryloylmorpholine)) Prepared by Diels–Alder Reaction for the Triggered Release of Doxorubicin. Materials 14, 7913 (2021).
• Sung-Han Jo, Seon-Hwa Kim, Changsu Kim, Sang-Hyug Park: Characterization of Marine Organism Extracellular Matrix-Anchored Extracellular Vesicles and Their Biological Effect on the Alleviation of Pro-Inflammatory Cytokines. Marine Drugs 19, 592 (2021).
• Huong Thi Hoang, Sung-Han Jo, Quoc-Thang Phan, Hansol Park, Sang-Hyug Park, Chul-Woong Oh, Kwon Taek Lim: Dual pH-/thermo-responsive chitosan-based hydrogels prepared using" click" chemistry for colon-targeted drug delivery applications. Carbohydrate Polymers 260, 117812 (2021).
• Sung-Han Jo, Changsu Kim, Sang-Hyug Park: Novel Marine Organism-Derived Extracellular Vesicles for Control of Anti-Inflammation. Tissue Engineering and Regenerative Medicine 18, 71–79 (2021).

Patents

• Sung-Han Jo, Won-Sang Yun, Seong-Jun Jung, and Sang-Hyug park “Tear collecting lens” (South Korea, Number: 1020314880000)
• Sung-Han Jo, Changsu Kim, and Sang-Hyug Park “Enhanced functional Pharmaceutical composition of extracellular vesicles  derived marine animal” (South Korea, Number: 1020220051297)
• Sung-Han Jo, Changsu Kim, Sang-Hun Lee, and Sang-Hyug Park “Pharmaceutical composition for preventing or treating osteoarthritis comprising extracellular matrix derived cartilage tissue” (South Korea, Number:  1020220051298)
• Sun-Han Jo, Seon-Hwa Kim, and Sang-Hyug Park “Composition for preventing and treating atopic dermatitis comprising extracellular vesicles derived from sea cucumbers” (South Korea, Number: 1020240003301)
• Sun-Han Jo, Seon-Hwa Kim, and Sang-Hyug Park “Extracellular matrix derived cartilage tissue based hydrogel and method for preparing the same” (South Korea, Number: 1020240014570)