Smith/Malhotra Laboratory

Yian Khai (Adrian) Lau, M.S.

Yian Khai (Adrian) Lau, M.S.

Research Engineer
University of Pennsylvania

Hometown

Penang, Malaysia

Education

M.S. (Biotechnology) University of Pennsylvania, 2020
B.S. (Biomedical Engineering) Pennsylvania State University, 2017

Areas of Special Interest

Pathogenesis and Treatment of Spine Disease in Mucopolysaccharidosis Disorders
Regeneration of Intervertebral Disc Using Notochord-derived Cells and Mesenchymal Stem Cells

Publications

Jiang Z, Lau YK, Wu M, Casal ML, Smith LJ. Ultrastructural Analysis of Different Skeletal Cell Types in Mucopolysaccharidosis Dogs at the Onset of Postnatal Growth. Journal of Anatomy In Press, 2020

Zhang C, Gullbrand SE, Schaer TP, Lau YK, Jiang Z, Elliott DM, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Inflammatory Cytokine and Catabolic Enzyme Expression in a Preclinical Goat Model of Intervertebral Disc Degeneration. Journal of Orthopaedic Research In Press, 2020

Abstracts

Zhang C, Schaer TP, Gullbrand SE, Jiang Z, Lau YK, Elliott DM, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Inflammatory Cytokine and Catabolic Enzyme Expression in a Goat Model of Intervertebral Disc Degeneration. 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020. (Poster)

Jiang Z, Lau YK, Casal ML, Smith LJ: Ultrastructural Analysis of Different Skeletal Cell Types in Mucopolysaccharidosis Dogs at the Onset of Postnatal Growth. 66th Annual Meeting. 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020. (Poster)

Jiang Z, Johnson CP, Nykänen O, Nissi M, Lau YK, Wu M, Ludwig K, Ellerman J, Casal ML, Smith LJ: Abnormal Vascularity and Extracellular Matrix Remodeling are Associated with Delayed Secondary Ossification in Mucopolysaccharidosis VII. 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020. (Poster)

Peck SH, Lau YKA, Bendigo JR, Lin M, Arginteanu T, Bagel JH, O’Donnell P, Malhotra NR, Klein PS, Shore EM, Casal ML, Smith LJ. Lithium-mediated effects on vertebral bone formation in mucopolysaccharidosis I dogs during postnatal growth. American Society of Bone and Mineral Research Annual Meeting, Montreal, Canada. September 2018. (Accepted for Poster)

Peck SH, Lau YKA, Bendigo JR, Lin M, Bagel JH, O’Donnell P, Fitzgerald CA, Molony C, Malhotra NR, Shore EM, Casal ML, Smith LJ. Effects of lithium treatment on bone turnover in mucopolysaccharidosis I dogs during postnatal growth. 15th International Symposium on MPS and Related Diseases, San Diego, CA. Aug 2018. (Poster)

Smith LJ, Peck SH, Lin G, Lau YKA, Bagel JH, O’Donnell P, Fitzgerald CA, Molony C, Malhotra Nr, Casal ML. Effects of enzyme replacement therapy on skeletal disease in mucopolysaccharidosis VII dogs: preliminary findings. 15th International Symposium on MPS and Related Diseases, San Diego, CA. Aug 2018. (Poster) 

Peck SH, Lau YA, Kang JL, Matalon DR, Lin M, Bagel JH, O’Donnell PA, Fitzgerald CA, Molony CM, Malhotra NR, Shore EM, Casal ML, Smith LJ. Impaired bone formation in mucopolysaccharidosis VII dogs during postnatal growth is associated with lower serum levels of bone-specific alkaline phosphatase. WORLD Symposium, Lysosomal Diseases Network, San Diego, CA. February 2018. (Late-Breaking Poster)

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