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Welcome to the Center For Advanced Metabolic Imaging in Precision Medicine (CAMIPM), a National Center for Biomedical Imaging and Bioengineering (NCBIB) in the Perelman School of Medicine at the University of Pennsylvania.
Principal Investigator: Ravinder Reddy, Ph.D., Director and Professor of Radiology
The CAMIPM develops and translates cutting edge noninvasive metabolic imaging biomarkers for use in biomedical research. Technology development is focused in four major application areas: Oncology, Cardiovascular disease, Neuropsychiatry, and Musculoskeletal disorders. These technologies will have substantial impact on the fundamental understanding of disease mechanisms, early diagnosis, and development of novel therapies for several diseases such as Alzheimer’s disease, Epilepsy, Arthritis, Cancer, Stroke, and heart disease, and thus contribute to precision medicine and enhanced patient care. The facility’s core sections provide research and computing resources for numerous user, collaborative, and training projects.
The focus of this center is on developing instrumentation, methodologies, and data analysis techniques for the quantitative assessment of functional, structural, and metabolic parameters in humans with the use of chemical exchange weighted molecular magnetic resonance imaging (MRI), MRI of oxygen consumption, down field spectroscopy, and diffuse optical imaging techniques.
We are supported by the NIBIB under Grant No. P41 EB029460.
CAMIPM Seminar Series
"Deep tissue optical spectroscopy using handheld, wearable, and implantable devices"
Thomas O'Sullivan, PhD
Associate Professor of Electrical Engineering
University of Notre Dame
URL: https://engineering.nd.edu/faculty/thomas-osullivan/
Abstract:
Diffuse optical spectroscopy (DOS) is a class of biomedical imaging and sensing modalities that use red and near-infrared light to noninvasively interrogate the composition and function of living tissues and cells. DOS-based modalities are advantageous because they offer sub-micromolar sensitivity to tissue composition, perfusion, and oxygen metabolism; low patient risk since DOS requires neither ionizing radiation nor contrast agents; and relatively low-cost instrumentation. Consequently, DOS methods are applied in several major areas of clinical research: neurological function and disease, cancer, cardiovascular disease, metabolic disease, and trauma/critical care.
In this presentation I will discuss our work to develop ultraportable quantitative DOS instrumentation based upon frequency-domain near-infrared spectroscopy. Our handheld and wearable DOS systems offer real-time sensing/imaging with high accuracy. Importantly, they are designed to be easy and fast to use to enable new investigations into clinical and consumer applications. I will conclude by describing our preclinical needle-injectable wireless optical devices for surgical guidance, tumor monitoring, and photodynamic therapy.
Date: Thursday, March 20, 2025
Location: Room 1412 BRB2
Time: 3:00 PM
Zoom link:
https://pennmedicine.zoom.us/j/93435730386?pwd=YmxHa2I5Ny9wWWlZNzBPU3ZJR05sQT09
Meeting ID: 934 3573 0386
Passcode: 897997