Yian Khai (Adrian) Lau, M.S.
Research Engineer
University of Pennsylvania
Hometown
Penang, Malaysia
Education
M.S. (Biotechnology) University of Pennsylvania, 2020
B.S. (Biomedical Engineering) Pennsylvania State University, 2017
Areas of Special Interest
Pathogenesis and Treatment of Spine Disease in Mucopolysaccharidosis Disorders
Regeneration of Intervertebral Disc Using Notochord-derived Cells and Mesenchymal Stem Cells
Publications
Lau YK, Peck SH, Arginteanu T, Wu M, Lin M, Shore EM, Klein PS, Casal ML, Smith LJ: Effects of Lithium Administration on Vertebral Bone Disease in Mucopolysaccharidosis I Dogs. Bone In press, 2021.
Peck SH, Lau YK, Kang JL, Lin M, Arginteanu T, Matalon DR, Bendigo JR, O’Donnell P, Haskins ME, Casal ML, Smith LJ : Progression of Vertebral Bone Disease in Mucopolysaccharidosis VII Dogs from Birth to Skeletal Maturity. Molecular Genetics and Metabolism In press, 2021
Jiang Z, Johnson CJ, Nykanen O, Nissi M, Lau YK, Wu M, Casal ML, Smith LJ: Epiphyseal Cartilage Canal Architecture and Extracellular Matrix Remodeling in Mucopolysaccharidosis VII Dogs at the Onset of Postnatal Growth. Connective Tissue Research In press, 2021
Jiang Z, Lau YK, Wu M, Casal ML, Smith LJ. Ultrastructural Analysis of Different Skeletal Cell Types in Mucopolysaccharidosis Dogs at the Onset of Postnatal Growth. Journal of Anatomy In Press, 2020
Zhang C, Gullbrand SE, Schaer TP, Lau YK, Jiang Z, Elliott DM, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Inflammatory Cytokine and Catabolic Enzyme Expression in a Preclinical Goat Model of Intervertebral Disc Degeneration. Journal of Orthopaedic Research In Press, 2020
Abstracts
Lau YK, Gawri R, Shetye S, Abdoun K, Dodge GR, Casal ML, Smith LJ: Mucopolysaccharidosis I And VII Dogs Exhibit Impaired Anterior Cruciate Ligament Mechanical Properties. 67th Annual Meeting, Orthopaedic Research Society, Tampa, USA 2021. (Poster)
Zhang C, Zhong L, Lau YK, Wu M, Qin L, Malhotra NR, Smith LJ: Single-cell Transcriptomics Reveals Emergent Nucleus Pulposus Cell Subpopulations In The Postnatal Mouse Disc. 67th Annual Meeting, Orthopaedic Research Society, Tampa, USA 2021. (Podium)
Zhang C, Lau YK, Kim DH, Gawri R, Schaer TP, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Effects Of Organ Culture And Mesenchymal Stem Cell Delivery On The Cellular Composition Of The Nucleus Pulposus. 67th Annual Meeting, Orthopaedic Research Society, Tampa, USA 2021. (Poster)
Zhang C, Gawri R, Lau YK, Casal ML, Dodge GR, Smith LJ: Proteomic Screening Identifies Novel Biomarker Candidates For Synovial Joint Disease In Mucopolysaccharidosis I Dogs. 67th Annual Meeting, Orthopaedic Research Society, Tampa, USA 2021. (Poster)
Zhang C, Schaer TP, Gullbrand SE, Jiang Z, Lau YK, Elliott DM, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Inflammatory Cytokine and Catabolic Enzyme Expression in a Goat Model of Intervertebral Disc Degeneration. 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020. (Poster)
Gawri R, Lau YK, Dodge GR, Scanzello CR, Mai W, Casal ML, Smith LJ: Local And Systemic Biomarkers Of Synovial Joint Disease In Mucopolysaccharidosis VII Dogs 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020. (Poster)
Jiang Z, Lau YK, Casal ML, Smith LJ: Ultrastructural Analysis of Different Skeletal Cell Types in Mucopolysaccharidosis Dogs at the Onset of Postnatal Growth. 66th Annual Meeting. 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020. (Poster)
Jiang Z, Johnson CP, Nykänen O, Nissi M, Lau YK, Wu M, Ludwig K, Ellerman J, Casal ML, Smith LJ: Abnormal Vascularity and Extracellular Matrix Remodeling are Associated with Delayed Secondary Ossification in Mucopolysaccharidosis VII. 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020. (Poster)
Peck SH, Lau YKA, Bendigo JR, Lin M, Arginteanu T, Bagel JH, O’Donnell P, Malhotra NR, Klein PS, Shore EM, Casal ML, Smith LJ. Lithium-mediated effects on vertebral bone formation in mucopolysaccharidosis I dogs during postnatal growth. American Society of Bone and Mineral Research Annual Meeting, Montreal, Canada. September 2018. (Poster)
Peck SH, Lau YKA, Bendigo JR, Lin M, Bagel JH, O’Donnell P, Fitzgerald CA, Molony C, Malhotra NR, Shore EM, Casal ML, Smith LJ. Effects of lithium treatment on bone turnover in mucopolysaccharidosis I dogs during postnatal growth. 15th International Symposium on MPS and Related Diseases, San Diego, CA. Aug 2018. (Poster)
Smith LJ, Peck SH, Lin G, Lau YKA, Bagel JH, O’Donnell P, Fitzgerald CA, Molony C, Malhotra Nr, Casal ML. Effects of enzyme replacement therapy on skeletal disease in mucopolysaccharidosis VII dogs: preliminary findings. 15th International Symposium on MPS and Related Diseases, San Diego, CA. Aug 2018. (Poster)
Peck SH, Lau YA, Kang JL, Matalon DR, Lin M, Bagel JH, O’Donnell PA, Fitzgerald CA, Molony CM, Malhotra NR, Shore EM, Casal ML, Smith LJ. Impaired bone formation in mucopolysaccharidosis VII dogs during postnatal growth is associated with lower serum levels of bone-specific alkaline phosphatase. WORLD Symposium, Lysosomal Diseases Network, San Diego, CA. February 2018. (Late-Breaking Poster)