Narayan Datt Soni, Ph.D.
Postdoctoral Researcher, Department of Radiology
Contact Information
Tel: 215-898-9357
Fax: 215-573-2113
Email: narayan.soni@pennmedicine.upenn.edu
Education:
PhD, 2021, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India
M.Sc. (Biochemistry), 2014, University of Hyderabad, Hyderabad, India
B.Sc. (Hons.) Chemistry, 2012, Banaras Hindu University, Varanasi, India
Research Interests:
Narayan’s research interest is primarily focused on development of novel strategies for the early diagnosis of Alzheimer’s (AD) and other neurodegenerative diseases. In addition, he is exploring the potential of ketogenic diets in alleviation of AD related pathologies. Currently he is leading following projects:
1) Investigation of age dependent and tauopathy induced changes in the level of regional cerebral glutamate and myo-Inositol in mouse models of Alzheimer’s disease (AD) using glutamate CEST (GluCEST), myo-Inositol CEST (MICEST) MRI respectively, followed by the validation of findings via localized in vivo 1H-MRS and immunohistochemical studies.
2) Development of novel strategies for the assessment of cerebral metabolism and neuronal activity through administration of 2H-labelled energy substrates followed by 2H-MRS/I.
Soni ND, Ramesh A, Roy D, Patel AB (2021), Brain energy metabolism in intracerebroventricularly administered streptozotocin mouse model of Alzheimer's disease: A 1H-[13C]-NMR study. J Cereb Blood Flow Metab. 2021;41(9):2344-2355.
Sarawagi A, Soni ND, Patel AB (2021), Glutamate and GABA Homeostasis and Neurometabolism in Major Depressive Disorder. Front Psychiatry. 2021;12:637863.
Papers presented in Scientific Conferences:
Soni ND, Nanga RPR, Halvor J and Reddy R (2022) Mapping of Early-Stage Changes in Cerebral Glutamate in APPNL-F/NL-F Mouse Model of Alzheimer’s Disease Using GluCEST MRI (Abstract ID-7984) Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting 07-12 May 2022, London, UK
Soni ND, Roy D, Ramesh A and Patel AB (2020) Neuronal and Astroglial Metabolism in icv-STZ Mouse Model of Alzheimer’s Disease: A 1H-[13C]-NMR Study (Abstract ID-6792), ISMRM & SMRT Virtual Conference & Exhibition 08-14 August 2020,
Soni ND, Sreemantula AK, Roy D and Patel AB (2018) Understanding the Role of Gender in Progression and Severity of Alzheimer’s Disease: A 1H-[13C]-NMR Investigation (Abstract ID-7699), Joint Annual Meeting ISMRM-ESMRMB 16-21 June 2018, Paris, France
Award:
“The ISMRM Magna Cum Laude Merit Award” for the research work presented at ISMRM & SMRT Virtual Conference & Exhibition 08-14 August 2020